• EAC comprises a heterogeneous group of tumors of varying etiology and morphology ( 10 - 12 ). (iiarjournals.org)
  • Загальні відомості про лімфоми Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)
  • Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
  • Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment. (spandidos-publications.com)
  • Tumor cells are influenced by both genetic factors and environmental elements in the microenvironment, resulting in a complex regulation process ( 1 ). (spandidos-publications.com)
  • Various subclonal tumor cells have the ability to modify the tumor microenvironment in order to obtain adaptations. (spandidos-publications.com)
  • Furthermore, tumor heterogeneity has a significant impact on both the immune microenvironment and the infiltration of various immune cells within tumors, such as cytotoxic T lymphocytes (CTLs) ( 5 ), myeloid antigen-presenting cells ( 6 ) and cancer-associated fibroblasts (CAFs) ( 7 ). (spandidos-publications.com)
  • It has been discovered that the genetic structure of tumor cells and the components of the immune microenvironment interact with each other. (spandidos-publications.com)
  • This interaction results in a more complex alteration of both the heterogeneity of tumor cells and the heterogeneity of the tumor microenvironment. (spandidos-publications.com)
  • Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. (elifesciences.org)
  • The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
  • It is considered that the proportional distribution of cells in peripheral blood count may reflect the severity of inflammation in the tumor microenvironment. (researchsquare.com)
  • The tumor microenvironment typically consists of host components including chronic inflammatory cells, stromal cells, growing vascular cells, and inflammatory infiltrate. (researchsquare.com)
  • Tumor-associated macrophages (TAMs) are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. (researchsquare.com)
  • Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
  • However, the cellular environment under 2D culture is very different and often a poor reflection of the complex tumor microenvironment (TME) in vivo [ 1 ]. (medsci.org)
  • In addition, heterogeneity of the tumor microenvironment was explored, and distinct subtypes of immune cells and fibroblasts in PDAC were characterized. (biomedcentral.com)
  • Exploring highly expressed pathways in stromal components, such as fibroblasts, will delineate the underlying mechanisms that are pivotal for tumor microenvironment maintenance. (biomedcentral.com)
  • New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
  • Thus, the term "carcinoid" was replaced by the term "gastroenteropancreatic neuroendocrine tumors, GEP-NETs"[ 2 ]. (wjgnet.com)
  • Pancreatic neuroendocrine tumors may be functional or nonfunctional. (medscape.com)
  • Overall, the age-adjusted incidence of neuroendocrine tumors increased sixfold from 1973 (1.09 per 100,000) to 2012 ((6.98 per 100,000), possibly because of increased early detection. (medscape.com)
  • Gallium‐68 ( 68 Ga)‐1,4,7,10‐tetraazacyclo‐dodecane‐1,4,7,10‐tetraacetic acid DOTA‐peptides highlight neuroendocrine tumors ( NETs ) through binding the somatostatin receptors that are overexpressed on the surfaces of their cells. (radiologykey.com)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
  • Previous studies have shown a relationship between monocyte count and prognosis in some solid tumors. (researchsquare.com)
  • The 5 year disease-free survival (DFS) per tumor origin was: 94% for PMP-LG, 85% for PMP-HG, 100% for benign multicyst peritoneal mesothelioma (MPM), 37.4% for colonic origin, and 54%(at 3 years) for ovarian origin. (unav.edu)
  • Benign and malignant smooth-muscle tumors of the esophagus in children account for fewer than 5% of all leiomyomas and leiomyosarcomas. (medscape.com)
  • Microcystic adenoma of the pancreas is a tumor that is benign in nature. (hindawi.com)
  • While ultrasonography is an effective method for localizing adrenal lesions, standardized ultrasound criteria to distinguish benign from malignant lesions or functional cortisol-secreting from non-functional tumors are lacking [ 12 ]. (biomedcentral.com)
  • Müllerian adenosarcoma (MA) is a rare mixed and low malignant tumor of female genital system, and is a biphasic differential tumor that is composed of admixed benign epithelial and sarcomatoid mesenchymal components. (scirp.org)
  • Nonfunctioning tumors usually are larger and present because of their size or metastatic spread. (medscape.com)
  • NT has shown to exert numerous oncogenic effects involved in tumour growth and metastatic spread. (springer.com)
  • Due to the high mortality rate of esophageal cancer, exploration of new prognostic biomarkers for this tumor is of paramount importance. (researchsquare.com)
  • To identify operable lung cancer patients with risk for metastatic relapse we search for new prognostic biomarkers based on analysis of genome-wide gene expression data and conventional protein marker validation based on analysis of primary tumor tissue. (lu.se)
  • Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
  • Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
  • In this study, we collected single-cell sequencing datasets of LUAD and applied an integrated bioinformatic method to depict the transcriptome characteristic of LUAD in normal, tumoral, and metastasis condition. (aging-us.com)
  • Furthermore, compared to the tumor, lymph node, metastasis (TNM) staging system, histone modifications can discriminate the survival difference more accurately, especially for patients with stage I or stage II tumors. (oncotarget.com)
  • In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)
  • Taking into consideration the large numbers of cytotoxic medications found in the treating neoplastic illnesses presently, much information is certainly missing to anticipate the anti-tumor response from the web host reliably. (treatmentforprostatecancer.info)
  • PD-L1 is expressed on tumor cells and interacts with PD-1 on cytotoxic T-cells, leading to reduced T-cell function and thereby lower anti-tumor activity of the host's immune system [ 1 ]. (biomedcentral.com)
  • In addition, intrinsic differences in subclonal tumor cells that arise from random mutations can create distinct niches within limited lesions. (spandidos-publications.com)
  • These studies reveal a wide range of genetic tumor heterogeneity in both spatial and temporal dimensions, encompassing diverse single-nucleotide mutations, insertions, deletions and copy number variations ( 9 , 10 ). (spandidos-publications.com)
  • In primary tumors, mutations in driver genes frequently provide a survival advantage and give rise to a dominant clonal population. (spandidos-publications.com)
  • By contrast, mutations in noncoding regions do not provide significant growth advantages during tumor evolution ( 11 ). (spandidos-publications.com)
  • Children born with germline mutations tend to have bilateral tumors. (molvis.org)
  • Patients with deleterious germline mutations: A heterogeneous population for pancreatic cancer screening? (cdc.gov)
  • In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. (lu.se)
  • Two recent studies from Dr. Wenming Wu's group at the Department of General Surgery, Peking Union Medical College Hospital (PUMCH), applied single-cell RNA sequencing and whole-genome sequencing (WGS) to delineate heterogeneity of pancreatic tumors, including pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PanNET). (biomedcentral.com)
  • applied single-cell RNA sequencing to 24 primary PDAC tumors and 11 control pancreases. (biomedcentral.com)
  • This elegant study provided valuable resources for deciphering heterogenous cell types in PDAC. (biomedcentral.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies, with a 5-year survival rate of only 5% and a median survival of less than 6 months[ 1 ]. (oncotarget.com)
  • In such cases, these biphasic tumors are classified as a form of pulmonary blastoma because the presence of the blastomatous cells dramatically worsens the prognosis. (wikipedia.org)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Significant parameters used in the determination of the prognosis and survival of esophageal cancer include tumor stage, surgical margin, and metastatic lymph node status. (researchsquare.com)
  • Accumulating evidence shows that in addition to the characteristics of the tumor, the immune response of the patient is also highly important for determining the prognosis. (researchsquare.com)
  • Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
  • however, as patients with the same tumor stage have a heterogeneous prognosis, additional reliable prognostic factors are needed. (biomedcentral.com)
  • In particular, a combinatorial pattern of elevated H2AK119Ub1 and decreased H3K27Me3 in tumors was significantly correlated with a poorer prognosis. (oncotarget.com)
  • These results demonstrated that H2AK119Ub1 and H3K27Me3 cooperate in tumors and are associated with the clinical prognosis in combinatorial patterns. (oncotarget.com)
  • The aim of this study was to report a clinical case of pleomorphic adenoma affecting the minor salivary gland and to discuss its characteristics, emphasizing the important role of the dentist in the correct and early diagnosis of this lesion, resulting in a more conservative treatment and better prognosis for the patient. (bvsalud.org)
  • Malignant transformation in the tumor with metastases is rare and only about 26 cases have been reported so far. (hindawi.com)
  • revealed for the first time carcinoma ex microcystic adenoma in which the tumor, without metastases, showed inherent malignant changes [ 7 ]. (hindawi.com)
  • Lesions based on histology were classified as cortical adrenal hyperplasia ( n = 67), adenocarcinoma ( n = 17), pheochromocytoma ( n = 10), metastases ( n = 7), adrenal adenoma ( n = 4), and adrenalitis ( n = 4). (biomedcentral.com)
  • Pathological examination of an open muscle biopsy showed a poorly differentiated adenocarcinoma, supporting a diagnosis of gastric cancer metastases in multiple skeletal muscles. (springeropen.com)
  • Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell characteristics that resemble fetal lung tissue upon microscopic examination. (wikipedia.org)
  • FA can occur in combination with other forms of lung cancer, particularly other variants of adenocarcinoma. (wikipedia.org)
  • A case of combined small cell lung carcinoma featuring components of FA and cells resembling those from carcinoid tumor has been reported, illustrating the unique complexity and heterogeneity of divergent histogenesis and cell differentiation in lung cancer. (wikipedia.org)
  • FA is an epithelial tumor whose cells and architecture resemble that of fetal lung tissues in the pseudoglandular stage of development (which occurs at about 10-16 weeks gestation in the human), with complex glandular structures and morules with cell nuclei that appear clear due to the accumulation of biotin. (wikipedia.org)
  • FA is a rare tumor, with a relative incidence estimated to be no more than 0.5% of all lung cancers. (wikipedia.org)
  • Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
  • Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
  • Two recent systematic reviews have shown that cryotechnology in bronchoscopy is useful for the diagnosis of lung diseases, including interstitial lung diseases and lung tumors [ 7 , 8 ]. (hindawi.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • By analysis of patient specific alterations in circulating tumor DNA in blood samples we aim to establish blood-based assays for early detection of lung cancer, treatment monitoring, and early detection of relapse in the primary and advanced setting. (lu.se)
  • Solitary fibrous tumor (SFT) has been increasingly reported in various anatomic sites. (cn1699.cn)
  • The currently accepted nomenclature is solitary fibrous tumor. (medscape.com)
  • Most FA's are well or moderately differentiated tumors, although high-grade, poorly differentiated variants have been described. (wikipedia.org)
  • the highest expression levels were associated with moderately or poorly differentiated tumors (p=0.011). (jcancer.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
  • Analysis of ultrasonographic predictive parameters showed a significant association between lesion size and malignant tumors. (biomedcentral.com)
  • Adenocarcinomas are most often highly heterogeneous peripheral tumors, and are thought to arise from malignant transformation of primitive cells that can exhibit differentiation characteristics of Club cells, Type II pneumocytes, bronchiolar surface cells, bronchial gland cells, or goblet cells. (wikipedia.org)
  • Not only do these wrap pancreatic tumours in a dense, protective layer, they also foster complex relationships with the cancerous cells: some fibroblasts may fuel tumour growth, while other may help to contain its spread. (elifesciences.org)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • Most of this classification is based on the histological characteristics of tumours seen in surgical or needle biopsy, and is primarily based on light microscopy, although immunohistochemistry and electron microscopy findings are provided when necessary. (ersjournals.com)
  • Additionally, we identified six tumours, termed supra-carcinoids, that displayed genuine carcinoid-like morphology, but had clinical and molecular characteristics of LNECs. (who.int)
  • Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
  • Although the latter is a relatively rare entity, it often presents diagnostic or therapeutic challenges owing to the distinct histological and molecular characteristics and different response to standard therapies ( 16 ). (iiarjournals.org)
  • Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
  • In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
  • Selective targeting of tumor-proximal subsets, potentially combined with HIF-1α inhibition and immune stimulation, may offer a multi-modal therapeutic approach for this disease. (elifesciences.org)
  • Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
  • To search for possible modes of action of retinoids as novel therapeutic options, primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids and a histone deacetylase (HDAC) inhibitor. (uni-wuerzburg.de)
  • Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
  • Pancreatic cancer tumorspheres display a heterogeneous pattern of surface and stemness markers, nevertheless they are characterised by an increased tumorigenic potential and higher chemoresistance. (lu.se)
  • relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)
  • Here, we performed immunohistochemistry on tissue microarrays (TMAs) containing 80 pairs of human pancreatic cancer specimens to assess the expression levels of Ring1B, H2AK119Ub1, EZH2, and H3K27Me3 in tumors. (oncotarget.com)
  • Simultaneous silencing of Ring1B and EZH2 via shRNA depleted H2AK119Ub1 and H3K27Me3 in the pancreatic cancer cells PanC1 and AsPC1, enhanced HOX gene derepression, and inhibited tumor cell growth in vitro and in tumor xenograft models. (oncotarget.com)
  • Precision Oncology in Pancreatic Cancer: Experiences and Challenges of the CCCMunich Molecular Tumor Board. (cdc.gov)
  • Compared to normal colon tissue, primary tumors were associated with increased expression of ALDH1B1 (p=0.008). (jcancer.org)
  • Despite its characteristic histological features, the cytological diagnosis of GEA is often challenging. (iiarjournals.org)
  • The Receiver Operating Characteristics (ROC) curve analysis determined a cut-off value of 515/μL for the monocyte count assessed at the time of diagnosis. (researchsquare.com)
  • In the present study involving a large sample of dogs, we asked which ultrasound characteristics of adrenal lesions could predict for malignancy and how accurate ultrasound diagnosis (specificity and sensitivity) was as compared with histopathological diagnosis. (biomedcentral.com)
  • Diagnosis is made with ultrasonography and/or computed tomography (CT), which reveal the characteristic heterogenous appearance, including fat, calcifications, and cystic areas. (medscape.com)
  • The tumor was completely resected, the pathological diagnosis being adenocarcinoma, and small clump of cancer cells having been found in the muscularis propria (pathological stage T2N0M0 (AJCC classification), pathological effect grade 2) (Fig. 2 ). (springeropen.com)
  • The diagnosis and treatment of the tumor are also discussed. (scirp.org)
  • The aim of this report is to analyze the histological features, diagnosis and treatments of the tumor. (scirp.org)
  • Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
  • Despite the declining incidence of cervical carcinoma, the proportion of adenocarcinomas arising from the uterine cervix has risen steadily ( 8 , 9 ). (iiarjournals.org)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • We established a 3D liver organoid cell culture model from primary mouse tissue and characterised the capacity of these organoids to model liver characteristics in vitro and used this model to define the interactions between organoid hepatocytes and hepatic stellate cells in a co-culture trans-well system. (edu.au)
  • World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002). (curehunter.com)
  • H-E staining showed tumor tissue-like structures specific to each cell line. (medsci.org)
  • In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)
  • Therefore, it is difficult to propose that 2D culture accurately reflects the original growth state of tumor tissue. (medsci.org)
  • Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
  • Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
  • Adenocarcinomas develop from the stomach mucosa (its innermost layer) that is composed of glandular tissue. (lab-ally.com)
  • We stained a tissue microarray consisting of 170 patients, including 72 intrahepatic cholangiocarcinomas (iCCAs), 57 perihilar cholangiocarcinomas (pCCAs) and 41 distal cholangiocarcinomas (dCCAs) by immunohistochemistry and evaluated PD-L1 positivity in tumor and stromal cells. (biomedcentral.com)
  • Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
  • Genetic counselling referral practices for patients with pancreatic adenocarcinoma: A French retrospective multicentre observational cohort study (CAPANCOGEN). (cdc.gov)
  • However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. (spandidos-publications.com)
  • Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. (elifesciences.org)
  • Here, we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of tumor-proximal and tumor-distal cancer-associated fibroblasts (CAFs) and link this to clinical outcome. (elifesciences.org)
  • Here the authors use innovative approaches to combine spatial profiling with single cell transcriptomics to define tumor-proximal populations of fibroblasts that predict clinical outcome. (elifesciences.org)
  • Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. (medsci.org)
  • The clinical implication of that knowledge reflected to surgical strategies which also vary from simple appendicectomy to radical abdominal procedures based on specific clinical and histological characteristics. (wjgnet.com)
  • Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are functional. (medscape.com)
  • Functioning tumors produce a clinical syndrome as a result of excessive hormone production. (medscape.com)
  • Clinical features of the syndrome depend on tumor cell type. (medscape.com)
  • Müllerian adenosarcomas are rare tumors with non-specific clinical features, and this forms a circumstance that poses significant challenges to the clinical practice or even delayed treatment when women presented with complaints of abdominal pain and irregular vaginal bleeding from the endometriosis postoperatively. (scirp.org)
  • Results: The association of retinoid signaling and clinical parameters could be validated in a large independent tumor set, but its relevance in primary nephrectomy tumors from very young children may be different. (uni-wuerzburg.de)
  • The focus of our work is to better understand the biological and clinical characteristics of these molecular groups of carcinoids. (who.int)
  • A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. (curehunter.com)
  • The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. (spandidos-publications.com)
  • Molecular imaging with whole‐body positron emission tomography (PET)/CT or PET/MRI utilizes metabolic and receptor‐based strategies for tumor detection in staging and restaging various cancers. (radiologykey.com)
  • Breast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. (lu.se)
  • In a bid to gain some insight into the molecular characteristics of CRC in our environment, we set out to investigate the expression of COX-2 and HER-2 among Nigerian subjects. (bvsalud.org)
  • ParetoTI theory identified four tumour archetypes within the tetrahedron, corresponding to the three previously reported molecular groups, and the fourth enriched for the aggressive supra-carcinoids. (who.int)
  • There is increasing evidence that the local immune response and systemic inflammation support tumor progression in patients with established cancer, adversely affecting their survival [ 3 ]. (biomedcentral.com)
  • Statistical analyses of PD-L1 expression (clone SP263) on tumor cells with clinicopathological data revealed a positive correlation with shortened overall survival in CCA patients. (biomedcentral.com)
  • Markers characteristic of liver injury and fibrosis, such as Actn1 and Lamb3 were upregulated in hepatic stellate cells, although collagen expression was downregulated in these cells. (edu.au)
  • Transcriptional profiling revealed a tumour necrosis factor-α mediated apoptotic response in organoids and an inflammatory response in both the organoids and hepatic stellate cells. (edu.au)
  • Patients undergoing yttrium‐90 ( 90 Y)‐microspheres therapy for hepatic tumors must first be evaluated with liver imaging using arterially infused 99m Tc‐ macroaggregated albumin ( MAA ) as part of the planning process for a safe and effective procedure. (radiologykey.com)
  • There was no significant correlation between COX-2 expression and age, gender, tumour location, tumour size, depth of invasion or lymph node status.However, COX-2 expression revealed a significant correlation with tumour grade (p= 0.013). (bvsalud.org)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Microcystic adenoma of the pancreas is a rare tumor that presents indolently with features of slow growth and abdominal pain secondary to mass effect. (hindawi.com)
  • Current 2D in vitro assays based on cell lines such as HepG2 that have reduced metabolic capacities compared to primary hepatocytes ex vivo, and the use of primary human hepatocytes suffers from high donor-to-donor variation and only retain in vivo characteristics for a short time ex vivo. (edu.au)
  • Liver organoids have demonstrated many advantages over conventional in vitro models such as long-term genetic stability, 2D in vivo-like organisation, and maintaining the necessary cellular cross talk and behavioural characteristics of their primary corresponding cells. (edu.au)
  • In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis. (uni-wuerzburg.de)
  • Monocyte, an element of the immune system, is a heterogeneous cell showing different responses to different stimuli. (researchsquare.com)
  • In this scholarly study, we demonstrated how different kinds and systems of cell loss of life, induced by different stimuli, influence the results of allogeneic tumor transplants in BALB/c immune-competent mice. (treatmentforprostatecancer.info)
  • [ 1 ] In 1960, the incidence of GI malignancies arising from the bowel was estimated at less than 1% of pediatric tumors, and most of the diagnoses were made during urgent exploration for an abdominal crisis. (medscape.com)
  • [ 1 ] In 1960, the incidence of GI malignancies arising from the bowel was estimated at less than 1% of pediatric tumors. (medscape.com)
  • The incidence of oesophageal adenocarcinoma is rising rapidly in the developed world. (nature.com)
  • Tumor-specific variations in splicing may generate new epitopes that can serve as a starting point for immune therapy or targeted delivery, as well as for the development of new diagnostic or prognostic tools [ 6 ]. (biomedcentral.com)
  • Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. (cancerindex.org)
  • T cell infiltration status and T cell characteristics are usually associated with different prognostic outcomes [ 7 ]. (biomedcentral.com)
  • The 5-year DFS per tumor origin was: 96% for perforated low grade appendiceal mucinous neoplasm (LAMN II) and 68.1% for colon origin. (unav.edu)
  • Tumors of the pancreas that contain substantial cystic components include mainly mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, solid pseudopapillary tumor, and cystadenomas (which encompass microcystic, macrocystic/oligocystic, and rare solid serous adenomas). (hindawi.com)
  • Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. (researchgate.net)
  • While FA can be diagnosed via biopsy, bronchial brushings, and immunocytochemistry, examination of the whole tumor is required to rule out biphasic pulmonary blastoma, a mixed tumor of higher aggressiveness, wherein FA occurs admixed with primitive blastoma cells. (wikipedia.org)
  • Conclusion: GEA can be identified cytologically based on the presence of flat, honeycomb-like sheets of tumor cells possessing vesicular nuclei, prominent nucleoli, and abundant vacuolated cytoplasm. (iiarjournals.org)
  • Glioblastoma (GBM) is characterized by significant genetic heterogeneity among tumor cells. (spandidos-publications.com)
  • This heterogeneity is referred to as 'polymorphism', as tumor cells rapidly undergo mitosis, resulting in the formation of numerous subclones and uncertainty regarding the state of the genome. (spandidos-publications.com)
  • However, rather than actively modifying the environment, multiple mechanisms guide the evolution of tumor cells through the selection of subclones with the most adaptive phenotype by environmental factors ( 1 ). (spandidos-publications.com)
  • Multiregional whole-exome or genome sequencing has revealed that there is significant variation in the genetic makeup of tumor cells across different anatomical locations and within the same tumor over time ( 4 ). (spandidos-publications.com)
  • This heterogeneity can vary greatly between different types of immune cells, leading to further complexity in understanding the immune response to tumors. (spandidos-publications.com)
  • Consequently, the heterogeneity of tumor cells is constantly evolving. (spandidos-publications.com)
  • High-throughput sequencing methods are utilized to analyze the mutational spectrum and evolutionary trajectories of tumor cells. (spandidos-publications.com)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • Furthermore, it is presumed that most of the characteristics inherent in cancer cells are lost. (medsci.org)
  • Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
  • Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
  • As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
  • Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)
  • Dying cells may exhibit different characteristics and immunological features completely. (treatmentforprostatecancer.info)
  • Because the suggestions for drug screening process in antineoplastic remedies need evaluation of individual tumors xenotransplanted into immune-compromised 4-Aminohippuric Acid mice (5), the function from the immune system continues to be neglected (6), producing studies centered on the interplay between disease fighting capability and dying cells required. (treatmentforprostatecancer.info)
  • However, as it turned out afterwards, cancer cells in the recurrent tumor were negative for HER2. (springeropen.com)
  • While all these entities are characterized by proliferation of highly atypical, anaplastic CD30+ T cells, the expression of T-cell specific antigens in the tumor cells is not consistently detectable. (uni-wuerzburg.de)
  • A cell line derived from cultured tumor cells. (lookformedical.com)
  • For PD-L1 antibody clone SP263, 5% of iCCAs, 4% of pCCAs and 3% of dCCAs exhibited PD-L1 expression on tumor cells, thereby showing the highest frequencies of PD-L1 positivity. (biomedcentral.com)
  • Agreement of PD-L1 positivity in tumor cells was moderate for clone 28-8 and SP263 ( κ = 0.44) and poor between 28-8 and SP142 ( κ = 0.13), as well as SP142 and SP263 ( κ = 0.11), respectively. (biomedcentral.com)
  • More than 50% of the tumor cells showed a high expression of H2AK119Ub1, Ring1B, and EZH2, whereas more than 50% of the tumor cells showed a low level of H3K27Me3. (oncotarget.com)
  • For example, certain fibroblasts close to the tumour resemble the myofibroblasts present in healing wounds, while those at the periphery show signs of being involved in inflammation. (elifesciences.org)
  • Malignant transformation of cystic adenomas of the pancreas was first described in 1989 wherein the tumor showed invasion into surrounding structures and into the liver [ 4 ]. (hindawi.com)
  • No universally agreed-upon algorithm exists in the radiologic investigation of pancratic neuroendocrine (islet cell) tumors of the pancreas. (medscape.com)
  • Evidence has shown that endoscopic ultrasonography (EUS) can be used to accurately diagnose and localize primary endocrine tumors of the pancreas, especially insulinomas and gastrinomas. (medscape.com)
  • Gastrointestinal stromal tumors (GISTs) account for less than 1% of GI tumors, but they are the most common mesenchymal neoplasms of the GI tract. (medscape.com)
  • This tumor is composed of a single mass that is encapsulated and consequently shows mobility, except when the lesion occurs in the palate. (bvsalud.org)
  • Since the 2014 World Health Organization (WHO) Classification of Tumors of Female Reproductive Organs ( 13 ) did not fully reflect the current understanding of diverse mechanisms underlying endocervical glandular carcinogenesis, a novel classification system was proposed to provide an updated framework for EAC classification. (iiarjournals.org)
  • The International Endocervical Adenocarcinoma Criteria and Classification (IECC) reliably segregated EACs into human papillomavirus (HPV)-related and HPV-unrelated tumors according to the presence or absence of HPV infection-related morphology (apical mitotic figures and basal apoptotic bodies), which is easily identifiable under scanning magnification ( 12 ). (iiarjournals.org)
  • With the adoption of the 2018 IECC, the updated 2020 WHO Classification of Female Genital Tumors ( 14 ) designated these tumors as HPV-associated (HPVA) and HPV-independent (HPVI) EACs. (iiarjournals.org)
  • An international system of tumour classification is important for consistency in patient treatments and to provide the basis of epidemiological and biological studies. (ersjournals.com)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • TAMs are known to play an important role in tumor angiogenesis and growth. (researchsquare.com)
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
  • Shown here is a gastric gastrointestinal stromal tumor (GIST). (medscape.com)
  • However, the continuous knowledge which was added by studying these tumors for nearly a century strengthen the notion that the above term was inaccurate or inadequate to describe several parameters of this heterogeneous group of gastrointestinal tumors (including the appendiceal one). (wjgnet.com)
  • In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
  • Endocervical adenocarcinoma (EAC) accounts for 20-25% of all cervical carcinomas ( 7 ). (iiarjournals.org)
  • The pleomorphic adenoma (PA) is the most common tumor affection the salivary glands 7,8 , accounting for 33.2% to 89.9% of the cases, followed by carcinomas. (bvsalud.org)
  • Gene ID: 5925, OMIM 614041 ) gene, which encodes a tumor suppressor protein. (molvis.org)
  • Landscape of tumor suppressor long noncoding RNAs in breast cancer. (cancerindex.org)
  • The landscape and biological functions of tumor suppressor long noncoding RNAs in breast cancer are still unknown. (cancerindex.org)
  • Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. (cancerindex.org)
  • Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)
  • The impact of inflammatory cytokines tumour necrosis factor-α and transformation growth factor-β on this model, as well as other variables such as hypoxia and the anti-fibrosis drug Halofuginone were assessed. (edu.au)
  • Through such investigations we have identified unusually high concentrations of intratumoral hyaluronan (HA) as the primary culprit in the extraordinarily elevated interstitial fluid pressures (IFP) in PDA that, in turn, cause the vascular collapse and hypoperfusion characteristic of this disease. (hhs.gov)