• expression
  • OGX-011 is a 2′-methoxyethyl modified phosphorothioate antisense oligonucleotide that is complementary to clusterin mRNA and has been reported to inhibit clusterin expression and enhance drug efficacy in xenograft models. (oup.com)
  • The primary objective of this clinical study was to determine a biologically effective dose of OGX-011 that would inhibit clusterin expression in human cancer. (oup.com)
  • Prostate cancer tissue, lymph nodes, and serial samples of peripheral blood mononuclear cells were assessed for clusterin expression using quantitative real-time polymerase chain reaction and immunohistochemistry. (oup.com)
  • OGX-011 is well tolerated and reduces clusterin expression in primary prostate tumors. (oup.com)
  • Laure Debure and co-workers have examined the effects of clusterin expression in COS-7 cells (see p. 3109 ). (biologists.org)
  • The authors also observe, however, that clusterin expression disrupts mitochondria and induces apoptosis through the mitochondrial pathway - this can be prevented by expression of the pro-survival molecule Bcl-2 or inhibition of caspases. (biologists.org)