Chaperone. Medical search. Frequent questions

The Drowsy Chaperone JR. (mtishows.com)
A Broadway Junior adaptation of the Tony-winning musical comedy, The Drowsy Chaperone JR. is a loving satire of the Golden Age musical, featuring hysterical numbers and colorful characters. (mtishows.com)
With plenty of hilarious roles, The Drowsy Chaperone JR. is a fun, delightful show for both performers and their audience. (mtishows.com)
For one magical night only, you have the opportunity for a rare behind the scenes look and 'sneak peek' into the Five-Time Tony Award Winning Musical, including Best Book and Best Original Score, 'The Drowsy Chaperone,' as performed by the Springfield Community Players. (springfieldvt.com)
The Drowsy Chaperone cast will sing, act, and dance scenes and musical numbers from this comedic call back to the Golden Age, as a sneak peek into the rehearsal process of the musical, which opens the following weekend. (springfieldvt.com)
With its infectious music, high energy dancing, and whimsical characters, the delicious aromas and tastes of Africa and the Middle East, Tony Award Winning musical The Drowsy Chaperone and Arabian Nights Pop-up Rehearsal Dinner has all the ingredients of a recipe for a delightful, delicious, and highly entertaining evening escape. (springfieldvt.com)
Join us at Studio One, #1 Main St, Springfield, VT, Saturday, April 13th at 6pm for the perfect cabin fever cure: Arabian Nights pop-up rehearsal dinner and the rare combination of modern wit and classical musical comedy of The Drowsy Chaperone. (springfieldvt.com)
Be he six-foot-seven or three-foot-two, big and mighty or underfed, he's your logical leading man for "Man in Chair" - the leading man of The Drowsy Chaperone . (mtishows.com)
Luckily, he does have a bootleg recording of his favorite one from 1928 which is indeed called The Drowsy Chaperone . (mtishows.com)
There's that Drowsy Chaperone, who's here to ensure that Janet's day goes well. (mtishows.com)
The Drowsy Chaperone harkens back to those '20s musicals that had daffy characters and plots, all to put a smile on one's face and a tap into one's toes. (mtishows.com)
Your props people won't be required to make a mock-up of a long-playing record cover of The Drowsy Chaperone because Ghostlight Records not only released the original cast album on CD but also on vinyl. (mtishows.com)
Drowsy Chaperone Auditions HELP! (musicals.net)
Winner of five Tony Awards (including Best Book and Best Original Score), The Drowsy Chaperone is a loving send-up of the Jazz-age musical featuring one show-stopping song and dance number after another. (edmontondowntown.com)
This is the conceit of "The Drowsy Chaperone," a fictitious musical from 1928. (berkshirefinearts.com)
The reality of the show's evolution is that "The Drowsy Chaperone" began as a spoof of old musicals that was performed at a stag party for a real engaged couple with the same names as the characters in the show. (berkshirefinearts.com)
The Drowsy Chaperone," with music and lyrics by Lisa Lambert and Greg Morrison and book by Bob Martin and Don McKellar is produced by Sonoma Arts Live and plays at the Sonoma Community Center, 476 East Napa Street, Sonoma, CA through July 31, 2022. (berkshirefinearts.com)
The Drowsy Chaperone tells the story of a modern day musical theater addict, known simply as 'Man in Chair' (Ricky Graham), To chase his blues away he drops the needle on his favorite LP- the 1928 musical comedy, 'The Drowsy Chaperone. (experienceneworleans.com)
Misfits Theatre announces auditions for The Drowsy Chaperone directed by Marissa Dienstag. (woub.org)
The recording comes to life and The Drowsy Chaperone begins as the man in the chair looks on. (theatreaspen.org)
Original Broadway production of The Drowsy Chaperone produced by Kevin McCollum, Roy Miller, Bob Boyett, Stephanie McClelland, Barbara Freitag and Jill Furman. (theatreaspen.org)
The Drowsy Chaperone is presented through special arrangement with Music Theatre International (MTI). (theatreaspen.org)
A scene from Curtain Call's Summer Youth Theatre production of The Drowsy Chaperone playing in The Kweskin Theatre, Stamford, August 5 thru 14. (stamfordplus.com)
Curtain Call's 31st annual Summer Youth Theatre production - The Drowsy Chaperone - is the winner of five Tony Awards, including Best Book and Best Original Score. (stamfordplus.com)
The Drowsy Chaperone is a masterful meta-musical, poking fun at all the tropes that characterize the musical theatre genre. (stamfordplus.com)

Chemical chaperones are a class of small molecules that function to enhance the folding and/or stability of proteins. (wikipedia.org)
Chemical chaperones are used for a range of applications, from production of recombinant proteins to treatment of protein misfolding in vivo. (wikipedia.org)
Another class of chaperones is composed of protein ligands, cofactors, competitive inhibitors, and other small molecules that bind specifically to certain proteins. (wikipedia.org)
Beside clinical applications, chemical chaperones have proved useful in in vitro production of recombinant proteins. (wikipedia.org)
Recently, a novel class of intramolecular chaperones has been identified in tailspike proteins of evolutionarily distant viruses, which require a C-terminal chaperone for correct folding. (rcsb.org)
The highly homologous chaperone domains are interchangeable between pre-proteins and release themselves after protein folding. (rcsb.org)
Sequence analysis shows a conservation of the intramolecular chaperones in functionally unrelated proteins sharing beta-helices as a common structural motif. (rcsb.org)
Upon stress exposure, these chaperones convert into high affinity binding platforms for unfolding proteins and protect cells against the accumulation of potentially toxic protein aggregates. (nih.gov)
We will give an overview over the different strategies that cells evolved to rapidly increase the pool of ATP-independent chaperones upon oxidative stress and provide mechanistic insights into how stress conditions are used to convert abundant cellular proteins into ATP-independent holding chaperones. (nih.gov)
It can reversibly bind to proteins, until ATP-hydrolysis is stimulated by a co-chaperone, so the mouse trap snaps shut. (bio.net)
As she explains, heat shock proteins in the Hsp70 family - molecular weight 70 - are "a really important class of molecular chaperones that have many important jobs in the cell, including binding to client proteins to assist their folding, or to keep them from pathologically aggregating, or to keep them unfolded so they can pass threadlike through a membrane. (bionity.com)
Metal chaperones (or metallochaperones) are compounds that function to shuttle metal ions to specific intracellular target proteins. (frontiersin.org)
Small heat shock proteins (sHsp) constitute an evolutionary conserved yet diverse family of chaperones acting as first line of defense against proteotoxic stress. (cam.ac.uk)
They promote the storage of misfolded proteins in native-like conformation facilitating disaggregation by ATP dependent chaperone systems. (cam.ac.uk)
Small heat shock proteins (sHSPs) are a class of ATP-independent molecular chaperones that play vital roles in maintaining protein solubility and preventing aberrant protein aggregation. (jascoinc.com)

Their chaperone activity is independent of ATP, a feature that becomes especially important under oxidative stress conditions, where cellular ATP levels drop and canonical ATP-dependent chaperones no longer operate. (nih.gov)

Figure 2: The HSP70 chaperone cycle. (nature.com)
HSP70, together with the DNAJA2 member of HSP40 co-chaperones, is the main chaperone involved in IRES-mediated translation of the viral genome, while HSP90 may play some role as well. (wjgnet.com)
In plants, fungi and bacteria the central disaggregation machinery is a powerful bi-chaperone system comprised by the AAA + disaggregase Hsp100 (Hsp104, ClpB) and the cooperating Hsp70 chaperone system. (cam.ac.uk)
Metazoan cells lack Hsp100 disaggregases, but have evolved a potent Hsp70-based disaggregation machinery which relies on synergistic action of Hsp70 and its co-chaperones. (cam.ac.uk)

The presence of the molecular chaperone, alphaA-crystallin, prevented precipitation of modified betaB1s. (nih.gov)
Multiple co-crystal structures of an adenine-based series of inhibitors bound to the molecular chaperone Hsp90 have been determined. (ub.edu)
An acidic protein found in the NEUROENDOCRINE SYSTEM that functions as a molecular chaperone for PROPROTEIN CONVERTASE 2. (bvsalud.org)

Figure 4: ATPase cycle of the HSP90 chaperone system. (nature.com)

The information in this guide is designed to provide a guide on expectations to parents who chaperone their children during entertainment performances, where the parent is not a licensed chaperone. (brent.gov.uk)
The independent report by Professor Ron Paterson, Professor of Law at the University of Auckland and Distinguished Visiting Fellow at Melbourne Law School, found the use of chaperones does not meet community expectations and does not always keep patients safe. (medicalboard.gov.au)
Set chaperone expectations early. (bobrogerstravel.com)
Physicians should establish clear expectations that chaperones will uphold professional standards of privacy and confidentiality. (svmic.com)

Morimoto, R. I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. (nature.com)
Of the various chaperones known to be associated with neurodegenerative disease, the small secretory chaperone known as proSAAS (named after four residues in the amino terminal region) has many attractive properties. (au.dk)

Molecular chaperones are known to play a role in stabilizing protein structure and function during events of cellular stress. (bioone.org)
In this review, we focus on thiol-based activation mechanisms of stress-sensing chaperones. (nih.gov)
To investigate how Mtb deals with IOPs that can neither be repaired nor degraded, we used new chemical and biochemical probes and improved image analysis algorithms for time-lapse microscopy to reveal a defense against stationary phase stress, oxidants, and antibiotics-the sequestration of IOPs into aggregates in association with the chaperone ClpB, followed by the asymmetric distribution of aggregates within bacteria and between their progeny. (epfl.ch)
Sarah A. Harvey , Keith O. Jensen , Lynne W. Elmore , and Shawn E. Holt "Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression," Cell Stress & Chaperones 7(2), 230-234, (1 April 2002). (bioone.org)
Cell Stress Chaperones , 14 , 591-601. (bvsalud.org)

Chemical compounds that have varying degrees of hydrophobicity that still are soluble in aqueous environments can act as chemical chaperones as well. (wikipedia.org)

Because these molecules are active only on a specific protein, they are referred to as pharmacological chaperones. (wikipedia.org)
Another important property of pharmacological chaperones is that they are able to bind to the unfolded or improperly folded protein, and then dissociate once the protein is properly folded, leaving a functional protein. (wikipedia.org)

Mall of America, the nation's largest shopping mall, imposed a chaperone policy back in 1996 and has been increasingly tightening it as recently as 2020 when it mandated that teens be accompanied by adults after 3 p.m. daily. (wtop.com)
In 1996 the General Medical Council recommended, where possible, offering chaperones to patients during intimate examinations. (bmj.com)

Brent's Education Welfare Service can approve adults resident in Brent to act as chaperones. (brent.gov.uk)

Chemical chaperones are a broad and diverse group of molecules, and they can influence protein stability and polypeptide organization through a variety of mechanisms. (wikipedia.org)
The parameters that define these groups are not strictly defined, and many small molecules that exert a chemical chaperoning effect do not readily fall into one of these categories. (wikipedia.org)
Because protein molecules are highly dynamic, constant chaperone surveillance is required to ensure protein homeostasis (proteostasis). (nature.com)
Unfolded protein molecules initially form a highly dynamic complex with the chaperone domain of SlyD, and they are then transferred to the prolyl isomerase domain. (unboundmedicine.com)
Protein molecules that left the prolyl isomerase site with an incorrect prolyl isomer can rapidly be re-bound by the chaperone domain because the association rate is very high as well. (unboundmedicine.com)

Secretion is facilitated by the chaperone protein DspF, but the portion of DspE required for secretion and chaperone interaction has not been previously determined. (actahort.org)

Chaperones have a duty to represent the child's interests and to help ensure that the law and licence conditions relating to the child's participation are complied with. (brent.gov.uk)
Since the chaperone/volunteer approval status lasts throughout the child's AACPS career, the chaperone/volunteer should carry the blue card and present to the school for verification. (aacps.org)

To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. (nature.com)

Girls in New America must have chaperones at all times until they marry, so Stella's lucky that Sister Helen is like a friend to her. (netgalley.com)

The SlyD (sensitive to lysis D) protein of Escherichia coli is a folding enzyme with a chaperone domain and a prolyl isomerase domain of the FK506 binding protein type. (unboundmedicine.com)

In addition, if the status of a chaperone/volunteer changes to "ineligible" during the time that their child is in AACPS, the Office of Investigations will contact the parent and the affected schools, to address the change in status. (aacps.org)

Chaperones are a director's trusted team mates, not a second set of responsibilities. (bobrogerstravel.com)

Sensitive examinations such as breast, pelvic, genital and rectal exams should always be chaperoned, regardless of the patient or physician's gender. (svmic.com)
Chaperones for Exams? (medscape.com)

The Michaelis constant of catalyzed folding reflects the substrate affinity of the chaperone domain, and the turnover number is presumably determined by the rate of productive substrate transfer from the chaperone to the prolyl isomerase site and by the intrinsic propensity of the refolding protein chain to leave the active site with the native prolyl isomer. (unboundmedicine.com)

Hartl, F. U. Molecular chaperones in cellular protein folding. (nature.com)
The current concepts of sperm biochemical markers and the central role of the HspA2 chaperone protein, a measure of sperm cellular maturity and fertilizing potential, are reviewed. (cdc.gov)

In August 2016 , the MBA and AHPRA commissioned a review to consider whether, and if so in what circumstances, it is appropriate to impose a chaperone condition on the registration of a health practitioner to protect patients while allegations of sexual misconduct are investigated. (medicalboard.gov.au)

Janet's drunken chaperone, played with great panache by the redoubtable Daniela Innocenti Beem, is charged with ensuring that the groom doesn't see the bride before the ceremony. (berkshirefinearts.com)

Protein-analysis] Re: why cant we say chaperone an enzyme? (bio.net)

Like "The Wife," "The Chaperone" takes its title from a reductive role women have been branded with throughout the generations, limiting the growth of their identity so that it may be defined by their caregiver status. (rogerebert.com)

Here we report the crystal structures of two intramolecular chaperone domains in either the released or the pre-cleaved form, revealing the role of the chaperone domain in the formation of a triple-beta-helix fold. (rcsb.org)
Being a chaperone in the entertainment industry is an interesting and rewarding role. (barnet.gov.uk)
Practice staff should serve as a chaperone while students should not fill the role. (svmic.com)
Are you a chaperone in the entertainment industry and want to better understand your role in protecting children and young people from abuse or harm? (nspcc.org.uk)

2 This study also concluded that chaperones should be offered to patients more widely during genital examinations in genitourinary medicine (GUM) clinics. (bmj.com)

The parent should be with or in sight of their child at all times , whether on set/stage, dressing rooms, during meals & breaks, unless the child is under the supervision of a licensed chaperone. (brent.gov.uk)
There's many different areas of the entertainment world where children are employed, all requiring appropriate supervision by chaperones. (barnet.gov.uk)

ALL chaperones or volunteers with one-on-one unrestricted access to students. (aacps.org)
Chaperones and volunteers must pay the cost of the fingerprint-supported background check. (aacps.org)
Well before the trip-perhaps before even accepting volunteers-make it clear what being a chaperone will entail. (bobrogerstravel.com)
At some point in the preparation (hopefully well before the tour departs) it may become clear to you that one of your volunteers is not suited for the chaperone job, and it will be up to you to remove them from the trip. (bobrogerstravel.com)

Phosphate is released and the resulting substrate-Hsc70-ADP complex is very stable, until ADP/ATP-exchange is stimulated by a second co-chaperone. (bio.net)
The efficiency of substrate transfer is high because dissociation from the chaperone site is very fast and because the two sites are close to each other. (unboundmedicine.com)

Figure 5: Organization of chaperone pathways in the cytosol. (nature.com)

We are auditing all practitioners subject to a chaperone requirement, in order to ensure the restriction is adequately protecting the public. (medicalboard.gov.au)

We also take up references and invites candidates for interview to ensure that they are suitable to act as chaperones. (brent.gov.uk)
Setting the standards ahead of time will ensure that your chaperones know well in advance whether they're right for the job. (bobrogerstravel.com)
a) Adopt a policy that patients are free to request a chaperone and ensure that the policy is communicated to patients. (svmic.com)

The MBA issued guidance to its boards and committees confirming it had accepted all the recommendations in the report and since then no new decisions have been made by the Board to require a practitioner to practise with a chaperone present. (medicalboard.gov.au)
When you and your chaperones present a united front, there is no travel challenge you won't rise to meet. (bobrogerstravel.com)
Having chaperones present can also help prevent misunderstandings between patient and physician. (svmic.com)
d) In general, use a chaperone even when a patient's trusted companion is present. (svmic.com)
e) Provide opportunity for private conversation with the patient without the chaperone present. (svmic.com)
In addition, about 58% of the participants concurred that a chaperone should be present. (bvsalud.org)

A putative chaperone binding domain was identified within the first 100 residues of DspE. (actahort.org)

Quantifying ATP-Independent Nucleosome Chaperone Activity with Single-Molecule Methods. (bvsalud.org)

Requiring an adult chaperone at malls, at least for certain times of the day, is not new. (wtop.com)
Even a Chik-fil-A franchise in southeast Pennsylvania caused a stir with its social media post earlier this year that announced its policy of banning kids under 16 without an adult chaperone, citing unruly behavior. (wtop.com)

Chaperones must have knowledge of the Children (Performances and Activities) (England) Regulations 2014 and the associated DfE guidance on child performances . (brent.gov.uk)

Yeast-two-hybrid experiments were conducted to map the chaperone binding domain of DspE. (actahort.org)

Mix in two lovebirds on the eve of their wedding, a bumbling best man, a desperate theatre producer, a not-so-bright hostess, gangsters posing as pastry chefs, a misguided Don Juan and a sleepy chaperone, and you have the ingredients for a show that will have everyone laughing. (mtishows.com)

Osmolytes exert their chaperoning effects indirectly by changing the interaction of the protein with solvent, rather than through any direct interaction with the protein. (wikipedia.org)

The Chaperone Licence Application form requires you to provide us details of relevant experience and asks for you to provide three reference contacts. (barnet.gov.uk)
Our new sets of Chaperones provide access to highly effective co-crystallization, which adds a powerful method to the toolbox of chemists and crystallographers. (bruker.com)
The chaperones can significantly increase the probability of successful crystallization and provide faster access to the absolute 3D structure of an organic analyte. (bruker.com)
The purpose of this mini-review is to highlight the emerging notion that metal chaperones, such as PBT2 (Prana Biotechnology), modulate a variety of critical pathways affecting key aspects of the AD cascade to provide a more "holistic" approach to the treatment of this disease. (frontiersin.org)

Even a small reward or memento of the trip will show your chaperones that you appreciate all they've done. (bobrogerstravel.com)
When shopping with us in person our customers often ask us to show them how to make their hoods in chaperones so we decide our long distance web customers also needed a visual primer to refer to. (revivalclothing.com)

As a licensed chaperone, you will effectively be carrying out the Local Authority's responsibility for the care of children in entertainment. (barnet.gov.uk)

These arrays are then exposed to FACT (FAcilitates Chromatin Transcription), a non- ATP -driven heterodimeric nuclear chaperone known to both disrupt and tether histones during transcription. (bvsalud.org)

A key recommendation was for the Board to stop using chaperone conditions when we take action to protect the public. (medicalboard.gov.au)
SVMIC's best practice recommendation is to offer a chaperone during any procedure that requires the patient to disrobe. (svmic.com)

Anatomy15

Organisms4

Diseases2

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes54

Information Science3

Named Groups1

Health Care2

Drowsy Chaperone25

Proteins15

Oxidative Stress1

HSP704

Molecular chaperone3

HSP901

Expectations4

Neurodegenerative disease2

Stress5

Compounds1

Pharmacological2

19962

Adults1

Molecules5

Secretion1

Child's2

Mechanisms1

America1

Escherichia1

Status of a chaperone1

Responsibilities1

Exams2

Affinity1

Cellular2

20161

Janet's1

Enzyme1

Reductive1

Role4

Widely1

Supervision2

Volunteers4

Substrate2

Organization1

Requirement1

Ensure3

Present6

Residues1

Activity1

Adult2

Performances1

Domain1

Theatre1

Interaction1

Provide4

Show2

Children in entertainment1

Transcription1

Recommendation2