Changes t lymphocyte subsets. Medical search. Frequent questions

We demonstrate here the use of Wavelength Modulated Raman Spectroscopy, to achieve label-free identification of purified, unfixed and untouched populations of major immune cell subsets isolated from healthy human donors. (st-andrews.ac.uk)
There are various subsets of each of these individual populations with specific cell-surface markers and function. (testcatalog.org)
Gridley, D.S. and Pecaut, M.J. Genetic background and lymphocyte populations after total-body exposure to iron ion radiation. (llu.edu)
These two different ADE risks have possible implications for SARS-CoV-2 B-cell vaccines for subsets of populations based on age, cross-reactive antibodies, variabilities in antibody levels over time, and pregnancy. (frontiersin.org)
The selective toxicity of 2-chloro-2´-deoxy-ß-D-adenosine towards certain normal and malignant lymphocyte and monocyte populations is based on the relative activities of deoxycytidine kinase and deoxynucleotidase. (nih.gov)
This induction was also seen on enriched populations of natural killer and B lymphocytes, suggesting a direct effect not dependent on bystander cells. (cargill.com)

The following lymphocyte subsets were studied in all participants: total B lymphocyte (CD19), total T lymphocyte (CD3), helper T lymphocyte (CD3/CD4), cytotoxic T lymphocyte (CTL) (CD3/CD8), natural killer T lymphocyte (CD16/56) and a T-lymphocyte activation marker (HLA-DR). (nih.gov)
This lymphocyte population had demonstrable antiviral activity early in the infection process even before class I major histocompatibility complex (MHC)-restricted CD8+ cytotoxic T-lymphocyte (CTL) activity was detectable. (edu.au)
Thus, 2-chloro-2´-deoxy-ß-D-adenosine can be distinguished from other chemotherapeutic agents affecting purine metabolism in that it is cytotoxic to both actively dividing and quiescent lymphocytes and monocytes, inhibiting both DNA synthesis and repair. (nih.gov)
The CD69 antibody, clone L78, is derived from hybridization of Sp2/0-Ag14 mouse myeloma cells with lymph node cells from BALB/c mice immunized with a CD8 + alloantigen-directed cytotoxic T-lymphocyte (CTL) cell line. (bdbiosciences.com)

What do you think about routinely assessing lymphocyte subpopulations in the peripheral blood of patients with multiple sclerosis (MS)? (medscape.com)
The chief of my department asks that all patients with MS undergo periodic measurement of all peripheral blood lymphocyte subpopulations, even when there are no clinical signs and symptoms of the disease. (medscape.com)
Is there a rationale for periodic (every 3 months) evaluations of peripheral blood lymphocyte subpopulations in patients under clinical observation for MS? (medscape.com)
Each of these lymphocyte subpopulations have distinct effector and regulatory functions and are maintained in homeostasis under normal physiological conditions. (testcatalog.org)
23. Subpopulations of the peripheral lymphocytes in the early clinical forms of Lyme disease. (nih.gov)
29. Radiotherapy-induced changes of peripheral blood lymphocyte subpopulations in cervical cancer patients: relationship to clinical response. (nih.gov)
30. Lymphocyte subpopulations and neutrophil function in calves during the first 6 months of life. (nih.gov)

Vanham, G, Ceuppens, JL & Bouillon, R 1989, ' T lymphocytes and their CD4 subset are direct targets for the inhibitory effect of calcitriol ', Cellular Immunology , vol. 124, pp. 320-333. (itg.be)

There were also concentration-related reductions in blood monocytes, basophils, and eosinophils and increased lymphocyte expression of the activation marker CD25. (nih.gov)
Since 2-chloro-2´-deoxy-ß-D-adenosine is resistant to deamination by adenosine deaminase and there is little deoxynucleotide deaminase in lymphocytes and monocytes, 2-CdAMP accumulates intracellularly and is subsequently converted into the active triphosphate deoxynucleotide, 2-chloro-2´-deoxy-ß-D-adenosine triphosphate (2-CdATP). (nih.gov)
The CD4 antigen, with a molecular weight of 55 kDa, is present on Thelper/ inducer lymphocytes and monocytes. (bdbiosciences.com)
Lymphocytes increased postexercise but reduced 2 h after exercise in both groups, while the number of monocytes increased only immediately after the exercise session in UTG and TG. (hindawi.com)

The counts of lymphocyte subset were changed more profound than their proportions. (biomedcentral.com)
Lymphocyte subset counts up to 6 months post transplant had no effect on relapse. (unibas.ch)
The absolute counts of lymphocyte subsets are known to be influenced by a variety of biological factors, including hormones, the environment, and temperature. (testcatalog.org)
The studies on diurnal (circadian) variation in lymphocyte counts have demonstrated progressive increase in CD4 T-cell count throughout the day, while CD8 T cells and CD19+ B cells increase between 8:30 a.m. and noon with no change between noon and afternoon. (testcatalog.org)
Linear regression analysis showed that, the absolute counts of total lymphocytes, CD3+, CD4+, CD4+CD38+, CD4+CD28+, were positively associated with formula-fed infants and infant's infections in the first 4 months of age. (cambridge.org)
In Oct. 2020, the following COVID-19 clinical application was added: determining counts of CD3 + CD4 + and/or CD3 + CD8 + lymphocytes may be useful in the immunological assessment of SARS-CoV-2 infected individuals with COVID-19 disease. (b3cnewswire.com)
Individuals with COVID-19 disease typically exhibit a decrease of CD3 + CD4 + and/or CD3 + CD8 + lymphocyte counts with increasing disease severity. (b3cnewswire.com)

Additionally, we have been able to distinguish between CD303+ plasmacytoid and CD1c+ myeloid dendritic cell subsets, the key initiator and regulatory cells of many immune responses. (st-andrews.ac.uk)
Rapid recovery of lymphocytes after T-cell depleted hematopoietic SCT (HSCT) protects from relapse of myeloid malignancies. (unibas.ch)
L-arginine metabolism in myeloid cells controls T-lymphocyte functions. (nature.com)

Are T-Lymphocyte Subsets Important Markers for Disease Progression in Patients With MS? (medscape.com)
The study revealed thymus atrophy in patients with PEM, especially the oedematous type, accompanied by changes in the peripheral lymphocyte subsets. (who.int)
The present study investigated the distributions of lymphocyte subsets in tumor tissue and peripheral blood samples from cervical cancer patients and precancerous lesion patients, and evaluated the correlations of lymphocyte subsets with clinicopathological and prognostic variables. (biomedcentral.com)
Present study aimed to investigate the lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients. (biomedcentral.com)
Lymphocyte subsets was classified using flow cytometry with peripheral blood collected from 106 patients. (biomedcentral.com)
Thus, the reported patterns of lymphocyte subsets in patients with COVID-19 were diverse and controversial, and necessitated to clear more. (biomedcentral.com)
Here, we first investigated alterations of lymphocyte subsets in severe COVID-19 patients. (biomedcentral.com)
Finally, we investigated the impacts of the lymphocyte subsets in patients with delayed hospitalization. (biomedcentral.com)
HIV positive patients may have reduced T-helper (CD4) lymphocytes or a reduced T-helper: T-suppressor (CD8) cell ratio, usually in conjunction with an absolute lymphocytopenia. (nwlpathology.nhs.uk)
The role of Tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with lung cancer is still controversial. (karger.com)
The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to investigate the association between TIL subsets and lung cancer patients' outcome. (karger.com)
This meta-analysis clarified that high level of CD8 + and CD3 + T cells infiltration in TS or TN, and high CD4 + T lymphocytes infiltration in TS showed better OS in lung cancer patients, whereas high density of FOXP3 + T cells infiltration in TS could be recognized as a negative prognostic factor. (karger.com)
A significant difference in total number of T lymphocytes and sub- units of helper T cell was observed in patients with concomitant TB and DM. (tanaffosjournal.ir)
Comparison of Lymphocyte Number and Their Subsets in Patients with Diabetes Mellitus Type II, Tuberculosis and Concomitant TB and Diabetes', TANAFFOS (Respiration) , 1(4(autumn)), pp. 45-50. (tanaffosjournal.ir)
22. Tumor-infiltrating lymphocytes contain higher numbers of type 1 cytokine expressors and DR+ T cells compared with lymphocytes from tumor draining lymph nodes and peripheral blood in patients with cancer of the uterine cervix. (nih.gov)
25. Flow cytometric analysis of T cell subsets in paired samples of cerebrospinal fluid and peripheral blood from patients with neurological and psychiatric disorders. (nih.gov)
28. Functional lymphocyte subset assessment of the Th1/Th2 profile in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocytes. (nih.gov)
33. Leukocytapheresis therapy modulates circulating t cell subsets in patients with ulcerative colitis. (nih.gov)
40. FACS analysis of peritoneal lymphocytes in ovarian cancer and control patients. (nih.gov)
As shown in peer-reviewed clinical studies, some patients with COVID-19 may exhibit a decrease of specific lymphocyte T-cell subsets (CD4 + and/ or CD8 + T-cells), and this decrease is associated with increased risk of IMV and mortality. (b3cnewswire.com)
Tolerant patients displayed an expansion of peripheral blood B and NK lymphocytes, fewer activated CD4+ T cells, a lack of donor-specific antibodies, donor-specific hyporesponsiveness of CD4+ T cells, and a high ratio of forkhead box P3 to α-1,2-mannosidase gene expression. (jci.org)

39. T lymphocytes and cytokine production in ascitic fluid of ovarian malignancies. (nih.gov)

Lymphocytes were collected from the tumor tissue and the peripheral blood, and isolated by Lymphoprep density gradient centrifugation. (biomedcentral.com)
The percentages of lymphocyte subsets were quantified by flow cytometry analysis, and the differences between lymphocyte subsets in the tumor tissue and peripheral blood were compared by SPSS. (biomedcentral.com)
These results suggested that distinct alterations in infiltrating lymphocyte subsets occurred in the tumor and were associated with clinicopathological and prognostic parameters. (biomedcentral.com)
Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer. (nature.com)

It might be useful to look at certain T cell subsets by assays examining cytokine production intracellularly especially in response to an antigen such as myelin basic protein. (medscape.com)

T lymphocyte and its subset negatively correlated with disease severity, CT manifestation and delayed hospitalization. (biomedcentral.com)

In addition, some lymphocyte subsets, especially CD4+ cells and CD8+ cells, and the CD4+/CD8+ cell ratio were closely associated with clinicopathological and prognostic parameters. (biomedcentral.com)
This modification accompanies with a decrease in the absolute number of T lymphocytes (CD3 + T cells), including CD4 + T and especially CD8 + T subsets [ 3 ]. (oncotarget.com)
Another important characteristics of immunosenscence is the exhaustion of CD95 - virgin T cells which are replaced by the progressive expansion of CD28 - T cells among both CD4 + and CD8 + subsets [ 4 ]. (oncotarget.com)
HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
Lymphocytes in peripheral blood (circulation) are heterogeneous and can be broadly classified into T cells, B cells, and natural killer (NK) cells. (testcatalog.org)
This assay provides absolute (cells/mcL) and relative (%) quantitation for the main categories of T cells, B cells, and NK cells, in addition to a total lymphocyte count (CD45+). (testcatalog.org)
We show that activation of Wnt/β-catenin signaling arrests human peripheral blood and cord blood T lymphocytes in the naive stage and blocks their transition into functional T effector cells. (nih.gov)
B1 B cells signify a distinctive subset of B lymphocytes distinctive from typical B2 B cells, and so are essential in the creation of organic antibodies. (mdm-inhibitors.com)
Immunophenotypic overlap of the subset with additional innate-like B cells referred to recently in human beings is limited. (mdm-inhibitors.com)
Compact disc20+Compact disc27+Compact disc43loCint cells might represent a definite B1 cell subset within Compact disc27+ B cells. (mdm-inhibitors.com)
These findings establish an absolute requirement for CD8+ and CD4+ T lymphocytes and macrophage subsets in the elimination of a natural murine poxvirus infection and support the idea that macrophages may be essential accessory cells for the generation of class I MHC-restricted antiviral CTL responses. (edu.au)
Infection of CD3+ CD8+ CD45RA+ cells was detected in 9 of 16 study subjects at frequencies ranging from 30 to 1,400 proviral copies/10(6) cells, more frequently than CD3+ CD8+ lymphocytes expressing the RO isoform of CD45 (n = 2, 70 and 260 copies /10(6) cells). (ox.ac.uk)
Destruction of cells destined to become CD8+ lymphocytes may be a major factor in the decline in CD8+ lymphocyte frequencies and function on disease progression and may contribute directly to the observed immunodeficiency in AIDS. (ox.ac.uk)
The CD4 antibody, clone SK3, is derived from hybridization of NS-1 mouse myeloma cells with spleen cells from BALB/c mice immununized with human peripheral blood T lymphocytes. (bdbiosciences.com)
An anti-inflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro. (cargill.com)
005). EpiCor treatment of peripheral blood mononuclear cells (PBMCs) caused induction of the activation markers CD80 and CD86 on B lymphocytes, and CD69 and CD25 on CD3−CD56+ natural killer cells. (cargill.com)

MEASUREMENTS AND MAIN RESULTS: The number of macrophages, neutrophils, and lymphocytes observed in airways of infected mice that had been exposed to hyperoxia as neonates was significantly greater than in infected siblings that had been exposed to room air. (nih.gov)
Like T lymphocytes, macrophages differentiate into distinct effectors including classically (M1) and alternatively (M2) activated macrophages. (frontiersin.org)

Lymphocyte subsets in peripheral blood and gut microbiota composition in faeces samples were studied at the age of 4 months by flow cytometry analysis and qPCR respectively. (cambridge.org)
Peripheral blood samples were collected and examined for lymphocyte subsets by flow cytometry. (cambridge.org)

This study focused on immunophenotypic analysis of lymphocyte subsets in newborns with BTD. (nih.gov)

The selection of antiinflammatory and lymphocyte activation assays was based on initial evidence for immunomodulating effects of EpiCor from an unusually low incidence of influenza among employees in a factory manufacturing EpiCor, along with a high oxygen radical absorbance capacity value. (cargill.com)

The abundance and activation of several leukocyte subsets were investigated with unsupervised clustering approaches FlowSOM and SPADE, as well as by manual gating. (edu.au)

Enumeration of CD4+ lymphocytes in HIV-positive participants and age-matched controls was performed on cryopreserved whole blood using the method reported by Fiebig et. (cdc.gov)

Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. (biomedcentral.com)

As far, the correlation of lymphocyte subsets with the lesion manifestation in lung CT was not be well documented and necessitated to clarify. (biomedcentral.com)

The functional change and shift of NK, NKT and T cell subsets by aging have been widely studied. (oncotarget.com)
The Cambridge Biotech HIV-1 Western Blot Kit is manufactured by Calypte Corporation from HIV-I propagated in an H9/HTLV-IIIb T-lymphocyte cell line. (cdc.gov)
Each of these lymphocyte subsets can be identified by a combination of one or more cell surface markers. (testcatalog.org)
Collectively, our data suggest that Wnt/β-catenin signaling is a negative regulator of naive-to-effector T cell differentiation in human T lymphocytes. (nih.gov)
26. Lymphocyte subsets and specific T-cell immune response in thalassemia. (nih.gov)
35. [Kinetic study on the variety of lymphocytes and CD34+ cell subsets during autologous peripheral blood stem cell transplantation]. (nih.gov)
Particular interest is on cytokine signaling and epigenetic mechanisms that regulate lymphocyte development and cell-fate decisions. (nih.gov)

In six of the seven study subjects investigated, variants infecting CD8+ lymphocytes were partially or completely genetically distinct in the V3 region from those recovered from CD4+ lymphocytes and showed a greater degree of compartmentalization than observed between naive and memory subsets of CD4+ lymphocytes. (ox.ac.uk)

This study aims to assess the association between the neutrophil-to-lymphocyte ratio (NLR) and the incidence of severe COVID-19 infection. (cambridge.org)
Infection of the CD45RA+ (naive) subset of peripheral CD8+ lymphocytes by human immunodeficiency virus type 1 in vivo. (ox.ac.uk)
To investigate the mechanism and functional significance of infection of CD8+ lymphocytes by human immunodeficiency virus type 1 (HIV-1) in vivo, we determined frequencies of infection, proviral conformation, and genetic relationships between HIV-1 variants infecting naive (CD45RA+) and memory (CD45RO+) peripheral blood CD4+ and CD8+ lymphocytes. (ox.ac.uk)
In agreement with previous studies, there was no evidence for a similar preferential infection of CD4+ naive lymphocytes. (ox.ac.uk)
The preferential distribution of HIV-1 in naive CD8+ lymphocytes indeed suggests that infection occurred early in T-lymphocyte ontogeny, such as during maturation in the thymus. (ox.ac.uk)

CD45 lymphocyte count was designated the total lymphocyte count. (cdc.gov)

Thymus size was assessed ultrasonographically and correlated to the percentage of CD4 and CD8 T-lymphocytes in peripheral blood in 32 infants with protein-energy malnutrition [‎PEM]‎ and compared with 14 healthy control infants. (who.int)
We sought to assess the effect of several early environmental factors on lymphocyte subsets and microbiota composition in infants at familial risk for CD. (cambridge.org)

In two study subjects, arginine substitutions at position 306, associated with use of the chemokine coreceptor CXCR4, were preferentially found in CD4 lymphocytes. (ox.ac.uk)
Fucoidan, a ligand for the homing molecule l-selectin (CD62L), is known to induce rapid up-regulation of several chemokine receptors on lymphocytes. (cargill.com)

Whether lymphocyte reconstitution has a similar role after non-manipulated transplantation is controversial. (unibas.ch)

37. [Lymphocyte subsets in blood donors]. (nih.gov)

Objective To investigate the effect of vitamin A nutrition on T lymphocyte subsets, related cytokines and prognosis in preschool children with asthma, in order to provide theoretical evidence for the prevention and treatment of bronchial asthma. (magtech.com.cn)
Effects of vitamin A nutrition on T lymphocyte subsets, inflammatory mediators and prognosis in preschool children with asthma[J]. journal1, 2020, 28(12): 1393-1397. (magtech.com.cn)

Multivariate logistic regression showed that chest tightness, lymphocyte count, and γ-glutamyl transpeptidase were the independent predictors for severe COVID-19. (biomedcentral.com)

Proviral sequences in both CD4+ and CD8+ lymphocyte subsets were complete, as assessed by quantitation using primers from the long terminal repeat region spanning the tRNA primer binding site. (ox.ac.uk)

In summary, there is really no evidence to suggest that routine monitoring of CD3/CD4/CD8 lymphocyte subsets from either blood or CSF would be at all helpful in the management of MS. (medscape.com)
Publication: Lymphocyte subset analysis on frozen whole blood. (nih.gov)
An approach to perform lymphocyte subset analysis on frozen-thawed whole blood (F/T WB) is described. (nih.gov)
In this study, we identified the largest reported cohort to our knowledge of tolerant renal transplant recipients, as defined by stable graft function and receiving no immunosuppression for more than 1 year, and compared their gene expression profiles and peripheral blood lymphocyte subsets with those of subjects with stable graft function who are receiving immunosuppressive drugs as well as healthy controls. (jci.org)

Are T-Lymphocyte Subsets Important Markers for. (medscape.com)
Lymphocyte subsets fluctuate even in healthy people with no underlying disease, and small changes in the overall pool of lymphocytes bearing certain phenotypic markers such as CD4 or CD8 are probably of little interest and benefit. (medscape.com)
Other lymphocyte surface markers can also be enumerated. (nwlpathology.nhs.uk)

In conclusion, the balance between the effects of the pre- and post-natal factors on lymphocyte subsets and microbiota composition might modify the risk for future development of immune-related diseases such as celiac disease. (cambridge.org)

Distinguishing between human lymphocyte subsets. (wikipedia.org)
Leu-23: an early activation antigen on human lymphocytes. (bdbiosciences.com)

It is concluded that lymphocyte subset analysis using F/T WB yields comparable results to fresh samples, which should prove useful for a number of practical applications. (nih.gov)

The importance of T-lymphocyte subsets in the control of poxvirus infections is controversial. (edu.au)

1984. Depression in B- and T-lymphocyte mitogen- induced blastogenesis in mice exposed to low concentrations of benzene. (cdc.gov)

Major research focus in the Egwuagu laboratory is on autoreactive lymphocytes that mediate CNS autoimmune diseases, such as Uveitis and Multiple Sclerosis. (nih.gov)

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