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AndrogensReceptors, AndrogenAndrogen AntagonistsAndrogen Receptor AntagonistsDihydrotestosteroneTestosteroneProstatic NeoplasmsTestosterone CongenersMetriboloneFlutamideAndrogen-Insensitivity SyndromeProstateAndrostenedioneNeoplasms, Hormone-DependentNandroloneAndrostane-3,17-diolDehydroepiandrosterone3-Oxo-5-alpha-Steroid 4-DehydrogenaseCyproterone AcetateTestisSteroid 17-alpha-HydroxylaseDehydroepiandrosterone SulfateCell Line, TumorCholestenone 5 alpha-ReductaseAromataseNitrilesFeminizationEstradiolHyperandrogenismGonadal Steroid HormonesEstrogensAndrogen-Binding ProteinTestosterone PropionateSeminal VesiclesSex Hormone-Binding GlobulinGenitalia, MalePolycystic Ovary SyndromeSex DifferentiationSex CharacteristicsCyproteroneSteroidsAntineoplastic Agents, HormonalHirsutismGene Expression Regulation, NeoplasticEpididymisRNA, MessengerAndrostenolsMethyltestosteroneReceptors, SteroidLuteinizing HormoneTranscriptional Activation5-alpha Reductase InhibitorsHypogonadismPhenylthiohydantoin3-Hydroxysteroid DehydrogenasesGenitaliaEstrenesAndrostenediolSertoli Cells17-alpha-HydroxyprogesteroneFinasterideNuclear Receptor CoactivatorsGonadotropin-Releasing HormoneProstatic HyperplasiaLeuprolideReverse Transcriptase Polymerase Chain ReactionOvarySignal TransductionAnabolic AgentsProstatic Neoplasms, Castration-ResistantLeydig CellsHypospadiasImmunohistochemistryTranscription, GeneticNuclear Receptor Coactivator 2GoserelinCell ProliferationReceptors, EstrogenAzasteroidsFollicle Stimulating HormoneTumor Cells, Cultured17-Hydroxysteroid DehydrogenasesOrgan SizeSexual MaturationSpermatogenesisPenisEstrogen Receptor betaTransfectionAlopeciaTheca CellsCryptorchidismCell NucleusBulbo-Spinal Atrophy, X-LinkedDisorders of Sex DevelopmentFluoxymesteroneMuscular Disorders, AtrophicProgesteroneAndropauseBase SequencePromoter Regions, Genetic
DeprivationReceptorsTestosteroneProstateAnti-androgenSelectiveEstrogensDeficiencyHuman androgen receptorSafety of androgenTherapyProduce androgensInsensitivity syndromeSupplementationSynthesisCastration-resistantLibidoHormonalSkeletalUptakeSARMsReceptor expressionPostmenopausal womenPatientsMutationLocalizationAdultOvariesChromosomeTherapeuticPotentGonadalMutationsTesticularExcessSubsetPubertyProteinClinicalCRPCLevelsAbsencePartialGeneHormonesInhibitorWomen
Deprivation21
  • PURPOSE: The authors ascertained the health care costs of androgen deprivation therapy and related skeletal events. (rand.org)
  • MATERIALS AND METHODS: Using data from the MarketScan Medicare Supplemental and Coordination of Benefits Database, the authors identified cases with International Classification of Disease, 9th Revision codes indicating a diagnosis of prostate cancer who initiated androgen deprivation therapy between 1999 and 2002. (rand.org)
  • The control group consisted of patients with prostate cancer with no androgen deprivation therapy use, matched by age, geographic region, insurance plan and index year. (rand.org)
  • RESULTS: Of the 8,577 eligible men with prostate cancer, 3,055 initiated androgen deprivation therapy and 5,522 did not. (rand.org)
  • Many male patients being treated for prostate cancer undergo androgen deprivation therapy, which has been shown to have several risky side effects, including osteoporosis. (pharmacytimes.com)
  • The consistent expression of AR in prostate cancer (PCa), and its continued activity in PCa that relapse after androgen deprivation therapy (castration-resistant prostate cancer (CRPC)), indicate that at least a subset of these genes are also critical for PCa development and progression. (harvard.edu)
  • Men with history of fracture and comorbidities are at an increased risk of fracture after long-term use of androgen deprivation therapy, and initiating this therapy should be carefully considered in older men with localized prostate cancer. (medicaldaily.com)
  • Androgen deprivation therapy (ADT) has remained the main therapeutic option for patients with advanced prostate cancer (PCa) for about 70 years. (urotoday.com)
  • Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. (harvard.edu)
  • Unfortunately, androgen deprivation rarely results in cure, as not all prostate cancer cells are androgen-dependent. (oncolink.org)
  • Many studies have been conducted to determine if androgen deprivation (surgical castration, estrogen, cyproterone, luteinizing hormone-releasing hormone agonists (LHRH), anti-androgens or a combination thereof) combined with radiotherapy is more effective than radiotherapy alone. (oncolink.org)
  • A MEDLINE search was used to identify all English language articles published between January 1990 and September 1998 in which prostate cancer patients were treated with a combination of radiotherapy and androgen deprivation. (oncolink.org)
  • Of these, only two found a significant improvement in survival with the addition of androgen deprivation. (oncolink.org)
  • In addition, of the four retrospective reviews that analyzed cancer-specific survival, none found that the addition of androgen deprivation to radiotherapy improved this endpoint. (oncolink.org)
  • Based on these trials the authors conclude that combined modality therapy may improve disease free survival compared to radiotherapy alone, but the impact of androgen deprivation combined with radiotherapy on overall survival remains unclear. (oncolink.org)
  • The addition of abiraterone acetate to androgen deprivation therapy improves overall survival but probably not quality of life. (cochrane.org)
  • It probably also extends disease-specific survival, and delays disease progression compared to androgen deprivation therapy alone. (cochrane.org)
  • Systemic androgen deprivation therapy (ADT), also referred to as hormone therapy, has long been the primary treatment for metastatic prostate cancer. (cochrane.org)
  • The study aimed to compare the efficacy and safety of androgen deprivation therapy (ADT) with abiraterone or docetaxel versus ADT alone as neoadjuvant therapy in patients with very-high-risk localized prostate cancer. (frontiersin.org)
  • The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men diagnosed with prostate cancer and are undergoing androgen deprivation therapy (ADT), and whether it will also improve physical fitness and function, body composition, and outcomes such as quality of life, cancer symptoms, and self-esteem. (dana-farber.org)
  • Additionally, we imaged one patient with castration-sensitive prostate cancer before and 4 wk after treatment with androgen deprivation therapy (ADT). (snmjournals.org)
Receptors9
  • An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. (wikipedia.org)
  • Dihydrotestosterone (DHT) is a metabolite of testosterone, and a more potent androgen than testosterone in that it binds more strongly to androgen receptors. (wikipedia.org)
  • Their research, published April 20, 2022, in the journal Molecular Cell , identifies unique features of the receptor that distinguish it from other hormone receptors and provide clues to how androgen signaling goes awry in prostate cancer . (mskcc.org)
  • has shown that within rats mosaic for wild-type and defective androgen receptors, only those SNB motoneurons with functional androgen receptors responded to adult androgen treatment with an increase in soma size. (jneurosci.org)
  • Thus, androgens appear to increase soma size through a direct action on SNB motoneurons where functional androgen receptors are necessary for the response to occur. (jneurosci.org)
  • Androgen receptor (AR) is one of the predominant nuclear hormone receptors in invasive breast cancer and can be explored as a biomarker of response for targeted anti-androgen therapy, especially in the setting of triple negative breast cancer (TNBC). (ecancer.org)
  • To categorise the immunostaining heterogeneity of androgen receptors in metastatic carcinoma of the prostate using a pattern oriented approach and to correlate the results with response to hormonal treatment. (bmj.com)
  • Studies in the past have shown that mere positivity and negativity for androgen receptors of tumour cells may or may not predict response to hormonal treatment. (bmj.com)
  • 4 On immunostaining, prostate carcinoma specimens show heterogeneity of androgen receptors in contrast to homogeneous staining of androgen receptors in normal prostate epithelium. (bmj.com)
Testosterone26
Prostate21
  • Prins GS, Birch L, Greene GL: Androgen receptor localization in different cell types of the adult rat prostate. (karger.com)
  • The androgen receptor (AR) is critical for the normal development of prostate and for its differentiated functions. (harvard.edu)
  • Selective androgen receptor modulators (SARMs) are essentially prostate sparing androgens, which provide therapeutic potential in osteoporosis, male hormone replacement, and muscle wasting. (rcsb.org)
  • OBJECTIVES: I. Establish whether changes between baseline and 2-month post androgen suppression endorectal coil MRI results predict for biochemical control following radiotherapy with androgen suppression in patients with adenocarcinoma of the prostate. (knowcancer.com)
  • We know a lot about the androgen receptor from studies conducted at the level of about 10,000 feet," says Charles Sawyers , Chair of the Human Oncology and Pathogenesis Program at MSK who researches the biology and treatment of prostate cancer. (mskcc.org)
  • More recently it has been proposed that prostate tumor cells synthesize their own androgens through de novo steroidogenesis, which involves the step-wise synthesis of androgens from cholesterol. (harvard.edu)
  • Our results are consistent with the hypothesis that cholesterol-fueled intratumoral androgen synthesis may accelerate the growth of prostate tumors, and suggest that treatment of CRPC may be optimized by inclusion of cholesterol reduction therapies in conjunction with therapies targeting androgen synthesis and the AR. (harvard.edu)
  • The role of medications that suppress androgen production is controversial in the treatment of prostate cancer. (oncolink.org)
  • When medications deplete the body's androgen supply or when the testes are removed (the testes supply 97% of a man's androgen), prostate cancer cells die. (oncolink.org)
  • The purpose of this work was to evaluate the effect of androgen receptor (AR) inhibition on prostate-specific membrane antigen (PSMA) uptake imaged using 68 Ga-PSMA-11 PET in a mouse xenograft model and in a patient with castration-sensitive prostate cancer. (snmjournals.org)
  • In fact, cellular PSMA expression is regulated by the androgen receptor (AR), which is frequently targeted during prostate cancer treatments and can therefore confound interpretation. (snmjournals.org)
  • The introduction of the 240mg tablet provides the first-and-only option for a once-daily, single-tablet Androgen Receptor Inhibitor (ARI) approved for the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC). (jnj.com)
  • ERLEADA ® (apalutamide) is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC). (jnj.com)
  • Flutamide is an androgen receptor (AR) antagonist approved by the United States Food and Drug Administration for the treatment of prostate cancer. (oregonstate.edu)
  • Identification of novel androgen receptor (AR) antagonists may lead to urgently needed new treatments for patients with prostate cancer resistant to current AR antagonists. (aacrjournals.org)
  • Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. (lu.se)
  • AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells. (lu.se)
  • Paraffin wax embedded tumour sections from 85 patients with metastatic carcinoma of the prostate were processed for immunocytochemistry and stained for the androgen receptor using antiandrogen receptor antibodies. (bmj.com)
  • Image analysis of androgen receptor immunostaining with a receptogram oriented approach provides important prognostic information that can be used to predict response to hormone treatment in patients with metastatic carcinoma of the prostate. (bmj.com)
  • In experiments, this molecule was able to regulate the androgen receptor, which is important to the growth of both cancerous and normal prostate cells. (lu.se)
  • The ability of this microRNA to inhibit the androgen receptor offers potential for further research on the possibilities of using miR-145 for treatment of patients with prostate cancer so that they do not develop aggressive tumours", says Olivia Larne. (lu.se)
Anti-androgen3
  • Use this transgender hormone therapy, anti-androgen transdermal cream provides for male hormone retardant ideal for those seeking a holistic male to female transformation and can be used in conjunction with any feminising hormone treatment 3 months supply. (transformation.co.uk)
  • The use of anti-androgen drugs, like 5-alpha reductase inhibitors (5ARIs), could protect from severe pulmonary disease. (medrxiv.org)
  • Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. (oregonstate.edu)
Selective6
  • This webinar will discuss the discovery, pharmacology, clinical development, regulatory considerations, and anti-doping efforts related to selective androgen receptor modulators (SARMs), a new class of drug being developed for acute and chronic muscle wasting conditions. (drugfreesport.com)
  • He began an entrepreneurial leave of absence from Ohio State in 2005 and left OSU in 2007 to devote his full-time effort as Chief Scientific Officer at GTx, Inc. (2007-2014) where he oversaw the preclinical and clinical development of selective androgen receptor modulators. (drugfreesport.com)
  • VK5211, the company's lead program for muscle and bone disorders, is an orally available, non-steroidal selective androgen receptor modulator (SARM) being developed for the treatment of patients recovering from non-elective hip fracture surgery. (prnewswire.com)
  • VK5211 is an orally available, non-steroidal selective androgen receptor modulator (SARM) entering Phase 2 development for the treatment of patients recovering from non-elective hip fracture surgery. (prnewswire.com)
  • ARCC 4 is a potent and selective androgen receptor (AR) PROTAC ® Degrader (DC 50 = 5 nM). (tocris.com)
  • Recently, our laboratory discovered selective androgen receptor modulators, which structurally resemble the nonsteroidal AR antagonists bicalutamide and hydroxyflutamide but act as agonists for the androgen receptor in a tissue-selective manner. (rcsb.org)
Estrogens1
Deficiency10
  • Androgen Deficiency in the Adult Male: Causes, Diagnosis and Treatment distills the knowledge acquired by author Dr. Malcolm Carruthers in his 25 years of research and clinical experience in diagnosing and treating the andropause into a comprehensive, detailed clinical resource. (routledge.com)
  • He discusses the causes of androgen deficiency, the male menopause or andropause, and recent advances in its diagnosis. (routledge.com)
  • This combination of features makes Androgen Deficiency in the Adult Male: Causes, Diagnosis and Treatment an invaluable and practical clinical guide, a complete and detailed reference volume, and a cohesive and readable textbook. (routledge.com)
  • Causes of Androgen Deficiency. (routledge.com)
  • The Diagnosis of Androgen Deficiency. (routledge.com)
  • This retrospective analysis examined patients who had androgen deficiency. (bernsteinmedical.com)
  • Androgen deficiency itself can be caused by complications in the ovarian, adrenal, pituitary, and hypothalamic systems. (health.am)
  • Conclusions Higher SHBG, independently of TT, is associated with either subjective or objective androgen deficiency features. (medscape.com)
  • Hence, increased SHBG could remarkably affect androgen status, possibly leading to features of androgen deficiency, despite apparently normal or borderline TT. (medscape.com)
  • In humans, the role of SHBG as a marker of androgen deficiency has been scarcely investigated. (medscape.com)
Human androgen receptor1
  • Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. (dtu.dk)
Safety of androgen1
  • and assessing the efficacy and long-term safety of androgen administration on outcomes that are important to women diagnosed with these conditions. (nih.gov)
Therapy6
  • for information on androgens as medications, see the androgen replacement therapy and anabolic steroid articles. (wikipedia.org)
  • Medical care for a patient with androgen insensitivity syndrome (AIS) has 2 aspects: hormone replacement therapy (HRT) and psychological support. (medscape.com)
  • Androgen Replacement Therapy. (routledge.com)
  • A recent set of symposium papers on the emerging role of estrogen and androgen therapy in the postmenopausal women was published in the Journal of Reproductive Medicine. (wdxcyber.com)
  • This warrants further exploration of the predictive and prognostic significance of its expression amongst TNBC and the potential for targeted therapy, specifically androgen antagonists to improve the outcome of this disease with limited therapeutic options. (ecancer.org)
  • Invasive Ductal Carcinoma in a 46,XY Partial Androgen Insensitivity Syndrome Patient on Hormone Therapy. (bvsalud.org)
Produce androgens2
Insensitivity syndrome9
  • Androgen insensitivity syndrome (AIS), formerly known as testicular feminization, is an X-linked recessive condition resulting in a failure of normal masculinization of the external genitalia in chromosomally male individuals. (medscape.com)
  • This failure of virilization can be either complete androgen insensitivity syndrome (CAIS) or partial androgen insensitivity syndrome (PAIS), depending on the amount of residual receptor function. (medscape.com)
  • Both individuals with partial androgen insensitivity syndrome and individuals with complete androgen insensitivity syndrome have 46,XY karyotypes. (medscape.com)
  • Individuals with complete androgen insensitivity syndrome have female external genitalia with normal labia, clitoris, and vaginal introitus. (medscape.com)
  • It detects upwards of 95% of the mutations for complete androgen insensitivity syndrome and partial androgen insensitivity syndrome. (medscape.com)
  • The basic etiology of androgen insensitivity syndrome is a loss-of-function mutation in the androgen receptor ( AR ) gene. (medscape.com)
  • While the genotypes causing complete androgen insensitivity syndrome are fairly consistent in phenotypic presentation, the genotype/phenotype relationships for the mutations causing partial androgen insensitivity syndrome remain unclear. (medscape.com)
  • This is a case report of complete androgen insensitivity syndrome and literature review of preoperative diagnostic methods. (bvsalud.org)
  • We present a 3 years and 6 months old child with female phenotype, born in São Paulo, Brazil which was diagnosed intraoperatively with complete androgen insensitivity syndrome, during inguinal hernia repair and present potential diagnostic alternatives that we consider viable options in order to avoid this kind of surprise during surgery. (bvsalud.org)
Supplementation2
  • One approach that has drawn recent attention is supplementation with androgens, hormones with anabolic properties whose levels naturally decline with age ( 9 - 12 ). (frontiersin.org)
  • Clinical studies of androgen supplementation in age-related diseases and muscle wasting are a focus of emerging interest ( 11 ). (frontiersin.org)
Synthesis3
  • Loss of AR function means that, despite normal levels of androgen synthesis, the typical postreceptor events that mediate the effects of hormones on tissues do not occur. (medscape.com)
  • In patients treated with ADT the pituitary-adrenal axis mediated by adrenocorticotropic hormone has a central role in the regulation of androgen synthesis. (urotoday.com)
  • Moreover, we show that circulating cholesterol levels are directly correlated with tumoral expression of CYP17A, the critical enzyme required for de novo synthesis of androgens from cholesterol (R = 0.4073, p = 0.025) Since hypercholesterolemia does not raise circulating androgen levels and the adrenal gland of the mouse synthesizes minimal androgens, this study provides evidence that hypercholesterolemia increases intratumoral de novo steroidogenesis. (harvard.edu)
Castration-resistant1
  • However, tumors eventually reemerge that have overcome the absence of gonadal androgens, termed castration resistant PCa (CRPC). (harvard.edu)
Libido3
  • Although androgens are commonly thought of only as male sex hormones, females also have them, but at lower levels: they function in libido and sexual arousal. (wikipedia.org)
  • Level 2 research has shown that all of the major types of androgen replacement approved for use in men, have demonstrated increased libido and arousal in women with female sexual dysfunction. (health.am)
  • The prevalent dogma is that androgens regulate libido in women, although a woman's sexual behavior is greatly affected by environmental, emotional, cultural and hormonal factors. (empowher.com)
Hormonal3
  • The adrenal glands develop abnormally and produce excess androgens which results in hormonal problems. (checkorphan.org)
  • Seventeen of the 19 patients who did not respond to hormonal treatment had either type 2 or type 4 receptograms, which are characterised by skewed or bimodal androgen receptor distribution. (bmj.com)
  • The hormonal management of patients with androgen insensitivity can be challenging. (bvsalud.org)
Skeletal1
  • Studies targeted at establishing such effects at cellular level and their correlations with in vivo models, will broaden our understanding of the roles played by androgens on skeletal muscle function in elderly. (frontiersin.org)
Uptake3
  • Theories underlying the development of CRPC include androgen receptor (AR) mutation allowing for promiscuous activation by non-androgens, AR amplification and overexpression leading to hypersensitivity to low androgen levels, and/or tumoral uptake and conversion of adrenally derived androgens. (harvard.edu)
  • We demonstrate tumoral expression of cholesterol uptake genes as well as the spectrum of steroidogenic enzymes necessary for androgen biosynthesis from cholesterol. (harvard.edu)
  • Nuclear uptake and retention of androgen by the pituitary gland of the hamster and the rat. (oregonstate.edu)
SARMs1
  • Herein we report crystal structures of the androgen receptor (AR) ligand-binding domain (LBD) complexed to a series of potent synthetic nonsteroidal SARMs with a substituted pendant arene referred to as the B-ring. (rcsb.org)
Receptor expression1
  • Androgen receptor expression in Breast cancer: An emerging marker of possible prognostic/predictive value? (who.int)
Postmenopausal women1
  • OBJECTIVE: To examine the possible beneficial effect of androgens in postmenopausal women with active rheumatoid arthritis. (bmj.com)
Patients3
  • Androgens as adjuvant treatment in postmenopausal female patients with rheumatoid arthritis. (bmj.com)
  • OUTLINE: Patients undergo a baseline endorectal coil MRI, followed by total androgen suppression (TAS) with either leuprolide IM or subcutaneous goserelin once a month plus oral flutamide 3 times a day for 2 months. (knowcancer.com)
  • 2, 3 Moreover, most patients eventually relapse to an androgen independent state and die. (bmj.com)
Mutation1
  • Mutation analysis of the androgen receptor gene is now commercially available. (medscape.com)
Localization1
  • Localization of the androgen was found in 10-15% of the cells of the pars distalis in both species. (oregonstate.edu)
Adult1
  • In adult male rats, spinal nucleus of the bulbocavernosus (SNB) motoneurons shrink after castration and are restored in size after androgen treatment. (jneurosci.org)
Ovaries3
  • Androgens are synthesized in the testes, the ovaries, and the adrenal glands. (wikipedia.org)
  • Regarding the relative contributions of ovaries and adrenal glands to female androgen levels, in a study with six menstruating women the following observations have been made: Adrenal contribution to peripheral T, DHT, A, DHEA and DHEA-S is relatively constant throughout the menstrual cycle. (wikipedia.org)
  • Tumors of the ovaries and polycystic ovary syndrome (PCOS) can both cause too much androgen production. (medlineplus.gov)
Chromosome1
  • It is a rare recessive genetic disorder linked to the X chromosome that results in different mutations in the androgen receptor. (bvsalud.org)
Therapeutic1
  • The objective was to provide guidelines for the therapeutic use of androgens in women. (nih.gov)
Potent1
  • Here, we show that (+)-JJ-74-138 is more potent than JJ-450 in the inhibition of androgen-independent AR activity in enzalutamide-resistant LN95 cells. (aacrjournals.org)
Gonadal1
  • Although the number of cells that concentrated the androgen in the pars intermedia and pars nervosa was small, this finding may be related to recent physiologic data that suggest that the gonadal steroids may play a role in regulating water retention and natriuresis. (oregonstate.edu)
Mutations1
  • To investigate why subtle structural changes to both the ligand and the receptor (i.e. mutations) result in drastic changes in activity, we studied structure-activity relationships for nonsteroidal AR ligands through crystallography and site-directed mutagenesis, comparing bound conformations of R-bicalutamide, hydroxyflutamide, and two previously reported nonsteroidal androgens, S-1 and R-3. (rcsb.org)
Testicular1
  • The morphology of SNB motoneurons is maintained by testicular androgens secreted in adulthood. (jneurosci.org)
Excess2
Subset2
Puberty1
  • Androgens increase in both males and females during puberty. (wikipedia.org)
Protein1
  • The androgen receptor is a protein that has an important role in the male reproductive system. (lu.se)
Clinical1
  • This necessary clinical research cannot occur until the biological, physiological, and psychological underpinnings of the role of androgens in women and candidate disorders are further elucidated. (nih.gov)
CRPC1
  • Also, this analogue noncompetitively inhibited androgen-stimulated AR activity in C4-2, LN95, and 22Rv1 CRPC cells. (aacrjournals.org)
Levels2
  • As many as two-thirds of those may have low androgen levels, according to Andre' Guay MD, endocrinologist at Harvard Medical School. (health.am)
  • The aim of the study was to assess whether changes in SHBG levels, independently of TT, are associated with subjective and objective androgen-dependent parameters. (medscape.com)
Absence2
  • MK-801 had no effect on non-androgen-responsive spinal motoneurons in the neighboring retrodorsolateral nucleus (RDLN), nor did the drug affect SNB soma size in the absence of androgen treatment. (jneurosci.org)
  • JJ-74-138 inhibited mRNA expression of AR and ARv7 target genes and reduced AR level in the nucleus in the absence of androgens. (aacrjournals.org)
Partial1
  • She was diagnosed as 46,XY Disorder of Sexual Development with partial androgen insensitivity . (bvsalud.org)
Gene2
  • In Kennedy disease (spinal and bulbar muscular atrophy [SBMA]), a motor neuron disease caused by a CAG expansion in the AR gene, androgen insensitivity appears later in life, with postpubertal gynecomastia being the most common sign. (medscape.com)
  • To be more precise: the length of your gene for coding the androgen receptor in your cells. (ergo-log.com)
Hormones2
Inhibitor1
  • ERLEADA® (apalutamide), First-and-Only Next-Generation Androgen Receptor Inhibitor with Once-Daily, Single-Tablet Option, Now Available in the U.S. (jnj.com)
Women6
  • Androgens from other parts of the body can also cause male characteristics to develop in women. (medlineplus.gov)
  • Tumors in the adrenal glands can also cause too much production of androgens and can lead to male body characteristics in women. (medlineplus.gov)
  • Plasma androgens in women. (wdxcyber.com)
  • At this time, there are no FDA-approved androgen replacements for women. (health.am)
  • Familial hypersecretion of adrenal androgens: A rare familial disorder that occurs in women. (checkorphan.org)
  • In physiological concentrations, androgens have no specific effects in women. (cdc.gov)