• mechanisms
  • In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of "realized" solar radiation dose and UV-induced injury. (mdpi.com)
  • Investigating the Life-extending Mechanisms of Apolipoprotein D: An Evolutionary Conserved Modulator of Oxidative Stress and Aging. (afar.org)
  • We are currently exploring further the regulation of the Notch and Wnt signaling pathways during satellite cell activation, the mechanisms underlying the transcriptional control of Delta expression, and epigenetic processes that may account for age-related changes in these pathways. (stanford.edu)
  • Second, we have pioneered the use of heterochronic parabiosis to study potential mechanisms of rejuvenation whereby an aged stem cell is reprogrammed to become a young stem cell. (stanford.edu)
  • pathways
  • For this, we will use online resources and tools for SNPs/genes/proteins annotating, gene-to-function and pathway analysis, to specify biological functions most relevant to the detected genes, and investigate their involvement in known aging pathways and networks. (grantome.com)
  • We will select subsets of SNPs for their: a) pleiotropic effects on aging phenotypes detected in Aim 2;b) relation to genes involved in similar biological functions in Aim 3;c) involvement in aging-related pathways. (grantome.com)
  • incidence
  • To determine the relationship between the severity of airflow obstruction based on modified Global Initiative on Obstructive Lung Disease (GOLD) criteria and the prevalence and incidence or recurrence of CVD in a cohort of US adults, aged 45-64 years, from 1987 to 2001. (bmj.com)
  • Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. (mdpi.com)
  • Achieving ZPG is difficult because a country's population growth is often determined by economic factors, incidence of poverty, natural disasters, disease, etc. (wikipedia.org)
  • Generally, the incidence of rotator cuff tears or injuries increases by age while corticosteroid injection for pain relief increases the risk of tendon tear and delays tendon healing. (wikipedia.org)
  • impairment
  • Lung function impairment may be a risk factor for cardiovascular disease (CVD) events. (bmj.com)
  • We observed a crude association between lung function impairment and prevalent and incident or recurrent CVD that was greatly reduced after adjusting for covariates, including age, sex, race, smoking, comorbid hypertension and diabetes, cholesterol levels and fibrinogen level. (bmj.com)
  • 5 16 Previous studies have linked lung function impairment with the risk of developing cardiovascular disease and stroke, even after adjusting for factors such as body mass index (BMI), physical activity, hypertension, diabetes and smoking status. (bmj.com)
  • Furthermore, we have found that the age-related impairment of muscle regeneration is due to a decline in effective Notch signaling, manifested initially as a failure of injured muscle to up-regulate the Notch ligand, Delta. (stanford.edu)
  • We have intriguing data that the impairment of regeneration and the development of these pathological changes may arise, at least in part, from the conversion of muscle stem cells from the myogenic lineage to other mesenchymal lineages. (stanford.edu)
  • Another factor in older populations is impairment of blood supply. (wikipedia.org)
  • decline
  • Electronmicroscopy and confocal microscopy (en face Mitotracker staining) revealed that in aortas of F344 rats, a decline in mitochondrial biogenesis occurs with aging. (physiology.org)
  • The vascular expression of complex I, III, and IV significantly declined with age, whereas aging did not alter the expression of complex II and V. Cytochrome c oxidase (COX) expression/activity exhibited the greatest age-related decline, which was associated with increased mitochondrial ROS production in the aged vessels. (physiology.org)
  • In conclusion, vascular aging is characterized by a decline in mitochondrial mass in the endothelial cells and an altered expression of components of the mitochondrial electron transport chain likely due to a dysregulation of mitochondrial biogenesis factors. (physiology.org)
  • Identification of genes associated with brain aging should improve our understanding of the biological processes that govern normal age-related decline," said John Blangero, Ph.D., a Texas Biomed geneticist and the senior author of the paper. (healthcanal.com)
  • cellular
  • Despite the central role of mitochondria in cellular aging and endothelial physiology, there are no studies extant investigating age-related alterations in mitochondrial biogenesis in blood vessels. (physiology.org)
  • UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. (mdpi.com)
  • Then, for an individual to progress from normal age-appropriate cognitive function to a condition where the full palette of clinical symptoms is expressed, three key steps are envisioned: (1) an initiating injury, (2) a chronic neuroinflammatory response, and (3) a discontinuous cellular change of state involving most, if not all, of the cell types of the brain. (jneurosci.org)
  • Symptoms
  • We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. (mdpi.com)
  • He documented the progression of symptoms that beset a farmer's wife, Auguste D., as her mental status deteriorated through a complex series of behavioral and cognitive changes that left her aggressive, delusional, and unable to remember recent events. (jneurosci.org)
  • occurs
  • Ultimately, most are the result of wear that occurs slowly over time as a natural part of aging. (wikipedia.org)
  • The final common factor is impingement syndrome, the most common non-sports related injury and which occurs when the tendons of the rotator cuff muscles become irritated and inflamed while passing through the subacromial space beneath the acromion. (wikipedia.org)
  • adults
  • Presbyphagia refers to characteristic changes in the swallowing mechanism of otherwise healthy older adults. (wikipedia.org)
  • Although age-related changes place older adults at risk swallowing disorders, an older adult's swallow is not necessarily an impaired swallow. (wikipedia.org)
  • Older adults are more vulnerable and with the increased threat of acute illnesses, medications and any number of age-related conditions, they can cross the line from having a healthy older swallow to being dysphagic. (wikipedia.org)
  • In those over age 65, the initiation of laryngeal and pharyngeal events, including laryngeal vestibule closure, are delayed significantly longer than in adults younger than 45 years of age. (wikipedia.org)
  • Dysphagia Swallowing Robbins JA, Hamilton JW, Lof GL, Kempster G. Oropharyngeal swallowing in normal adults of different ages. (wikipedia.org)
  • effects
  • Young individual recover faster as well are left with less residual effects following recovery when compared with aged. (healthcaremagic.com)
  • A special emphasis of the research will be on pleiotropic effects (both antagonistic and non-antagonistic) of a genotype on different traits, and on one trait at different ages. (grantome.com)
  • For these subsets of SNPs, we will evaluate epistatic genetic effects on aging phenotypes.Results of this study will significantly improve our understanding of genetic regulation of aging, and its role in health and longevity. (grantome.com)
  • In large pedigrees including 1,129 people aged 18 to 83, the scientists documented profound aging effects from young adulthood to old age, on neurocognitive ability and brain white matter measures. (healthcanal.com)
  • Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study the long-term effects of aging. (mdpi.com)
  • Tracy F, Logemann JA, Kahrilas PJ, Jacob P, Kobara M, Krugla C. Preliminary observations on the effects of age on oropharyngeal deglutition. (wikipedia.org)
  • Health
  • Not only does this stop our body and our mind performing to the best it can, for those of an older age this can have more serious health implications . (waterlogic.com)
  • The potential health benefits of esculeoside A appear to change with factors such as the age of the tomato fruit, the heat used in processing tomatoes, and the pH used in processing. (wikipedia.org)
  • significantly
  • Despite the universal acceptance on the importance of hydration, people across our blue planet, at all ages, live their lives at levels of hydration significantly below what leading organizations recommend. (waterlogic.com)
  • promotes
  • In this context we have demonstrated that increased mitochondrial ROS production promotes endothelial NF-κB activation, which contributes to the upregulation of adhesion molecules and increased monocyte adhesiveness in the aged arteries ( 43 ). (physiology.org)
  • younger
  • This analysis presents findings separately for a younger age group (25-49 years) and an older age group (50-74 years). (ehesp.fr)
  • body
  • OK, so maybe a woman over the age of puberty being displeased with some aspect of her body isn't exactly news , but stick with me here. (yourtango.com)
  • Due to its anatomic location at the external boundary of the body, skin is exposed to a variety of environmental factors such as UV radiation that derives naturally from the sun. (mdpi.com)
  • Some risk factors of experiencing a rotator cuff tear cannot be changed: age, body mass index, and height. (wikipedia.org)
  • circulation
  • Aging may also result in decreased circulation to the toenails, and diabetes or other medical conditions put people in an immuno-compromised state which makes them more susceptible to these infections. (orlandosentinel.com)
  • functional
  • Such changes combined with naturally diminished functional reserve, the resilient ability to adapt to physiological stress, make the older population more susceptible to dysphagia. (wikipedia.org)
  • mechanism
  • When we are at a young age, the human body's thirst mechanism and heat awareness is under developed . (waterlogic.com)
  • Work focused primarily on the anatomy and physiology of the oropharyngeal swallowing mechanism indicates a progression of change that may put the older population at increased risk for swallowing disorders. (wikipedia.org)
  • breasts
  • When I take my bra off now, I know my spouse has likely seen a few other women's bare breasts and has seen their breasts change with time and/or babies, and I know mine really aren't all that bad as far as his current comparative memories go. (yourtango.com)
  • It's important to know the density factor of your breasts as you age because the higher the density, the greater the risk for breast cancer . (yourtango.com)
  • It's common for women of a certain age to say their breasts feel empty or that they aren't as perky as they once were. (yourtango.com)
  • dominant
  • Based on repetitive interactions a social order is created that is subject to change each time a dominant animal is challenged by a subordinate one. (wikipedia.org)
  • several
  • A. As we age, several factors can contribute to changes in nails. (orlandosentinel.com)
  • In addition, if a country's fertility is at replacement level, and has been that way for at least several decades (to stabilize its age distribution), then that country's population could still experience coincident growth due to continuously increasing life expectancy, even though the population growth is likely to be smaller than it would be from natural population increase. (wikipedia.org)
  • Several factors contribute to degenerative, or chronic, rotator cuff tears of which repetitive stress is the most significant. (wikipedia.org)
  • study
  • A key advantage of this study is that we specifically focused on large extended families and so we were able to disentangle genetic from non-genetic influences on the aging process," said Glahn. (healthcanal.com)
  • A scintigraphic study revealed increased pharyngeal residue with age, possibly related to the limited UES opening. (wikipedia.org)
  • That study and additional evidence indicates that under stressful conditions or system perturbations, older individuals are less able to compensate due to the age-related reduction in reserve capacity (add Pendergast reference) and are more at risk to experience airway penetration or aspiration. (wikipedia.org)
  • expression
  • In aged vessels, the expression of the mitochondrial biogenesis factors (including mitochondrial transcription factor A and peroxisome proliferator-activated receptor-γ coactivator-1) was decreased. (physiology.org)
  • To achieve that goal, we determined whether aging is associated with alterations in mitochondrial mass in the endothelial cells (confocal microscopy, electron microscopy), altered vascular expression of the nuclear-encoded components of the electron transport chain, and mitochondrial biogenesis factors. (physiology.org)
  • chronic
  • Chronic tears are indicative of extended use in conjunction with other factors such as poor biomechanics or muscular imbalance. (wikipedia.org)
  • Interaction
  • Persuasive technologies can also be categorized by whether they change attitude and behaviors through direct interaction or through a mediating role: do they persuade, for example, through human-computer interaction (HCI) or computer-mediated communication (CMC)? (wikipedia.org)
  • time
  • The related calculations are complex because the population's overall death rate can vary over time, and mortality also varies with age (being highest among the old). (wikipedia.org)
  • result
  • It has been demonstrated that social impact can result in greater behavior changes than the case where the user is isolated. (wikipedia.org)
  • important
  • These lumps are most typically benign cysts , but it's important to check with a medical professional - especially if you're a woman over the age of 30 - to ensure they aren't a form of malignant cancer. (yourtango.com)
  • One of the most important factors in language is continuity and in turn intelligibility. (wikipedia.org)
  • Based on the empirical observation of the strong, consistent connection between criminal behavior and age, Hirschi and Gottfredson theorized the single most important factor behind crime is individual lack of self-control. (wikipedia.org)
  • normal
  • Males of many, and perhaps the majority of, long-lived species, express periodic changes in testicular activity and behaviour during their normal life cycle. (wikipedia.org)
  • known
  • They are known to increase in frequency with age and the most common cause is age-related degeneration and, less frequently, sports injuries or trauma. (wikipedia.org)
  • theory
  • The self-control theory of crime, often referred to as the general theory of crime, is a criminological theory about the lack of individual self-control as the main factor behind criminal behavior. (wikipedia.org)
  • The self-control theory of crime suggests that individuals who were ineffectually parented before the age of ten develop less self-control than individuals of approximately the same age who were raised with better parenting. (wikipedia.org)
  • years
  • Everyone over the age of 60 in England, Wales and Northern Ireland (50 in Scotland) is sent a bowel cancer screening kit through the post every two years and we would urge everyone who is eligible to take it up. (saga.co.uk)
  • level
  • Therefore, equilibrium, with a static population, will not be reached until the first "replacement level" birth cohorts reach old age and die. (wikipedia.org)
  • high
  • The doctors are pretty optimistic that due to his age, with proper therapy, there is a a high chance of recovery. (healthcaremagic.com)
  • From October, The Xtra Factor was also shown in high definition, simulcast on the new channel ITV2 HD. (wikipedia.org)
  • Outside these ages, the Earth seems to have been ice-free even in high latitudes. (wikipedia.org)
  • consistent
  • In my own experience, I have had my fair share of women who have pedicures suddenly developed changes in the nails that are consistent with a fungus infection. (orlandosentinel.com)
  • different ages
  • We will test hypotheses about the pleiotropic (including trade-offs)influence of a genotype on: (i) different traits;and (ii) one trait at different ages. (grantome.com)