Chagas cardiomyopathy. Medical search. Frequent questions

Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). (preprints.org)
To determine the comparative efficacy and safety of a fixed dose of benznidazole (BZN) with an adjusted- dose for Trypanosoma cruzi -seropositive adults without cardiomyopathy . (bvsalud.org)
BACKGROUND: Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America. (hal.science)
Benznidazole is registered for the treatment of Chagas disease caused by Trypanosoma cruzi in adjusted-dose schemes. (dndial.org)
Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)
Caracterizacao de cepas do Trypanosoma cruzi isoladas no Reconcavo Baiano (contribuicao ao estudo geral da doenca de Chagas em nosso meio). (degruyter.com)
The US Food and Drug Administration (FDA) announced yesterday that it has granted accelerated approval for the nation's first treatment for Chagas disease, a parasitic infection caused by Trypanosoma cruzi spread by kissing bugs that has increasingly been found in the United States, especially in Texas's Rio Grande Valley area. (umn.edu)
Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease. (harvard.edu)
Treatment of children aged 2-12 years with Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi . (medscape.com)
Chagas disease, an infection caused by a protozoan parasite, Trypanosoma cruzi , is a major public health problem with a considerable global disease burden and costs. (revportcardiol.org)
Chagas disease (CD) is a disease caused by the protozoan flagellates of the Kinetoplastid order Trypanosoma cruzi . (bvsalud.org)
Chagas disease (CD) is a disease caused by the protozoan flagellate of the Kinetoplastid order Trypanosoma cruzi , whose vector is an insect belonging to the Reduviidae family and subfamily Triatominae popularly known as barber 1 . (bvsalud.org)
Trypanosoma cruzi (T. cruzi) causes Chagas disease. (fapesp.br)
Chagas disease (American trypanosomiasis) is a tropical parasitic disease caused by the protozoan Trypanosoma cruzi transmitted by blood sucking triatomine insects, also known as "kissing" bugs for their habit of feeding on people's faces while they sleep. (medscape.com)

Chagas cardiomyopathy is known as Chagas disease with cardiac involvement, with ≥1 electrocardiographic abnormality in patients who test positive for T cruzi . (thecardiologyadvisor.com)
Randomised controlled trials (RCTs) allocating participants to fixed or adjusted doses of BZN for T. cruzi-seropositive adults without cardiomyopathy were included. (bvsalud.org)
Thirty percent of infected individuals develop chronic Chagas cardiomyopathy (CCC), an inflammatory dilated cardiomyopathy that is, by far, the most important clinical consequence of T. cruzi infection. (hal.science)
The authors conducted a systematic review and individual participant data meta-analysis to compare the efficacy and safety of fixed and adjusted doses for T. cruzi -seropositive adults without cardiomyopathy. (dndial.org)
The organism T cruzi and infection in humans were first described in 1909 by the Brazilian physician Carlos RJ Chagas. (medscape.com)
A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)
Different Transcriptomic Response to T. cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy. (harvard.edu)
Additionally, the CDC recommends antiparasitic treatment for all cases of acute (ie, congenital) or reactivated Chagas disease and for chronic T cruzi in children up to age 18 years. (medscape.com)

Nine cases of Chagas disease (CD), although rare in normal. (cdc.gov)
It is typically used as the first-line of treatment in cases of chagas disease (a form of cardiomyopathy caused by a. (computerwise.com)

Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways. (hal.science)
The pathogenesis of Chagas disease cardiomyopathy (CCC), an endemic disease affecting millions of patients in Latin America, is the focus of Dr. Cunha-Neto's group at the Heart Institute (InCor) of Hospital das Clínicas (HC), the hospital complex run by the Medical School of the University of São Paulo (FM-USP) in Brazil. (fapesp.br)

The parasite-driven immune response and autoreactivity that is triggered by the infection are 2 mechanisms that may be responsible for initiating acute and chronic myocarditis in Chagas heart disease. (thecardiologyadvisor.com)
These included 1 case of acute Chagas myocarditis (ACM), hyperexcitability in 2 patients). (cdc.gov)
The most common cause of inflammatory cardiomyopathy is lymphocytic myocarditis, which is most usually triggered by a viral infection, and occasionally by other infectious agents. (intechopen.com)
Rare causes of specific inflammatory cardiomyopathies include cardiac sarcoidosis, giant cell myocarditis and eosinophilic myocarditis. (intechopen.com)

The term inflammatory cardiomyopathy (ICM) refers to a group of disorders for which an acute or chronic myocardial inflammation is the central cause of abnormal cardiac structure or impaired cardiac function. (intechopen.com)
Galectin 3 and chagas cardiomyopathy: relationship of this myocardial fibrosis marker with myocardial deformation measured by speckle tracking in patients with chagas disease. (escardio.org)
Dilated cardiomyopathy is myocardial dysfunction causing heart failure in which ventricular dilation and systolic dysfunction predominate. (msdmanuals.com)

Chronic Chagas heart disease usually develops several decades after the disease first appears, which implies an imbalance between the parasite and the host immune response. (thecardiologyadvisor.com)
Echeverría LE, Rojas LZ, Rueda-Ochoa OL, Gómez-Ochoa SA, Mayer MA, Becerra-Motta LP, Luengas C, Chaves AM, Rodríguez JA, Morillo CA. Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy. (upf.edu)
To analyze the prognostic value of left ventricular global longitudinal strain (LV-GLS) and other echocardiographic parameters to predict adverse outcomes in chronic Chagas cardiomyopathy (CCM). (upf.edu)
Direct evidence gap on fixed versus adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: Systematic review and individual patient data meta-analysis. (bvsalud.org)
To analyze the association of circulating dehydroepiandrosterone sulfate (DHEA-S) levels with cardiovascular outcomes in patients with chronic Chagas cardiomyopathy (CCM) diagnosis. (imsbrogancapabilities.com)

Epidemiology, control and surveillance of Chagas disease - 100 years after its discovery. (degruyter.com)

The acute phase of Chagas diseases can last 8 to 12 weeks, but is often not diagnosed because many patients are asymptomatic or only present with mild or nonspecific symptoms (eg, fever, malaise, and splenomegaly). (thecardiologyadvisor.com)

The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. (preprints.org)
In the present study, we examined whether treating infected mice with an ER stress inhibitor can modify the pathogenesis of cardiomyopathy during chronic stages of infection. (preprints.org)

It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. (edu.au)
Since 2007, all potential blood donors in the U.S. are screened for exposure to the Chagas parasite. (medscape.com)
In a study of Texas blood donors between 2008 and 2012, about one in 6,500 tested positive for the Chagas parasite, reported Melissa N. Garcia, epidemiologist at Baylor College of Medicine in Houston. (medscape.com)
The Baylor team followed 17 Houston-area blood donors infected with the Chagas parasite and found that seven (41%) had undiagnosed electrocardiographic abnormalities consistent with Chagas cardiomyopathy. (medscape.com)
While it's unclear how many triatomine bugs in the United States may carry the Chagas parasite, a pilot study conducted by the Baylor team may shed some light on the issue. (medscape.com)

Idiopathic dilated cardiomyopathy. (msdmanuals.com)

Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients. (preprints.org)
Determining which patients will develop Chagas heart disease remains an ongoing challenge and an important area of research. (thecardiologyadvisor.com)
Materials and methods: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. (fiocruz.br)
Conclusion: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation. (fiocruz.br)
The Batista procedure was invented by Brazilian physician and cardiac surgeon Randas Batista in 1994 for use in patients with non-ischemic dilated cardiomyopathy. (wikipedia.org)
Many of his patients were victims of Chagas disease. (wikipedia.org)
ABSTRACT Chagas disease (CD) is a neglected tropical disease associated with poverty in which patients are surrounded by stigma. (scielo.br)
Both pharmaceutical care and exercise training have a positive effect on the HRQoL of patients with Chagas cardiomyopathy, and the mental component can be a prognostic marker in this population. (scielo.br)
Similarly, new molecular-based methods and therapies tailored to specific pathogeneses have a potential to improve diagnosis and outcomes in patients with inflammatory cardiomyopathy. (intechopen.com)
More effective prediction of mortality in Chagas heart disease patients? (revportcardiol.org)
Cardiac involvement is found in 25-30% of cases, 4 and it is reported that a third of infected patients in Brazil have Chagas cardiomyopathy. (revportcardiol.org)
The high rate of infectious bugs, combined with the high rate of feeding on humans, should be a cause of concern and should prompt physicians to consider the possibility of Chagas disease in U.S. patients with heart rhythm abnormalities and no obvious underlying conditions," Dr. Kristy Murray, associate professor of tropical medicine at Baylor, said in a statement. (medscape.com)

Chagas disease represents a parasitic nonischemic cardiomyopathy targeting parasympathetic inflow to the heart. (wikipedia.org)

In many cases of cardiomyopathy, endomyocardial biopsy is class II (uncertain efficacy and may be controversial) or class III (generally not indicated). (medscape.com)

The American Heart Association (AHA) has released an update of clinical knowledge and management of Chagas cardiomyopathy, which has been endorsed by the Inter-American Society of Cardiology and published in Circulation . (thecardiologyadvisor.com)

To celebrate the event and the creation of the International Consortium of Trypanocidal and Leishmanicidal Drugs , 13 perspective articles were written by different Brazilian specialists, discussing promising alternative therapeutic approaches/strategies to combat Chagas disease and leishmaniasis. (fiocruz.br)

Dilated cardiomyopathy is 1 of the 3 traditional classes of cardiomyopathy, along with hypertrophic and restrictive cardiomyopathy. (medscape.com)

Without successful treatment, infection can persist for a lifetime and can result in serious cardiovascular conditions including dilated cardiomyopathy with heart failure, ventricular arrhythmias and conduction disturbances, stroke, and other systemic or pulmonary embolisms. (thecardiologyadvisor.com)
1,3 These mechanisms lead to dilated cardiomyopathy and ventricular arrhythmias that may be malignant, sudden death, heart failure and thromboembolic phenomena. (revportcardiol.org)

The drug benznidazole, made by Chemo Research, SL, of Madrid, is approved for use in children ages 2 to 12 years old who have Chagas disease. (umn.edu)
But the CDC provided only 422 courses of benznidazole or nifurtimox used to treat Chagas during this period. (medscape.com)

Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. (who.int)

The agent of South American trypanosomiasis or CHAGAS DISEASE. (harvard.edu)

Various explanations have been put forward for this cardiomyopathy, including the neurogenic theory (development of parasympathetic disautonomy leading to sympathetic predominance and catecholamine toxicity), microvascular dysfunction, autoimmune reactions, and immune responses to surviving parasites, with lymphocyte infiltration into cardiac tissues. (revportcardiol.org)

In addition, "dilated Chagas cardiomyopathy refers to the hemodynamic pattern of the Chagas cardiomyopathy that is characterized by left ventricular enlargement with segmental or global systolic function impairment, regardless of electrocardiographic findings. (thecardiologyadvisor.com)

Garcia and her colleagues have been working with physicians in Texas to increase awareness and diagnosis of Chagas disease. (medscape.com)

Typical manifestations of inflammatory cardiomyopathy include chest pain, heart failure, and arrhythmias, but these symptoms and signs are unspecific. (intechopen.com)

Inflammatory cardiomyopathy can also occur in connection with autoimmune inflammatory diseases. (intechopen.com)

Changes such as right branch-bundle block (with or without left anterior hemiblock) can signal the transition from the indeterminate form to the chronic cardiac form, and the presence of a typical electrocardiographic abnormality has been associated with an increased risk for progressing to a more severe cardiomyopathy. (thecardiologyadvisor.com)

Secondary Cardiomyopathy are due to extrinsic/systemic causes (e.g. (fpnotebook.com)

Although Chagas disease is typically regarded as a tropical disease found primarily in Central and South America, it now affects ≥300,000 residents in the United States and its prevalence is growing elsewhere. (thecardiologyadvisor.com)

Laboratório de Pesquisa Clínica em Doença de Chagas. (fiocruz.br)

More recently, there is evidence that the persistence of high parasitemia and tissue parasitism, a proinflammatory immunological profile with sustained oxidative stress, and genes related to natural killer/CD8 + T-cell cytotoxicity may be determinant in the development of Chagas cardiomyopathy, although the exact mechanism remains to be elucidated," the authors wrote. (thecardiologyadvisor.com)

Dilated cardiomyopathy is a progressive disease of heart muscle that is characterized by ventricular chamber enlargement and contractile dysfunction. (medscape.com)

however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance. (fiocruz.br)
Therefore, the identification of inflammatory cardiomyopathy is elusive and the true incidence of the condition remains unknown. (intechopen.com)

Nearly a third of the people sickened by Chagas can develop potentially fatal cardiomyopathy. (umn.edu)
The overall goal of this study is to understand the risk of Chagas disease in hunters, a potentially high-risk population. (bcm.edu)

There are very specific cardiac abnormalities associated with Chagas. (medscape.com)

Elimination of Chagas disease transmission: perspectives. (degruyter.com)

Dilated cardiomyopathy is the third most common cause of heart failure and the most frequent reason for heart transplantation. (medscape.com)
Treatment of dilated cardiomyopathy is essentially the same as treatment of chronic heart failure (CHF). (medscape.com)
The Batista procedure (also called a reduction left ventriculoplasty) was an experimental heart procedure that proposed the reversal of the effects of remodeling in cases of end-stage dilated cardiomyopathy refractory to conventional medical therapy. (wikipedia.org)
Chagas cardiomyopathy thus represents a unique method of study of diastolic heart failure. (wikipedia.org)
We were astonished to not only find such a high rate of individuals testing positive for Chagas in their blood, but also high rates of heart disease that appear to be Chagas-related," Garcia said in a conference statement. (medscape.com)
About one-third of people with Chagas disease will develop heart disease from it," she noted in an interview with Reuters Health. (medscape.com)
Anyone that doesn't have diabetes or hypertension and is otherwise in pretty good health, but has heart problems, that's the kind of person you think of for Chagas. (medscape.com)

Researchers from the National School of Tropical Medicine are offering educational material and free screening for Chagas disease at hunting conventions and gatherings across Texas. (bcm.edu)

However, the classification of cardiomyopathies continues to evolve, based on the rapid evolution of molecular genetics as well as the introduction of recently described diseases. (medscape.com)

We've actually had a long history of Chagas in the state of Texas and in the United States," said Garcia, adding that the first case of locally acquired infection dates back to 1955. (medscape.com)

We searched (December 2021) Cochrane, MEDLINE , EMBASE, LILACS and trial registries and contacted Chagas experts. (bvsalud.org)

The CDC also strongly recommends treatment for adults aged 50 years or younger with chronic infection who do not already have advanced Chagas cardiomyopathy. (medscape.com)
What is the place of partial left ventriculectomy in the treatment of delated cardiomyopathy? (rbccv.org.br)

Organisms1

Diseases7

Geographicals1

Trypanosoma14

Cruzi8

Cases of Chagas disease2

Disease cardiomyopathy2

Myocarditis4

Myocardial3

Chronic Chagas5

Epidemiology1

Acute1

Pathogenesis2

Parasite5

Idiopathic1

Patients12

Parasitic1

Endomyocardial1

Clinical1

Leishmaniasis1

Restrictive1

Ventricular arrhythmias2

Benznidazole2

Inhibition1

Trypanosomiasis1

Neurogenic1

Left ventricular1

Diagnosis1

Arrhythmias1

Autoimmune1

Electrocardiographic1

Systemic1

Prevalence1

Pesquisa1

Mechanism1

Dysfunction1

Inflammatory2

Potentially2

Abnormalities1

Perspectives1

Heart7

Screening1

Diseases1

Garcia1

20211

Treatment2