• alkaloids
  • In addition to inducing skeletal muscle relaxation under general anesthesia, certain curare alkaloids are widely employed as relaxants to facilitate endotracheal intubation (the insertion of a tube into the windpipe to keep the upper airway open in a person who is unconscious or unable to breathe on his or her own). (britannica.com)
  • Curare alkaloids produce their effects with a minimal concentration of anesthetic agent, which allows patients to recover promptly and reduces the risk of postoperative pneumonias and other complications associated with surgery under general anesthesia. (britannica.com)
  • Curare contains two alkaloids: curine, which paralyzes the muscle fibers of the heart, and curarine, which paralyzes the motor nerve endings in voluntary muscles. (encyclopedia.com)
  • Among the alkaloids are strychnine and curare. (wikipedia.org)
  • 1942
  • The outstanding achievement of his career was the introduction of muscle relaxants to the practice of anaesthesia on January 23, 1942, when he and resident Enid Johnson used curare for the first time during anesthesia to produce muscle relaxation. (wikipedia.org)
  • extracts
  • Curare is a name used to identify a variety of highly toxic (poisonous) extracts from some types of woody vines that grow in South America . (encyclopedia.com)
  • During the nineteenth century, doctors tried to use curare as a muscle relaxant in the treatment of rabies, tetanus (an infectious disease that usually enters the body through a wound), and epilepsy (a chronic, or lasting, disease of the nervous system characterized by convulsions), but these trials were unsuccessful because available curare extracts were not of equal quality and potency (strength). (encyclopedia.com)
  • widely
  • One of these compounds, succinylcholine, became a widely used and effective curare substitute that could be given in precise dosages with predictable effects. (encyclopedia.com)
  • surgery
  • In the 1870s curare was used to keep conscious animals from moving during experimental surgery. (encyclopedia.com)
  • That same year, a country doctor and part-time anesthetist named Harold Griffith of Montreal , Quebec , tested the use of curare in surgery. (encyclopedia.com)
  • certain
  • He conducted extensive studies on the actions of digitalis, muscarine (a product of certain mushrooms), choline and curare. (wikipedia.org)
  • effects
  • He succeeded in 1947 with the medicine gallamine, and then went on to make more than 400 compounds that had the same effects as curare. (encyclopedia.com)
  • Among
  • Folk Medicine and Folk Therapeutic Principle among the Zeme Nagas of N. C. Hills in Assam (India) Curare: Journal of Ethnomedicine and Transcultural Psychiatry [Germany] Sole 2001, Vol. 24, No. 1 & 2, pages 161-164. (wikipedia.org)
  • less
  • For dogs that had been under the influence of curare when they first learned the response, after the curare was no longer in their system, they were less likely to remember to draw their paw away on hearing the buzzer. (wikipedia.org)