• Embedding Task-Based Neural Models into a Connectome-Based Model of the Cerebral Cortex. (modeldb.science)
  • Cerebral Cortex. (kcl.ac.uk)
  • Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture. (indiana.edu)
  • Livne T , Kim D, Metcalf NV, Zhang L, Pini L, Shulman GL, Corbetta M . Spontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements. (neurotree.org)
  • This week in Nature, an article with the uncomfortable sounding title, A Multi-Modal Parcellation of Human Cerebral Cortex, increased the number of recognized, distinct areas in the human cortex from 83 to 180. (smallpocketlibrary.com)
  • Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates [2] "Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. (edu.au)
  • As human telencephalic NSCs develop from pluripotency in vitro, they transition through organizer states that spatially pattern the cortex before generating glutamatergic precursor fates. (edu.au)
  • This article is a comparative study of white matter projections from ventral prefrontal cortex (vPFC) between human and macaque brains. (jneurosci.org)
  • In this study, we investigate the connectional anatomy of the ventral prefrontal cortex (vPFC) in macaques and humans. (jneurosci.org)
  • A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)
  • Implement the HCP Life-Span protocols with additional anatomical, functional, & positron emission tomography (PET) sequences tailored for aging and AD. (humanconnectome.org)
  • INTRODUCTION: In vivo clinical, anatomical and metabolic differences between posterior cortical atrophy (PCA) patients presenting with different Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers profiles are still unknown. (lingualab.ca)
  • Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRß, a marker of blood brain barrier breakdown, in older adults Res Sq. 2023 Mar 07. (usc.edu)
  • My research program focuses on understanding the general organizational and functional principles of connectomes - network maps of the connectivity among neurons, neuronal populations, and large-scale brain areas. (indiana.edu)
  • Thus, single neurons specify a mixture of endpoints and displacements for different body parts, not overall displacement, with displacements for different body parts computed at distinct anatomical stages. (bvsalud.org)
  • The production and study of connectomes, known as connectomics, may range in scale from a detailed map of the full set of neurons and synapses within part or all of the nervous system of an organism to a macro scale description of the functional and structural connectivity between all cortical areas and subcortical structures. (smallpocketlibrary.com)
  • This map of the Internet has been compared to complex connections exhibited by neurons in the human brain. (smallpocketlibrary.com)
  • Additionally, the connectome of an insect brain was mapped, revealing intricate networks of interconnected neurons in the Drosophila larva. (whatsthatbug.com)
  • This groundbreaking connectome consists of 3,016 neurons and 548,000 connections between them. (whatsthatbug.com)
  • These results demonstrate a novel link between neuroinflammation and vascular physiological dysfunction in the cerebral white matter, and could indicate enduring loss of vascular compliance associated with imperfect repair of blood-brain barrier damage after resolution of acute neuroinflammation. (biorxiv.org)
  • Together, these findings indicate that the influx of peripheral inflammatory cells into the brain via the cerebral venous system leads to enduring anatomical and physiological changes to the vessels. (biorxiv.org)
  • To further investigate physiological changes in the cerebral venous system, we assessed the blood oxygen-level dependent (BOLD) signal in the white matter using functional MRI. (biorxiv.org)
  • The human brain has an overall leftward posterior and rightward anterior asymmetry (or brain torque). (wikipedia.org)
  • Furthermore, each of these localized, dynamic connectivity states is associated with global changes in the whole-brain functional connectome. (stanford.edu)
  • A deeper knowledge of these principles gives us insight the connectome's role in shaping human behavior and cognition and helps reveal how abnormal connectivity can lead to disease. (indiana.edu)
  • Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. (lingualab.ca)
  • A connectome (pronounced con-nec'-tome) is the complete description of the structural connectivity of an organism's nervous system. (smallpocketlibrary.com)
  • In the current analysis we used data from two sites (n=143, male and female humans), and performed Canonical Correlation Analysis (CCA), relating resting-state functional connectivity (RSFC) with a broad range of migraine symptoms ranging from headache characteristics to sleep abnormalities. (stanford.edu)
  • Graph-theoretical analyses have shown that the functional connectivity in the human brain is divided into well-organized modules or subnetworks which are densely connected within themselves and sparsely connected to each other. (biorxiv.org)
  • Investigations of the human brain's connectomic architecture have produced two alternative models: one describes the brain's spatial structure in terms of static localized networks, and the other describes the brain's temporal structure in terms of dynamic whole-brain states. (stanford.edu)
  • Much headway has been made in the last decade in refining the brain's connectome. (smallpocketlibrary.com)
  • This study is the first to quantitatively assess human brain cortical folding in the presence of intracranial AVMs and no significant differences between AVM-affected versus unaffected hemispheres were found in a small dataset. (biomedcentral.com)
  • Though smaller and simpler than human brains, fly brains reveal fascinating neural networks that contribute to their complex cognitive abilities. (whatsthatbug.com)
  • Measure longitudinal changes in brain connectome, diseases stage development, and cognitive changes in the ADCP cohort and prospectively validate the probability distribution of biomarker-based AD stages on an individual subject basis using Markov chain estimation. (humanconnectome.org)
  • The longitudinal proportions of this region are a major source of anatomical variation among adult humans and, being much larger in Homo sapiens , is the main characteristic differentiating human midsagittal brain morphology from that of our closest living primate relative, the chimpanzee. (karger.com)
  • We suggest longitudinal, larger human MRI-based cortical folding studies to assess whether AVMs are congenital lesions of vascular development or de novo , dynamic lesions. (biomedcentral.com)
  • Numerous studies are under way to identify specific imaging markers for different types of dementia, including cerebral volumetric measurements, diffusion imaging, spectroscopy, very-high-field MRI scans of senile plaques, and PET scan markers of senile plaques. (medscape.com)
  • The Alzheimer's Disease Connectome Project (ADCP) will collect data from participants who range from cognitively healthy to those with dementia due to Alzheimer's disease. (humanconnectome.org)
  • To address this question, we present a novel approach that combines direct tracer measurements of entire white matter trajectories in macaque monkeys with diffusion MRI tractography of both macaques and humans. (jneurosci.org)
  • Here, we explicitly test these macaque-human predictions. (jneurosci.org)
  • The approach allows us to provide explicit validation of diffusion tractography and transfer tractography strategies across species to test the extent to which inferences from macaques can be applied to human neuroanatomy. (jneurosci.org)
  • Using a signal modelling technique, we assessed the anatomical distribution of white matter BOLD signal abnormalities and detected reduced power in the periventricular white matter, a region of known venous damage in multiple sclerosis patients. (biorxiv.org)
  • The modular organization of human anatomical brain networks: Accounting for the cost of wiring. (indiana.edu)
  • Axons from medial cortical areas travel ventral to those originating from lateral vPFC regions both in the IC and the corpus callosum (CC). Despite the precision with which such organizational principles can be investigated in macaques, the extent to which they apply in humans is not clear. (jneurosci.org)
  • Large-scale neural model of visual short term memory embedded into a 998-node connectome. (modeldb.science)
  • More broadly, a connectome would include the mapping of all neural connections within an organism's nervous system. (smallpocketlibrary.com)
  • The term "connectome" is used primarily in scientific efforts to capture, map, and understand the organization of neural interactions within the brain. (smallpocketlibrary.com)
  • Local structure-function relationships in human brain networks across the lifespan. (indiana.edu)
  • Mapping the functional connectome has the potential to uncover key insights into brain organisation. (stanford.edu)
  • Anatomical fibers that constitute the white matter architecture of the human brain are visualized color-coded by traversing direction (xyz-directions mapping to RGB colors respectively). (smallpocketlibrary.com)
  • For example, human male brains are more asymmetrically lateralized than those of females. (wikipedia.org)
  • Previously, we argued that the precuneus expanded in recent human evolution, based on a combination of paleontological, comparative, and intraspecific evidence from fossil and modern human endocasts as well as from human and chimpanzee brains. (karger.com)
  • In summary, flies do have brains with unique anatomical features that help them navigate and perceive their environment more effectively. (whatsthatbug.com)
  • Therefore, comparative studies of WM anatomy are needed to determine the extent to which inferences from macaques can inform us about human brains. (jneurosci.org)
  • We test whether the organizational rules that vPFC connections follow in macaques are preserved in humans. (jneurosci.org)
  • Furthermore, the organizational principles followed by vPFC tracts in macaques are preserved in humans. (jneurosci.org)
  • Thus, frontal WM is likely to be more complex in humans, and organizational rules found in macaques may not be preserved. (jneurosci.org)
  • NSCs derived from multiple human pluripotent lines vary in these early patterning states, leading differentially to dorsal or ventral telencephalic fates. (edu.au)
  • Neurovascular dysfunction, including blood-brain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, is increasingly recognized as contributing to Alzheimer disease. (medscape.com)
  • Integrating brain function and structure in the study of the human attentional networks. (googleapis.com)
  • Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging study. (modeldb.science)
  • To date, no hypothesis or human study explains what happens in the 16 week interval between intracranial vasculature maturation and cortical folding initiation [ 6 ]. (biomedcentral.com)
  • In this respect, the connectional anatomy of the human frontal lobes is of particular relevance. (jneurosci.org)
  • Using resting fMRI data, we investigated the assumptions undergirding current models of the human connectome. (stanford.edu)
  • A sample of 105 pregnant women participated in human fetal resting-state fMRI studies (fetal gestational age between 20 and 40 weeks). (edu.au)
  • Here we identified which architectural principles of functional connectome organization are initiated prior to birth , and contrast those with topological characteristics observed in the mature adult brain. (edu.au)
  • Diffusion imaging (DWI) is considered an optimal technique to detect hyperacute cerebral ischemia and has thus enriched the clinical management of patients with suspected stroke. (lingualab.ca)
  • Therefore, these lectures will cover a wide range of recent neuroscience review and research papers on visual, sensorimotor, task positive, and task negative processing in the human brain. (edu.pl)
  • Four-dimensional maps of the human somatosensory system. (edu.pl)
  • Generative models of the human connectome. (indiana.edu)
  • In the current shape analysis, we examine precuneus variation in non-human primates through landmark-based models, to evaluate the general pattern of variability in non-human primates, and to test whether precuneus proportions are influenced by allometric effects of brain size. (karger.com)
  • Ulloa A , Horwitz B . Incorporating the connectome into large-scale neuro-computational models to simulate neuroimaging experiments of short-term memory F1000research . (neurotree.org)
  • In this chapter we present a review of computational models for studying the dynamic mechanisms that describe the function of the human brain, with a specific focus on epilepsy. (springer.com)
  • Spadone S, Betti V, Sestieri C , Pizzella V, Corbetta M , Della Penna S. Spectral signature of attentional reorienting in the human brain. (neurotree.org)
  • While Emergent Bicameral Brain above reported a consistent presence of bilateral faculties across evolutionary animal lineages, this section records their developmental fulfillment in human beings with distinctive left and right hemisphere qualities. (naturalgenesis.net)
  • This work furthers systematic analyses of the earliest patterning events that generate the major neuronal trajectories of the human telencephalon . (edu.au)
  • This database was founded as part of the SenseLab project which was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS), by MURI (Multidisciplinary University Research Initiative), and by R01 DC 009977 from the National Institute for Deafness and other Communication Disorders. (modeldb.science)
  • Markram is also the founder of the Brain Mind Institute and the founder of the European Human Brain Project, one of two ten-year one billion Euro Flagship Projects selected in January 2013 by the European Commission. (epfl.ch)
  • The white matter is highly vascularised by the cerebral venous system. (biorxiv.org)
  • Optimally controlling the human connectome: the role of network topology. (indiana.edu)
  • Connectome analysis was used to analyze weighted network characteristics of fetal macroscale brain wiring. (edu.au)
  • The rs-fc MRI analysis revealed an independent association between the anti-P serum levels and many altered brain ROI properties but no anti-NR2 and prednisone effects on the cerebral network. (bmj.com)
  • Specificity and robustness of long-distance connections in weighted, interareal connectomes. (indiana.edu)
  • This result further supports the hypothesis that precuneus expansion in modern humans is not merely a consequence of increasing brain size or of allometric scaling, but rather represents a species-specific morphological change in our lineage. (karger.com)