• cortex
  • One main objective of the treatment is to re-establish the physiological inhibition exerted by the cerebellar cortex over cerebellar nuclei. (wikipedia.org)
  • These parallel grooves conceal the fact that the cerebellar cortex is actually a continuous thin layer of tissue tightly folded in the style of an accordion. (wikipedia.org)
  • It is estimated that, if the human cerebellar cortex were completely unfolded, it would give rise to a layer of neural tissue about 1 meter long and averaging 5 centimeters wide-a total surface area of about 500 square cm, packed within a volume of dimensions 6 cm × 5 cm × 10 cm. (wikipedia.org)
  • seizures
  • The classification of this disease varies from patient to patient, since many individuals do not fall into one specific disease category.The primary features displayed on a person with MERRF include myoclonus, seizures, cerebellar ataxia, myopathy and ragged ref fibers (RRF) on muscle biopsy, leading to the diseases name. (wikipedia.org)
  • ADCA
  • ADCA is a genetically inherited condition that causes deterioration of the nervous system leading to disorder and a decrease or loss of function to regions of the body. (wikipedia.org)
  • nervous system
  • The gastrointestinal tract is controlled by the sympathetic and parasympathetic nervous systems and, additionally, the enteric nervous system which, through Meissner's and Auerbach's plexuses, control motility and secretion in the small and large intestines. (bmj.com)
  • 1 This is consistent with the Braak hypothesis suggesting that PD patients have Lewy body pathology in autonomic centres and nerves that include the dorsal motor nucleus of the glossopharyngeal and vagal nerves, gastrointestinal submucosal plexus and postganglionic sympathetic nervous system, which is present in the pre-motor stage before nigral involvement. (bmj.com)
  • Over time, these clumps (which are known as inclusions) damage cells in parts of the nervous system that control movement, balance and coordination, and autonomic functioning. (nih.gov)
  • In MSA, the protein Alpha-Synuclein (SNCA) appears in the central nervous system as misfolded protein aggregates primarily in oligodendrocytes. (wmich.edu)
  • Multiple sclerosis (MS) can be pathologically defined as the presence of distributed glial scars (sclerosis or scleroses, in its plural form) in the central nervous system that must show dissemination in time (DIT) and in space (DIS) to be considered MS lesions. (wikipedia.org)
  • The disease in dogs can affect the lungs and skin, but more commonly the eye and central nervous system. (wikipedia.org)
  • As it is an intrinsic property of the nervous system, it cannot be changed through voluntary control, exercise, or diet. (wikipedia.org)
  • Cellular death or dysfunction causes a break or faulty signal in the line of communication from the central nervous system to target muscles in the body. (wikipedia.org)
  • Myoclonus
  • Methods We report two siblings from a consanguineous Pakistani family who presented with cerebellar ataxia and severe myoclonus from adolescence. (bmj.com)
  • genes
  • Presents a current understanding of the normal and pathological functioning of the genes responsible for ataxias and spastic paraplegias. (elsevier.com)
  • OPCA
  • OPCA is characterized by progressive cerebellar ataxia, leading to clumsiness in body movements, veering from midline when walking, wide-based stance, and falls without signs of paralysis or weakness. (wikipedia.org)
  • A challenge-oriented treatment program has previously been shown to be beneficial for individuals with ataxia from OPCA. (wikipedia.org)
  • Overground harness systems may be used to allow OPCA patients to challenge their balance without chance of falling. (wikipedia.org)
  • cerebral
  • This complex system is mediated by two major efferent pathways, the sympathetic and parasympathetic nervous systems, which obtain afferent signals from different parts of the body, neurons in the spinal cord and cerebral autonomic centres primarily in the hypothalamus, midbrain and brainstem. (bmj.com)
  • Non-progressive congenital ataxia (NPCA) is a classical presentation of cerebral ataxias. (wikipedia.org)
  • cognitive
  • Individuals with cerebellar ataxia have full cognitive awareness: it is usually only the physical deterioration that prohibits them from participating in activities of daily living and any other relevant or desired interests. (wikipedia.org)
  • lesions
  • The classification system for the lesions was updated in 2007. (wikipedia.org)
  • This system classifies MS lesions as active, mixed active/inactive, or inactive lesions based on the presence and distribution of macrophages/microglia. (wikipedia.org)