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  • reactions
  • Common adverse drug reactions (ADRs) (≥ 1% of patients) associated with the cephalosporin therapy include: diarrhea, nausea, rash, electrolyte disturbances, and pain and inflammation at injection site. (wikipedia.org)
  • Hypersensitivity reactions to cephalosporins occur rarely. (wikipedia.org)
  • The most common adverse effects of cefalexin, like other oral cephalosporins, are gastrointestinal (stomach area) disturbances and hypersensitivity reactions. (wikipedia.org)
  • Abraham
  • In 1959 Abraham reported that his N-phenylacetyl derivative of cephalosporin C was much more potent against Staphylococcus aureus strains than the parent compound. (wikipedia.org)
  • During a skiing holiday in 1958 Abraham conceived the structure of cephalosporin C, which he then went on to establish with Newton, and was confirmed by Dorothy Hodgkin through X-ray crystallography. (wikipedia.org)
  • Through the registration of the patent on cephalosporin, he was able to generate a regular income, which he devoted almost entirely to the establishment of two charitable trusts for the support of biomedical research, the Edward Penley Abraham Research Fund, the E.P.A. Cephalosporin Fund and The Guy Newton Research Fund. (wikipedia.org)
  • strains
  • Some Morganella morganii, Proteus vulgaris, Providencia rettgeri, Pseudomonas aeruginosa, and Serratia marcescens strains have also developed resistance to cephalosporins to varying degrees. (wikipedia.org)
  • analogues
  • Today we are left with thousands of semisynthesized analogues of natural cephalosporin compounds based on the knowledge gained by intensive research on the chemistry of those two starting materials. (wikipedia.org)
  • compounds
  • The cephalosporin compounds in severe neonatal infection. (biomedsearch.com)
  • The new cephalosporin compounds have increased in vitro activity against gram-negative enteric bacilli and penetrate well into cerebrospinal fluid. (biomedsearch.com)
  • The core itself can also be referred to as 7-aminocephalosporanic acid which can be derived by hydrolysis from the natural compound cephalosporin C. Chemical compounds containing this core are relatively stable to acid hydrolysis and tolerance to β-lactamases. (wikipedia.org)
  • infections
  • Most people who take cephalosporin as directed by their doctors experience full recoveries in one to four weeks, depending on the nature and severity of their infections. (wisegeek.com)
  • enzyme
  • This is thought to be due to the N-methylthiotetrazole side-chain of these cephalosporins, which blocks the enzyme vitamin K epoxide reductase (likely causing hypothrombinemia) and aldehyde dehydrogenase (causing alcohol intolerance). (wikipedia.org)
  • The systematic name of this enzyme class is cephalosporin-C acetylhydrolase. (wikipedia.org)
  • The systematic name of this enzyme class is cephalosporin-C:2-oxoglutarate aminotransferase. (wikipedia.org)
  • generation
  • This, however, should be viewed in the light of recent epidemiological work suggesting, for many second-generation (or later) cephalosporins, the cross-reactivity rate with penicillin is much lower, having no significantly increased risk of reactivity over the first generation based on the studies examined. (wikipedia.org)