• Abraham
  • In 1959 Abraham reported that his N-phenylacetyl derivative of cephalosporin C was much more potent against Staphylococcus aureus strains than the parent compound. (wikipedia.org)
  • During a skiing holiday in 1958 Abraham conceived the structure of cephalosporin C, which he then went on to establish with Newton, and was confirmed by Dorothy Hodgkin through X-ray crystallography. (wikipedia.org)
  • Through the registration of the patent on cephalosporin, he was able to generate a regular income, which he devoted almost entirely to the establishment of two charitable trusts for the support of biomedical research, the Edward Penley Abraham Research Fund, the E.P.A. Cephalosporin Fund and The Guy Newton Research Fund. (wikipedia.org)
  • bacteria
  • First-generation cephalosporins are active predominantly against Gram-positive bacteria, and successive generations have increased activity against Gram-negative bacteria (albeit often with reduced activity against Gram-positive organisms). (wikipedia.org)
  • It is a third-generation cephalosporin that works by preventing bacteria from making a cell wall. (wikipedia.org)
  • enzyme
  • This is thought to be due to the N-methylthiotetrazole side-chain of these cephalosporins, which blocks the enzyme vitamin K epoxide reductase (likely causing hypothrombinemia) and aldehyde dehydrogenase (causing alcohol intolerance). (wikipedia.org)
  • The systematic name of this enzyme class is cephalosporin-C acetylhydrolase. (wikipedia.org)
  • The systematic name of this enzyme class is cephalosporin-C:2-oxoglutarate aminotransferase. (wikipedia.org)
  • Serratia
  • Some Morganella morganii, Proteus vulgaris, Providencia rettgeri, Pseudomonas aeruginosa, and Serratia marcescens strains have also developed resistance to cephalosporins to varying degrees. (wikipedia.org)
  • severe
  • Thus, consumption of alcohol after taking Cephalosporin orally or intravenously is contraindicated, and in severe cases can lead to death. (wikipedia.org)
  • Oral
  • In this report, the global Oral Cephalosporin market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (medgadget.com)
  • The cephalosporins are diverse in their antibacterial spectrum, water solubility, acid tolerability, oral bioavailability, biological half-life and other properties. (wikipedia.org)
  • drug
  • Unfortunately, the spelling of cephalosporin drug names shows an apparently arbitrary distribution of 'ceph', 'cep' and 'cef', with a strong tendency to the latter, assisted by the recent requirement to adopt European nomenclature regulations. (thefreedictionary.com)
  • System
  • The core of the basic cephalosporin molecule consists of a two ring system which includes a β-lactam ring condensed with dihydrothiazine ring. (wikipedia.org)