• formation
  • Patrick Heun's research group at the Max Planck Institute of Immunobiology and Epigenetics and colleagues from the Helmholtz Research Center in Munich have now discovered that CenH3 alone is sufficient to trigger the formation of the centromere. (redorbit.com)
  • function
  • Here, by combining structural, biochemical, and yeast genetic studies, we show that the oligomerization of S. pombe Mis18, mediated via its conserved N‐terminal Yippee‐like domain, is crucial for its centromere localization and function. (embopress.org)
  • While the conserved N‐terminal "Yippee‐like" domain possesses an intrinsic ability to dimerize, the full‐length S. pombe Mis18 forms a tetramer and this oligomeric structure, mediated via its "Yippee‐like" domain, is crucial for Mis18 centromere localization and function. (embopress.org)
  • Mutations disrupting the dimerization of "Yippee‐like" domain reduce Mis18 centromere localization and compromise its function. (embopress.org)
  • Defective centromere function results in chromosome segregation errors that can contribute to genomic instability implicated in cancer [ 4 ]. (embopress.org)
  • specific
  • This study presents the structural characterization of Mis18, a key regulator responsible for the centromere localization of the CENP‐A‐specific chaperone HJURP in humans and Scm3 in S. pombe . (embopress.org)