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  • opioid
  • Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid, among others, is a centrally acting pain medication of the opioid class. (wikipedia.org)
  • pain
  • Tenderness, pain or fatigue of the muscles of mastication, which may get worse during chewing or other jaw movement. (wikipedia.org)
  • Headaches, particularly pain in the temples, caused by muscle pain associated with the temporalis muscle. (wikipedia.org)
  • Others consider TMD a "central sensitivity syndrome", in reference to evidence that TMD might be caused by a centrally mediated sensitivity to pain. (wikipedia.org)
  • These disorders have also been theorized to be caused by centrally mediated sensitivity to pain, and furthermore they often occur together. (wikipedia.org)
  • nerve
  • Chang CC, Chuang ST, Lee CY, Weio JW (1972) Role of cardiotoxin and phospholipase A in the blockade of nerve conduction and depolarization of skeletal muscle induced by cobra venom. (springer.com)
  • occur
  • Following treatment with TranquiVed (xylazine), the heart rate is decreased and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by a partial atrioventricular block. (drugs.com)
  • multiple sclerosis
  • Tumefactive multiple sclerosis is a condition in which the central nervous system of a person has multiple demyelinating lesions with atypical characteristics for those of standard multiple sclerosis (MS). It is called tumefactive as the lesions are "tumor-like" and they mimic tumors clinically, radiologically and sometimes pathologically. (wikipedia.org)
  • cause
  • The generation of the neuronal signals in motor neurons that cause muscle contractions are dependent on the balance of synaptic excitation and inhibition the motor neuron receives. (wikipedia.org)
  • mechanism
  • Search for the exact mechanism of action is ongoing but limited due to the existence of more-effective safe muscle relaxers (ex. (wikipedia.org)