• viral
  • The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. (wikipedia.org)
  • clinical
  • Subjects randomized to the intervention arm will receive a dose equivalent to 80 ppm iNO in air using an INOpulse delivery system for 24 hours per day for a minimum of two days and until clinical improvement (coma recovery), death or a maximum of 5 days. (clinicaltrials.gov)
  • disease
  • The severity of congenital infection varies, but in France, where maternal seroconversions during pregnancy are treated, the manifestations of the disease are often infraclinical at birth and only appear during the first years of life in the form of retinochoroiditis. (clinicaltrials.gov)
  • Drug
  • Controls will receive small pulses of placebo study drug via the INOpulse delivery system. (clinicaltrials.gov)
  • The placebo will be administered using an INOpulse delivery system that delivers small pulses of study drug to the patient via a nasal cannula. (clinicaltrials.gov)
  • increases
  • As these treatments carry certain risks, which may be severe, notably with regard to haematological or skin conditions, they have to be supervised closely with biological tests, which adds further constraints for both the children and their parents and increases the cost to health care systems. (clinicaltrials.gov)
  • functional
  • Suramin contains six aromatic systems - four benzene rings, sandwiched by a pair of naphthalene moieties - plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. (wikipedia.org)
  • list
  • It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. (wikipedia.org)
  • skin
  • 112) Candidiasis (112.0) Moniliasis, oral (112.1) Moniliasis, vulva/vagina (112.2) Monilial balanitis (112.3) Moniliasis, skin/nails (114) Coccidioidomycosis (115) Histoplasmosis (115.0) Histoplasma infection, unspec. (wikipedia.org)