IntramembranousHyaline cartilageChondrocytesMetaphysisArticularCalled the epiphyseal plateOsteogenesisDiaphysisProcessesResearch CentreHypertrophySystemicSecondary ossification centerOccursOsteoidPathwayReplaced by boneBone formationOsteoblastsMesenchymalProximalDifferentiationBonesLong boneCartilaginous ossificationDevelopsDevelopmentLongitudinalChondrocyteSpongyLateralEpiphyseal platesDistinctPhysisOsteochondrosisVascular endothTumorVEGFConnective tissueExtracellularMarrowIrregularMembranous ossificationZoneFracturesFormationPrimaryDeformitiesMutationsTibia
Intramembranous16
- Unlike intramembranous ossification, the other process by which bone tissue is produced, cartilage is present during endochondral ossification. (wikipedia.org)
- The disease affects both endochondral and intramembranous ossification. (medscape.com)
- Within intramembranous ossification there is no cartilage present as the bones develop from other connective tissues. (ukessays.com)
- The begin of intramembranous ossification starts from stem cells, these cells then have to develop into a particular cell type, such as osteoblasts which are cells that create bone tissue, spongy inner tissue of the marrow and the mineralised compact bone tissue which encloses the marrow. (ukessays.com)
- There are many different stages which take place throughout intramembranous ossification due to the stem cells change, differentiate and develop into specific types of bone cells. (ukessays.com)
- The bones which progress through the intramembranous ossification develop into the patella, the parietal, frontal, occipitial and temporal bones in the skull, the patella and the upper and low jawbones. (ukessays.com)
- The majority of bones occur from a mixture of intramembranous and endochodral ossification. (ukessays.com)
- There are two osteogenic pathways-intramembranous ossification and endochondral ossification-but bone is the same regardless of the pathway that produces it. (edu.vn)
- During intramembranous ossification , compact and spongy bone develops directly from sheets of mesenchymal (undifferentiated) connective tissue. (edu.vn)
- The flat bones of the face, most of the cranial bones, and the clavicles (collarbones) are formed via intramembranous ossification. (edu.vn)
- Intramembranous ossification follows four steps. (edu.vn)
- Intramembranous ossification begins in utero during fetal development and continues on into adolescence. (edu.vn)
- The last bones to ossify via intramembranous ossification are the flat bones of the face, which reach their adult size at the end of the adolescent growth spurt. (edu.vn)
- Endochondral ossification takes much longer than intramembranous ossification. (edu.vn)
- For your kind information, I have published the intramembranous ossification previously. (anatomylearner.com)
- If you don't read that article, please go and know how intramembranous ossification occurs. (anatomylearner.com)
Hyaline cartilage2
Chondrocytes12
- Calcification of matrix Chondrocytes in the primary center of ossification begin to grow (hypertrophy). (wikipedia.org)
- The cartilaginous zone between primary and secondary ossification centers consists of well-arranged chondrocytes forming the physeal plate, allowing for postnatal growth in length of the long bones. (vin.com)
- The reserve zone is the region closest to the epiphyseal end of the plate and contains small chondrocytes within the matrix. (chezbebeny.com)
- These mutations cause decreased endochondral ossification, decreased cellular hypertrophy, decreased cartilage matrix production, and inhibited proliferation of chondrocytes in growth plate cartilage. (medscape.com)
- Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways. (pfmjournal.org)
- The growth plate can be stratified into three distinct zones based on the size, morphology, orientation, proliferative potential, and function of chondrocytes: resting, proliferative, and hypertrophic zone. (pfmjournal.org)
- The resting zone, a source of stemlike progenitor cells that restores the reservoir of proliferative chondrocytes, is located farthest from the primary ossification center and assumes responsibility for preserving the architectural integrity of the growth plate [ 4 ]. (pfmjournal.org)
- Transience of development plate cartilage chondrocytes is thus a PKCγ Activator Molecular Weight essential attribute. (rockinhibitor.com)
- However, determined by the common embryology of cartilage and bone, as well as current proof MMP-12 Inhibitor Synonyms supporting distinct origins of growth plate and articular cartilage chondrocytes, it truly is not surprising that this hypothesis has been controversial (168). (rockinhibitor.com)
- Regardless, an exploration on the mechanisms controlling alterations that chondrocytes undergo through their transition through the many stages of endochondral ossification could support to decipher these that underlie pathologic ossification in OA. (rockinhibitor.com)
- Using a combination of mouse genetics, cell biology and pharmacological approaches my lab has recently demonstrated that autophagy is induced in growth-plate chondrocytes during post-natal development and regulates the secretion of type II collagen (Col2), the major component of cartilage ECM. (ectsoc.org)
- Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1β (IL-1β)-induced chondrocytes. (oncotarget.com)
Metaphysis8
- Intraarticular Fracture extending completely through Growth Plate and out of metaphysis. (chezbebeny.com)
- The metaphysis is the junctional region between the growth plate and the diaphysis. (medscape.com)
- Thinning of the zone of calcified cartilage is evident, along with deficiency of the primary spongiosa of the metaphysis and delay of the secondary centers of ossification in the epiphysis. (medscape.com)
- The growth plate, a complex of cartilaginous structures situated between the epiphysis and the metaphysis of the long bones, orchestrates the process of endochondral ossification, which determines the linear growth of long bones [ 1 - 3 ]. (pfmjournal.org)
- Once the growth plate has fused, the epiphysis and metaphysis are joined. (radiopaedia.org)
- Coronal (2A) and sagittal (2B) fat-suppressed proton density-weighted images of the knee reveal high signal intensity at the mid to lateral growth plate (arrowheads) with a triangular fracture of the medial metaphysis (arrow), indicating a Salter-Harris type 2 fracture. (radsource.us)
- The Salter-Harris system was expanded and modified by Ogden in 1981 to account for more complicated combination injuries as well as injury to other growth mechanisms including the metaphysis, diaphysis, periosteum, zone of Ranvier and epiphyseal perichondrium. (radsource.us)
- 1 Subclass 1B occurs in children with systemic disorders affecting endochondral ossification in the metaphysis (myeloproliferative, thalassemia or neuromuscular sensory disorders) so that the fracture passes through the zones of degenerating cartilage and primary spongiosa. (radsource.us)
Articular5
- In the long bones, the epiphysis is the region between the growth plate or growth plate scar and the expanded end of bone, covered by articular cartilage. (medscape.com)
- In the proximal humeral epiphysis, one of the centers forms the articular surface, and the other two become the greater and lesser tuberosities. (medscape.com)
- Articular cartilage and growth plate zone analy. (rockinhibitor.com)
- It's hard to tell if there's any evidence of new mesenchymal chondrogenesis or articular cartilage endochondral ossification which would be what increases height. (heightquest.com)
- Bioactive agents, including cytokines and growth factors such as stromal cell-derived factor-1, platelet-derived growth factor, VEGF, and others, were shown to promote cell recruitment and have a helpful effect on the repair of articular cartilage injuries ( 8 , 10 , 11 ). (spandidos-publications.com)
Called the epiphyseal plate2
- The cartilage between the primary and secondary ossification centers is called the epiphyseal plate, and it continues to form new cartilage, which is replaced by bone, a process that results in an increase in length of the bone. (wikipedia.org)
- Other articles where Epiphyseal plate is discussed: cartilage: …plate of cartilage, called the epiphyseal plate, persists at the ends of growing bones, finally becoming ossified itself only when the bone behind it has completed its growth. (chezbebeny.com)
Osteogenesis5
- Disturbances in skeletal development can occur in each sequential step of skeletal development including cartilage growth, cartilage maturation and eventually mineralization, osteoid quality or osteoclast activity causing skeletal diseases as chondrodysplasia, osteochondrosis of growth plates and epiphyseal surface, osteogenesis imperfecta, and osteopetrosis. (vin.com)
- By the sixth or seventh week of embryonic life, the actual process of bone development, ossification (osteogenesis), begins. (edu.vn)
- The terms osteogenesis and ossification are often used synonymously to indicate the process of bone formation. (gynecoloncol.com)
- Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodeling, and repair. (springeropen.com)
- Vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) are two key regulators of angiogenesis and osteogenesis and promote the endothelial and osteogenic differentiation of stem cells respectively. (springeropen.com)
Diaphysis5
- The first site of ossification occurs in the primary center of ossification, which is in the middle of diaphysis (shaft). (wikipedia.org)
- The growth in diameter of bones around the diaphysis occurs by deposition of bone beneath the periosteum. (wikipedia.org)
- In children and young adults, the epiphyses are separated from the diaphysis by epiphyseal cartilage or plates, where bone grows in length. (chezbebeny.com)
- The line of junction of the epiphysis and diaphysis of a long bone where growth in length occurs. (chezbebeny.com)
- What is the space in the center of the diaphysis called? (onteenstoday.com)
Processes6
- Endochondral ossification is one of the two essential processes during fetal development of the mammalian skeletal system by which bone tissue is produced. (wikipedia.org)
- First, I would like to summarize endochondral ossification - what happened in different steps or processes of this ossification. (anatomylearner.com)
- Chondrocyte growth, metabolism, and differentiation are complex processes. (pfmjournal.org)
- We decided to focus on the bone because the role that catabolic processes play in the regulation of skeletal growth has not been defined yet. (ectsoc.org)
- These studies will have the potential to identify new pathways through which growth factors regulate cellular catabolism, to explain how catabolic processes support anabolic pathways in vivo, and to provide proof of principle that developmental disorders may be treated by modulation of cellular metabolism. (ectsoc.org)
- We narrowed our search to exclude patients with a history of growth plate disorders due to trauma, malignancy, or other pathological processes, as well as patients with growth arrest due to endocrine factors. (degruyter.com)
Research Centre3
Hypertrophy2
- responsible for growth spurt and closing of epiphyseal plate, resting cartilage, the proliferation zone, hypertrophy zone, calcification zone. (chezbebeny.com)
- Growth hormone (GH), sex hormone, thyroid hormone, as well as glucocorticoids affect chondrocyte proliferation and hypertrophy. (pfmjournal.org)
Systemic2
- 1. Enderle A. Changes in the epiphysis and epiphyseal plate in systemic and genetically-induced diseases. (radiopaedia.org)
- This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. (taeush.best)
Secondary ossification center3
- About the time of birth in mammals, a secondary ossification center appears in each end (epiphysis) of long bones. (wikipedia.org)
- Where does the secondary ossification center begin? (chezbebeny.com)
- It is a secondary ossification center. (medscape.com)
Occurs5
- The process of appositional growth occurs when the cartilage model also grows in thickness due to the addition of more extracellular matrix on the peripheral cartilage surface, which is accompanied by new chondroblasts that develop from the perichondrium. (wikipedia.org)
- This process also occurs during embryonic development which is endochondrial ossification, this is where bones are produced from cartilage. (ukessays.com)
- Endochodrial ossification is the process when the development of long bones occurs such as the development of arms and legs. (ukessays.com)
- Where endochondral ossification occurs? (anatomylearner.com)
- Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders. (mdpi.com)
Osteoid1
- Formation of bone collar The osteoblasts secrete osteoid against the shaft of the cartilage model (Appositional Growth). (wikipedia.org)
Pathway4
- Recently it has been shown that biomimetic bone like apatite inhibits formation of bone through endochondral ossification pathway via hyperstimulation of extracellular calcium sensing receptor (CaSR). (wikipedia.org)
- In particular, keeping in mind that the lysosomal-autophagy pathway is dynamically regulated in response to changes in the extracellular environment, my laboratory is exploring the hypothesis that the developmental regulation of this pathway is an important contributor to organismal development and growth. (ectsoc.org)
- Currently, my laboratory is investigating the role of the lysosomal autophagy pathway during skeletal development and growth. (ectsoc.org)
- One such pathway, angiogenesis mediated by vascular endothelial growth factor (VEGF), is important for the coupling of cartilage resorption and mineralized bone formation during endochondral ossification in bone development (Huang et al. (springeropen.com)
Replaced by bone2
- Growth continues until the individual is about 20 years old or until the cartilage in the plate is replaced by bone. (wikipedia.org)
- B. the cartilage of each epiphyseal plate is replaced by bone and is called the periosteum. (chezbebeny.com)
Bone formation3
- Other findings are reduced cortical bone thickness, lack of normal cortical bone formation, and disorganization of the growth plate. (medscape.com)
- The process of bone formation in pre-existing cartilage models is known as endochondral ossification. (anatomylearner.com)
- The bone morphogenetic protein (BMP-2) family of growth factors plays critical roles in bone formation. (springeropen.com)
Osteoblasts2
- During this process the osteoblasts occur in regions of cartilage called the ossification centres. (ukessays.com)
- Osteoblasts , osteocytes and osteoclasts are the three cell types involved in the development, growth and remodeling of bones. (gynecoloncol.com)
Mesenchymal1
- a) Mesenchymal cells group into clusters, and ossification centers form. (edu.vn)
Proximal4
- For instance, the proximal end of the humerus is developed from three separate ossification centers, which later coalesce to form a single epiphyseal mass. (medscape.com)
- An exception can occur in the proximal femur if the major blood supply to the epiphysis is disrupted which can lead to osteonecrosis, premature physeal closure and severe growth deformity. (radsource.us)
- Widening and abnormal signal intensity across the growth plate of the proximal humerus, indicating little league shoulder, a variation of a SH 1 fracture. (radsource.us)
- Based on this study, isotretinoin appears to impact the growth plates of proximal tibia and distal femur. (degruyter.com)
Differentiation3
- 1 Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. (jci.org)
- Platelet-rich fibrin (PRF), commonly known as a second-generation PC, was shown to have a high capacity to improve wound healing and tissue repair owing to the gradual release of growth factors during its slow degradation along with its intrinsic fibrin scaffolding, which offers a unique three-dimensional (3-D) microstructure for promoting proliferation and differentiation of recruited cells ( 12 , 13 ). (spandidos-publications.com)
- Part of the cells were grown in extracellular matrix coated plates with serum containing culture medium containing 5% FBS plus the antibiotic cock tail to induce differentiation. (kinasepathway.com)
Bones14
- Endochondral ossification is also an essential process during the rudimentary formation of long bones, the growth of the length of long bones, and the natural healing of bone fractures. (wikipedia.org)
- Tubular and flat bones, vertebrae, the skull base, ethmoids, and the ends of the clavicles are formed by endochondral ossification. (wikipedia.org)
- The well-arranged cartilage is continued to cover the bony ends of the long bones, i.e., epiphyses, allowing for growth in diameter of these epiphyses. (vin.com)
- The epiphyseal line the part of the bone that replaces the epiphyseal growth plate in long bones once a person has reached their full adult height. (chezbebeny.com)
- To accomplish this, the bones in the human body contain epiphyseal plates. (chezbebeny.com)
- Imtramembranous ossification starts during the development within the womb and where the flat bones and some bone of the skull and the collarbone are formed from connective tissue. (ukessays.com)
- Inramembranous ossification also adds to bone growth particularly in short bones and the thickening of long bones as they grow. (ukessays.com)
- The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. (onteenstoday.com)
- The relative predilection of osteosarcoma for the metaphyseal region of long bones in children has been attributed to the rapid bone turnover due to extensive bone remodeling during growth spurts (see Growth, Modeling, and Remodeling of Bone below). (medscape.com)
- Bones at the base of the skull and long bones form via endochondral ossification. (edu.vn)
- Thinning of the skull and multiple ossification centers (wormian bones) are present, particularly in the occiput. (medscape.com)
- Development of bones of skull vault is closely correlated with the expanding growth of the underlying brain. (openaccesspub.org)
- Most of the bones of our body develop and grow by way of a cartilage template in a process called endochondral ossification. (manchester.ac.uk)
- Specifically, while the primary ossification centers of the middle phalanges were the last to appear in the manus and pes, all the carpals were absent, and only the calcaneous was evident in the tarsal bones. (ac.ir)
Long bone3
- True: The presence of an epiphyseal line indicates that long bone growth is still in process. (chezbebeny.com)
- Long bone growth is a fundamental determinant of final height. (pfmjournal.org)
- Long bone growth plays a pivotal role in determining overall height. (pfmjournal.org)
Cartilaginous ossification1
- Let's head to the entire process of Intra cartilaginous ossification. (anatomylearner.com)
Develops3
- This cartilage ultimately develops into new bone tissue through the process of endochondral ossification. (wikipedia.org)
- OC arise in any bone that develops from endochondral ossification [4,5]. (jocr.co.in)
- However, patella develops through membranous ossification, and an OS arising from patella as in our case is a rare occurrence. (jocr.co.in)
Development10
- During what week of embryonic development does ossification begin? (chezbebeny.com)
- Endorchondral ossification is where cartilage eventually gets replaced with bone during the development. (ukessays.com)
- The epiphysis is the location of secondary ossification centers during development. (medscape.com)
- Throughout fetal development and into childhood growth and development, bone forms on the cartilaginous matrix. (edu.vn)
- Development of bone (known as ossification ) proceeds by the laying down of dense connective tissue and its replacement by a trabecular network forming a primary spongiosum. (kids.net.au)
- Understanding molecular mechanisms underlying normal growth plate function has provided valuable insights into the genetic defects that impact growth and foundation for the development of effective therapeutic strategies for individuals with growth disorders. (pfmjournal.org)
- In this review, we summarized key regulatory factors and signaling pathways involved in chondrocyte functions, to understand how they affect chondrocyte growth and development. (pfmjournal.org)
- We thus aimed to establish no matter whether an aberrant deployment of the transient chondrocyte phenotype is observed in STR/Ort mouse joints and regardless of whether this can be attributed to modified growth dynamics underpinned by an inherent endochondral development defect. (rockinhibitor.com)
- The cartilage template of the skeleton deposited during development is transformed to bone in a highly organised developmental sequence that drives bone growth. (manchester.ac.uk)
- The IPA evaluation also groups the differentially expressed genes into biological mechanisms which can be linked to can cer groups, hematological condition, cell death, cell development and proliferation, cardiovascular technique growth and perform, tumor morphology and hematological method advancement and function. (micrornainhibitors.com)
Longitudinal2
- This review provides an overview of the structural aspects of the growth plate, factors influencing chondrocyte function, and their impact on longitudinal bone growth. (pfmjournal.org)
- Here's a study on lateral loading for the jaw that predates the LSJL longitudinal growth studies that may provide some insight on how to grow taller via the spine or how to get a bigger jaw. (heightquest.com)
Chondrocyte2
- Surprisingly, the post-natal induction of chondrocyte autophagy is mediated by the FGF signaling, demonstrating that autophagy is a developmentally regulated process necessary for bone growth. (ectsoc.org)
- Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification. (ectsoc.org)
Spongy2
- Spongy bone consists of plates (trabeculae) and bars of bone adjacent to small, irregular cavities that contain red bone marrow. (gynecoloncol.com)
- A spongy bone in which the matrix forms connecting bars and plates, partially enclosing many intercommunicating spaces filled with bone marrow. (flyinggiraffeteas.com)
Lateral3
- Transient suppression or CRISPR/Cas9-mediated deletion of mmp21 in zebrafish embryos induced cardiac looping defects, with concomitant disruption of laterality markers in the lateral plate mesoderm and disrupted notch signalling in vitro and in vivo. (bmj.com)
- Once a break of symmetry is initiated, leftward flow induces the asymmetric distribution of Nodal ( southpaw , in zebrafish) in the lateral plate mesoderm (LPM) where Lefty and Pitx2 are subsequently expressed. (bmj.com)
- Growth can be stimulated in the mandible by lateral loading. (heightquest.com)
Epiphyseal plates2
- b) Epiphyseal lines are the remnants of epiphyseal plates in a mature bone. (chezbebeny.com)
- OCs grow during childhood through adolescence, but usually growing ends when the epiphyseal plates close. (jocr.co.in)
Distinct1
- During endochondral ossification, five distinct zones can be seen at the light-microscope level. (wikipedia.org)
Physis4
- Conditions that affect the physis and the growth disturbances that may result can create challenging issues in management. (medscape.com)
- Injuries to the extremities of children frequently involve the physis, partially because the ligaments and joint capsule can be 5 times stronger than the growth plate. (radsource.us)
- Displacement is frequently prevented by an intact periosteal attachment into the zone of Ranvier, the region responsible for peripheral growth of the physis. (radsource.us)
- A fat-suppressed T2-weighted coronal image of a SH 1 fracture through the distal femoral physis demonstrating increased signal intensity (arrowheads) in the growth plate relative to the tibial growth plate. (radsource.us)
Osteochondrosis2
- Osteochondrosis (OC), simply defined as a failure of endochondral ossification, is a complex disease with both genetic and environmental risk factors that is commonly diagnosed in young horses, as well as other domestic species. (biomedcentral.com)
- Osteochondrosis (OC) is a commonly diagnosed developmental orthopedic disease that is defined as a focal failure of endochondral ossification, the process by which a cartilage template becomes bone in the limbs of a growing animal [ 1 ]. (biomedcentral.com)
Vascular endoth2
- Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. (springeropen.com)
- Expression of particular growth factors such as vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) during the healing suggests a possible role for these secreted factors in bone repair. (springeropen.com)
Tumor2
- In the radiological evaluation, tumor with bone density in the lower center of the patella of the left knee was shown. (jocr.co.in)
- The diagnosis of patellar OC was made, and surgical resection was planned because of the tumor growth. (jocr.co.in)
VEGF1
- Although VEGF can control hypertrophic cartilage structure and vascularity within the developing growth plate (Gittens & Uludage, 2001 ), BMP-2 pro-protein contains four glycosylation sites. (springeropen.com)
Connective tissue1
- By the end of the eighth week after conception, the skeletal pattern is formed in cartilage and connective tissue membranes and ossification begins . (gynecoloncol.com)
Extracellular1
- The extracellular matrices used for coating plates integrated collagen IV, fibronectin, laminin, and Matrigel. (kinasepathway.com)
Marrow1
- Here, you will know - when does endochondral ossification begins, how the primary center of ossification start, how the marrow cavity is formed, and much more. (anatomylearner.com)
Irregular2
- The bone spicules appear thicker and randomly organised, whilst the growth plate is irregular with a poorly formed secondary ossification centre and delayed endochondral ossification. (ostargloves.com)
- Ossification of the body begins about the second month of fetal life, by an irregular quadrilateral plate of bone forming, immediately behind the glenoid cavity. (vetcan.org)
Membranous ossification1
- A study by Di Rocco et al using murine and human subjects indicated that FGFR3 mutations in achondroplasia also affect membranous ossification. (medscape.com)
Zone2
- These multiply under the influence of growth factors in the zone of multiplication, and rounded cells are then seen. (medscape.com)
- It is the zone of endochondral ossification in an actively growing bone or the epiphyseal scar in a fully grown bone. (medscape.com)
Fractures1
- 1 About 15% of fractures of children involve the growth plate. (radsource.us)
Formation1
- This can cause formation of an osseous bridge after growth of the secondary center reaches the damaged area. (radsource.us)
Primary4
- Periosteal buds carry mesenchyme and blood vessels in and the process is similar to that occurring in a primary ossification center. (wikipedia.org)
- The point of union of the primary and secondary ossification centers is called the epiphyseal line. (wikipedia.org)
- Before birth the primary and some of the secondary ossification centers have been developed via the process of endochondral ossification. (vin.com)
- 7. Establishment of primary center of ossification. (anatomylearner.com)
Deformities1
- Isotretinoin-induced premature epiphyseal closure and growth plate deformities seem to be linked to higher doses of isotretinoin for the duration of months to years. (degruyter.com)
Mutations2
- Achondroplasia is caused by mutations in the fibroblast growth factor receptor-3 ( FGFR3 ) gene. (medscape.com)
- The observation that mutations in more than 20 genes encoding for lysosomal proteins causes defects in skeletal growth in human suggests that lysosomal pathways play an important, yet unexplored, role during skeletogenesis. (ectsoc.org)
Tibia1
- Masson Goldner trichrome stain of growth plate in a rabbit tibia. (wikipedia.org)