• maintains
  • It maintains specific transmembrane receptor proteins involved in initiating of the downstream signalling of the UPR in an inactive state by binding to their luminal domains. (wikipedia.org)
  • immune responses
  • Since lymphocytes must be positioned correctly to interact with other cells, the pattern of chemokine receptors and the type and distribution of chemokines in tissues critically influence immune responses. (wikipedia.org)
  • Cells
  • In response to Ag and follicular T cell help, B cells form germinal centers that generate high-affinity long-lived plasma cells. (jimmunol.org)
  • however, the cells were not compromised in type I IFN production or responses. (sciencemag.org)
  • ERLIN2 may confer a selective growth advantage for breast cancer cells by facilitating a cytoprotective response to various cellular stresses associated with oncogenesis. (biomedcentral.com)
  • It has been shown to downregulate expression of translationally controlled tumor protein (TCTP), and this has been associated with antiproliferative activity against MDA-MB-231 cancer cells in vitro and in a xenograft setting ( 20 ). (aacrjournals.org)
  • The sgRNA expression vector design will depend largely on the experiment performed but requires the following central components: Promoter Restriction sites Primer Binding Sites sgRNA Guide Barcode Reporter gene: Fluorescent gene: vectors are often constructed to include a gene encoding a fluorescent protein, such that successfully transduced cells can be visually and quantitatively assessed by their expression. (wikipedia.org)
  • gene
  • In Arabidopsis, BiP3 has been used as a UPR marker gene whose expression is strongly induced in response to ER stress. (deepdyve.com)
  • By whole genome sequencing, we identified a causal gene in the mutant as SUPPRESSOR OF SALICYLIC ACID INSENSITIVITY2 (SSI2), which encodes stearoyl‐acyl carrier protein desaturase that converts stearic acids to oleic acids in the chloroplasts. (deepdyve.com)
  • Polyubiquitin-C is a protein encoded by the UBC gene in humans. (wikipedia.org)
  • UBC gene transcription is induced during stress and provides extra ubiquitin necessary to remove damaged/unfolded proteins. (wikipedia.org)
  • Loss of a single UBC allele has no apparent phenotype, while homozygous deletion of UBC gene leads to mid-gestation embryonic lethality due to a defect in fetal liver development, as well as a delay in cell-cycle progression and increased susceptibility to cellular stress. (wikipedia.org)
  • complexes
  • The chaperone EDEM guides the retrotranslocation of the misfolded protein back into the cytosol in transient complexes with PDI and Grp784. (wikipedia.org)
  • sequence
  • CHAPTER 1: Comparative genomic and protein sequence analyses of a complex system controlling bacterial chemotaxis. (bookdepository.com)
  • The proteins destined to be secreted or sorted to other cell organelles carry an N-terminal signal sequence that will interact with a signal recognition particle (SRP). (wikipedia.org)
  • Once the sequence has "docked", the protein continues translation, with the resultant strand being fed through the polypeptide translocator directly into the ER. (wikipedia.org)
  • translation
  • Protein folding commences as soon as the polypeptide enters to the luminal environment, even as translation of the remaining polypeptide continues. (wikipedia.org)
  • component
  • Group 2 chaperonins also contain an additional helical component which acts as a lid for the cylindrical protein chamber, unlike Group 1 which instead relies on an extra cochaperone to act as a lid. (wikipedia.org)
  • production
  • Actually mitochondrial ROS (mtROS) production, but not oxygen consumption is required for hypoxic HIF-1alpha protein stabilization. (springer.com)
  • These pauses provide an opportunity for an individual protein domain to have the necessary time to become folded before the production of following domains. (wikipedia.org)
  • chain
  • The newly synthesized peptide chain exits the ribosome into the cellular environment through the narrow ribosome exit channel (width: 10Å to 20Å, length 80Å). (wikipedia.org)
  • Hsp70 surrounds an unfolded peptide chain, thereby preventing aggregation and promoting folding. (wikipedia.org)