• Defects observed in Hat1 +/- mice are consistent with an early-onset aging phenotype. (nih.gov)
  • Senp2 knockout mice exhibited a lipodystrophy-like phenotype. (deepdyve.com)
  • In Atm-knockout (Atm-KO) mice, complete loss of Atm leads to a very mild neurological phenotype, suggesting that Atm loss is not sufficient to markedly abrogate cerebellar structure and function in this organism. (eur.nl)
  • Expression of inactive ("kinase-dead") Atm (AtmKD) in mice leads to embryonic lethality, raising the question of whether conditional expression of AtmKD in the murine nervous system would lead to a more pronounced neurological phenotype than Atm loss. (eur.nl)
  • However, both strains exhibited normal life span and displayed no gross cerebellar histological abnormalities or significant neurological phenotype. (eur.nl)
  • Greater pressure needs to be exerted on genome stability to obtain a mouse model that recapitulates the severe A-T neurological phenotype. (eur.nl)
  • Continuous EEG monitoring after status epilepticus revealed an accelerated and exacerbated epilepsy phenotype whereby spontaneous seizures began sooner, occurred more frequently and were of longer duration in miR-22-deficient mice. (researchsquare.com)
  • The P2X7 receptor was identified as a miR-22 target and co-injection of a P2X7 receptor antagonist mitigated the epilepsy phenotype in mice given the ASO inhibitor of miR-22 [ 16 ]. (researchsquare.com)
  • Results: CKO mice developed an obese phenotype, more severely under high-fat diet (HFD) feeding. (tmu.edu.tw)
  • Eye phenotype and lens histology and ultrastructure were analyzed in adult mice. (molvis.org)
  • Mutations in the human WISP3 gene are associated with progressive pseudorheumatoid dysplasia, a juvenile onset autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. (wikipedia.org)
  • Working with Swaroop, research investigator Alan J. Mears, Ph.D., deleted the gene that makes Nrl in mice, creating an Nrl-knockout strain that developed a retina without rod photoreceptors. (sciencedaily.com)
  • To address this issue, we generated E4F knockout mice by gene targeting. (cnrs.fr)
  • In the new mutant mice, a planted bacterial phage enzyme turns on with Wnt1, which excises a gene necessary for cells to respond to the hedgehog signal. (harvard.edu)
  • They developed a 'knockout' mouse, in which the gene that codes for Abcc10 was missing, or knocked out. (news-medical.net)
  • The researchers isolated cells from the knockout mice and tested the cells' reactions to taxanes and two other anticancer drugs, vincristine and Ara-C. Compared to cells from normal mice that still possessed the gene for Abcc10, the knockout mouse cells were much more sensitive to the drugs. (news-medical.net)
  • This study reveals a novel posttranslational cleavage event that controls CDP activity and gene expression during normal development of the mammary gland. (utexas.edu)
  • After gene manipulation, we further investigated the characteristics of cellular HMGB1 in HEI-OC1 cells. (frontiersin.org)
  • Her group reduced cognitive flexibility in mice by deleting a gene from dopamine neurons that causes TSC when mutated, which lowered the amount of dopamine released. (berkeley.edu)
  • Dopamine neurons (green) in the mouse midbrain with the Tsc1 gene knocked out show high activation of mTORC1 signaling (red). (berkeley.edu)
  • In the study , which was published in Nature Communications , they used a conditional gene knockout approach to selectively delete the Tsc1 gene in dopamine neurons in mice. (berkeley.edu)
  • Simultaneous knockout of both IRP1 and IRP2 leads to embryonic lethality in mice. (nature.com)
  • To understand the broader biological role of Hat1, we have generated a conditional mouse knockout model of this enzyme. (nih.gov)
  • In this case, the researchers used a neat genetic trick called a conditional knockout to shut down the signaling of sonic hedgehog only in the neural crest cells. (harvard.edu)
  • For the in vivo studies, Plasmodium berghei ANKA (PbA)-infected CBA and C57BL/6 mice have been used as a CM susceptible model. (biomedcentral.com)
  • Lung inflammation was assessed following oropharyngeal aspiration of CB or oxidized CB(ox) particles (20g per mouse) in C57BL/6J mice. (cdc.gov)
  • Under physiological conditions, the main- PPARγ mutation has been shown to link to familial partial lipody- tenance of normal adipose tissue mass is mainly the result of a strophy, a clinical disorder characterized by the loss of adipose balance of lipid storage and lipolysis (Bouchard et al. (deepdyve.com)
  • Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
  • Cellular interactions within the expanded white adipose tissue (WAT) in obesity contribute to inflammation and studies have suggested that inflammation is triggered by inflamed adipocytes that recruit M1 macrophages into WAT. (tmu.edu.tw)
  • However, mice with WISP3 knockout or overexpression are normal and suffer no apparent developmental defect. (wikipedia.org)
  • Brain-specific knockout of Sirt1 results in exacerbation of brain pathology in HD mice, whereas overexpression of Sirt1 improves survival, neuropathology and BDNF expression in HD mice. (harvard.edu)
  • These studies will employ multiple innovative reagents including mouse models of inducible, cardiomyocyte-specific L2A deletion and overexpression, a recently developed small molecule activator of CMA, and a new CMA reporter mouse. (elsevierpure.com)
  • We report here that the Fgf2 null mutant mice show an ∼40% decrease in cortical glutamatergic pyramidal neurons. (jneurosci.org)
  • Because Fgf2 −/− mice lacked 45% of cortical neurons at birth, the progenitor loss is compensated only in part during neurogenesis. (jneurosci.org)
  • Because the dorsal PVE was depleted of progenitors but the ganglionic eminences were not affected in Fgf2 −/− mice, we predicted that these mice should lack a population of pyramidal neurons, but their cortical GABA interneurons should have remained unchanged. (jneurosci.org)
  • We identified BDNF as an important target of Sirt1 and TORC1 transcriptional activity in normal and HD neurons. (harvard.edu)
  • This finding was very surprising because these genes- HLA genes in humans- are involved in cellular immunity and were previously not thought to be expressed by neurons at all! (stanford.edu)
  • The latter represents a conformationally modified form of a normal cellular PrP C , which is a normal host protein found on the surface of many cells, in particular neurons. (medscape.com)
  • Bateup explains that Tsc1 is active throughout the body and controls a variety of cellular functions, so this targeted approach allowed them to specifically hone in on its effects in dopamine neurons. (berkeley.edu)
  • Tsc1 KO) were much bigger than normal dopamine neurons. (berkeley.edu)
  • Indeed, they found that dopamine neurons projecting to a brain area called the dorsal striatum released 60% less dopamine than normal dopamine neurons, despite actually making more of the neurotransmitter. (berkeley.edu)
  • In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)
  • Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. (hindawi.com)
  • Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
  • In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)
  • The maintenance of "healthy" and fully functional mitochondria is thus essential for cellular homeodynamics. (hindawi.com)
  • The protein can exist in multiple isoforms , the normal PrP C , and as Protease resistant PrP Res like the disease-causing PrP Sc(scrapie) and an isoform located in mitochondria . (wikidoc.org)
  • We have taken a major interest in how mitochondria are genetically regulated, given their pivotal role in cellular energy metabolism and control of insulin secretion from beta-cells. (lu.se)
  • The lethality of mdm2 −/− mice before implantation makes it impossible to analyze Mdm2 interaction with p53 in vivo at specific times of development, at postnatal/adult stages, or in specific cell types. (molvis.org)
  • The ubiquitously expressed E4F protein was originally identified as an E1A-regulated cellular transcription factor required for adenovirus replication. (cnrs.fr)
  • The function of this protein in normal cell physiology remains largely unknown. (cnrs.fr)
  • PURA encodes Pur-α, a highly conserved multifunctional protein that has an important role in normal postnatal brain development in animal models. (bmj.com)
  • Sirt1, an NAD-dependent protein deacetylase has emerged as important regulator of mammalian transcription in response to cellular metabolic status and stress. (harvard.edu)
  • In addition, the expression of Hat1 is linked to the normal aging process as Hat1 mRNA and protein becomes undetectable in many tissues in old mice. (nih.gov)
  • We found that SET domain bifurcated 1 Since no difference in food intake was observed between adqcKO f/f (Setdb1) was a SUMOylated protein and that Senp2 de-SUMOylated Senp2 and Senp2 mice fedeitherwithNCD or HFD and regulated Setdb1 action in trimethylation at histone 3 lysine 9 (Supplementary Figure S2A). (deepdyve.com)
  • Here, we show that ependyma-derived matricellular protein CCN1 (cellular communication network factor 1) negatively regulates niche capacity and NSC number in the adult ventricular-subventricular zone (V-SVZ). (stanford.edu)
  • The fact that mice lacking the protein have no obvious health problems is encouraging, suggesting that Abcc10 inhibitors could be used in human patients without causing side effects that might be expected to result from interfering with the pump's normal functions. (news-medical.net)
  • The cellular factor, CCAAT displacement protein (CDP), is a transcriptional repressor of MMTV. (utexas.edu)
  • Here we demonstrate that the previously uncharacterized scaffolding protein Caskin2 is a novel regulator of EC quiescence and that loss of Caskin2 in mice results in elevated blood pressure at baseline. (duke.edu)
  • This study aims to understand the action of Cellular Retinoic Acid Binding Protein 1 (CRABP1) in WAT inflammation. (tmu.edu.tw)
  • In contrast, no change in pyramidal or granule cell number is detected in the hippocampus of Fgf2 −/− mice. (jneurosci.org)
  • Basal macroautophagy (thereafter referred to as autophagy), a catabolic recycling system in cells, is key to maintaining cellular homeostasis and survival. (hindawi.com)
  • p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. (molvis.org)
  • Adult ependyma-specific deletion of Ccn1 transiently enhanced NSC proliferation and reduced neuronal differentiation in mice, increasing the numbers of NSCs and NSC units. (stanford.edu)
  • Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice. (omicsdi.org)
  • Moreover, in the Imiquimod (IMQ) mouse model of psoriasis, topical administration of LUT-7G leads to a marked reduction of acanthosis and re-expression of epidermal differentiation markers. (omicsdi.org)
  • Therefore, MMTV has adopted a normal cellular process to control viral expression during mammary differentiation. (utexas.edu)
  • Accordingly, pregnancy success rates currently achieved by natural or assisted conception for women at high-risk for EPL or RPL can only be increased by an improved understanding of the cellular and molecular mechanisms that control endometrial function during the periimplantation period. (frontiersin.org)
  • 2019). We are currently working on generating testis-specific Usp26 knockout mice to elucidate the mechanisms of USP26 in spermatogenesis and sperm maturation. (tulane.edu)
  • The cellular and molecular mechanisms of cognitive inflexibility have largely been a mystery, but a new study from Helen Bateup's lab has revealed that dopamine plays an important role. (berkeley.edu)
  • Her team, led by postdoctoral fellow Polina Kosillo, wanted to understand the cellular and molecular mechanisms that lead to TAND in TSC patients. (berkeley.edu)
  • Some of the more interesting cellular and molecular mechanisms are reviewed briefly in this article. (cdc.gov)
  • OTUD3 knockout mice display nigral iron accumulation, motor deficits, and nigrostriatal dopaminergic neurodegeneration, which resembles the pathology of PD. (nature.com)
  • SV40 immortalized mouse embryonic fibroblasts derived from Bax-Bak double-knockout mice were significantly more resistant to GL-induced cell killing compared with wild-type cells. (aspetjournals.org)
  • Hat1 +/- mouse embryonic fibroblasts (MEFs) display modest increases in endogenous DNA damage but have significantly higher levels of reactive oxygen species (ROS). (nih.gov)
  • Although proliferation of NSCs and neurogenesis seen in Ccn1 knockout mice eventually returned to normal, the expanded NSC pool was maintained in the V-SVZ until old age. (stanford.edu)
  • Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model. (omicsdi.org)
  • These predictive bioanalytic results were confirmed by the demonstration that SRC-3 is required for the expansion, migratory and invasive activities of the HESC population, cellular properties that are required in vivo in the formation or functioning of the decidua. (frontiersin.org)
  • This project will explore the role of F4/80 in tumour-host interactions in vivo and identify cellular and extracellular binding partners of this adhesion GPCR. (ox.ac.uk)
  • Likewise, loss of Caskin2 in vivo promotes increased vascular branching and permeability in mouse and zebrafish models. (duke.edu)
  • To address this knowledge gap, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform to enable the genetic interrogation of hematopoiesis and broad aspects of immune cell function in vivo. (biorxiv.org)
  • In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. (hindawi.com)
  • This schematic view of the morpho-functional unit of the lung (alveolus) depicts the main differences in cellular composition in idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) compared with normal physiological cellular components. (ersjournals.com)
  • Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. (frontiersin.org)
  • However, there has been no means to assess the functional significance of CMA in healthy or diseased hearts until recently, when we generated mice with an inducible, cardiomyocyte-specific knockout of LAMP2A (iCS- L2AKO). (elsevierpure.com)
  • Currently, the cellular pathways and regulatory molecules that determine exactly how photoreceptors develop are poorly understood. (sciencedaily.com)
  • Even though the mice do not have a well-defined macula (a region of the retina that is richer in cones than other parts of the retina), Kellogg researchers hope that this mouse model will allow them to identify the molecules needed for cone function and survival. (sciencedaily.com)
  • By studying and/or generating knockout mice, the lab is exploring a role for these molecules in synaptic plasticity, learning, memory and neurological disorders. (stanford.edu)
  • Adhesion of macrophage cell lines from wild type and F4/80 knockout mice to purified matrix molecules, and complex 3D matrices, will be assessed, and binding sites mapped and downstream signalling examined. (ox.ac.uk)
  • More specifically, DAMPs include pathogen-associated molecular patterns (PAMPs) and "alarmins," endogenous molecules that signal tissue and cellular damage. (frontiersin.org)
  • At the cellular level, fibroblasts from Hat1 haploinsufficient embryos undergo early senescence and accumulate high levels of p21. (nih.gov)
  • Studies with mouse embryo fibroblasts lacking endogenous nuclear CDP confirmed that CDP150 lacks transcriptional repressor or activator function for the MMTV LTR and β-casein. (utexas.edu)
  • Consistently, decreased levels of OTUD3 are detected in transgenic PD mice expressing A53T mutant of human α-synuclein. (nature.com)
  • Mice with the required genotypes were obtained by crossing transgenic, mdm2 +/− , and p53 −/− mice. (molvis.org)
  • This problem has been circumvented with the use of several knockout, knock-in, and overexpressing transgenic mouse models. (molvis.org)
  • This project builds on the complementary research interests and expertise of Kim Midwood and Anja Schwenzer (Kennedy Institute) in Matrix Biology and Siamon Gordon (Dunn School), a macrophage cellular pathologist, whose group identified and characterized the F4/80 antigen, supplemented by the biochemical expertise of collaborator Hsi-Hsien Lin, (Chang Gung University, Taipei, Taiwan), who developed the F4/80 knockout mouse strain. (ox.ac.uk)
  • WATs and serum were collected for cellular and molecular analyses to determine affected signaling pathways. (tmu.edu.tw)
  • We generated two mouse strains in which AtmKD was conditionally expressed as the sole Atm species: one in the CNS and one specifically in Purkinje cells. (eur.nl)
  • This study demonstrated that reduction of full-length CDP levels in two independent strains of CDP knockout mice increased endogenous MMTV and other mammary-specific cellular genes in undifferentiated mammary glands, suggesting a critical role for CDP in the MMTV life cycle. (utexas.edu)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
  • In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
  • It was during my postdoctoral stay in Dallas at Southwestern Medical Center that I really developed my understanding of cellular metabolism. (lu.se)
  • We analyzed mice expressing human p53 transgene (Tg p53 ) selectively in the lens in the presence or absence of Mdm2 . (molvis.org)
  • Here, we used mice with a genetic deletion of miR-22 to extend these insights. (researchsquare.com)
  • In a wild-type genetic background ( mdm2 +/+ ), lens damage and microphthalmia were observed only in mice homozygous for Tg p53 ( t/t ). (molvis.org)
  • These mice appeared normal and healthy in every other respect, suggesting that Abcc10 is not essential for overall health and survival. (news-medical.net)
  • These studies suggest a key role of Sirt1 in transcriptional networks in normal and HD brain and offer an opportunity for therapeutic development. (harvard.edu)
  • The results also demonstrate that a famous signaling molecule, sonic hedgehog, is essential for neural crest cells to grow and form normal faces. (harvard.edu)
  • A major breakthrough in our understanding of its immunological function derived from studies using F4/80 knockout mice, which revealed this molecule to be dispensible for macrophage development, but responsible for peripheral tolerance. (ox.ac.uk)
  • However, the Rag2 knockout mouse showed significantly less species diversity. (broadinstitute.org)
  • While these investigations were in progress, Mears started to develop the Nrl-knockout mouse to study the role of Nrl in a living animal. (sciencedaily.com)
  • New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. (ersjournals.com)
  • USP26 is a member of deubiquitinases (DUBs) involved in various cellular functions and plays a vital role in cancer development. (tulane.edu)
  • We are currently generating prostate-specific Usp26 knockout mouse models using CRISP/Cas9 techniques to elucidate the role of USP26 in PCa. (tulane.edu)
  • In the new research, Hopper-Borge and colleagues wanted to further explore, in both cultured cells and mice, the role of Abcc10. (news-medical.net)
  • Specifically, damage-associated molecular patterns (DAMPs), the cellular byproducts of damage, are known to play an essential role in this inflammation. (frontiersin.org)
  • It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. (lookformedical.com)
  • not worsened, as might be expected from the traditional role of autophagy in ameliorating cellular stresses. (elsevierpure.com)
  • In paper №1, I detail the neurodegenerative and behavioural outcomes in a mouse lesion model of PD, which can be used as a platform for the development of novel therapeutic strategies. (lu.se)
  • 2009). We have generated an Usp26 KO mouse model, the first of its kind, and found that disruption of Usp26 causes male subfertility associated with spermatogenesis defects in mice (Biol Reprod. (tulane.edu)
  • miR-22-3p (hereafter miR-22), a conserved miRNA that is expressed throughout the body, including the brain [ 14 , 15 ], was previously identified among upregulated miRNAs within the mouse hippocampus contralateral to the epileptogenic zone in the intraamygdala kainic acid model of status epilepticus [ 16 ]. (researchsquare.com)
  • I'd like to stress that we did this work in a mouse model,' Hopper-Borge says. (news-medical.net)
  • We will investigate the cellular and molecular basis of F4/80-mediated tolerance using a syngeneic, orthotopic breast cancer grafting model [5] in wild type or F4/80 null mice. (ox.ac.uk)
  • The mouse model manifests the neurological symptoms within 6-14 days after infection and then dies [ 10 ]. (biomedcentral.com)
  • We showed how insulin deficiency in Friedreich's ataxia is likely to evolve, and that a mouse model for Huntington's disease develops diabetes due to loss of beta-cells. (lu.se)
  • C57BL6 male mice were exposed for 3hours by whole body inhalation and acute toxicity determined after 24h. (cdc.gov)
  • Iron is an essential nutrient element required in cellular biosynthetic and metabolic processes [ 15 ]. (nature.com)
  • adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
  • Cellular and matrix interactions of F4/80, an adhesion GPCR which defines murine tissue macrophages, in the normal and tumor microenvironment. (ox.ac.uk)
  • Many of these programs generated rich public data sets containing a variety of multi-dimensional molecular and phenotypic data from several organisms including mouse and human. (nih.gov)
  • Several Abcc10 inhibitors already have been identified, but they also inhibit other cellular transporters, which could have deleterious effects. (news-medical.net)
  • Furthermore, Mdm2 in only one allele was sufficient to rescue these deleterious effects, since the mdm2 +/− /Tg p53 t/0 mice had eye size and lens morphology similar to the control mice. (molvis.org)
  • Dr. Zhang received a bachelor degree in biology from Shaanxi Normal University, China in 1987. (tulane.edu)
  • In 2009, she joined Tulane University School of Medicine as a postdoctoral fellow in molecular cancer biology in the Department of Structural & Cellular Biology. (tulane.edu)
  • Due to its relatively independent function accompanying its different cellular localization, a deeper understanding of HMGB1 biology in the cochlea is indispensable for guiding future precise therapeutic interventions. (frontiersin.org)
  • Uriel Sanchez, a junior molecular and cellular biology major at The Johns Hopkins University, identified relationships between species diversity in pulmonary bacterial communities and the adaptive immune system. (broadinstitute.org)
  • As part of the study, researchers also examined the effect of age on cone function in the absence of rods, recording electrical activity in the retina of Nrl knockout mice at different times after birth. (sciencedaily.com)
  • In addition, the soma of the pyramidal cells in the frontal and parietal cortices are smaller in Fgf2 knock-out mice. (jneurosci.org)
  • Using HSL knock out mice, we were able to demonstrate that the lipase controls insulin secretion. (lu.se)
  • It is interesting to note that a representative normal prostate epithelial cell line (PrEC) was relatively more resistant to GL-mediated cellular responses compared with prostate cancer cells. (aspetjournals.org)
  • We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
  • New findings from the lab of MCB department chair Andrew McMahon, the Frank B. Baird Jr. Professor of Science, suggest that five members of the Fox family of transcription factors may work in different combinations to sculpt certain facial structures in mice. (harvard.edu)
  • These processes to severe lipodystrophy and induces insulin resistance in mice (He et al. (deepdyve.com)
  • This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
  • This has implications both for normal control of insulin release as well as disease processes in islets, also known as lipotoxicity. (lu.se)
  • Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)
  • In that regard, a disruption in the balance of pro-inflammatory CD4+ T helper (Th) 17 cells and homeostatic regulatory T (Treg) cell responses in favor of Th17 cells has been reported in non-cancer-related aging humans and mice. (tulane.edu)
  • The higher cell viability observed in the HMGB1 knocked-down group after stimulation with H 2 O 2 indicated the possible negative effect of HMGB1 on cellular lifespan. (frontiersin.org)
  • High-mobility group box 1 (HMGB1), a representative damage-associated molecular pattern (DAMP), acts as a mediator of inflammation or an intercellular messenger according to its cellular localization. (frontiersin.org)
  • We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
  • We are focused on Wnt signaling because this appears to be a key signal that confers stem cell potency in both mouse and human lung, and is overactive in diseases like lung adenocarcinoma and Idiopathic Pulmonary Fibrosis (IPF). (stanford.edu)
  • Methods: Eight weeks-old wild type (WT) and Crabp1 knockout (CKO) mice were fed with a normal diet (ND) or high-fat diet (HFD) for 8 weeks. (tmu.edu.tw)
  • Swaroop believes that the Nrl knockout mouse - that is, the mouse bred to have only cone cells - can be used to investigate this behavior. (sciencedaily.com)
  • PrP Sc , when introduced into normal healthy cells, causes the conversion of PrP C into PrP Sc , initiating a self-perpetuating vicious cycle. (medscape.com)
  • The strong antiproliferative activity of p53 may have detrimental effects in normal cells if it is activated inappropriately. (molvis.org)
  • Our experimental approaches involve mouse genetics, single cell genomics, organoid culture, lung slice culture, and we perform histological analysis of lung tissue using advanced fluorescence microscopy technologies. (stanford.edu)
  • We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
  • These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
  • Next, the research team studied the effects of one particular taxane, paclitaxel, on mice and found that the knockout mice were more sensitive to the drug, as reflected in body weight, white blood cell count, and ability to survive escalating doses of the drug. (news-medical.net)
  • I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)
  • Cellular and animal models for mitochondrial complex I deficiency: a focus on the NDUFS4 subunit. (nih.gov)
  • Moreover, galectin-7-deficient mice showed enhanced epidermal hyperplasia and skin inflammation in response to intradermal IL-23 injection. (omicsdi.org)
  • Noise-induced hearing loss (NIHL) is characterized by cellular damage to the inner ear, which is exacerbated by inflammation. (frontiersin.org)