• viruses
  • CroV's enormous, and surprising, genetic code further blurs the boundary between viruses and cellular life, according to the researchers who described it. (nbcnews.com)
  • C . roenbergensis 's diet of bacteria and viruses may explain the strange collection of genes possessed by the giant virus that infects it. (nbcnews.com)
  • This is actually a low proportion - about 90 percent of the genes within certain viruses are unknown, Fischer said. (nbcnews.com)
  • Because they were clearly biological themselves and could be spread from one victim to another with obvious biological effects, viruses were then thought to be the simplest of all living, gene-bearing life-forms. (scientificamerican.com)
  • Moreover, the presence of the gene in only some monkey viruses, suggests that it could make the difference between viruses causing virulent rather than latent infections. (rochester.edu)
  • Cells infected by viruses can exhibit diverse patterns of viral and cellular gene expression. (rsc.org)
  • Additionally, A/Chicken/HK/G9/97 (H9N2) virus has PB1 and PB2 genes that are highly related to those of A/HK/156/97 (H5N1), A/Teal/HK/W312/97 (H6N1), and A/Quail/HK/G1/97 (H9N2) viruses. (pubmedcentralcanada.ca)
  • Additionally, viruses of the H6N1 subtype that are similar to A/Teal/HK/W312/97, which possesses seven gene segments (PB2, PB1, PA, NA, NP, M, and NS), are highly related genetically to those of the H5N1 influenza viruses isolated from humans in 1997 and continue to circulate in domestic poultry ( 18 ). (pubmedcentralcanada.ca)
  • This family of viruses have not been assigned to a viral order. (wikipedia.org)
  • Generally these types of viruses have become highly evolved, and have lost the expression of many gene products. (wikipedia.org)
  • anti-viral
  • Earlier viral or anti-viral gene expression favored or hindered virus growth, respectively. (rsc.org)
  • The overall goal of the CMV Research Group is to define the mechanisms by which CMV causes life-threatening disease in these at-risk individuals, so as to provide a rational basis for the design of novel anti-viral therapeutics to prevent or treat CMV disease. (edu.au)
  • novel
  • Zhou's research is directed at understanding the fundamental molecular mechanisms that govern cellular signal transduction and epigenetic control of gene transcription in human biology of health and disease by using combined structural/chemical biology and molecular/cell biology approaches.He received the GlaxoSmithKline Drug Discovery Research Award in 2003 for his work in novel anti-HIV/AIDS therapy development. (wikipedia.org)
  • His recent work includes the development of a novel gene transcriptional silencing technology. (wikipedia.org)
  • Some examples of such neofunctionalization is the apparent mutation of a duplicated digestive gene in a family of ice fish into an antifreeze gene and duplication leading to a novel snake venom gene and the synthesis of 1 beta-hydroxytestosterone. (wikipedia.org)
  • vivo
  • They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
  • In vivo gene delivery of AP-2 alpha suppressed spontaneous intestinal polyps in the Apc(Min/+) mouse. (wikipedia.org)
  • regulation
  • We are taking both genetic and biochemical manipulations to dissect the involvement of cellular factors and signaling pathways in the regulation of IRFs and their roles in EBV-mediated oncogenesis. (unl.edu)
  • By controlling the miRNA that regulate mRNAs in cells, AMOs can be used as further regulation as well as for therapeutic treatment for certain cellular disorders. (wikipedia.org)
  • Mutations
  • Mutations in the TFAP2A gene cause Branchio-oculo-facial syndrome often with a midline cleft lip. (wikipedia.org)
  • Sequencing of candidate genes in that region in 4 additional unrelated BOFS patients revealed 4 different de novo missense mutations in the exons 4 and 5 of the TFAP2A gene. (wikipedia.org)
  • Mutations in IRF6 gene cause Van der Woude syndrome (VWS) that is a rare mendelian clefting autossomal dominant disorder with lower lip pits in 85% of affected individuals. (wikipedia.org)
  • Mutations in the AP-2 alpha gene also cause branchio-oculo-facial syndrome, which has overlapping features with Van der Woude syndrome such as orofacial clefting and occasional lip pits what make rs642961 a good candidate for an etiological variant. (wikipedia.org)
  • Duplication creates genetic redundancy, where the second copy of the gene is often free from selective pressure-that is, mutations of it have no deleterious effects to its host organism. (wikipedia.org)
  • Thus, duplicate genes accumulate mutations faster than a functional single-copy gene, over generations of organisms, and it is possible for one of the two copies to develop a new and different function. (wikipedia.org)
  • lytic
  • The result of this is that the virus can reactivate and begin producing large amounts of viral progeny without the host being infected by new outside virus, denoted as the lytic part of the viral life cycle, and stays within the host indefinitely. (wikipedia.org)
  • processes
  • The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
  • Her lab focuses on elucidating the cellular processes and signaling pathways that are involved in the initiation and progression of epithelial tumors, primarily of the breast and ovary. (wikipedia.org)
  • neuronal
  • We, and others have determined that although Adeno-Associated Viral (AAV) vectors preferentially target neuronal cells in the central nervous system (CNS) there remain certain limitations to their employment. (grantome.com)
  • degrades
  • Kaposi's sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta interferon (TRIF). (unl.edu)
  • cells
  • The Section on Directed Gene Delivery assesses the ability of viral vectors to efficiently deliver genes to appropriate target cells with the end goal of transferring therapeutic genes to cells of the central nervous system. (grantome.com)
  • The newly created viral bits assemble and, voilà, more virus arises, which also may infect other cells. (scientificamerican.com)
  • particles
  • These cell lines offer distinct advantages over previous vector producing cell lines in that they capable of being continuously modified using enzyme based recombination or gene editing to change the types of viral particles they produce. (grantome.com)
  • KSHV
  • Spearman rank correlation analysis will be used to evaluate the relationship between the qualification of baseline KSHV/HHV-8, HIV viral load and time to progression, and response duration. (clinicaltrials.gov)
  • genetic
  • Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. (wikipedia.org)
  • Gene duplications are an essential source of genetic novelty that can lead to evolutionary innovation. (wikipedia.org)
  • virus
  • CroV may have acquired these genes by picking up DNA from the remains of a bacterium eaten by a cell the virus later infected, according to the researchers. (nbcnews.com)
  • This is a possible explanation for the origin of 10 to 20 percent of the giant virus genes. (nbcnews.com)
  • The researchers could not recognize 51 percent of the genes they encountered in the new virus. (nbcnews.com)
  • Every virus you pull out has a new set of genes that is unique to this virus, that has never been seen before," he said. (nbcnews.com)
  • Future work involves molecular paleontology of the gene and examination of its role in promoting virus growth. (rochester.edu)