Cellular cargo proteins schizosaccharomyces pombe proteins. Medical search. Frequent questions

Here we probe these fundamental questions using peroxisomal compartmentalization of the last steps of lysine and histidine biosynthesis in the fission yeast Schizosaccharomyces japonicus . (biorxiv.org)
The fission yeast Schizosaccharomyces japonicus provides an attractive stripped-down model for metabolic compartmentalization in peroxisomes. (biorxiv.org)
In the fission yeast S. pombe, the targeting complex, MTREC, consists of a core complex with the zinc-finger protein, Red1 ( Q9UTR8 ), and an RNA-helicase, Mtl1. (eu.org)

describe the identification of two homologous genes in the yeasts Saccharomyces cerevisiae and Pichia pastoris involved in targeting cytoplasmic proteins and organelles to the vacuole for degradation. (rupress.org)

Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells . (wikipedia.org)
In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport . (wikipedia.org)

Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation. (db-engine.de)

the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)

Actin therefore contributes to processes such as the intracellular transport of vesicles and organelles as well as muscular contraction and cellular migration. (wikipedia.org)
The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
Success will represent an unprecedented level of control over nanoscale motion, building an engineering capacity that will eventually be used to design protein nanoassemblies capable of sophisticated intracellular therapeutic functions such as genome repair. (nih.gov)
Many viruses use the microtubule transport system to transport nucleic acid/protein cores to intracellular replication sites after invasion host the cell membrane. (wikipedia.org)

We found that the FERM domain in the tail region, which is known to bind to lipids as well as other proteins, is essential for both nuclear and chloroplast positioning, whereas the proximal MyTH4 domain plays a supporting role in chloroplast transport. (go.jp)
A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

Protein modules such as FVYE domains and PH domains that bind specifically to PtdIns 3-phosphate (PtdIns-3-P) and polyphosphoinositides, respectively, can direct such membrane targeting. (embl.de)
Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)

Dynein transports various cellular cargos , provides forces and displacements important in mitosis , and drives the beat of eukaryotic cilia and flagella . (wikipedia.org)
While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)

The PI3K/Akt/mTOR signaling pathway is a key regulator of diverse physiological functions such as proliferation, global protein, and lipid synthesis as well as many metabolic pathways interacting to increase secretory capabilities. (go.jp)
For instance, how can cells control the diverse patterns of glycosylation of various secretory proteins in the endoplasmic reticulum and Golgi in an orderly manner with high accuracy? (go.jp)
The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)
This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)

Many of these processes are mediated by extensive and intimate interactions of actin with cellular membranes. (wikipedia.org)

A large number of illnesses and diseases are caused by mutations in alleles of the genes that regulate the production of actin or of its associated proteins. (wikipedia.org)
Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)

Proteins synthesized at the ER are subject to covalent modifications that include N- and O-glycosylation, disulfide bond formation, and in some cases, proline and lysine hydroxylation. (stanford.edu)

An actin protein is the monomeric subunit of two types of filaments in cells: microfilaments, one of the three major components of the cytoskeleton, and thin filaments, part of the contractile apparatus in muscle cells. (wikipedia.org)
N-SLIT2 amplifies reactive oxygen species production in response to the bacteria by activating p38 mitogen-activated protein kinase that in turn phosphorylates NCF1, an essential subunit of the NADPH oxidase complex. (elifesciences.org)
It forms a stable complex with CBC through its C-terminal disordered tail and interacts with RNA, proteins and multi-subunit complexes. (eu.org)

A next step in studying the complex interaction between host and microbe is to "directly" define the molecular factors that govern biological function (i.e. proteins, metabolites, posttranslational modifications) and delineate their associated mechanisms of action. (keystonesymposia.org)

The actin protein is found in both the cytoplasm and the cell nucleus. (wikipedia.org)
Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. (swisspalm.org)

Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
In S. cerevisiae , the Cvt9 gene is a required component for the uptake of the prAPI protein into vacuoles, while the P. pastoris gene Gsa9 was identified by its role in the turnover of peroxisomal enzymes. (rupress.org)

Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. (wikipedia.org)
functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)

In most proteins the motif is highly conserved among vertebrates, but in some cases also in for example, invertebrates and yeasts ( Foucher,2022 ). (eu.org)

Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Nat. (db-engine.de)

Transformation of Chaetomium thermophilum and affinity-purification of native thermostable protein complexes. (db-engine.de)

Biochemical and morphological studies demonstrate that the selective uptake of peroxisomes into the vacuole for degradation requires Cvt9 or Gsa9, but nonselective macroautophagy induced by nitrogen starvation does not require either protein. (rupress.org)

Third, actin filaments can bind to many other proteins, which together help modify and organize microfilaments for their diverse functions. (wikipedia.org)
The C-terminal arm is a ZnF domain that can bind RNA and protein partners through adjacent surfaces. (eu.org)

each organelle has functionally distinct zones, and zones in different organelles closely interact each other in order to perform complex cellular functions. (go.jp)

Taking into account a crystal structure of Mtr4 interacting with a truncated, short Trf4 fragment (interaction of Mtr4 and short Air2 fragment is shown as well), one can argue for ring-interaction between the phenylalanine position and a tyrosine on the interacting protein (Mtr4). (eu.org)
It is a large modular protein with several well-described interaction surfaces and partners. (eu.org)
The interaction of Red1 with Ars2 ( O94326 ) is mediated by the Red1 EDGEI motif that recruits the Ars2-Cbc submodule, with cap-binding proteins, Cbc1 ( O14253 ) and Cbc2 ( Q9P383 ). (eu.org)

The duplication of the polymerase Trf and the zinc knuckle protein Air arose due to a whole genome duplication event in Saccharomyces cerevisiae ( 15004568 ). (eu.org)

It can be present as either a free monomer called G-actin (globular) or as part of a linear polymer microfilament called F-actin (filamentous), both of which are essential for such important cellular functions as the mobility and contraction of cells during cell division. (wikipedia.org)
Actin participates in many important cellular processes, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement, cell signaling, and the establishment and maintenance of cell junctions and cell shape. (wikipedia.org)
The ER is the 'port of entry' for proteins destined for the cell surface and beyond. (stanford.edu)
[1] It also helps transport cargo needed for cell function such as vesicles made by the endoplasmic reticulum , endosomes , and lysosomes (Karp, 2005). (wikipedia.org)
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. (biologists.com)

This work aimed to clarify the solubilization mechanism by deciphering myosin thick filaments assembly as affected by protein-glutaminase deamidation. (bvsalud.org)

Thus, GCGs contain proteins involved in translation initiation, translation control, and mRNA decay, which is consistent with their proposed role in the regulation ofs maternal mRNA expression. (rupress.org)
Proteins of diverse protein families harbour such a motif often in two or three adjacent copies ( Foucher,2022 ), enabling mutually exclusive binding of different RNA decay/processing/splicing factors to the CBC-ARS2 complex ( Schulze,2018 ). (eu.org)

At its core, the laboratory develops and applies multiplexing quantitative proteomics tools to simultaneously track thousands of protein dynamics and associated post-translational modifications in an accurate and high throughput fashion. (keystonesymposia.org)

Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)
Enzymatic deamidation is a promising approach in enhancing the solubility of myofibrillar proteins (MPs) in water paving the way of tailor manufacturing muscle protein-based beverages. (bvsalud.org)

It has a positively charged patch on its surface that is bound by diverse protein partners involved in different steps of RNA processing through the acidic EDGEI motif. (eu.org)

Actin is extremely abundant in most cells, comprising 1-5% of the total protein mass of most cells, and 10% of muscle cells. (wikipedia.org)

As peroxisomes grow and mature, cargo import into the peroxisomal matrix takes place. (biorxiv.org)

The TRAMP complex consists of a RNA helicase (MTR4), a poly(A)polymerase (Trf4 or Trf5) and a RNA-binding zinc knuckle protein (Air1 or Air2). (eu.org)
The selection of RNAs is determined by binding of protein sub-modules to the MTREC core complex. (eu.org)

Unlike DNA, which can be repaired if damaged or incorrectly made, proteins cannot be mended. (stanford.edu)

However, domains required for cargo transport in vivo have not been mapped. (go.jp)

Some mRNAs are programmed for immediate translation, a process that remodels the protein coat and assembles a polysome. (rupress.org)

The evolutionary origin of actin can be traced to prokaryotic cells, which have equivalent proteins. (wikipedia.org)

Anatomy16

Organisms5

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes36

Information Science3

Health Care1

Fission yeast3

Involved in targeting c1

Microtubules2

Cytoplasmic2

Homologous1

Intracellular4

Nuclear2

Membrane2

Mitosis2

Secretory5

Interactions1

Regulate2

Lysine1

Subunit3

Mechanisms1

Cytoplasm2

Enzymes2

Functional2

Vertebrates1

Eukaryotic1

Complexes1

Degradation1

Bind2

Organelles1

Interaction3

Saccharomyces1

Cell5

Filaments1

Decay2

Quantitative1

Enzymatic2

Diverse1

Total1

Import1

Complex2

Made1

Domains1

Process1

Cells1