Cellular calcium signaling. Medical search. Frequent questions

Yet, NOX2 can also be recruited to the plasma membrane of phagocytes leading to the generation of extracellular H 2 O 2 ( Aviello and Knaus, 2018 ), and NOX2-derived ROS participate in major signaling pathways, both within the individual phagocyte and surrounding cells. (frontiersin.org)
The discovery of calcium-mediated signalling pathways in the regulation of cellular function has truly revolutionized the fields of life science and medicine. (shawprize.org)
These discoveries represent one of the most important cell signalling pathways in biology and have changed forever the way we think about prevention and treatment of disease. (shawprize.org)
Cellular communication occurs through chemical signals such as hormones, neurotransmitters and nitric oxide, which act via specific receptors or receptive molecules and are linked to diverse intracellular and extracellular signalling pathways. (shawprize.org)
The molecular components of key Ca2+ signalling pathways have been identified. (hstalks.com)
Consequently our understanding of Ca2+ signalling is now advancing rapidly through experimental approaches that involve the controlled expression, inhibition of expression and use of naturally occurring or engineered mutations of channels, pumps, effectors and other proteins related to Ca2+ signalling pathways. (hstalks.com)
Neuronal control of behavior arises from the activity of underlying neural circuits, which in turn are specified by the interaction of various signaling pathways. (jneurosci.org)
After that, manifold proteins and their related molecules were demonstrated to participate in novel signaling pathways related to various cytokines in different types of cells. (novapublishers.com)
The author of this book discovered a novel protein known as "regucalcin", which suppresses manifold signaling pathways related to transcription activity. (novapublishers.com)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
Some studies demonstrated that the intracellular calcium signaling pathways may influence the migration of osteoclast precursors under fluid flow [ 6 , 12 , 14 - 16 ]. (hindawi.com)
In addition, some pathways that are typically altered during cardiac aging-induced damage, including the generation of radical oxidative species, the mitochondrial metabolic activity, the modulation of the mitochondrial calcium buffering capacity, and the regulation of estradiol and estrogen-regulated gene expression, were investigated [ 20 - 22 ]. (hindawi.com)
We use molecular modeling methods to study how signaling pathways and cell biology processes involved with synaptic plasticity are influenced by the detailed morphology of neurons and by the stochastic behavior of the reactions due to the small number of molecules. (oist.jp)
With respect to diabetes, I would maintain that the hormone signaling pathways involving leptin and insulin are more explanatory than pancreatic dysfunction. (herbscientist.com)
median, 1.5), signaling pathways are far from fully understood. (lu.se)

In deuterosome eggs (mammals, fish, amphibians, ascidians, sea urchins, etc.), successful sperm entry leads to a distinct rise in intracellular calcium ions (Ca2+), with mammals and ascidians displaying a series of intracellular calcium spikes required for completion of meiosis. (wikipedia.org)
This gene provides instructions for making a protein that forms specialized structures called channels through which positively charged calcium atoms (calcium ions) flow. (medlineplus.gov)
The protein is found in the membrane of a cell structure called the endoplasmic reticulum, which acts as a storage center for calcium ions. (medlineplus.gov)
The proper balance of calcium ions in cells and cell compartments is important for the development and function of various tissues and organs. (medlineplus.gov)
The imbalance of calcium ions disrupts development of the brain and structures in the head, face, and torso, resulting in the features of cerebro-facio-thoracic dysplasia. (medlineplus.gov)
further, there may be different amount of extracellular calcium ions entering cytoplasm through MSCC at different location, and the gradient of intracellular calcium concentration may result in the migration of osteoclasts toward low FSS region. (hindawi.com)
Calcium ions act as second messenger in many cell types. (videolectures.net)
leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. (thermofisher.com)
In addition, Nar stimulates the mitochondrial calcium-dependent potassium channel (mitoBKCa), which causes an influx of potassium ions, a mild depolarization, and a decrease in the mitochondrial matrix calcium uptake, all of which contribute to stabilizing the mitochondria during cellular damage [ 3 , 4 ]. (hindawi.com)
When parathyroid hormone (PTH) binds to receptors on these cells, the osteocytic membrane pumps calcium ions from the bone fluid into the extracellular fluid. (medscape.com)

We now report an alternate mechanism of GAS-mediated apoptosis of primary human keratinocytes, initiated by extracellular GAS and involving dysregulation of intracellular calcium to produce endoplasmic reticulum stress. (lu.se)
Two bacterial virulence factors are required for effective induction of apoptosis by extracellular GAS: (i) hyaluronic acid capsule that inhibits bacterial internalization and (ii) secreted cytolysin, streptolysin O (SLO), that forms transmembrane pores that permit extracellular calcium influx into the cytosol. (lu.se)
We propose that cell signalling initiated by extracellular GAS compromises the epithelial barrier by inducing premature keratinocyte differentiation and apoptosis, thereby facilitating GAS invasion of deeper tissues. (lu.se)
Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. (swansea.ac.uk)
These organelles primarily produce cellular energy, but they also maintain cellular homeostasis by regulating redox state, proliferation, apoptosis and calcium signaling. (mayo.edu)

Calcium plays an important role in this communication, because it exerts regulatory effects on many cellular proteins and cellular processes. (uib.no)
Lastly, we used RNA knockdown methods to diminish the expression of connexin proteins, which generate so-called "gap junctions" between cells - channels of communication which calcium and other molecules can traverse. (uib.no)
When there is too much calcium in the endoplasmic reticulum, four TMCO1 proteins come together to form a channel that releases the excess calcium into the surrounding fluid inside the cell ( cytoplasm ). (medlineplus.gov)
The project will investigate the function of several proteins that are important to generate calcium signals in a model plant-pathogen interaction system. (usda.gov)
Preliminary study also implicates calcium transport proteins including ACA10/8, CCX4 and GLR2 as CPK3 target in a feedback regulation of calcium signaling. (usda.gov)
Free Ca 2+ is then rapidly sequestered by the action of calcium pumps and exchangers and also with buffering by cytosolic calcium binding proteins. (jneurosci.org)
Afterwards, calmodulin and protein kinase C were discovered as modulator proteins of intracellular calcium signaling in hormonal action. (novapublishers.com)
At the sub-cellular scale, maps document the spatial organization of proteins, RNA, DNA, and metabolites with nanometer precision and temporal acuity on the order of seconds. (stanford.edu)
The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs. (nih.gov)
S100 proteins exist in cells as anti-parallel hetero- and homodimers and upon calcium binding interact with target proteins to regulate cell function. (nih.gov)
S100 proteins are of interest as mediators of calcium-associated signal transduction and undergo changes in subcellular distribution in response to extracellular stimuli. (nih.gov)
They also function as chemotactic agents and may play a role in the pathogenesis of epidermal disease, as selected S100 proteins are markedly overexpressed in psoriasis, wound healing, skin cancer, inflammation, cellular stress, and other epidermal states. (nih.gov)
We have reported that many insults can trigger cells to activate a cellular death pathway (Nature, 361:739-742, 1993), that several viruses encode proteins to block attempted cell suicide (Proc. (hopkinsmedicine.org)
This study is designed to test how presenilin interacts with calcium signaling proteins, resulting in changes to the presenilin function. (brightfocus.org)
One of these proteins, presenilin, causes the amount of calcium in cells to be abnormally regulated. (brightfocus.org)
DACT is a reactive electrophile known to form covalent protein adducts both in vitro and in vivo following ATRA exposure and might therefore target proteins involved in GnRH-induced calcium signaling and subsequent LH release. (cdc.gov)
These data suggest that DACT forms adducts on proteins involved in calcium handling within the ER and that dysfunction in this critical signaling system is associated with loss of normal sensitivity to GnRH and subsequent decreased release of LH. (cdc.gov)

Intracellular Ca 2+ signals of oligodendroglia, the myelin-forming cells of the central nervous system, regulate vital cellular processes including myelination. (biorxiv.org)
Calcium signaling participates in different cellular processes leading to cell migration. (ibecbarcelona.eu)
This IP 3 /Ca 2+ signalling system is of fundamental importance in regulating diverse cellular processes such as muscle contraction, cell growth and differentiation, secretion, fertilization, synaptic plasticity and information processing. (shawprize.org)
This series is designed to cover the key processes that contribute to cellular Ca2+ homeostasis and includes topical issues and recent developments described by the fields' leading scientists. (hstalks.com)
Evidences suggest that Ca 2+ channels TRP and Orai participate in the intracellular Ca 2+ signaling involved the physiological angiogenesis processes [17]. (researchgate.net)
Maps also chart the connectivity between these molecules, elucidating the circuits and signaling processes that give rise to function. (stanford.edu)
While the role of morphogens has received enormous attention in developmental contexts, it is now becoming clear that juxtacrine signaling, which occurs between cells in physical proximity, can also play a key role in shaping the outcomes of such processes. (imsc.res.in)
Interestingly, cell death regulators also regulate many other cellular processes prior to a death stimulus, including neuronal activity, mitochondrial dynamics and energetics. (hopkinsmedicine.org)
Aberrant Wnt signaling is important in several different disease processes. (lu.se)

Cyclic AMP was a major molecule of interest, which played an important role as second messenger, contributing to signal transduction in the regulation of cellular function by peptide hormones. (novapublishers.com)
Using the information-theoretic measure Transfer Entropy (Schreiber 2000) we studied the properties of this signal transduction under different conditions. (videolectures.net)

Calcium acts both to modulate intracellular signaling as a secondary messenger and to facilitate structural changes as cells progress through division. (wikipedia.org)
We hypothesized that H. cordata might modulate intracellular Ca2+ signaling and could help relieve asthmatic airway remodeling. (bvsalud.org)

Calmodulin dependent kinase II was shown to be the protein responsible for converting the Ca2+ influx signal into inhibition of CSF and activation of cyclin degradation machinery to degrade cyclin B, resulting in progression through meiosis II. (wikipedia.org)
It was found that sustained cellular Ca 2+ signals arising via chronic inhibition of SERCA were pro-autophagic. (open.ac.uk)
The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates. (thermofisher.com)
ERp57 was identified by mass spectrometry as a target of DACT adduction in the ER that could potentially mediate the effects of DACT on inhibition of GnRH-induced calcium signaling and inhibition of LH release. (cdc.gov)
Feedback inhibition of parathyroid hormone (PTH) release occurs primarily by direct effect of calcium at the level of the parathyroid gland. (medscape.com)
AChE inhibition induces an acetylcholine build-up, disrupting signals between nerves and muscles, which in high doses leads to asphyxiation. (cdc.gov)

Novel information will be obtained on characteristics of calcium signatures in response to bacterial pathogens, calcium transport molecules for generating calcium signature, as well as regulatory mechanisms of calcium signature and its decoding in defense responses. (usda.gov)
By providing detailed understanding of calcium signaling and electrical signaling in the brain, we extended prospects to precisely understand how functional mechanisms get disrupted in neurodegenerative diseases and what can be future druggable targets" says co-first author and UVM Assistant Professor of Pharmacology Amreen Mughal, Ph.D. (uvm.edu)
However, our understanding of how network and intrinsic cellular mechanisms. (springeropen.com)
The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. (hindawi.com)
We have extended our stochastic modeling to the cellular level and using the STEPS simulator (1) we demonstrated that the variability of dendritic calcium spikes, which has been observed experimentally, is caused by stochastic calcium mechanisms (12). (oist.jp)
This thesis highlights the complexity of Wnt signaling in general and Wnt5a signaling in melanoma in particular and extends our knowledge of the mechanisms behind progression of malignant melanoma. (lu.se)

Furthermore, by analyzing the effects of Wnt5a on the malignant melanoma proteome, we provide evidence for a cell context dependent reprogramming of cellular metabolism induced by Wnt5a. (lu.se)

It is hypothesized that prednisone reduces tissue inflammation, suppresses cytotoxic cells, improves calcium homeostasis, and stimulates myoblasts. (medscape.com)
Calcium homeostasis is a complex process involving the following 4 key components: serum calcium, serum phosphate, 1,25-dihydroxyvitamin D-3, and parathyroid hormone (PTH). (medscape.com)
A schematic diagram of calcium homeostasis can be seen below. (medscape.com)
Schematic diagram of calcium homeostasis. (medscape.com)
It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)

Additional studies used a well-characterised Ca 2+ transport pathway to generate cellular Ca 2+ signals, and examined their ability to trigger autophagy. (open.ac.uk)
The Wnt signaling pathway is highly conserved and crucial during embryonic development. (lu.se)
Activation of the non-canonical Wnt signaling pathway via Wnt5a has been correlated with increased migration and invasion as well as a poor prognosis in malignant melanoma patients. (lu.se)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

It can activate the InsP3 calcium channel on the endoplasmic reticular membrane, triggering the release of calcium from intracellular stores, leading to a calcium-influx of extracellular calcium. (fishersci.com)
read more keep the cytoplasmic calcium ([Ca2+]c) low and then allow selective increases in [Ca2+]c by stimulating either Ca2+ release from the cells' internal Ca2+ stores or the influx of Ca2+ from the extracellular environment. (hstalks.com)

The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient antimicrobial defense system against microorganisms. (frontiersin.org)

Together, these findings in the Cacna1f-mutant mouse reveal that the Ca(v)1.4 calcium channel is vital for the functional assembly and/or maintenance and synaptic functions of photoreceptor ribbon synapses. (nih.gov)

Here, CaMKII activates MEK/ERK, which degrades the cell cycle arresting p27 protein In general, transformed cells proliferate in a calcium-independent manner, whereas non-transformed cells show high sensitivity to extra-cellular calcium concentration, suggesting oncogenic growth may include disruption of calcium signaling. (wikipedia.org)
Intriguingly, pretreatment with H. cordata essential oil rectified the disruption of Ca2+ signaling, mitigated asthma development, and prevented airway narrowing. (bvsalud.org)

In addition, distinct NOX homologs expressed by non-phagocytic cells and mitochondrial ROS are interlinked with phagocytic NOX functions and thus affect the overall redox state of the tissue and the cellular activity in a complex fashion. (frontiersin.org)
In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. (hindawi.com)
Mitochondrial physiology has a much broader impact and is more complicated than merely generating cellular energy. (herbscientist.com)

In this recently published study , we dynamically imaged changes in intracellular calcium concentration in the early embryos of Oikopleura dioica using the genetically encoded calcium indicator GCaMP6. (uib.no)
To test this hypothesis, LbetaT2 pituitary cells were exposed to 300 microM DACT for 24 h and examined by fluorescence microscopy for GnRH-induced changes in intracellular calcium and LH release. (cdc.gov)

In summary, our findings suggest that H. cordata is a potential alternative treatment choice that may reduce asthma severity by targeting the dysregulation of Ca2+ signaling. (bvsalud.org)

Yet, NOX participates in cellular signaling in a cell-intrinsic and -extrinsic manner, e.g., via the release of ROS into the extracellular space. (frontiersin.org)

Without this protein, TMCO1 channels cannot form, and excess calcium builds up in the endoplasmic reticulum. (medlineplus.gov)

This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Figure 1 shows how the Ca 2+ /cAMP signaling interaction could be pharmacologically modulated by the combined use of the Ca 2+ channel blockers (CCB) and drugs that promote the increase of [cAMP] c (cAMP-enhancer compounds). (researchgate.net)
The pharmacological modulation of Ca2+/cAMP signalling interaction is also cited. (researchgate.net)

Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, together, the data have prompted us to investigate the effects of Nar in a cellular model of aged myocardial cells. (hindawi.com)

NIGMS supports basic biomedical research that contributes to the understanding of fundamental cellular and physiological principles. (nih.gov)

There, he has been mostly devoted to the study of Ca2+ and redox modulation/signalling impact on cancer cell motility. (cienciavitae.pt)

The major downstream calcium effectors are the calcium-binding calmodulin protein and downstream calmodulin-dependent protein kinases I / II. (wikipedia.org)

Therefore, a reasonable hypothesis is that the polarization of wall FSS on a cell may correlate with that of membrane tension and intracellular calcium concentration, which finally determines the extent of cell migration opposite to the FSS polarization direction. (hindawi.com)

The functional properties and localization of the channels as well as the pumps, exchangers, and buffers are thought to play a crucial role in generating a range of calcium signals that vary from a brief local increase to repetitive calcium spikes and waves spreading over a larger region. (jneurosci.org)
Now published in PNAS, their study presents a methodology which monitors calcium ion fluctuations in the brain using a molecular functional MRI approach. (compamed-tradefair.com)
Functional studies show that SFRP3 can inhibit Wnt5a signaling and induce a decrease in migration and invasion. (lu.se)

New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)

Calcium was found to concentrate on condensed DNA to much higher levels compared to normal cytosolic calcium concentration. (wikipedia.org)
The Ca 2+ signal is characterized by a rapid increase in the concentration of free cytosolic calcium ([Ca 2+ ] i ) attributable to the opening of calcium channels located in the plasma membrane and in the membranes of intracellular calcium stores. (jneurosci.org)
After stimulation, the calcium concentration in the cytosol of hepatocytes, for example, can display complex dynamic behavior including spiking and bursting oscillations. (videolectures.net)
Development of an organism from the embryonic stage involves a number of precisely timed events that arise as a result of interactions between several components including (i) morphogens which set up concentration gradients, (ii) cell-cycle oscillators which regulate mitosis and (iii) inter-cellular communication. (imsc.res.in)
Specifically, they used a calcium-sensitive contrast agent as a biomarker, which enabled the changes in calcium concentration to be traced and thus correlated with the spatiotemporal dynamics of cerebral ischemia. (compamed-tradefair.com)
Calcium in cells is precisely regulated, because it is toxic if its concentration is too high. (brightfocus.org)

The scope of the systems covered ranges from cellular to tissue, organ, systems studies, and up to populational dynamics. (nih.gov)
Beyond the single cell, we also strive to map cellular ensembles, such as brain tissue. (stanford.edu)
We develop tools that can be used to construct cell and tissue atlases, and map the cellular circuits that give rise to function and behavior. (stanford.edu)
Finally, it is shown that coupling cell-cycle oscillators in a tissue via contact-induced signals can lead to arrest of further growth of an organ once it reaches an appropriate size. (imsc.res.in)
The researchers reported observations from high-resolution imaging of the changing amount of calcium in the brain tissue during stroke. (compamed-tradefair.com)

Since a number of different effectors and cellular targets exist, it has been suggested, that specific information is encoded in the amplitude, frequency and waveform of the Ca-signal and decoded again, later on, by cellular targets. (videolectures.net)

The Arabidopsis BON1 is found to work closely with auto-inhibitory calcium ATPases ACA10/8 and a calcium dependent protein kinase CPK3 to modulate calcium signature and signaling in Arabidopsis. (usda.gov)

Further, progression through division requires the presence of calcium (G1/S, G2/M, and metaphase/anaphase), suggesting checkpoints require a calcium-dependent signaling mechanism Entry into S-phase is calcium dependent. (wikipedia.org)
They transfer extracellular signals (e.g. from hormones) to targets within the cell, like Ca2+-dependent enzymes or transcription factors. (videolectures.net)
Therefore, we coupled a simple Ca2+-dependent enzyme activation process to a model of calcium oscillations (Kummer 2000) and to experimentally measured calcium time series. (videolectures.net)
We found that Wnt5a could activate regulated secretion of IL-6 and VEGF, dependent on cytoskeletal re-arrangements mediated via calcium signaling and Cdc42 activation. (lu.se)

The atrazine metabolite diaminochlorotriazine suppresses LH release from murine LbetaT2 cells by suppressing GnRH-induced intracellular calcium transients. (cdc.gov)

This study aims to identify calcium signal generating molecules and their regulation by BON1 and CPK3 in plant immunity. (usda.gov)
To achieve these goals, our laboratory has focused on the development of scalable technologies to detect, measure, and manipulate molecules and circuits, both at the sub-cellular level, and at the level of cell populations. (stanford.edu)

These data suggest that Ca 2+ signals arising from InsP 3 Rs suppress autophagy. (open.ac.uk)
By altering intracellular Ca 2+ and InsP 3 levels through genetic means, we now show that signaling through the InsP 3 R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. (jneurosci.org)

Mamo S, Kobolak J, Borbíró I, Bíró T, Bock I, Dinnyes A. Gene targeting and Calcium handling efficiencies in mouse embryonic stem cell lines. (wjgnet.com)

Ca2+ signals are attenuated by sequestration of Ca2+ into intracellular organelles that function as Ca2+ stores or by the expulsion of Ca2+ back across the plasma membrane. (hstalks.com)

The primary response to parathyroid hormone (PTH) by the kidney is to increase renal calcium resorption and phosphate excretion. (medscape.com)
In the kidney, parathyroid hormone (PTH) blocks reabsorption of phosphate in the proximal tubule while promoting calcium reabsorption in the ascending loop of Henle, distal tubule, and collecting tubule. (medscape.com)
Parathyroid hormone (PTH) promotes absorption of calcium from the bone in 2 ways. (medscape.com)
Compared to parathyroid hormone (PTH), vitamin D exerts a much slower regulatory effect on calcium balance. (medscape.com)

The absence of post-receptoral ERG responses and the diminished photoreceptor calcium signals are consistent with a loss of Ca((2+)) channel function in photoreceptors. (nih.gov)
It is known that calcium acts as a signal and messenger to mediate such an induction of immune responses. (usda.gov)
Specific features of calcium ion in the cell, such as its level, shape, amplitude, and frequency, in response to environment may carry stimulus information and induce distinct responses. (usda.gov)
How the signal of calcium is generated in response to pathogen and how it translates into responses are not understood. (usda.gov)
Four specific aims are to: 1) determine the impact of ACA10/8, CCX4 and GLR2 on defense responses and calcium signature, 2) investigate the regulatory role of BON1 on ACA10/8, 3) investigate the potential regulation of ACA10/8 by CPK3 in defense response, and 4) identify components acting in parallel with CPK3 in dampening defense responses. (usda.gov)
Th researchers detected 5,000 calcium signals per second in the capillaries in the tiny section of brain visible through the window, which they say amounts to about one million of these responses each second in the entire brain's blood vessel system. (uvm.edu)
Ca2+ signals can be complex with some involving periodic oscillations of varying frequencies or responses that are restricted to specific regions of the cell. (hstalks.com)
The P2Y(11) receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses. (nih.gov)
Intracellular calcium responses to GnRH and release of LH were restored in DACT-treated cells with the addition of a calcium ionophore (A23187). (cdc.gov)

For example, mutations in the calcium channel subunit gene CACNA1F cause incomplete X-linked congenital stationary night blindness (CSNB2 or iCSNB), a human retinal disorder with abnormal electrophysiological response and visual impairments consistent with a retinal neurotransmission defect. (nih.gov)
We have found that rapid changes in calcium levels travel from cell to cell in a choreographed wave, and that disrupting this wave leads to abnormal development. (uib.no)
Here we found that knockdown of connexin expression, and therefore of gap junction expression, disrupted the coordination of the intercellular calcium wave, and resulted in abnormal development. (uib.no)
Chronic abnormal calcium regulation as a result of mutations in presenilin may therefore cause cellular toxicity that leads to cell death. (brightfocus.org)

Calcium acts as a signal for many cellular functions including control of cell growth and division and gene activity. (medlineplus.gov)
Thus, although NOX orthologs have been identified in organisms as diverse as plants, fruit flies, rodents, and humans, ROS functions have developed and diversified to affect a multitude of cellular properties, i.e., far beyond direct antimicrobial activity. (frontiersin.org)
Overall, the systematic and comparative analysis of cellular ROS functions in organisms of lower complexity provides clues for understanding the contribution of ROS and ROS deficiency to human health and disease. (frontiersin.org)
The study will also examine how altered calcium signaling in turn affects other cell functions. (brightfocus.org)
Because calcium regulates many brain functions, this abnormality may be a key part of the disease. (brightfocus.org)
We plan to study how presenilin interacts with this important calcium signaling protein to alter its function, and how altered calcium signaling in turn affects cell functions. (brightfocus.org)

What Is Required for Neuronal Calcium Waves? (springeropen.com)
Neuronal calcium signals propagating by simple diffusion and reaction with mobile and stationary buffers are limited to cellular microdomains. (springeropen.com)

Negatively charged phosphate ion may passively flow through the intestinal cell because of flux of the positively charged calcium ion. (medscape.com)

By introducing GCaMP6 into the unfertilized egg, after which the indicator is transmitted to all the cells in the embryo, we were able to track calcium signals with a camera by filming the accompanying changes in GCaMP6 fluorescence. (uib.no)
Once the egg is fertilized, and the egg starts to divide, the signals continue with the same regularity, but are initiated in particular cells (those that eventually give rise to the muscle cells of the body) before propagating through other cells in a stereotyped wave-like pattern. (uib.no)
However, studies on oligodendroglia Ca 2+ signal dynamics are still scarce, especially during myelin repair, and there are no software solutions to properly analyze the unique Ca 2+ signal characteristics in these cells. (biorxiv.org)
They found that when neurons fire electrical signals, they cause an increase in calcium in the cells lining the blood vessels. (uvm.edu)
Enzymes detect this calcium and direct the cells to make nitric oxide. (uvm.edu)
In some cells the Ca2+ signals are very brief, taking only milliseconds, whilst in other cells they can persist over several hours. (hstalks.com)
For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. (hindawi.com)
Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. (hindawi.com)
Various cellular senescence hallmarks (the percentage of X-gal staining cells, the mRNA levels of the p16 and p21 cell cycle regulators, and the percentage of cell cycle-arrested cells) were investigated. (hindawi.com)
We have discovered a mechanism whereby mutant forms of presenilin that cause AD alter the function of an important protein that regulates calcium signals in cells. (brightfocus.org)
Because intracellular calcium (Ca2+) signaling plays an essential role in regulating the contractility and remodeling of airway smooth muscle cells, the targeting of Ca2+ signaling is a potential therapeutic strategy for asthma. (bvsalud.org)
LbetaT2 cells exposed to DACT had markedly diminished GnRH-induced intracellular calcium transients and a significant decreased LH release in response to GnRH. (cdc.gov)
DACT appeared to cause a selective decrease in caffeine-sensitive ryanodine receptor-operated calcium stores in LbetaT2 cells, rather than in thapsigargin-sensitive ER calcium stores. (cdc.gov)
The primary action of 1,25-(OH) 2 D3 is to promote gut absorption of calcium by stimulating formation of calcium-binding protein within the intestinal epithelial cells. (medscape.com)

This is followed by showing that the same inter-cellular communication mechanism can change the collective behavior of oscillatory gene expression (involving so-called ``clock genes'') thereby reproducing all the empirically observed dynamical transitions in somitogenesis, a fundamental developmental process in all vertebrates. (imsc.res.in)

nVue enables imaging of two distinct brain signals to gain deeper insight into how an ensemble of brain signals interacts during free behaviour in a single imaging session. (lu.se)

His group uses molecular and cellular tools combined with network theory to explore the links between calcium signaling, cellular behavior and the early events leading to the destruction of normal heart rhythm (arrhythmia). (swansea.ac.uk)

Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. (lu.se)
Blood lead was significantly higher in the malignant case croups, as were zinc, iron, and calcium. (who.int)

It is highly specific for calcium, a messenger of various cellular signals, allowing better differentiation of damaged regions at an early stage of brain injury. (compamed-tradefair.com)

CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. (thermofisher.com)

Autophagy is a catabolic process that is important for degradation of cellular components, and for cell survival, and has also been associated with pathological disorders and tumour growth. (open.ac.uk)
The structure of spiking activity in cortical networks has important implications for how the brain ultimately codes sensory signals. (springeropen.com)

It is designed to give an insight into the broad range of pathologies that involve a disturbance of Ca2+ signalling. (hstalks.com)

To better understand how Ca 2+ has these opposing effects, this study investigated in what ways particular sources of Ca 2+ , and the characteristics of Ca 2+ signals impacted on autophagy. (open.ac.uk)
It comes on the heels of another ARS-funded study suggesting that today's current recommended amount of dietary calcium for American adults may be greater than actually needed. (sciencedaily.com)
This work was reliant on several significant methodological advances pioneered at UVM ranging from 4D in-vivo blood vessel imaging, novel approaches to fluorescent event extraction & analysis and spatio-temporal mapping that allowed us to study the 'universe' of capillary calcium signaling in exquisite detail" says co-first author and UVM Assistant Professor of Pharmacology Grant Hennig, Ph.D. (uvm.edu)
One previous study has found that the directional movement of a cell may be influenced by the front-to-rear polarization of intracellular calcium [ 17 ]. (hindawi.com)

Calcium plays a crucial role in regulating the events of cellular division. (wikipedia.org)
Exquisite control of intracellular calcium dynamics are required, as calcium appears to play a role at multiple cell cycle checkpoints. (wikipedia.org)
The role of calcium in condensation was independent of CAMK function, suggesting a purely structural role of Ca2+ in chromatin compaction. (wikipedia.org)
Thus, we can now propose that intricately choreographed calcium signaling through gap junctions plays a pivotal role in steering the early development of the embryo. (uib.no)
In this review, we focus on the role of NOX and ROS signaling in professional phagocytes, where ROS have mainly been studied for their role in pathogen elimination. (frontiersin.org)
The researchers then dissected the intricate cellular mechanism behind calcium's role in directing blood branch-by-branch through the tiny vessels of the brain. (uvm.edu)
Calcium (Ca2+) plays a major role in controlling cell function. (hstalks.com)

Therapeutic strategies for the dystrophinopathies can be categorized into 3 groups based on their approach: (1) Supportive pharmacologic therapy, (2) research gene therapy, and (3) research cellular therapy. (medscape.com)

Later, it became clear that ROS are versatile in function and integral to cellular signaling in most organisms. (frontiersin.org)

The aim of the PhD thesis, for which this is a pre-synopsis submission talk, is to investigate the precise mechanism by which contact-mediated signaling affects specific developmental phenomena. (imsc.res.in)

Anatomy28

Organisms10

Diseases17

Chemicals and Drugs143

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes39

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Health Care2

Pathways15

Ions10

Apoptosis5

Proteins17

Processes9

Transduction2

Modulate intracellular2

Inhibition6

Mechanisms6

Metabolism1

Homeostasis5

Pathway4

Influx2

Reactive oxygen1

Synaptic1

Disruption2

Mitochondrial3

Changes in intracellular calcium2

Dysregulation1

Participates1

Endoplasmic1

Interaction3

Cardiac1

Physiological1

Modulation1

Calmodulin-dependent protein1

Intracellular calcium concentration1

Functional3

Proliferation1

Concentration6

Tissue5

Effectors1

Protein kinase1

Dependent4

Murine1

Molecules2

InsP2

Embryonic1

Membrane1

Hormone4

Responses9

Abnormal4

Functions6

Neuronal2

Positively charged calcium1

Cells14

Fundamental1

Interacts1

Behavior1

Malignant2

Differentiation1

Receptor1

Important2

Insight1

Study4

Role7

Gene1

Function1

Affects1