• Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene. (wikipedia.org)
  • Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. (wikipedia.org)
  • The mitotic checkpoint kinase is evolutionarily conserved in organisms as diverse as Saccharomyces cerevisiae and humans. (wikipedia.org)
  • The protein kinase Bub1 possesses versatile and distinct functions during the cell cycle, mainly in the SAC and chromosome alignment during metaphase. (wikipedia.org)
  • AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. (rcsb.org)
  • Allosterically regulated proteins that require an activator are sometimes based on a thiol exchange interaction involving cysteines, for example, pyruvate kinase uses fructose bisphosphate (FBPs) as a heterotrophic activator and it contains a cysteine in its FBP binding site [ 8 ]. (hindawi.com)
  • Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
  • In addition, calcofluor white sensitivity of the strain was enhanced by the protein kinase inhibitor staurosporine, a phenotype shared with the Ada components of the SAGA/SLIK complex. (biomedcentral.com)
  • Serine/Threonine Kinases (STKs), Fungal Mitogen-Activated Protein Kinase (MAPK) Sty1/Hog1 subfamily, catalytic (c) domain. (umbc.edu)
  • The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
  • A time lapse experiment of Saccharomyces cerevisiae expressing GFP tagged Cdc15, a protein kinase involves in cytokinesis. (cellimagelibrary.org)
  • Protein kinases (PKs), MAP kinase kinase (MAPKK) subfamily, fungal PBS2-like proteins, catalytic (c) domain. (umbc.edu)
  • The mitogen-activated protein (MAP) kinase signaling pathways are important mediators of cellular responses to extracellular signals. (umbc.edu)
  • Jan 31, 2017 when cellular energy is low, cells activate the kinase ampk, which promotes mitochondrial biogenesis and function. (web.app)
  • Actin is one of the most abundant proteins in yeast, mammalian and other eukaryotic cells. (elifesciences.org)
  • These proteins are needed for many other processes in yeast and other cells, including mammalian cells. (elifesciences.org)
  • Additionally, we study how RNA binding proteins (RBPs) interact with various RNA structures using global analysis of RBP binding sites, the functions of nuclear RNA foci (biomolecular condensates) generated by pathogenic STR expansions, and how RNA-based mechanisms promote mammalian tissue regeneration. (ufl.edu)
  • The ~200 amino acid TBC/rab GTPase-activating protein (GAP) domain is well conserved across species and has been found in a wide range of different proteins from plant adhesion molecules to mammalian oncogenes. (embl.de)
  • This basic two-step process has been confirmed in most mammalian cells, although its regulation and the repertoire of specific accessory proteins are likely to be highly context dependent. (centrodinoferrari.com)
  • Igor Stagljar, the study's senior author, told ProteoMonitor this week that his team has been interested broadly in how integral membrane proteins interact at the genome-wide level. (genomeweb.com)
  • Results: A total of 3108 sequence signatures were found, each of which was shared by a set of guest proteins interacting with one of 944 host proteins in Saccharomyces cerevisiae genome. (ku.edu)
  • Conclusion: We reported a method of PPI data mining that facilitated the discovery of novel sequence signatures using a large PPI dataset from S. cerevisiae genome as input. (ku.edu)
  • Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure. (cam.ac.uk)
  • This facilitates quantitative modelling of the relation between genome content, gene expression and cellular physiology. (ucsd.edu)
  • The telomeres are the DNA-protein structures at the ends of eukaryotic chromosomes, which serve to protect and stabilize the genome. (lu.se)
  • They form into a protein complex that has helicase activity and is involved in a variety of DNA-related functions including replication elongation, RNA transcription, chromatin remodeling, and genome stability. (bvsalud.org)
  • Since protein secretion is important for this organism to cause infection, a better understanding of the machinery involved in protein secretion could lead to the identification of future drug targets to prevent and treat Candida infections. (umwestern.edu)
  • We are using the yeast model organism Saccharomyces castellii, which has telomere traits and telomerase activity that are highly similar to human cells. (lu.se)
  • Saccharomyces cerevisiae (often known as budding yeast, or brewers yeast) is a single-celled micro- organism that is easy to grow and genetically manipulate. (lu.se)
  • As it has a cellular organisation that has much in common with the cells of humans, it is often used as a model organism for studying genetics. (lu.se)
  • Sharan, R., Ideker, T., Kelley, R., Shamir, R., Karp, R.: Identification of Protein Complexes by Comparative Analysis of Yeast and Bacterial Protein Interaction Data. (crossref.org)
  • addressed this question by studying yeast cells with genetic mutations affecting one or more of these proteins. (elifesciences.org)
  • The phenotypes and genetic interactions of these strains also point to a role for Tra1 in the cellular response to stress. (biomedcentral.com)
  • A differential genetic interaction map was generated using growth measurements of over 45,000 Saccharomyces cerevisiae double mutants before and after UV radiation. (ucsd.edu)
  • Integrating this genetic data with networks of physical interactions resulted in a global map of 89 UV-induced functional interactions and 62 protein complexes, including a number of links between the remodel the structure of chromatin (RSC) complex and several nucleotide excision repair (NER) factors. (ucsd.edu)
  • Collins, S., Miller, K., Maas, N., Roguev, A., Fillingham, J., Chu, C., Schuldiner, M., Gebbia, M., Recht, J., Shales, M., Ding, H., Xu, H., Cheng, B., Andrews, B., IngVarsdottir, K., Han, J., Boone, C., Berger, S., Hieter, P., Zhang, Z., Emili, A., Alic, C., Toczyski, D.P., Weissmann, J.: Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. (crossref.org)
  • Kelley, R., Ideker, T.: Systematic interpretation of genetic interactions using protein networks. (crossref.org)
  • Dr. Morrow regularly teaches Discover Biology (BIOB101), Principles of Living Systems (BIOB160), Cellular and Molecular Biology (BIOB260), General Microbiology (BIOM260) and Advanced Cellular and Molecular Biology (BIOB425). (umwestern.edu)
  • Interestingly, there was no significant difference in the expression of genes encoding heat shock proteins or antioxidant enzymes in L. trifolii treated with microwave radiation as compared to the untreated control. (bvsalud.org)
  • Interactions with other proteins or molecules are another feature of cysteines that can affect protein activity. (hindawi.com)
  • Researchers from the University of Toronto have created a map of the protein interactions of 19 members of the ATP-binding cassette transporter class in a species of yeast, combining this data with previously-reported ABC transporter interactions into a comprehensive "interactome. (genomeweb.com)
  • Overall, membrane protein interactions are difficult to study because of their biochemical features," he said. (genomeweb.com)
  • Stagljar and his colleagues previously developed a method, called a membrane yeast two-hybrid, or MYTH assay to allow them to study interactions of full-length membrane proteins in their natural cellular environment. (genomeweb.com)
  • Briefly, MYTH adapts a previously developed split ubiquitin method as an in vivo sensor of protein-protein interactions. (genomeweb.com)
  • Overall, the study yielded a map covering 537 unique binary interactions across 366 proteins, the study authors wrote, which they annotated with functional classifications to create a standard map, as well as a map showing protein conservation in humans and known disease associations. (genomeweb.com)
  • The largest group - about 26 percent of the interactions - corresponds to proteins involved in transport and related processes. (genomeweb.com)
  • The second largest, with 16 percent, marks interactions with proteins of unknown function. (genomeweb.com)
  • Our results demonstrate that SH3 (Src homology 3) domain-PRM (proline-rich motif) interactions involving multivalent linker proteins play central roles in concentrating NPFs at endocytic sites. (elifesciences.org)
  • The experiments show that WASP, myosin and WIP are recruited to sites where endocytosis is about to occur through specific interactions with other proteins. (elifesciences.org)
  • A hierarchal cluster analysis revealed that the pattern of SSL interactions for tra1 SRR 3413 most closely resembles deletions of a group of regulatory GTPases required for membrane sorting/protein trafficking. (biomedcentral.com)
  • The network-extracted ontology (NeXO) is a gene ontology inferred from large networks of gene and protein interactions in Saccharomyces cerevisiae . (ucsd.edu)
  • 10 Galectins can function inside the cells by modulating signaling pathways, 11 although they also act extracellularly by establishing multivalent interactions with cell surface glycans and delivering signals that lead to disruption of cellular homeostasis. (nature.com)
  • Recent work constructing protein interaction networks in Saccharomyces cerevisiae suggested the methyltransferase Bud23 was involved in ribosome biogenesis (1). (utexas.edu)
  • Bader, G., Hogue, C.: An automated method for finding molecular complexes in large protein interaction networks. (crossref.org)
  • Ulitsky, I., Shamir, R.: Pathway redundancy and protein essentiality revealed in the Saccharomyces cerevisiae interaction networks. (crossref.org)
  • Taken together, these results demonstrate that curcumin is a PPARα activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner. (elifesciences.org)
  • The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. (wikipedia.org)
  • The group hopes the map, published online this week in Nature Chemical Biology , will be a resource for future applied research, providing insight into these molecules' roles in a variety of cellular processes with implications for drug development and other clinical areas. (genomeweb.com)
  • Ubiquitin functions as a reversible post-translational modifier of proteins to regulate many different cellular processes such as DNA repair, chromatin dynamics, cell cycle regulation, membrane and protein trafficking, endocytosis, autophagy, but most notably proteasome-dependent protein degradation [2-4]. (123dok.net)
  • Actin-related protein 2/3 (Arp2/3) complex activation by nucleation promoting factors (NPFs) such as WASP, plays an important role in many actin-mediated cellular processes. (elifesciences.org)
  • Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)
  • But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)
  • A large and still-growing number of PP2A substrates have been identified, which makes PP2A an important player in the regulation of a plethora of cellular processes. (ac.be)
  • The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
  • The interacting genes are involved in a range of cellular processes including gene expression, mitochondrial function, and membrane sorting/protein trafficking. (biomedcentral.com)
  • Mitochondrial fusion and fission are fundamental processes underlying cellular dynamics [1]. (centrodinoferrari.com)
  • These data suggest that the organizing structure guiding cellular processes is observed at omics-wide scale, and not at single molecule level. (elsevierpure.com)
  • Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
  • IMPORTANCE Optogenetic switches are molecular devices which allow the control of different cellular processes by light, such as gene expression, providing a versatile alternative to chemical inducers. (nih.gov)
  • Importantly, FUN-LOV can be implemented in diverse biological platforms to orthogonally control a multitude of cellular processes. (nih.gov)
  • The Sec61 protein plays a role in the translocation of secretory proteins across the endoplasmic reticulum membrane in the pathogenic yeast Candida albicans. (umwestern.edu)
  • Protein modules such as FVYE domains and PH domains that bind specifically to PtdIns 3-phosphate (PtdIns-3-P) and polyphosphoinositides, respectively, can direct such membrane targeting. (embl.de)
  • Genes involved in transcription, RNA processing, mitochondrial function and membrane sorting/protein trafficking were prevalent. (biomedcentral.com)
  • The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
  • Functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in the differentially expressed proteins in the FM and OA groups are mostly involved in the coagulation and complement system-related pathways, serotonin pathways, dopamine pathways, glutamate pathways and acute phase reactions. (ncl.edu.tw)
  • At Montana Western, Dr. Morrow and his undergraduate student researchers are studying some of the proteins that play roles in the early secretory pathway of the pathogenic yeast Candida albicans. (umwestern.edu)
  • Transcriptomic studies of L. trifolii indicated significant enrichment of differentially expressed genes (DEGs) in 'post-translational modification, protein turnover, chaperones', 'sensory perception of pain/transcription repressor complex/zinc ion binding' and 'insulin signaling pathway' when analyzed with the Clusters of Orthologous Groups, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes databases, respectively. (bvsalud.org)
  • These proteins take part in the fusion pathway in two consecutive steps. (centrodinoferrari.com)
  • The signal transduction pathway of the receptor starts from sensing outside signal and then activates G proteins. (tennessee.edu)
  • A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus Aspergillus fumigatus and Suggests Noncanonical Functions within the Pathway. (uc.edu)
  • In yeast, a member of the WASP family of proteins promotes the assembly of actin filaments around the site where endocytosis will occur. (elifesciences.org)
  • A family of proteins that were originally identified in SACCHAROMYCES CEREVISIAE as being essential for maintaining the structure of minichromosomes00. (bvsalud.org)
  • It is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a polyubiquitin precursor of head-to-tail monomers, or as a single N-terminal moiety to ribosomal proteins. (123dok.net)
  • Understanding the role of the ubiquitin fused to ribosomal proteins becomes relevant, as these proteins are practically invariably eS31 and eL40 in the different eukaryotes. (123dok.net)
  • We conclude that ubiquitin might serve as a cis-acting molecular chaperone that assists in the folding and synthesis of the fused eL40 and eS31 ribosomal proteins. (123dok.net)
  • In most eukaryotes studied, ubiquitin is encoded by two classes of genes: (i) The first comprises genes coding for a single copy of ubiquitin fused to ribosomal proteins (r-proteins), most commonly eL40 and eS31. (123dok.net)
  • Ubiquitin fusion to other r-proteins, such as P1 or P2, and even to non-ribosomal proteins such as actin, has been reported in diverse genera of rare single-celled algae as, for example, Bigelowiella [6]. (123dok.net)
  • Indeed, it has been demonstrated that cysteines are characterized by the most extreme conservation pattern, being highly conserved in functional positions of proteins but poorly conserved otherwise [ 5 ]. (hindawi.com)
  • Amyloidosis is a group of diseases characterized by abnormal aggregation of proteins to form amyloid fibrils, and subsequent deposition in various tissues and organs, which can lead to severe functional failures. (elifesciences.org)
  • Substitution of Val 113 in Sendai virus (SeV) M protein generates non-functional polypeptides, characterized by their exclusion from virus particles and by their ability to interfere with virus particle production. (microbiologyresearch.org)
  • Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca2+-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of Aspergillus fumigatus. (uc.edu)
  • These experiments reveal a previously unappreciated role for transcriptional fidelity in cellular health and aging. (nih.gov)
  • Smoothed networks were then combined into a single global map resulting in the identification of 40 HIV-human protein complexes involved in transcriptional control, translation, transport, and posttranslational modification, most of which have not yet been associated with HIV infection. (ucsd.edu)
  • Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. (umbc.edu)
  • These attachment sites are linked to actin-bundles that surround the nucleus via an Ndj1-Mps3-Csm4 protein bridge that spans the inner and outer nuclear membranes. (biorxiv.org)
  • To achieve this, WASP interacts with several other proteins including WIP and myosin, a motor protein that moves along actin filaments to generate mechanical forces. (elifesciences.org)
  • However, it was not clear how these proteins work together to trigger actin filaments to assemble at the right place and time. (elifesciences.org)
  • suggest that WASP and WIP play key roles in establishing the network of proteins needed for actin filaments to assemble during endocytosis. (elifesciences.org)
  • Consistent with a role for Tra1 in cellular stress, the tra1 SRR 3413 strain was sensitive to rapamycin. (biomedcentral.com)
  • The identity of the SSL genes also connects Tra1 with cellular stress, a result confirmed by the sensitivity of the tra1 SRR 3413 strain to a variety of stress conditions. (biomedcentral.com)
  • 2011). The Candida albicans Kar2 protein is essential and functions during the translocation of proteins into the endoplasmic reticulum. (umwestern.edu)
  • Brodsky, J.L. and Morrow, M.W. (2010) Protein Import into the Yeast Endoplasmic Reticulum: Methods. (umwestern.edu)
  • The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components. (uc.edu)
  • Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
  • While these disorders can still be considered rare, defective mitochondrial dynamics seem to play a significant role in the molecular and cellular pathogenesis of more common neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. (centrodinoferrari.com)
  • Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
  • Mitochondrial biogenesis is activated by numerous different signals during times of cellular. (web.app)
  • Cellular energy demand can vary by great length and it is now well known that one way to adjust adenosine triphosphate atp synthesis to energy demand is through modulation of mitochondrial. (web.app)
  • Background information mitochondrial proteins are encoded by both mitochondrial and nuclear genomes. (web.app)
  • In proteins where cysteine is not within the active site, activity can be modulated by changing conformation or by influencing its regulatory role, for example, iron sulfur complexes (ISCs) in aconitase possess cysteines required for its activity [ 7 ]. (hindawi.com)
  • It won't work if you want to co-immunoprecipitate them or apply any proteomic biochemical method because you will have to use detergents, and then you destroy all the protein complexes. (genomeweb.com)
  • Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)
  • In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)
  • In in vitro experiments, curcumin has been shown to suppress the aggregation and cytotoxicity of Aβ, αSyn, islet amyloid precursor protein, ATTR, and prion protein ( Stefani and Rigacci, 2013 ). (elifesciences.org)
  • Aggregation of VSV M protein is reversible and mediated by nucleation sites: implications for viral assembly. (microbiologyresearch.org)
  • This problem can be overcome by using dynamic control: inducible expression of enzymes and pathways, typically using chemical- or nutrient-based additives, to balance cellular growth and production. (princeton.edu)
  • Wang, H., Kakaradob, B., Karotki, L., Fiedler, D., Shales, M., Shokat, K., Walther, T., Krogan, N., Koller, D.: A Complex-Based Reconstruction of the S. cerevisiae Interactome. (crossref.org)
  • 1 Reversible protein phosphorylation is an important regulatory mechanism that controls the activities of a myriad of proteins and is thus involved in virtually every major physiological process. (ac.be)
  • 4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
  • Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1. (umbc.edu)
  • STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
  • Microbial cell factories offer a sustainable alternative for producing chemicals and recombinant proteins from renewable feedstocks. (princeton.edu)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • Cysteines are one of the most rarely used amino acids, but when conserved in proteins they often play critical roles in structure, function, or regulation. (hindawi.com)
  • In addition many of the genes have roles in the cellular response to stress. (biomedcentral.com)
  • We therefore focus on elucidating the roles of the telomere binding proteins in this process. (lu.se)
  • A yeast open reading frame sharing homology with the two known yeast Rab GTPase-activating proteins (GAPs), Gyp6p and Gyp7p, was found in a data base search. (embl.de)
  • The finding that yeast Rab GAPs share homology with proteins in other species, such as Caenorhabditis elegans and human, suggests the existence of a conserved Rab GAP family. (embl.de)
  • Ubiquitin is a highly conserved small eukaryotic protein. (123dok.net)
  • Szyjka, S., Viggiani, C., Aparicio, O.: Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae. (crossref.org)
  • Reversible cysteine modifications allow for potential redox regulation of proteins. (hindawi.com)
  • Thus, reversible cysteine modifications can influence protein activity and the relative quantification of the status of the thiol can potentially provide valuable insights into protein activity where the protein exists in a range of redox states. (hindawi.com)
  • This broad association "suggests that [ABC transporters] involvement in cellular function is more complex than previously demonstrated," the authors wrote. (genomeweb.com)
  • The synthesis of eukaryotic ribosomes is a complex process involving more than 200 factors and spans three cellular compartments: the nucleolus, the nucloplasm, and the cytoplasm. (utexas.edu)
  • King, A., Przulj, N., Jurisica, I.: Protein complex prediction via cost-based clustering. (crossref.org)
  • Mayer, M., Gygi, S., Aebersold, R., Hieter, P.: Identification of RFC (Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. (crossref.org)
  • Purification of a RAS - responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. (microbiologyresearch.org)
  • A hexameric protein complex of minichromosome maintenance proteins. (bvsalud.org)
  • Background: The development of high-throughput technologies such as yeast two- hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction ( PPI) datasets. (ku.edu)
  • Ubiquitin is a small eukaryotic protein of 76 amino acids whose name (i.e., it occurs ubiquitously) results from its remarkable evolutionary conservation [1]. (123dok.net)
  • In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
  • Note that there are additional groups showing time series of other cell cycle regulation proteins by the same authors in the Library. (ucsd.edu)
  • Normally, the conjugation of ubiquitin to other proteins involves the formation of an isopeptide bond between the α-carboxyl group of the C-terminal glycine of a ubiquitin molecule with an ε-amino group of a specific lysine residue within the target protein [2,3]. (123dok.net)
  • Normal cellular ageing involves the shortening of telomeres in each cell division. (lu.se)
  • Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
  • This domain occurred 356 times on human genes ( 810 proteins). (umbc.edu)
  • This domain occurred 388 times on human genes ( 899 proteins). (umbc.edu)
  • Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
  • Bub1 generally protects sister chromatide cohesion by enhancing Shugoshin protein (Sgo1) localization to the centromeric region. (wikipedia.org)
  • The signature sharing information was then applied in predicting sub-cellular localization of yeast proteins and the novel signatures were used in identifying possible interacting sites. (ku.edu)
  • Though the group did the mapping with ABC transporters from a yeast species - Saccharomyces cerevisiae - many of the proteins are homologous to disease-linked human ABC proteins. (genomeweb.com)
  • Cysteine is the most important redox-responsive amino acid within proteins largely due to the wide range of oxidation states that sulfur can occupy-so called, "sulfur switches" [ 4 ]. (hindawi.com)
  • The expression of DEGs encoding cuticular protein and protein takeout were silenced by RNA interference, and the results showed that knockdown of these two DEGs reduced the survival of L. trifolii exposed to microwave radiation. (bvsalud.org)
  • Lengronne, A., McIntyre, J., Katou, Y., Kanoh, Y., Hopfner, K., Shirahige, K., Uhlmann, F.: Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. (crossref.org)