• Sarcomas are rare, malignant tumors, consisting of only 1% of all neoplasms. (ascopost.com)
  • It was not until the 19th century that bone and soft-tissue tumors were distinguished from other cancers. (ascopost.com)
  • Of these, inflammatory or pelioid pattern usually presents as a focal finding within the tumor, but very rarely, they become the predominant pattern [ 4 ], creating great diagnostic confusion with other tumors such as inflammatory myofibroblastic tumor (IMT), follicular dendritc cell (FDC) tumor and other hepatic mesenchymal neoplasms. (biomedcentral.com)
  • This scheme is straightforward and essentially divides the vasoformative tumors into 2 broad groups: hemangiomas and vascular malformations (see Table 1 below). (medscape.com)
  • All categories of soft tissue tumors have been reported to involve the upper aerodigestive tract. (basicmedicalkey.com)
  • These tumors have markedly different prognoses and require different treatments than those for soft tissue tumors. (basicmedicalkey.com)
  • Fibroblastic or myofibroblastic tumors make up the majority of soft tissue tumors of the aerodigestive tract and range from nonneoplastic or benign proliferations (fibromas) to high-grade malignancies (undifferentiated high-grade pleomorphic sarcomas). (basicmedicalkey.com)
  • Malignant vascular tumors (MVTs), mainly composed of angiosarcoma (AS) and hemangioendothelioma (HE), are considered one of the rarest soft tissue neoplasms in contrast to their benign counterparts. (turkjpath.org)
  • High-resolution positron emission tomography and dual-contrast DCE-MRI of immobilized dorsal skin window tumors confirmed postradiotherapy HIF-1 signaling to spatiotemporally coincide with impaired stromal vascular function. (lincoln.ac.uk)
  • Gliomas, the most common primary brain neoplasms in adults, are very heterogeneous tumors. (ajnr.org)
  • High-grade gliomas can be highly invasive and extremely vascular tumors. (ajnr.org)
  • It also binds and activates neuropilin-1, leading to a temporary opening of the tumor and an enhanced delivery of anti-cancer agents into the tumor tissue. (wikipedia.org)
  • Angiomyolipoma (AML) is a rare mesenchymal neoplasm of the tumor, composed of a varying heterogeneous mixture of three tissue components: blood vessels, smooth muscle and adipose cells. (biomedcentral.com)
  • Mature adipocytes and thick-walled blood vessels were focally observed at the boundaries between the tumor and surrounding liver tissues. (biomedcentral.com)
  • Rhabdomyoblastic differentiation in a malignant peripheral nerve sheath tumor (MPNST) is termed malignant triton tumor (MTT), a rare neoplasm that poses a diagnostic dilemma in the differential diagnosis of neck masses and portends poor prognosis. (hindawi.com)
  • Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue neoplasm with a poor prognosis. (hindawi.com)
  • One of the proteins associated with dense extracellular matrices is fibromodulin, a collagen fibrillogenesis modulator expressed in tumor stroma but scarce in normal loose connective tissues. (lu.se)
  • Fibromodulin can therefore be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function. (lu.se)
  • Tumor size, the presence of hemorrhage and necrosis, growth pattern, cellularity, cellular characteristics and mitotic activity were recorded as morphological variables. (turkjpath.org)
  • Although Kaposi's sarcoma is also classified as a malignant vascular neoplasm, there are contradictory data about the vascular origin and differentiation of this tumor. (turkjpath.org)
  • Conclusions: Our results illustrate that tumor radioresistance is mediated by a capacity to compensate for stromal vascular disruption through HIF-1 - dependent proangiogenic signaling and that clinically relevant vascular imaging techniques can spatially define mechanisms associated with tumor irradiation. (lincoln.ac.uk)
  • Papillary intralymphatic angioendothelioma (Dabska tumor) is a rarely metastasizing lymphatic vascular neoplasm that usually affects children and young adults. (anaisdedermatologia.org.br)
  • An incisional biopsy was performed, whose anatomopathological study evidenced an intralymphatic lesion, with prominent papillary formations and vascular axes lined by rounded and hyperchromatic cells, projecting into the lumen (hobnail cells), compatible with papillary intralymphatic angioendothelioma - Dabska tumor ( Figs. 3 and 4 ). (anaisdedermatologia.org.br)
  • In this population, features of malignancy include large tumor size (weight greater than 400 grams and tumor size greater than 10.5 cm), vena cava invasion, confluent necrosis, higher mitotic rate (more than 15 mitoses per HPF), atypical mitoses, and invasion of adjacent soft tissue. (cap.org)
  • Although vascular and capsular invasion cannot be assessed, cytologic features on fine needle aspiration (FNA) such as hypercellularity, necrosis, and cellular dyscohesion, in conjunction with radiologic features of tumor size (greater than 4.0 cm), heterogeneity, and enhancement, favor ACC over other adrenal neoplasms. (cap.org)
  • Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
  • 3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
  • The current standard for tumor grading is histopathologic assessment of tissue, which has inherent limitations, such as sampling error, interobserver variation, and a wide variety of classification systems that are available, the most common of which is the WHO grading system. (ajnr.org)
  • The tumor was soft and moderately vascular. (surgicalneurologyint.com)
  • The tissue plane between tumor and brain was easily developed using standard microsurgical technique. (surgicalneurologyint.com)
  • The histology showed a well differentiated malpighian epithelium on a richly vascularised connective tissue containing histiocytes, lymphocytes and plasmocytes. (ispub.com)
  • One of his few mistakes was his theory of the connective-tissue origin of carcinoma. (ascopost.com)
  • During the 20th century, numerous other connective tissue cell types were identified as sources of sarcoma. (ascopost.com)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • The mouth is lined by stratified squamous epithelium overlying richly vascular connective tissue. (clinicalgate.com)
  • Introduction to anatomy, general features of epithelial tissue, general organization of connective tissue, development of and hstology of cartilage and bone tissues, embryology and histology of skin, biochemistry of connective tissue, and bone tissue, skin and tissue parasites and fungi, arthropods and arthropods borne viruses. (atilim.edu.tr)
  • X-ray relies on differentiation of adjacent structures using four basic tissue densities: air, fat, water (which includes soft tissues, both solid organs such as muscle and fluids such as blood), and bone (sometimes called metal density ). (radiologykey.com)
  • Another opinion suggested a differentiation-metaplasia capacity of neuroectodermal tissue [ 20 ]. (hindawi.com)
  • LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
  • The outcome of LPA signaling is dependent on cellular context and impacts on biological processes such as wound healing, differentiation, neurogenesis, and survival, to name a few [ 4 ]. (hindawi.com)
  • ATX is also important in adipogenesis since it is upregulated during preadipocyte differentiation to adipocytes and secreted into circulation by the adipose tissue [ 24 ]. (hindawi.com)
  • Recently, some studies have proposed new markers such as FLI1 6 and FKBP12 7 for vascular differentiation. (turkjpath.org)
  • N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
  • This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
  • A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
  • Because of this, one should be comfortable using immunohistochemistry or other methods with the diagnosis of these lesions, and to help exclude epithelial or melanocytic neoplasms ( Table 11.1 ). (basicmedicalkey.com)
  • Lipoblastoma is an exceptional, benign, lobulated, mesenchymal neoplasm arising from embryonal adipose tissue cells or lipoblasts or immature adipocytes. (lupinepublishers.com)
  • As lipoblastoma arises from embryonic adipose tissue, it is additionally nomenclated as "embryonic lipoma or foetal or embryonal lipoblastoma" [1]. (lupinepublishers.com)
  • A predominantly lobulated, well circumscribed, encapsulated tumefaction simulating foetal adipose tissue, lipoblastoma is commonly situated within subcutaneous tissue. (lupinepublishers.com)
  • In contrast, lipoblastomatosis is a poorly defined, non-encapsulated, multi-centric, infiltrative, generally deep- seated neoplasm composed of an accumulation of foetal adipose tissue. (lupinepublishers.com)
  • Essentially comprised of immature, persistent, embryonic adipose tissue which proliferates rapidly within the post natal period, lipoblastoma can configure an enlarged tumefaction wherein the variable tumour magnitude can extend up to 25 centimetres [3,4]. (lupinepublishers.com)
  • As a lobulated, mesenchymal neoplasm comprised of embryonal or foetal adipose tissue, lipoblastoma, characteristically demonstrates a benign biological behaviour, preliminary discernment, male predominance and brisk tumour evolution. (lupinepublishers.com)
  • Lipoblastoma is commonly observed within sites of persistent immature adipose tissue. (lupinepublishers.com)
  • Lipoblastoma can simulate foetal adipose tissue aggregates or a myxoid liposarcoma. (lupinepublishers.com)
  • Histologically similar to those in the kidney, hepatic AML consists of a mixture of myoid cells, adipose tissue and thick-walled vessels. (biomedcentral.com)
  • Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. (nih.gov)
  • Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females. (biomedcentral.com)
  • The advantages of this method were good and free control of the vascular caliber and shape during vascular anastomosis and a diminishment of endothelial damage. (go.jp)
  • K. Kokame, H. Kato and T. Miyata, "Homocysteine-Respondent Genes in Vascular Endothelial Cells Identified by Differential Display Analysis. (scirp.org)
  • DSRCT was first described by Gerald and Rosai in 1989 as a primitive neoplasm of children and young adults that most frequently occurs in the serosa of the pelvic cavity. (medscape.com)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • A few notes on each cancer site and its subgroups staining techniques (e.g., glandular and diffuse neoplasms of are included in this chapter. (who.int)
  • In 1829, John Lobstein, MD (1777-1835), described soft-tissue sarcomas that arise in the retroperitoneal space. (ascopost.com)
  • Treatment of bone and soft-tissue sarcomas requires specific pathologic diagnosis, but it wasn't until the 1970s that histologic analysis became reliable enough to make differential diagnosis accurate. (ascopost.com)
  • Lipoblastoma arises as a gradually progressive, painless, superficial, subcutaneous, soft tissue nodule or a well circumscribed mass wherein an estimated 75% tumefaction appear upon the left side. (lupinepublishers.com)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • On examination of the oral cavity, the vascular malformations of the mucosa and the adjacent soft tissues are usually readily apparent. (medscape.com)
  • Imaging of soft tissues of the neck can be essential in the evaluation of patients with a variety of chief complaints, including neck trauma, ingested or aspirated foreign body, nontraumatic neck pain and swelling, dysphagia and voice change, visible or palpable mass, and central nervous system complaints with possible vascular causes. (radiologykey.com)
  • In this chapter, we explore the modalities available for soft-tissue cervical imaging, discuss clinical indications for imaging in a variety of chief complaints, and review some characteristic findings of important pathology, using the figures throughout the chapter. (radiologykey.com)
  • Imaging of the soft tissues of the cervical spinal cord and ligaments are discussed in Chapter 3 . (radiologykey.com)
  • Who Needs Soft-Tissue Imaging? (radiologykey.com)
  • Given the range of potential pathology discussed earlier, it should come as little surprise that no single clinical decision rule can be used to inform decisions for soft-tissue neck imaging. (radiologykey.com)
  • Some soft-tissue neck abnormalities are best assessed with neither x-ray nor CT but rather with ultrasound, magnetic resonance imaging (MRI), fluoroscopy, or techniques such as bronchoscopy and esophagoscopy. (radiologykey.com)
  • Plain x-ray ( Figures 4-1 and 4-2 ) provides limited information about the soft tissues of the neck. (radiologykey.com)
  • For this reason, x-rays can demonstrate abnormal soft-tissue air ( Figures 4-3 to 4-5 ), deviation or compression of normal air-filled structures (the trachea particularly) ( Figures 4-3 and 4-6 to 4-10 ), air-fluid levels suggesting abscess, and radiopaque foreign bodies ( Figures 4-11 to 4-15 ), as all of these involve a contrast between two key tissue densities. (radiologykey.com)
  • Unfortunately, many of the soft-tissue abnormalities of interest to us as emergency physicians may not involve such a contrast. (radiologykey.com)
  • Instead, one soft-tissue structure may abut a second soft-tissue structure, and these are indistinguishable on x-ray. (radiologykey.com)
  • Examples include vascular dissections, abscesses, and subtle soft-tissue masses that may not be seen on x-ray. (radiologykey.com)
  • A soft-tissue neck series consists of an anterior-posterior (AP) (A) and a lateral (B) x-ray of the neck. (radiologykey.com)
  • Compared with a cervical spine x-ray, the images are intentionally underexposed to allow soft tissues to be examined. (radiologykey.com)
  • Some neoplasms appear more unique to the area, e.g., angiofibroma, while most can occur throughout the soft tissues of the entire body. (basicmedicalkey.com)
  • It can occur in association with neurofibromatosis type 1 (NF-1) or sporadically accounting for 5-10% of soft tissue sarcomas [ 1 - 4 ]. (hindawi.com)
  • The majority of these cases occur in soft tissues of extremities, and to date less than 40 cases have been described. (anaisdedermatologia.org.br)
  • 7 ] They can occur at both osseous and extraosseous sites and are most commonly found in the axial skeleton (pelvis, vertebrae, and ribs) as well as peripheral soft tissue. (surgicalneurologyint.com)
  • If used correctly in a timely manner, it can treat possible vascular complications that would progress to irreversible damage. (rbcp.org.br)
  • In situ ultrasound imaging and dynamic contrast-enhanced (DCE) MRI indicated that HIF-1 signaling followed acute disruption of stromal vascular function. (lincoln.ac.uk)
  • The second explanation was more plausible, where neoplastic Schwann cells can transform into rhabdomyoblasts, suggesting the possibility of some mesenchymal tissue derivation from neuroectodermal cells. (hindawi.com)
  • Chondrosarcoma is an uncommon malignant neoplasm in which the neoplastic cells produce chondroid and fibrillar matrix (Durham, Popovitch, & Goldschmidt, 2008). (ac.ir)
  • To further elucidate the natural history and prognosis of this rare neoplasm in the head and neck, we present a case of sporadic MTT arising in the neck with an unusual prognosis. (hindawi.com)
  • Even with low complication rates, it is prudent for the plastic surgeon to be attentive to the signs of vascular occlusion because the interruption of the progression towards necrosis and permanent sequelae depends on rapid medical action. (rbcp.org.br)
  • Foci of hemorrhage and necrosis are commonly seen and a subset exhibit cystic change or vascular invasion. (cap.org)
  • Rudolf L.C. Virchow, MD (1821-1902), the legendary founder of cellular pathology (1858), set in motion a new way of looking at the body as a "cell state. (ascopost.com)
  • The course therefore aims to provide knowledge of the causes and mechanisms of the diseases and the alterations that derive from them at a tissue, cellular and molecular level. (uninsubria.eu)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • We are elucidating the cellular and molecular mechanisms of how LSCs interact with the fibrotic niche in mouse models and how this negatively impacts normal HSCs. (lls.org)
  • A systematic review of the literature was conducted from January 2003 to January 2018, using descriptors of vascular complications after facial filling with HA and its treatment. (rbcp.org.br)
  • Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by the overproduction of RBCs. (lecturio.com)
  • This is a prospective cohort study of patients undergoing breast reconstruction with prosthesis or expander under pectoralis major muscle flap that compared histological skin patterns, subcutaneous cell tissue, pectoralis major muscle, and implant capsule of irradiated and non-irradiated breasts in paired samples of the same patient. (rbcp.org.br)
  • The main histological findings in the skin and subcutaneous cellular tissue of the irradiated breast were as follows: epidermal hyperplasia, flattening of the papillary layer, atrophy of the skin appendages, vascular congestion in fatty tissue, high density of skin collagen fibers, hyalinization, and reduction of elastic fibers in the deep dermis and unidirectional alignment of collagen fibers. (rbcp.org.br)
  • The vascular malformations can be further subdivided into arterial, venous, capillary, and lymphatic malformations. (medscape.com)
  • it is also affected by venous return, peripheral vascular tone, and neurohumoral factors. (msdmanuals.com)
  • The goal of conformal radiation techniques is to improve local tumour control through dose escalation to target volumes while at the same time sparing surrounding healthy tissue. (ndltd.org)
  • Radiation creates ionized oxygen species that react with cellular DNA. (medscape.com)
  • invasive micropapil- in up to 35 % of cases.3 This syndrome lary carcinoma of the right breast, with right is a rare multisystem disease character- mastectomy seven years ago, and endome- ized by multiple hamartomas in various trial cancer, with a hysterectomy five years tissues, particularly in the skin and mucous ago. (bvsalud.org)
  • Since it is a systemic condition, amyloid deposits should be present in other tissues, such as spleen, liver, kidney, and intestine, particularly in vascular and perivascular sites. (nih.gov)
  • When two tissues of different density abut one another, the transition is clear. (radiologykey.com)
  • Furthermore, vascular density, pericyte coverage and macrophage amount were unaffected. (lu.se)
  • PMF is a stem cell-derived blood malignancy with the characteristics of too many cells in the blood and a large amount of scar tissue formation (fibrosis) in the bone marrow. (lls.org)
  • The etiological diagnosis was based on the International Society for the Study of Vascular Anomalies 2014 classification. (rbcp.org.br)
  • This neoplasm should be considered in the differential diagnosis of vascular dermatoses, allowing early diagnosis and treatment. (anaisdedermatologia.org.br)
  • Non-resected lipoblastoma generally matures into lipoma with prominent fibrous tissue septa [4]. (lupinepublishers.com)
  • Jaffe described lipoblastoma as an atypical lipoma with cellular constituents simulating embryonic fat or lipoblasts, in 1926. (lupinepublishers.com)
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
  • A deformable, tissue equivalent tumour, suitable for holding radiochromic film for dose measurements was embedded in the sponge. (ndltd.org)
  • Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes. (cancerindex.org)
  • It differs from bone, however, in that its cellular constituents (odontoblasts) form a layer over the surface of the dentine, from which long tubular processes ramify through the tissue. (clinicalgate.com)
  • We use mouse genetics to model myelofibrosis and understand the cellular and molecular makeup of the diseased microenvironment. (lls.org)
  • ATX is essential for development since Enpp2 −/− is lethal at embryonic day 9.5-10.5, with marked vascular and neural tube defects [ 20 , 21 ]. (hindawi.com)
  • Two of the most important factors in determining the malignancy of gliomas are their ability to infiltrate the brain parenchyma and to recruit or synthesize vascular networks for further growth (ie, neoangiogenesis). (ajnr.org)