Cellular membrane lipids. Medical search. Frequent questions

Lipid bilayer membranes are among the most ubiquitous structures in the living world, with intricate structural features and a multitude of biological functions. (nature.com)
The formation ofinvaginations (or tubules) is regulated by the composition of negativecharged lipids in membrane bilayer or electrostatic residues on the BARdomain. (kth.se)
its localization within the unsaturated fatty acid esters in the phospholipid bilayer of cell membranes provides a means of controlling lipid oxidation at a likely initiation site ( Hafeman and Hoekstra 1977 ). (dsm.com)
Plasma membrane composed of an amphipathic lipid bilayer. (pharmacology2000.com)
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. (yeastgenome.org)
The phospholipid bilayer is made out of lipids and phosphates. (databasefootball.com)
A combination of fluorescence microscopy, neutron reflectometry, and time-of-flight secondary-ion mass spectrometry data will be presented which characterizes the structure and composition of this new supported lipid bilayer category. (lu.se)
We also investigate the properties of model membranes such as supported lipid bilayer and vesicles on a variety of nanowire substrates. (lu.se)

With this new technology known as "Membrane coated-FET (lipid-FET)," molecules suspended in highly ionic concentrated solution, to a level of human blood, can be detected with higher sensitivity compared to that of the existing sensor, and dilution of the solution up to 100,000-fold is not required. (eurekalert.org)
ABC (ATP binding cassette) transporters catalyze the transport of a wide variety of molecules across lipid bilayers into or out of cells and organelles. (rug.nl)
Either stereo reactants or stereo catalysis from achiral or chiral molecules are a prerequisite to obtain pure enantiomeric lipid derivatives. (mdpi.com)
Lipids are a group of hydrophobic molecules that include triglycerides, which are used to store energy, and phospholipids, which are the major structural components of cell membranes. (jove.com)
With these molecules in hand, it became possible to investigate the phase behaviour of liquid ordered/liquid disordered supported membranes doped with the Gb 3 species by means of fluorescence and atomic force microscopy. (springer.com)
In contrast, globosides are neutral lipid molecules. (springer.com)
haracteristics ofC the plasma membrane include high electrical resistance and low permeability to highly polar drug molecules. (pharmacology2000.com)
Glycoproteins are proteins that have a carbohydrate chain linked to them, and they assist cells in communicating with other cells and transporting molecules across the cell membrane. (databasefootball.com)
Transport proteins, as the name implies, are responsible for transporting molecules through the cell membranes and into the body of the cell through the process of facilitated diffusion. (databasefootball.com)
Although its function is unknown, researchers suggest that the C19orf12 protein plays a role in the maintenance of fat (lipid) molecules, a process known as lipid homeostasis. (medlineplus.gov)
Bile salts aid in forming lipid micelles, which create a hydrophilic surface with a hydrophobic core of lipid molecules, including FFA. (medscape.com)
The energy transferred from the activated photosensitizer to available oxygen results in the formation of highly reactive oxygen species, which may eliminate microorganisms by damaging their essential cellular molecules, including proteins, nucleic acids and lipid membranes (10). (bvsalud.org)

Another possible function of the plasmalogen ether lipids is as antioxidants, as protective effects against oxidative stress have been demonstrated in cell culture and these lipids might therefore play a role in serum lipoprotein metabolism. (wikipedia.org)
The activity of purified FAM92A1-NT* was verified bynegative stain EM.IIFourth, we were interested in the regulation of the lipid metabolism. (kth.se)
Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control. (uci.edu)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
We detected phosphorylation on S155 and identified S155 as a functionally important site for lipid metabolism. (uci.edu)
Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis compared with wild-type PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism. (uci.edu)
Calcium is also important in the metabolism of the intercellular lipids. (purinamills.com)

Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. (cdc.gov)
The ultrafine particles also caused significant increases in H2O2 production by monocytes and lipid peroxidation. (cdc.gov)
GR and GST- and the lipid peroxidation hydroperoxides and free radicals. (who.int)

We imaged split fluorescence reporters for six different contact sites, two of which have never been studied before, on the background of 1165 strains expressing a mCherry-tagged yeast protein that have a cellular punctate distribution (a hallmark of contact sites). (ucl.ac.uk)
Analysis of another candidate, Ypr097w, which we now call Lec1 (Lipid-droplet Ergosterol Cortex 1), revealed that this previously uncharacterized protein dynamically shifts between lipid droplets and the cell cortex, and plays a role in regulation of ergosterol distribution in the cell. (ucl.ac.uk)
Synthetic ether lipid analogs have cytostatic and cytotoxic properties, probably by disrupting membrane structure and acting as inhibitors of enzymes within signal transmission pathways, such as protein kinase C and phospholipase C. A toxic ether lipid analogue miltefosine has recently been introduced as an oral treatment for the tropical disease leishmaniasis, which is caused by leishmania, a protozoal parasite with a particularly high ether lipid content in its membranes. (wikipedia.org)
One of the ABC transporters that is studied in detail is the osmoregulatory ABC transporter OpuA (class D). Osmotic control of OpuA involves gating by intracellular ionic strength and is mediated by lipid-protein interactions. (rug.nl)
Cell membranes need to change their shapes during many cellular processeslike protein trafficking, cytokinesis and membrane homeostasis. (kth.se)
Here, we employed transmission electronmicroscopy and other biophysical methods to elucidate how BAR domainproteins steer processes at the membrane.In this work we studied the BAR protein bridging integrator 1 (BIN1), whichhas an established role in cancer, Alzheimer's disease and skeletalmyopathies. (kth.se)
Thisimplies that BIN1 rather bundles actin than decorates single filaments.Third, we explored a strategy to purify an aggregation prone BAR protein.Aggregation is a property common in Peripheral Membrane Proteins. (kth.se)
Stomatin/STOPP (stomatin operon partner protein) gene pairs are present in both archaeal and bacterial species, and their protein products may be involved in the quality control of membrane proteins. (rcsb.org)
This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
In addition, structural as well as functional aspects of the different classes of membrane proteins are discussed along with an outline of experimental approaches used to achieve an understanding of membrane protein structure and function at a molecular level. (yale.edu)
Whereas the trisaccharidic head group of Gb 3 defines the specificity of Shiga toxin binding, the lipophilic part composed of sphingosine and different fatty acids is suggested to determine its localization within membranes impacting membrane organisation and protein binding eventually leading to protein internalisation. (springer.com)
Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
Scientists discovered a protein that modifies a microbe's membrane and helps it survive in hot, acidic environments, proving a long-standing hypothesis that these structures have a protective effect. (stanford.edu)
Stanford University researchers have identified a protein that helps these organisms form a protective, lipid-linked cellular membrane - a key to withstanding extremely highly acidic habitats. (stanford.edu)
The team directly proved this idea by identifying the protein that creates the unusual membrane structure in the species Sulfolobus acidocaldarius . (stanford.edu)
That mutated organism was able to grow at high temperatures but withered in a highly acidic environment, suggesting that the protein is necessary to both make the unusual membrane and withstand acidity. (stanford.edu)
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a disorder of the nervous system. (medlineplus.gov)
Dogu O, Krebs CE, Kaleagasi H, Demirtas Z, Oksuz N, Walker RH, Paisan-Ruiz C. Rapid disease progression in adult-onset mitochondrial membrane protein-associated neurodegeneration. (medlineplus.gov)
Hartig M, Prokisch H, Meitinger T, Klopstock T. Mitochondrial membrane protein-associated neurodegeneration (MPAN). (medlineplus.gov)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
Finally, NSP8 and NSP9 bind to the 7SL RNA in the Signal Recognition Particle and interfere with protein trafficking to the cell membrane upon infection. (cdc.gov)

In a biochemical sense, an ether lipid usually implies glycerophospholipids of various type, also called phospholipids, in which the sn-1 position of the glycerol backbone has a lipid attached by an ether bond and a lipid attached to the sn-2 position via an acyl group. (wikipedia.org)
There are two types of ether lipids, plasmanyl- and plasmenyl-phospholipids. (wikipedia.org)
Another type of lipid, phospholipids, is an important structural feature of biological membranes. (jove.com)
The lipid and phosphate construction means that the heads of the phospholipids are attracted to water, while the tales repel water. (databasefootball.com)
A component of the lipids in animal cells is cholesterol, which is dispersed in between the phospholipids and parts of the membrane. (databasefootball.com)
In these patients, antibodies against PLs are specific for a neoepitope constituted by the union of β 2 GPI, a lipid-binding coagulation inhibitor, to the cellular membrane phospholipids ( 2 ). (cdc.gov)

Using human macrophages as a proxy for microglia, we found that MS4A4A and TREM2 colocalized on lipid rafts at the plasma membrane, that sTREM2 increased with MS4A4A overexpression, and that silencing of MS4A4A reduced sTREM2 production. (lu.se)

Probing lipid mobility of raft-exhibiting model membranes by Fluorescence Correlation Spectroscopy. (rug.nl)
Combined AFM and two-focus SFCS study of raft-exhibiting model membranes. (mpg.de)

Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Precursor compounds for abiotic proto cellular membranes are necessary for the origin of life. (nih.gov)
The results indicate that condensation reactions and abiotic synthesis of organic lipid compounds under hydrothermal conditions occur easily, provided precursor concentrations are sufficiently high. (nih.gov)
Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. (420magazine.com)
Non-polar substances are more soluble in lipids and can therefore access the nervous tissue more easily than polar compounds, which are less soluble in lipids. (news-medical.net)
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. (bvsalud.org)
Bile salts are released in the duodenum in response to cholecystokinin release occurring in the presence of lipid compounds within the ingesta. (medscape.com)
Absorption of lipid compounds into the enterocyte for biochemical usage occurs through diffusion across the cellular membrane and also through lipid transporters that are located on the luminal side of the enterocyte. (medscape.com)

Writing ( Fig. 1a-b ), Dynamic control of composition ( Fig. 1c-d ), Erasing ( Fig. 1e ) and Localized lipid film modification and decoration ( Fig. 1f-g ). 2D-networks are directly written by providing liposomes through the pipette, while simultaneously translating the substrate by means of a motorized stage. (nature.com)
To obtain information about BIN1's interaction with themembrane in near native environments, we used artificial lipid systems suchas liposomes and lipids nanotubes.First, we have shown that electrostatic interactions are more important forBIN1 when binding to membranes with low curvature. (kth.se)
Although these liposomes have high concentrations of fusogenic lipids, which are needed to cross cellular membrane barriers, these lipids lead to toxicity when tested in vivo. (uh.edu)
This problem could be solved through membrane phase-separation, a mechanism to locally concentrate specific lipids in dense "patches" on the surface of liposomes. (uh.edu)
The cells are built from liposomes, or bubbles with a cell-like lipid membrane, and purified cellular components including proteins, DNA and metabolites. (lifeboat.com)

This class provides an introduction to the biochemistry and biophysics of lipids, lipid bilayers, and lipid-derived second messengers. (yale.edu)
We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)

Drastic enhancement of molecular detectability over potentiometric sensor surface via ion-impermeation across the lipid membrane. (eurekalert.org)
The Korean team of researchers successfully developed a proprietary biosensor technology with significantly enhanced molecular sensitivity using the artificial lipid membrane that mimics cellular membrane. (eurekalert.org)
After repeated tests for applying the cellular membrane to the surface of the FET-based molecular detection chip, it was confirmed that molecule detection is available without additional pretreatment, even in a high-concentration ionic solution. (eurekalert.org)
In this "lab on a molecularly thin membrane", various chemical and physical operations, such as writing, erasing, functionalization and molecular transport, can be applied to user-defined regions of a membrane circuit. (nature.com)
This concept is an enabling technology for research on molecular membranes and their technological use. (nature.com)
We demonstrate how such networks are conveniently generated and locally restructured and show how various design possibilities such as diffusional barriers and hydrodynamic trapping points can be used in a "lab on a biomembrane" to directly address biomembrane functions and properties, or to perform membrane-assisted studies of molecular interactions. (nature.com)
Quaini and Olshankii's mathematical and computational expertise at UH's College of Natural Sciences and Mathematics will pair with Majd's research of molecular processes across biological membranes. (uh.edu)
The course considers the basic physical chemistry required in cellular and molecular biology but does not require a previous course in physical chemistry. (yale.edu)
2002), which is associated with a loss of ability at the molecular, cellular and whole organism levels (Hall et al . (scialert.net)
The structures of some organisms' membranes are retained in the fossil record and can serve as molecular fossils or biomarkers, leaving hints of what lived in the environment long ago. (stanford.edu)
Being able to show how this protective membrane is created could help researchers understand other molecular fossils in the future, offering new evidence about the evolution of life on Earth. (stanford.edu)
These genetic, molecular, and cellular findings suggest that MS4A4A modulates sTREM2. (lu.se)

How does crowding affect mobility of proteins and lipids? (rug.nl)
Endocytosis serves the opposite function, removing proteins and lipids from the cell membrane and bringing them into the interior of the cell, decreasing the size of the cell membrane and the cell itself. (databasefootball.com)
There are two layers made out of a variety of proteins and lipids. (databasefootball.com)

Thus, the interplay between these antioxidants and the specific synergy between the vitamins, is very important for the protection of cellular membranes. (dsm.com)
Selenium is important as an antioxidant for the protection of cellular membranes. (purinamills.com)

Extraction procedures are optimized to precipitate and remove proteins and nucleic acids while maximizing solubilization of GSLs along with other lipids. (springer.com)

We investigate the mobility of proteins in the bacterial cytoplasm and cytoplasmic membrane as well as membrane model systems, using optical microscopy-based techniques such as fluorescence correlation spectroscopy (FCS) and pulsed-FRAP (panel a). (rug.nl)
Characterization of Interaction between Cationic Lipid-Oligonucleotide Complexes and Cellular Membrane Lipids Using Confocal Imaging and Fluorescence Correlation Spectroscopy. (mpg.de)

All biological membranes contain enantiomerically pure lipids in modern bacteria, eukarya and archaea. (mdpi.com)
Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)
In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. (lu.se)

Most substances cannot penetrate the cellular membrane, so a number of specialized transport mechanisms (cofactors, transport vesicles, etc.) are employed to allow necessary substances to move into the cell in a controlled and well-regulated fashion. (doterra.com)
Exocytosis has vesicles that contain lipids and proteins combine with the cell membrane, which has the effect of increasing the overall size of the cell. (databasefootball.com)

Ether lipids can also act directly in cell signaling, as the platelet-activating factor is an ether lipid signaling molecule that is involved in leukocyte function in the mammalian immune system. (wikipedia.org)
Lipid A is a glycophospholipidic structure that anchors the LPS molecule to the cellular membrane. (scirp.org)
From previous research in archaea, Welander and her team knew that the organisms produce a membrane containing a ringed molecule called a calditol. (stanford.edu)
With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)

Differences between the catabolism of ether glycerophospholipids by specific phospholipases enzymes might be involved in the generation of lipid second messenger systems such as prostaglandins and arachidonic acid that are important in signal transduction. (wikipedia.org)

Because essential oils are lipid soluble and small, they have no problem crossing the membrane. (doterra.com)
The lipid soluble nature of essential oils offers them independent function and cell accessibility. (doterra.com)
Being the nature's most effective lipid-soluble, chain-breaking antioxidant, it protects cellular membranes from being attacked by lipid peroxyl radicals. (dsm.com)
All VOCs are to some extent fat/oil-soluble (ie, lipid-soluble). (greenplantsforgreenbuildings.org)
and other sparingly soluble polar lipids. (lu.se)

Among sets of cellular machines that coordinate their functions, certainly one of the finest examples is the metabolic machinery operating in mitochondria. (evolutionnews.org)
A beautiful animation of the cellular factory in mitochondria was released by Science X on YouTube. (evolutionnews.org)

The cellular membrane of humans not only controls the ion concentration of the internal and external environment but also prevents a high concentration of ions from entering the cell. (eurekalert.org)
Plasmalogens as well as some 1-O-alkyl lipids are ubiquitous and sometimes major parts of the cell membranes in mammals and anaerobic bacteria. (wikipedia.org)
In archaea, ether lipids are the major polar lipids in the cell envelope and their abundance is one of the major characteristics that separate this group of prokaryotes from the bacteria. (wikipedia.org)
We have proposed that under conditions of severe osmotic stress (panel b, lower figure), the cell membrane contacts the nucleoid, which creates pools of proteins and hinders free diffusion through the cell. (rug.nl)
Every cell is enclosed in a protective barrier called a membrane that serves to maintain the cell as a closed system separate from the outside environment. (doterra.com)
Imbedded in the membrane are surface receptors that serve as a line of communication between that individual cell and the rest of the body. (doterra.com)
When the proper substance binds with these receptors, it initiates a cascade of chemical changes on the inner side of the cellular membrane, triggering modifications in the function of the cell. (doterra.com)
Substances with certain structural properties can directly traverse the membrane and move into the cell without being limited by the cell's transport machinery in a process known as passive diffusion. (doterra.com)
Similarly to Gram-negative bacteria, cyanobacterial cell wall contains Lipopolysaccharides (LPSs) in the outer membrane layer. (scirp.org)
In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis (break- down). (silvermedicine.org)
Glycosphingolipids (GSLs) are a subclass of glycolipids that are found in cell membranes of various organisms ranging from bacteria to humans. (springer.com)
2002). However, during aging an oxidant challenge exceeds the capacity of the cell s defense system, membrane damage may occur. (scialert.net)
Thus they tend to dissolve in and disrupt cellular membranes, and hence cell function. (greenplantsforgreenbuildings.org)
The cell membrane is a thin membrane that encases the cytoplasm of the cell , and holds the cytoplasm (as well as the cell's organelles) within it, separating the interior of the cell from the outside environment. (databasefootball.com)
The cell membrane is semi-permeable, meaning that it allows certain substances to move into the cell while it keeps certain other substances out of the cell. (databasefootball.com)
Let's examine the cell membrane in more detail. (databasefootball.com)
The cell membrane serves a variety of functions. (databasefootball.com)
As previously mentioned, the cell membrane serves as a barrier that can open to allow certain needed substances into the cell while keeping other substances outside of the cell. (databasefootball.com)
However, the cell membrane also gives support and balance to a cell, helping it maintain its shape. (databasefootball.com)
The cell membrane also serves as an anchor point for the cytoskeleton of the cell in some organisms, and it attaches to the cell wall in plant cells. (databasefootball.com)
The cell membrane also helps regulate the growth of the cell, by controlling the processes of exocytosis and endocytosis . (databasefootball.com)
The cholesterol helps hold the cell membrane together and prevent the membrane from becoming too stiff by limiting how closely the lipids can be to one another. (databasefootball.com)
Cholesterol isn't a part of the cell membrane in plant cells , only animal cells. (databasefootball.com)
Glycolipids are found on the surface of the cell membrane, and they have carbohydrate sugars attached to them. (databasefootball.com)
There are different kinds of proteins associated with the cell membrane. (databasefootball.com)
Although the cell membrane is the most well-known membrane in a cell, some of the organelles found within a cell also have their own respective membranes. (databasefootball.com)
These membranes help protect the organelle from the other chemical functions going on in the cell, separating their components from the rest of the cell. (databasefootball.com)
As cell membranes are both dynamic and compositionally complex, replicating these aspects in a model membrane are essential. (lu.se)
The sphingomyelin that accumulates in the lysosomes of Niemann-Pick disease-affected cells is thought to arise from the degradation of the cells and their organelles because it is a major component of all mammalian cell membranes. (medscape.com)
In order to deepen our understanding of the interactions between the cell membrane and nanostructures, we perform STED microscopy live imaging of the membrane of cells cultured on nanostructures. (lu.se)

Here we introduce a microfluidic toolbox to write 2D nanofluidic networks composed of supported phospholipid membranes and dynamically modify their connectivity, composition and local function. (nature.com)
Diffusively continuous fluidic networks can be produced in this way, where the topology is defined by the x, y scanning sequence and the composition depends on the lipids supplied by the pipette. (nature.com)
Influence of membrane lipid composition on cellular process i.e. (edu.au)
The role of membrane lipid composition in ageing i.e. (edu.au)
Analysis of the biomass composition of H. panicea from Kiel Bight revealed glycogen and lipid contents of 10-30 mg per g ash-free dry weight and 80-140 mg per g ash-free dry weight, respectively ( Barthel, 1986 ). (frontiersin.org)
We hypothesize that the composition of lipids plays an important role in phenol tolerance. (biomedcentral.com)
These results indicate that phenol adaptation affected mycolic acid membrane composition. (biomedcentral.com)
Our results suggest that the alteration of the mycolic acid and phospholipid membrane composition may be a strategy of R. opacus for phenol tolerance. (biomedcentral.com)

Rezanka and Sigler, 2009 ) and used as structural components in cellular membranes ( Rod'kina, 2005 ). (frontiersin.org)
In addition to being an efficacious membrane antioxidant, vitamin E has a much broader physiological importance, ranging from maintaining tissue's structural integrity to supporting neural growth and reproduction as well as modulating immunity. (dsm.com)
Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. (yale.edu)

The headline says, "A massive supercomplex induces membrane curvature for cellular respiration. (evolutionnews.org)

It is known that GSLs interact with both intracellular as well as exogenous proteins and are critical for membrane organisation, signalling, and recognition events. (springer.com)
1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)

[ 4 ] If pancreatitis is likely or potentially threatening and levels of triglycerides are found to be 1000 mg/dL or greater, immediate institution of lipid lowering therapy should begin. (medscape.com)

Stomatin, prohibitin, flotillin, and HflK/C (SPFH) domain proteins are found in the lipid raft microdomains of various cellular membranes. (rcsb.org)
Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)

Actively maintained close appositions, or contact sites, between organelle membranes, enable the efficient transfer of biomolecules between the various cellular compartments. (ucl.ac.uk)

Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)

The peripheral membrane proteins are only linked to the membrane through interactions with different proteins, they are exterior and not part of the membrane itself. (databasefootball.com)

The advantages of homochiral membranes compared to those of heterochiral membranes were analysed in terms of specific recognition, optimal functions of enzymes, membrane fluidity and topological packing. (mdpi.com)

Ozone reacts with the unsaturated fatty acids of the lipid layer in cellular membranes, forming hydro peroxides. (silvermedicine.org)
The results clearly highlight the influence of the different fatty acids of the Gb 3 sphingolipids on the phase behaviour and the binding properties of Shiga toxin B subunits, even though the membranes were only doped with 5 mol% of the receptor lipid. (springer.com)

Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1β−induced gene expression of inducible NO synthase (iNOS) and NO release from β-cells. (diabetesjournals.org)
IL-1β treatment also increased (within 20 min) the translocation of H-Ras into lipid rafts. (diabetesjournals.org)

In an organic chemistry general sense, an ether lipid implies an ether bridge between an alkyl group (a lipid) and an unspecified alkyl or aryl group, not necessarily glycerol. (wikipedia.org)
Chemistry and Physics of Lipids. (wikipedia.org)
Welander became interested in studying this microbe because of its rare chemistry, including its unusual lipid membranes. (stanford.edu)

The contemporary archaea , comprising of methanogens, halobacteria and thermoacidophiles, are living under extreme conditions reminiscent of primitive environment and may indicate the origin of one ancient evolution path of lipid biosynthesis. (mdpi.com)
Scientists had known that this group of microbes - called archaea - were surrounded by a membrane made of different chemical components than those of bacteria, plants or animals. (stanford.edu)
This is the first time we've actually linked some part of a lipid to an environmental condition in archaea. (stanford.edu)

PyruvateCarboxylase (PC) is a pivotal enzyme to generate lipid precursors. (kth.se)
Two sets of experiments were conducted to study dehydration reactions of model lipid precursors in aqueous media to form acyl polyols and wax esters, and to evaluate the stability and reactions of the products at elevated temperatures. (nih.gov)

This study relates the lipid content of two marine filter-feeding demosponges, Halichondria panicea and H. bowerbanki to the seasonal availability of their suspended food, mainly free-living bacteria and phytoplankton at two study sites in Danish waters. (frontiersin.org)
The aim was to investigate if the lipid content of sponges is linked to food availability and season, and to what extend free-living bacteria are available in starvation periods where the phytoplankton biomass is low. (frontiersin.org)
Unlike plants and fungi, archaeal organisms do not produce protective outer walls of cellulose and their membranes do not contain the same chemicals as bacteria. (stanford.edu)

The effects of neurotoxicity depends on various different factors such as the characteristics of the neurotoxin, the dose a person has been exposed to, ability to metabolise and excrete the toxin, the ability of affected mechanism and structures to recover and how vulnerable a cellular target is. (news-medical.net)

A dynamic view of cellular processes by in vivo fluorescence auto- and cross-correlation spectroscopy. (mpg.de)
Our results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses. (cdc.gov)

These proteins share their lipid transport domain, thus expanding this family of lipid transporters. (ucl.ac.uk)

Study of function at cellular, systemic, and organismic level, with emphasis on the integrated organism and associated control systems. (cuny.edu)

The present study was aimed to evaluate the oxidants, enzymatic and nonenzymatic antioxidants, glycoproteins and membrane adenosine triphosphatases (ATPases). (scialert.net)

2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)

The results again demonstrate that the fatty acid of Gb 3 plays a pivotal role for the overall membrane organisation. (springer.com)

Ether lipid may also refer to alkylglycerols, such as chimyl (16:0), batyl (18:0), and selachyl (18:1 n-9) alcohols, with an ether-bound lipid on position sn-1, and the other two positions on the glycerol backbone unoccupied. (wikipedia.org)

Researchers are working to determine whether there is a link between problems with lipid homeostasis and brain iron accumulation and how these abnormalities might contribute to the features of this disorder. (medlineplus.gov)

Many livestock species have their semen processed in these ways, but not all species and individuals are equally susceptible to cellular stress. (selectbreeders.com)
Scientists had explored how the species produced its unusual membrane for about 10 years before experimentation stopped in 2006, she said. (stanford.edu)

and consequently membrane deformation.Second, we clarified BIN1's role in actin dynamics. (kth.se)
Accurate Determination of Membrane Dynamics with Line-Scan FCS. (mpg.de)
The scope of the systems covered ranges from cellular to tissue, organ, systems studies, and up to populational dynamics. (nih.gov)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

2018 ). Here, we will solely focus on the less recognized globosides and in particular the globoside Gb 3 , which is the membrane receptor for vero toxins. (springer.com)

Triglyceride is the most abundant dietary lipid compound found throughout the diet and is the method with which energy is stored in the body. (medscape.com)

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Metabolism7

Peroxidation3

Protein24

Phospholipids6

Plasma membrane1

Raft-exhibiting mode2

Carbohydrates2

Compounds8

Liposomes5

Bilayers2

Molecular12

Proteins and lipids3

Protection of cellular membranes2

Nucleic acids1

Fluorescence Correlation2

Biological3

Vesicles2

Molecule4

Signal transduction1

Soluble5

Mitochondria2

Cell31

Composition8

Structural3

Curvature1

Intracellular2

Triglycerides1

Microdomains2

Biomolecules1

Antioxidant1

Peripheral Membrane1

Fluidity1

Acids2

Rafts2

Chemistry3

Archaea3

Precursors2

Bacteria3

Structures1

Processes2

Transporters1

Integrated organism1

Antioxidants1

Concentrations1

Fatty acid1

Glycerol1

Homeostasis1

Species2

Dynamics4

20181

Dietary1