Cellular hepatocyte nuclear factor 1. Medical search. Frequent questions

The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. (wikipedia.org)
The overall goal of my research program is to understand the role of nuclear receptors in hepatic metabolism and chronic liver disease. (bcm.edu)
Wilson's disease patients and Atp7b -/- mice have profound mitochondria and nuclear ultrastructural changes that are likely due to copper induction of redox stress in the hepatocyte and develop spontaneous hepatic nodules between 10-16 months of age. (bcm.edu)
Unlike hepatic expression, hepatocyte nuclear factor-4 binding to the promoter is not required for ectopic FVII expression, although Sp1 binding is essential. (figshare.com)

The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
Therefore, the expression of a number of growth factors and their receptors, all of which affect fetal lung development, is temporally and spatially regulated. (medscape.com)
Our current projects aim to understand the mechanisms driving metabolic and hepatocellular changes in Atp7b -/- mice and whether ligand activation of nuclear receptors lessens the hepatocellular dysfunction in Wilson's disease. (bcm.edu)
Dr. Wooton-Kee's research interests include the study of Wilson's disease, nuclear receptors, liver regeneration, and nonalcoholic fatty liver disease. (bcm.edu)
Members of the family of nuclear receptors, the three peroxisome proliferator-activated receptors (PPARs), PPARα, PPARβ/δ, and PPARγ take part in the modulation of these pathways. (encyclopedia.pub)
Free circulating insulin activates insulin receptors on the surface of target cells eliciting a signaling cascade initiated by the activation of insulin receptor substrates (IRS 1-4) followed by phosphorylation of phosphoinositide 3-kinase (PI3K), which manages metabolic response including PDK1 and Akt stimulation by phosphorylation. (encyclopedia.pub)

However, only half of the genetic regulation of gene expression is expected to be in cis, e.g. by genetic variation within 1 Mb of the gene. (ucsd.edu)
As a result, our ability to identify disease-associated genes via TWAS should substantially improve due to (1) the enhanced identification of genes regulated by genetic variation and (2) the increased accuracy with which we can predict an individual's gene expression. (ucsd.edu)
Transposable elements (TEs) or mobile elements are genetic components that can have a significant effect on the host genome [ 1 , 2 ]. (ecancer.org)
We consider how, over the last 20 years, advances in genetic engineering and cell culture techniques have improved the efficiency and efficacy of the transdifferentiation process and brought us closer to a clinically relevant therapy for type 1 diabetes (T1D). (silverchair.com)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)

Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene. (wikipedia.org)
Mutations in the HNF4A gene are associated with a form of diabetes called maturity onset diabetes of the young (MODY), specifically MODY 1. (wikipedia.org)
Our lab identified that excessive copper concentrations decreased metabolic nuclear receptor activity (FXR - farnesoid X receptor, HNF4a - hepatocyte nuclear factor, and LRH-1 - liver receptor homolog-1) in vivo, Atp7b -/- mice, and Wilson's disease patients. (bcm.edu)

Here, we found that XPOT (Exportin-T), a nuclear export protein receptor of tRNAs, is associated with poor prognosis in breast cancer and directly orchestrates the nuclear export of a subset of tRNAs, subsequently promoting protein synthesis and proliferation of human TNBC cells. (bvsalud.org)
Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)
Recently, a molecular evolution study of the HERV-W provirus in several ape species and 24 humans demonstrated the conservation of syncytin-1, as well as its retention of receptor-mediated fusogenic activity [ 14 ]. (ecancer.org)
Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. (bu.edu)
Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. (bu.edu)
We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. (bu.edu)
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily - Update 2023. (bu.edu)
upstream of AMPK and mTORC1, Akt and IGF-1 receptor were activated. (uthscsa.edu)
The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)

Genes expressed in LRECe revealed retention of some stem-like properties along with up-regulation of differentiation factors. (frontiersin.org)
Transcription of the fibrinogen genes is mediated by hepatocyte nuclear factor 1 and modulated by interleukin 6. (mhmedical.com)
The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
Furthermore, a genome-wide RNAi screen for genes that regulate cellular clock functions in human cells identified the insulin signaling pathway as the most overrepresented pathway [ 15 ] . (encyclopedia.pub)
However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)

Signals from these growth factors are integrated with environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. (medscape.com)
We develop methods that are based in statistics, machine learning, optimization and graph theory to understand how changes in the 3D genome affect cellular outcome such as development, differentiation and gene expression. (ucsd.edu)
Autophagy also regulates cell proliferation, differentiation, survival, and apoptosis, highlighting its role in maintaining cellular homeostasis [ 1 ]. (hindawi.com)
Nuclear corepressor SMRT acts as a strong regulator of both ß-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. (bu.edu)
Both transcription factor-based reprogramming and directed differentiation approaches ultimately exploit transcription factors to influence cellular identity. (silverchair.com)
Here, we explore the evolution of reprogramming and directed differentiation approaches within the context of hepatocyte to β-cell transdifferentiation focussing on how the introduction of new techniques has improved our ability to generate β-cells. (silverchair.com)
Reprogramming techniques continue to evolve as we learn more about the developmental and molecular cues which govern cellular differentiation and identity. (silverchair.com)

Through codon preferential analysis and protein mass spectrometry, we found that XPOT preferentially transported nuclear tRNA-Ala-AGC-10-1 to the cytoplasm, driving the translation of TPR Repeat Protein 19 (TTC19). (bvsalud.org)
Western blotting was performed to examine the protein expression levels of endoplasmic reticulum stress (ERS)‑associated factors. (spandidos-publications.com)
Insulin signaling affects multiple downstream pathways including mitogen-activated protein kinase (MAPK), which controls growth, sterol regulatory element-binding protein 1 (SREBP-1), which stimulates the synthesis of lipid and cholesterol as well as the family of Forkhead (FOXO) transcription factors regulating metabolism and autophagy [ 9 ] [ 10 ] . (encyclopedia.pub)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
Tau protein aggregation is associated with cellular senescence in the brain. (uthscsa.edu)
at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. (stanford.edu)

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. (usc.edu)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
The Part 1 post was concerned principally with interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)
In both sexes, aging promoted kidney activation of transforming growth factor β-1 signaling pathway. (uthscsa.edu)

Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo J Virol. (usc.edu)
In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)

No effect of fibrates on synthesis of apolipoprotein(a) in primary cultures of cynomolgus monkey and human hepatocytes: apolipoprotein A-I synthesis increased. (embl.de)
Because lp(a) levels in vivo are mainly regulated at synthesis level, we studied the effect of fibrates on the synthesis of apolipoprotein(a) (apo(a)) in primary cultures of cynomolgus monkey and human hepatocytes. (embl.de)
BA synthesis in the liver is the primary form of cholesterol catabolism ( Fig. 1 ). (aspetjournals.org)

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. (bu.edu)
Liver carcinogenesis is a multistep, long process associated with multiple risk factors, e.g. viral hepatitis, alcohol abuse, metabolic disorders, and obesity [ 2 ]. (aging-us.com)

Krüppel-like factor 15 activates hepatitis B virus gene expression and replication Hepatology. (usc.edu)
Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH. (ucdenver.edu)
Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)

A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
Ischemia-reperfusion injury, which involves complex inflammatory pathways, is a significant cause of liver damage and an important factor in a variety of diseases, injuries, and procedures that include (but not limited to) transplant and trauma. (ectrx.org)
In this report, a comprehensive analysis of those factors is provided, and the fundamental molecular inflammatory mediators present after liver ischemia and reperfusion are discussed. (ectrx.org)
Investigations involving animal models and human trials are reviewed, a summary of significant studies in human subjects is presented ( Table 1 ), and the pathways and mediators important in liver ischemia-reperfusion injury are described ( Figure 1 ). (ectrx.org)
To further study the role of tTG in liver disease, we initiated investigations into the effect of a proinflammatory mediator, tumor necrosis factor (TNF)-alpha, on tTG activity in cultured liver cells. (nih.gov)
Liver biopsy sample shows typical findings of perivenular polymorphonuclear infiltrate and ballooning degeneration of hepatocytes (hematoxylin and eosin [H&E] stain). (medscape.com)
Thus, liver nLD and cLD are both dynamic cellular organelles. (unlp.edu.ar)

Treatment of human Hep G2 cells with 1 ng/ml TNF-alpha increased [14C]putrescine cross-linking to cellular proteins. (nih.gov)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)
nLD could be involved in nuclear-lipid homeostasis serving as an endonuclear buffering system that would provide or incorporate lipids and proteins involved in signalling pathways as transcription factors and as enzymes of lipid metabolism and nuclear processes. (unlp.edu.ar)
And d) Another very basic problem is that cancer cells tend to be remarkably clever and naturally seek to take advantage of numerous cellular survival mechanisms to stay alive under stress, for example by upregulating heat shock proteins or DNA repair mechanisms. (anti-agingfirewalls.com)
Two of these WW domains, in the proteins FBP11 and FBP21, are strikingly similar to those found in the yeast splicing factor PRP40. (embl.de)
5 , 6 In concordance with the role of nodal cilia in L-R asymmetry, mutations in the motor proteins Kif3A and Kif3B, and the transcription factor Foxj1 in the mouse have demonstrated that ciliary motility is important for L-R asymmetry. (bmj.com)
Cellular identity is determined by the transcriptional profile which comprises the subset of mRNAs, and therefore proteins, being expressed by a cell at a given point in time. (silverchair.com)

TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism PLoS Pathog. (usc.edu)
Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling PLoS One. (usc.edu)
Induction of canonical autophagy is mainly controlled by the AKT/mTOR and AMPK signaling pathways and relies on the activation and assembly of two macromolecular complexes, the ATG1/ULK1 and the Class III phosphatidylinositol 3-kinase (PI3K) complex (Figure 1 ) [ 5 ]. (hindawi.com)
Akt signaling prompts glucose transporter 4 (GLUT4) to translocate to the cell membrane where it initiates cellular glucose uptake. (encyclopedia.pub)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
The limitations of current therapeutics primarily reflect incomplete understanding of the complex molecular signaling processes contributing to the heterogeneous nature of the disease [ 1 ]. (aging-us.com)

One well-established example of transdifferentiation is the conversion of hepatocytes to pancreatic β-cells. (silverchair.com)
Here, we discuss how transcription factors, and their unique position as the gatekeepers of cellular identity, are exploited in cell reprogramming protocols by exploring work focusing on one reprogramming paradigm - the transdifferentiation of hepatocytes to pancreatic beta cells (β-cell). (silverchair.com)

A decrease in the level of tumor necrosis factor α and the expression of inducible nitric oxide synthase as well as a (possibly) preserved mitochondrial redox status have also been noted as a result of exogenous melatonin treatment (39). (ectrx.org)
Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)

Increasingly, complimentary cell culture techniques, which recapitulate the developmental microenvironment, are employed to coax cells to adopt new identities by indirectly regulating transcription factor activity via intracellular signalling pathways. (silverchair.com)

Primary hepatocytes isolated from a transgenic mouse line containing the mouse tTG promoter driving the beta-galactosidase reporter, show similar time-dependent increases in promoter activity when treated with TNF-alpha. (nih.gov)

An analysis of an interactome for apoptosis factor, Ei24/PIG8, using the inducible expression system and shotgun proteomics. (nih.gov)

[ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
[ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 1.5 cases per 100,000 individuals in the United States. (medscape.com)

Neutral lipids - involved in many cellular processes - are stored as lipid droplets (LD), those mainly cytosolic (cLD) along with a small nuclear population (nLD). (unlp.edu.ar)
These results would imply that nLD are actively involved in nuclear processes that include lipids. (unlp.edu.ar)
For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell interaction and internalization, intracellular sorting, long-range retrograde axonal transport, endosomal liberation, and nuclear import. (frontiersin.org)

Ectopic expression of vector-delivered transcription factors (particularly the triumvirate of Pdx1, Ngn3 and MafA) induces reprogramming through broad transcriptional remodelling. (silverchair.com)

Lung development is regulated by several transcription factors, such as thyroid transcription factor 1 (TTF-1) family, hepatocyte nuclear family, and peptide growth factors. (medscape.com)
The antimicrobial peptide, beta-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. (cdc.gov)

One of the restrictive nutritional approaches, caloric restriction (CR) achieves stunning results in extending health span and life span via coordinated changes in multiple biological functions from the molecular, cellular, to the whole-body levels. (encyclopedia.pub)
It is highly probable that therapeutic manipulation of one ecosystem affects the others, a phenomenon that needs to be analyzed in view of the increasing cellular and molecular complexity of therapy responses (Barker et al. (biomedcentral.com)
Due to its conserved genome, transparent body, and relatively simple neuroanatomy, C. elegans has become a powerful model organism for studying the cellular and molecular mechanisms underlying axon regeneration. (uthscsa.edu)
Identifying the underlying molecular mechanisms by which BA regulation is disrupted by endogenous and/or xenobiotic factors will aid in not only understanding disease pathogenesis, but also providing novel strategies to prevent and/or treat diseases associated with BA dysregulation. (aspetjournals.org)

Cellular Physiology and Biochemistry (2018) 49 (5): 1943-1958. (karger.com)

Amongst their many roles, mitochondria play a crucial function in energy production, iron homeostasis, and the biosynthesis of lipids, amino acids and nucleic acids [ 1 , 2 ]. (nature.com)

Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)

Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1 (HIV) infection has led to marked improvement in life-expectancy for those infected with HIV. (opencardiovascularmedicinejournal.com)
These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)

Gel shift experiments using nuclear extracts from TNF-alpha-treated cells and oligonucleotides containing the tTG nuclear factor (NF)-kappa B motif revealed increased binding, concordant with mRNA data. (nih.gov)
Tissue factor/coagulation factor VII (fVII) complex formation on the surface of cancer cells plays important roles in cancer biology, such as cell migration and invasion, angiogenesis, and antiapoptotic effects. (figshare.com)
Oleic-acid (OA) added to rat hepatocytes or HepG2 cells in culture produced cellular-phenotypic LD modifications: increases in TAG, CE, C, and PL content and in cLD and nLD numbers and sizes. (unlp.edu.ar)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

Mitochondria contain several DAMPs that can be released upon mitochondrial stress or damage (Fig. 1 ). (nature.com)

Furthermore, we found novel nuclear targets of basal hepatocytic and ectopic FVII expression. (figshare.com)
The direct interconnection between CR and circadian rhythms has been evinced by the fact that Igf-1 expression is regulated by both CR and the circadian clock [ 14 ] . (encyclopedia.pub)
Interestingly, Igf-1 expression is rhythmic and shows sexual dimorphism [ 14 ] . (encyclopedia.pub)
Insulin secreted upon refeeding-after-fasting stimulates Per2 and reduces Rev-erbα expression in hepatocytes [ 18 ] . (encyclopedia.pub)
These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. (bu.edu)
We examine how transdifferentiation protocols are evolving to ever more faithfully recapitulate normal developmental biology using increasingly sophisticated biomimetic techniques and ectopic transcription factor expression. (silverchair.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

The activation of nuclear factor-κB (NF-κB) was also evaluated using immunofluorescence. (molvis.org)

Canonical autophagy initiates with the formation of a small vesicular sac called a phagophore (Figure 1 ). (hindawi.com)

A total of 48 pregnant Crl:CD-1 mice were purchased from Orientbio (Seongnam, South Korea). (molvis.org)
Accordingly, the impact of CR on plasma IGF-1 and insulin level is compromised in mice deficient for Bmal1 [ 16 ] . (encyclopedia.pub)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

25(1): 90, 2023 07 28. (bvsalud.org)

A better understanding of the levers governing transcription factor activity benefits our ability to generate therapeutic cell types at will. (silverchair.com)
Such ``priming'' is also clear that both GATA-1 and PU.1 cross-antagonize each behavior for progenitors could allow for rapid deployment of other's activity. (lu.se)

Life Sci, 2021 Jan 1. (nih.gov)

The study also reported that recurrence risk factors for these lesions included positive and uncertain resection margins, as well as younger age at diagnosis. (medscape.com)

In addition, we assessed whether sex was a significant factor in either baseline assessment or as an interaction with rapamycin treatment. (uthscsa.edu)

Increased amplification of hepatocyte nuclear factor 4 alpha has been observed in colorectal cancer. (wikipedia.org)
An increase in tTG mRNA content was observed 1 h after addition of TNF-alpha, and levels of tTG mRNA remained elevated after 24 h. (nih.gov)

Correction to: ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures. (ottawaheart.ca)
In Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. (ottawaheart.ca)

Immunohistochemical demonstra- inflammation has also been noted in the peripheral nerves tion of viral antigen within the brain and vegetative nerve ( 5 ), myocardium ( 1 , 6 , 7 ), and adrenal glands ( 7 ). (cdc.gov)

2019). Disorders of fibrinogen and factor xiii. (mhmedical.com)

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