• expression
  • Expression of MAL antigen, a lipid raft component, is another unique characteristic feature of PMBCL, not found in other DLBCL. (clinicaladvisor.com)
  • 3. The stem cell of claim 1, wherein the gene product comprises a lineage-specific or cell fate gene that is integrated into the genome such that expression of the lineage-specific or cell fate gene is driven by an endogenous promoter. (patentsencyclopedia.com)
  • 16. A method of treating a disease characterized by reduced expression of a functional gene product in a subject in need of treatment, the method comprising:administering a population of stem cells according to claim 15 to the subject, wherein the stem cells express the functional gene product. (patentsencyclopedia.com)
  • 19. A method of reducing or eliminating positional variation effects associated with transgene insertion into a specified region of a stem cell, the method comprising:providing a stem cell in which the transgene inserted at one allele of the specified region comprises a gene expression construct comprising a regulatable construct and in which the other allele of the specified region comprises a transactivator for the regulatable promoter. (patentsencyclopedia.com)
  • receptor
  • Single H/RS cells with cytotoxic T cell phenotype were micromanipulated from three cases of cHD and analyzed by single cell polymerase chain reaction for immunoglobulin heavy (IgH) and light chain (IgL) gene rearrangements, T cell receptor (TCR)-β gene rearrangements, and germline configuration of the IgH and TCR-β loci. (rupress.org)
  • and soluble IL-2 receptor (sCD25) have been recorded in patients with HLH in combination with impaired/absent natural killer (NK) cell activity. (gotoper.com)
  • Recall the biological reason that many lymphomas contain balanced translocations involving the immunoglobulin and T cell receptor genes. (brainscape.com)
  • due to natural susceptibility of genome to translocations in periods of genomic instability, especially in initial Ig/Tcell receptor rearrangement -this occurs during B/T cell maturation and class recombination and somatic hypermutation in B cell activation. (brainscape.com)
  • hematopoietic
  • Bone marrow examination often reveals characteristic hemophagocytes- histocytes with engulfed hematopoietic elements, including nucleated erythroid precursors, white blood cell precursors, and platelets-which are best depicted in marrow aspirate smears. (gotoper.com)
  • solid mass -extramedullary myeloid tumor (granulocytic sarcoma): malignancy of hematopoietic cells, from myeloid cells or precursors (granulocytes, monocytes) presents as solid mass -many prefer one type of manifestation, these types of disease manifestations are not exclusive-often overlap -overlap of CLL and SLL: same biologic disease, but differs if blood and marrow (CLL) vs. enlarged lymph node due to growth (SLL). (brainscape.com)
  • Myelodisplastic syndrome (MDS): clonal population of neoplastic hematopoietic stem cells takes over marrow. (brainscape.com)
  • 4. The stem cell of claim 1, wherein the stem cell is selected from the group consisting of a hematopoietic stem cell, a mesenchymal stem cell, an embryonic stem cell, a neuronal stem cell, a muscle stem cell, a liver stem cell, a skin stem cell, an induced pluripotent stem cell and combinations thereof. (patentsencyclopedia.com)
  • characteristic
  • The effect of nanoparticles on magnetic fields can be used to determine the location of a disease, and a measure of the number of cells characteristic of the disease. (google.de)
  • 1 . A method for treating disease, comprising (a) determining the location and number of cells characteristic of the disease according to claim 2 , and (b) applying a therapy to the patient. (google.de)
  • 6 . A method according to claim 1 , further comprising (c) determining a measure of the number of cells characteristic of the disease after treatment, then repeating steps (b) and (c) until a desired number of cells characteristic of the disease have been eliminated from the tumor. (google.de)
  • b4) treating the patient such that the inhibitor is overcome and drug acts on the cells characteristic of the disease. (google.de)
  • 9 . A method as in claim 1 , further comprising (c) determining from the magnetic effect of nanoparticles a measure of the number of cells characteristic of the disease remaining after such treatment, (d) repeating steps (b) and (c) until the number of cells characteristic of the disease remaining is below a threshold value. (google.de)
  • 11 . A method as in claim 1 , further comprising (c) determining a measure of the number of cells characteristic of the disease by the magnetic effect of nanoparticles introduced into the cells, (d) repeating steps (b) and (c) until the number cells characteristic of the disease is below a threshold value, wherein the number of cells characteristic of the disease remaining is determined from a plurality of measurements. (google.de)
  • lymphocytes
  • 1% of cells within a complex admixture of lymphocytes, plasma cells, histiocytes, and eosinophils ( 1 ). (rupress.org)
  • To clarify whether H/RS cells in such cases are indeed derived from T lymphocytes, H/RS cells were micromanipulated and subjected to single cell PCR analysis for rearranged Ig heavy chain (IgH), Igκ, and Igλ light chain genes, TCR-β VDJ and DJ gene rearrangements, as well as IgH and TCR-β germline configuration (i.e., absence of rearrangements). (rupress.org)
  • diffuse
  • PMBCL tumors have a diffuse growth pattern of large cells with clear cytoplasm and it is commonly associated with fibrosis, which tends to compartmentalize the tumor. (clinicaladvisor.com)
  • pleomorphic
  • MGZL typically are composed of confluent sheet-like growths of pleomorphic tumour cells in diffusely fibrotic stroma. (clinicaladvisor.com)
  • The cells are usually larger and more pleomorphic than in PMBCL. (clinicaladvisor.com)
  • Histopathological findings may simulate mycosis fungoides with a superficial lymphocytic infiltrate with epidermotropism, but can also have a dense infiltration of medium-sized to large pleomorphic and epidermotropic T-cells. (oncologynurseadvisor.com)
  • Interestingly, cyclin D1 was also expressed by cells consistent with LP cells (large, pleomorphic cells having highly lobated nuclei). (gotoper.com)
  • tissue
  • Preparation of the sample is critical to maintain cell morphology, tissue architecture and the antigenicity of target epitopes. (wikipedia.org)
  • The specific features of a reactive mesothelial proliferation that may mimic a neoplasm include high cellularity, the presence of numerous mitotic figures and cytologic atypia, the presence of necrosis, the formation of papillary groups, and entrapment of mesothelial cells within fibrous tissue mimicking invasion (Figure 1). (biomedsearch.com)
  • 10. The stem cell of claim 7, wherein the sequence encoding the protein is expressed constitutively, inducibely or tissue-specifically. (patentsencyclopedia.com)
  • nuclei
  • The LP cells have scant cytoplasm and one folded or multilobated nuclei with prominent, mostly basophilic nucleoli. (wikipedia.org)
  • All morphological variants are characterized by a variable proportion of large hallmark cells with eccentric horse-shoe or kidney-shaped nuclei, often with eosinophilic region near the nucleus (Figure 1 ). (hindawi.com)
  • Primary
  • Though lesions in primary cutaneous ALCL frequently spontaneously resolve, resolution may be prolonged without therapy and typically occurs with scarring, and, thus the course is more often altered by initiation of a therapeutic regimen. (oncologynurseadvisor.com)
  • stroma
  • It consists of mixed inflammatory infiltrates with nodules of epithelioid, spindled and bizarre-appearing cells within a fibrosclerotic-to-myxoid stroma. (thedoctorsdoctor.com)
  • type
  • Skin lesions in the smoldering type may have sparse dermal infiltrates with only slightly atypical cells. (oncologynurseadvisor.com)
  • 1. A stem cell comprising a transgene, wherein the transgene comprises a gene product, wherein the transgene is integrated into a specified region of the genome of the stem, cell such that gene product is transcribed or translated upon or during differentiation of the stem cell into a lineage-specific or mature cell type. (patentsencyclopedia.com)
  • 13. A method of isolating cells of a selected cell type, the method comprising:culturing a population of stem cells according to claim 1, wherein the gene product is expressed in cells of the selected cell type and isolating the cells that express the gene product, thereby isolating cells of the selected type. (patentsencyclopedia.com)
  • tumors
  • Immunohistochemical staining is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. (wikipedia.org)
  • erythroid
  • myeloid malignancies: arising from mature/immature members of granulocytic, monocytic, erythroid, megakaryociytic, mast cells -lymphoid malignancies: arising from mature/immature members of B, T, NK cells -acute leukemia: majority are classified as AML or ALL. (brainscape.com)
  • benign
  • and so are the intraepidermal benign, clear, Toker cells located singly or as small groups around the nipple duct orifices) & especially in distinguishing intraepidermal Paget's from melanoma (both can be S100 pos. (palpath.com)
  • Lymphocyte
  • This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. (cancerindex.org)
  • wherein
  • 4 . A method as in claim 1 , wherein step (b) comprises applying hyperthermia to the region of the cells. (google.de)
  • 5 . A method as in claim 4 , wherein applying hyperthermia comprises applying an oscillating magnetic field to the region of the cells, wherein the oscillating magnetic field generates heat by its effect on the nanoparticle/feature conjugates. (google.de)
  • 2. The method of claim 1, wherein the cell is a diseased cell. (patentsencyclopedia.com)
  • 2. The stem cell of claim 1, wherein the transgene further comprises a lineage-specific or cell fate promoter operably linked to the gene product. (patentsencyclopedia.com)
  • 5. The stem cell of claim 1, wherein the stem cell is a mammalian stem cell. (patentsencyclopedia.com)
  • 6. The stem cell of claim 5, wherein the stem cell is a human induced pluripotent stem cell (hiPSC). (patentsencyclopedia.com)
  • 7. The stem cell of claim 1, wherein the gene product comprises a protein. (patentsencyclopedia.com)
  • 8. The stem cell of claim 1, wherein the gene product comprises sequences that are transcribed into an RNA product. (patentsencyclopedia.com)
  • 11. The stem cell of claim 1, wherein the transgene is flanked by recombinase sites. (patentsencyclopedia.com)
  • 15. A method of producing a gene product in a stem cell, the method comprising:providing a population of stem cells according to claim 1, wherein the sequence is integrated into a non-essential site in the stem cells, andculturing the population of stem cells, wherein the population of cultured stem cells uniformly expresses the gene product. (patentsencyclopedia.com)
  • 18. The method of claim 13, wherein the transgene is introduced into the stem cell using a plasmid, linear DNA, an adenovirus vector or a retroviral vector. (patentsencyclopedia.com)
  • inflammatory
  • The tumor presented as a mass in the dorsum of the foot in a 53-year-old woman and showed the typical virocyte-like and lipoblast-like cells in a myxoid and inflammatory background. (thedoctorsdoctor.com)
  • contrast
  • In contrast, H/RS cells from an additional case harbored clonal TCR-β variable/diversity/joining (VDJ) and DJ gene rearrangements, whereas the IgH locus was in germline configuration on both alleles. (rupress.org)