• tissues
  • The authors revise the concept of anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. (hindawi.com)
  • For formalin-fixed paraffin-embedded tissues, antigen-retrieval is often necessary, and involves pre-treating the sections with heat or protease. (wikipedia.org)
  • B-cell chronic lymphocytic leukemia (CLL) is marked by the accumulation of CD5+ B lymphocytes within the blood, bone marrow (BM), and secondary lymphoid tissues. (cancerindex.org)
  • Upon antigen encounter, they are activated, differentiate into a specific subtype, expand, and fulfill their role as effector cells, e.g., by migrating into various tissues and organs. (miltenyibiotec.com)
  • Hodgkin
  • According to the WHO classification, ALCL is not sustained by a unique histotype but actually includes five morphologic variants (common, giant cell-rich, lympho-histiocytic, small-cell type, and Hodgkin-like) [ 1 , 2 , 13 , 14 ]. (hindawi.com)
  • characteristic
  • Its diagnosis is based on the identification of characteristic multinucleated giant cells within an inflammatory milieu. (hindawi.com)
  • Bone marrow examination often reveals characteristic hemophagocytes- histocytes with engulfed hematopoietic elements, including nucleated erythroid precursors, white blood cell precursors, and platelets-which are best depicted in marrow aspirate smears. (gotoper.com)
  • The effect of nanoparticles on magnetic fields can be used to determine the location of a disease, and a measure of the number of cells characteristic of the disease. (google.de)
  • 1 . A method for treating disease, comprising (a) determining the location and number of cells characteristic of the disease according to claim 2 , and (b) applying a therapy to the patient. (google.de)
  • 6 . A method according to claim 1 , further comprising (c) determining a measure of the number of cells characteristic of the disease after treatment, then repeating steps (b) and (c) until a desired number of cells characteristic of the disease have been eliminated from the tumor. (google.de)
  • b4) treating the patient such that the inhibitor is overcome and drug acts on the cells characteristic of the disease. (google.de)
  • 9 . A method as in claim 1 , further comprising (c) determining from the magnetic effect of nanoparticles a measure of the number of cells characteristic of the disease remaining after such treatment, (d) repeating steps (b) and (c) until the number of cells characteristic of the disease remaining is below a threshold value. (google.de)
  • 11 . A method as in claim 1 , further comprising (c) determining a measure of the number of cells characteristic of the disease by the magnetic effect of nanoparticles introduced into the cells, (d) repeating steps (b) and (c) until the number cells characteristic of the disease is below a threshold value, wherein the number of cells characteristic of the disease remaining is determined from a plurality of measurements. (google.de)
  • whereas
  • H/RS cells from two cases of cHD harbored clonal, somatically mutated Ig gene rearrangements, whereas TCR-β loci were in germline configuration. (rupress.org)
  • In contrast, H/RS cells from an additional case harbored clonal TCR-β variable/diversity/joining (VDJ) and DJ gene rearrangements, whereas the IgH locus was in germline configuration on both alleles. (rupress.org)
  • Whereas IgH VDJ gene rearrangements are specific for and restricted to B lineage cells, the presence of TCR-β VDJ gene rearrangements identifies a T cell. (rupress.org)
  • lymphocytes
  • 1% of cells within a complex admixture of lymphocytes, plasma cells, histiocytes, and eosinophils ( 1 ). (rupress.org)
  • To clarify whether H/RS cells in such cases are indeed derived from T lymphocytes, H/RS cells were micromanipulated and subjected to single cell PCR analysis for rearranged Ig heavy chain (IgH), Igκ, and Igλ light chain genes, TCR-β VDJ and DJ gene rearrangements, as well as IgH and TCR-β germline configuration (i.e., absence of rearrangements). (rupress.org)
  • Lymph node biopsy findings at diagnosis were typical of NLPHL, including macronodular architecture with a predomi- nance of small lymphocytes, lesser numbers of histocytes, and a minor population of admixed lymphocyte-predominant (LP) cells (Figure). (gotoper.com)
  • variants
  • Molecular studies have only recently shown that in most if not all cases RS cells, Hodgkin's cells, and cell variants belong to the same clonal population, which is derived from peripheral B cell [ 1 - 9 ]. (hindawi.com)
  • All morphological variants are characterized by a variable proportion of large hallmark cells with eccentric horse-shoe or kidney-shaped nuclei, often with eosinophilic region near the nucleus (Figure 1 ). (hindawi.com)
  • precursors
  • solid mass -extramedullary myeloid tumor (granulocytic sarcoma): malignancy of hematopoietic cells, from myeloid cells or precursors (granulocytes, monocytes) presents as solid mass -many prefer one type of manifestation, these types of disease manifestations are not exclusive-often overlap -overlap of CLL and SLL: same biologic disease, but differs if blood and marrow (CLL) vs. enlarged lymph node due to growth (SLL). (brainscape.com)
  • diffuse
  • PMBCL tumors have a diffuse growth pattern of large cells with clear cytoplasm and it is commonly associated with fibrosis, which tends to compartmentalize the tumor. (clinicaladvisor.com)
  • pleomorphic
  • MGZL typically are composed of confluent sheet-like growths of pleomorphic tumour cells in diffusely fibrotic stroma. (clinicaladvisor.com)
  • The cells are usually larger and more pleomorphic than in PMBCL. (clinicaladvisor.com)
  • Histopathological findings may simulate mycosis fungoides with a superficial lymphocytic infiltrate with epidermotropism, but can also have a dense infiltration of medium-sized to large pleomorphic and epidermotropic T-cells. (oncologynurseadvisor.com)
  • tissue
  • Preparation of the sample is critical to maintain cell morphology, tissue architecture and the antigenicity of target epitopes. (wikipedia.org)
  • The specific features of a reactive mesothelial proliferation that may mimic a neoplasm include high cellularity, the presence of numerous mitotic figures and cytologic atypia, the presence of necrosis, the formation of papillary groups, and entrapment of mesothelial cells within fibrous tissue mimicking invasion (Figure 1). (biomedsearch.com)
  • nuclei
  • The LP cells have scant cytoplasm and one folded or multilobated nuclei with prominent, mostly basophilic nucleoli. (wikipedia.org)
  • Lymphocyte
  • This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. (cancerindex.org)
  • Primary
  • Though lesions in primary cutaneous ALCL frequently spontaneously resolve, resolution may be prolonged without therapy and typically occurs with scarring, and, thus the course is more often altered by initiation of a therapeutic regimen. (oncologynurseadvisor.com)
  • stroma
  • It consists of mixed inflammatory infiltrates with nodules of epithelioid, spindled and bizarre-appearing cells within a fibrosclerotic-to-myxoid stroma. (thedoctorsdoctor.com)
  • inflammatory
  • The tumor presented as a mass in the dorsum of the foot in a 53-year-old woman and showed the typical virocyte-like and lipoblast-like cells in a myxoid and inflammatory background. (thedoctorsdoctor.com)
  • tumors
  • Immunohistochemical staining is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. (wikipedia.org)
  • erythroid
  • myeloid malignancies: arising from mature/immature members of granulocytic, monocytic, erythroid, megakaryociytic, mast cells -lymphoid malignancies: arising from mature/immature members of B, T, NK cells -acute leukemia: majority are classified as AML or ALL. (brainscape.com)
  • benign
  • and so are the intraepidermal benign, clear, Toker cells located singly or as small groups around the nipple duct orifices) & especially in distinguishing intraepidermal Paget's from melanoma (both can be S100 pos. (palpath.com)
  • contrast
  • Furthermore, their characteristics definitely contrast with a possible "stem cell" potential. (hindawi.com)
  • wherein
  • 4 . A method as in claim 1 , wherein step (b) comprises applying hyperthermia to the region of the cells. (google.de)
  • 5 . A method as in claim 4 , wherein applying hyperthermia comprises applying an oscillating magnetic field to the region of the cells, wherein the oscillating magnetic field generates heat by its effect on the nanoparticle/feature conjugates. (google.de)
  • 2. The method of claim 1, wherein the cell is a diseased cell. (patentsencyclopedia.com)