• 2017
  • In 2017, two CAR T-cell therapies were approved by the Food and Drug Administration (FDA), one for the treatment of children with acute lymphoblastic leukemia (ALL) and the other for adults with advanced lymphomas. (cancer.gov)
  • 2018
  • The ISSCR 2018 Annual Meeting went "down under" to Melbourne, Australia where 3,000 stem cell scientists, clinicians, and professionals from 52 countries gathered to share their latest research, network with colleagues, and explore the latest technologies driving the field forward. (isscr.org)
  • Dead Cells is an upcoming roguelike-Metroidvania hybrid video game being developed by Motion Twin, and currently is in early access testing for Microsoft Windows, with plans to bring it to macOS, Linux, Nintendo Switch, PlayStation 4, and Xbox One by the end of 2018. (wikipedia.org)
  • receptor
  • If all goes as planned, the engineered cells further multiply in the patient's body and, with guidance from their engineered receptor, recognize and kill cancer cells that harbor the antigen on their surfaces. (cancer.gov)
  • Janovjak, Grusch and colleagues re-engineered receptor tyrosine kinases (RTKs), essential cell surface receptors that sense growth factors and hormones, to be under the control of light. (medicalnewstoday.com)
  • More specifically, they are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR). (wikipedia.org)
  • J.RT3-T3.5 cells have a mutation in the T cell receptor beta chain locus precluding expression of this chain. (wikipedia.org)
  • They do not express surface CD3 or produce the T cell receptor alpha/beta heterodimer. (wikipedia.org)
  • Since they are deficient in the TCR complex, these cells are a useful tool for transfection studies using T cell receptor alpha and beta chain genes and are widely used in labs in which T cell receptor gene transfer technologies are studied. (wikipedia.org)
  • The D1.1 cell line does not express CD4 molecule, an important co-receptor in the activation pathway of helper T cells. (wikipedia.org)
  • The J.gamma1 subline contains no detectable phospholipase C-gamma1 (PLC-γ1) protein and therefore has profound defects in T cell receptor (TCR) calcium mobilization, and nuclear factor of activated T-cells (NFAT) activation (an important transcription factor in T cells). (wikipedia.org)
  • Nonetheless, OK cells have been used extensively to study functional interactions between the parathyroid hormone 1 receptor (PTH1R) and the sodium-hydrogen exchange regulatory factor 1 (NHERF1). (wikipedia.org)
  • Kit (CD117) is the receptor of Stem Cell Factor. (wikipedia.org)
  • The intracellular aryl hydrocarbon receptor (AhR), which is activated by certain aromatic compounds, is specifically expressed in Treg17 cells. (wikipedia.org)
  • The mechanism of Treg17 cell action is expression of chemokine receptor CCR6, which facilitates trafficking into areas of Th17 inflammation. (wikipedia.org)
  • embryonic
  • The amazing thing is that if you take an aged cell that is fully committed to a certain function, and you transplant its nucleus into an immature egg cell called an oocyte, then you revert its function to a pluripotent, embryonic one, which means it can become any other cell of the body-and you also revert the age of that cell to the youngest age possible. (nautil.us)
  • Since embryonic cells are naturally endowed with a pluripotency program, if you then take that embryo and put it in culture, you can establish pluripotent stem cell lines. (nautil.us)
  • He showed that if you simply boost the expression of four particular transcription factors inside a non-pluripotent cell for a few weeks, you also could create an embryonic-like program. (nautil.us)
  • The primary mouse embryonic fibroblast cells were transferred (the "T") every 3 days (the first "3"), and inoculated at the rigid density of 7005300000000000000♠3×105 cells per 20 cm2 dish (the second "3") continuously. (wikipedia.org)
  • 1962
  • The PtK2 cell line was established by Kristen Walen and Spencer Brown in 1962. (wikipedia.org)
  • 3T3 cells come from a cell line established in 1962 by two scientists then at the Department of Pathology in the New York University School of Medicine, George Todaro and Howard Green. (wikipedia.org)
  • Biology
  • Also visit our affiliated journals, Cell Stem Cell and Current Protocols in Stem Cell Biology , included in Professional Resources. (isscr.org)
  • Journal of Cell Science publishes cutting-edge science, e ncompassing all aspects of cell biology. (biologists.org)
  • they are supported by an outstanding Editorial Advisory Board that reflects all relevant areas in cell biology, including recently emerging fields. (biologists.org)
  • We are pleased to accept submissions for our upcoming Special Issue on Reconstituting Cell Biology , guest edited by Manuel Théry. (biologists.org)
  • Have you seen our latest special issue on Plant Cell Biology , guest edited by Jenny Russinova? (biologists.org)
  • The research professor of reproductive biology at Stanford University keeps the cells warm and moist deep inside the Lorry I. Lokey Stem Cell Research Building, one of the nation's largest stem cell facilities. (nautil.us)
  • The Cells for Sight Team is aiming to understand the biology and therapeutic potential of stem cells (and the cells with which they interact) to develop and deliver novel cell-based therapies and anti-scarring strategies for patients with blinding corneal and conjunctival disease. (ucl.ac.uk)
  • Cells from these lines are also often transfected to produce recombinant proteins for molecular biology, biochemistry, and cell biology experiments. (wikipedia.org)
  • receptors
  • These receptors are "synthetic molecules, they don't exist naturally," explained Carl June, M.D., of the University of Pennsylvania Abramson Cancer Center, during a recent presentation on CAR T cells at the National Institutes of Health campus. (cancer.gov)
  • When a signaling molecule binds to RTKs at the cell surface, two receptors bind to each other in a process called dimerization. (medicalnewstoday.com)
  • In the engineered receptors, the dimerization step and subsequently cell signaling can now be turned on and off by light as the algal proteins sense light and bind to each other. (medicalnewstoday.com)
  • The newly developed receptors trigger complex cellular programs in both cancer and blood endothelial cells. (medicalnewstoday.com)
  • Jurkat cells are an immortalized line of human T lymphocyte cells that are used to study acute T cell leukemia, T cell signaling, and the expression of various chemokine receptors susceptible to viral entry, particularly HIV. (wikipedia.org)
  • Stem Cell
  • The ISSCR advocates worldwide for ethical stem cell research and its translation to the clinic. (isscr.org)
  • Find the resources and connections you need to further drive your career and skills in the ever-changing and exciting field of stem cell research. (isscr.org)
  • Whether you are a job seeker or employer, the ISSCR Job Board is the best place to find and post jobs or CVs within the stem cell science community. (isscr.org)
  • When you join the ISSCR, you become part of the world's largest and most renowned stem cell and regenerative medicine community. (isscr.org)
  • A recent public forum in Melbourne, Australia, "Stem Cell Research - Now and in the Future," allowed scientists and experts to share with the public the potential of this rapidly advancing research. (isscr.org)
  • In this blog post, three Australian stem cell scientists who attended the session describe their personal reflections on public engagement. (isscr.org)
  • The International Society for Stem Cell Research (ISSCR) is an independent nonprofit organization and the voice of the stem cell research community. (isscr.org)
  • The ISSCR was founded in 2002 to foster the exchange of information on stem cell research and now claims more than 4,100 members worldwide. (isscr.org)
  • Stem Cell Reports is the official journal of the ISSCR and is published by Cell Press. (isscr.org)
  • The ISSCR provides a platform for professional and public education and the promotion of rigorous scientific and ethical standards in stem cell research and regenerative medicine. (isscr.org)
  • The Cells for Sight Stem Cell Therapy Research Unit is a MHRA licensed state-of-the-art GMP facility is available to internal and external researchers (academic and commercial) for the manufacture of Advanced Therapy Medicinal Products. (ucl.ac.uk)
  • pathogens
  • As its name implies, the backbone of CAR T-cell therapy is T cells , which are often called the workhorses of the immune system because of their critical role in orchestrating the immune response and killing cells infected by pathogens. (cancer.gov)
  • Treg17 cells regulate the function of Th17 cells that are important role in the host defense against fungal and bacterial pathogens and participate in the pathogenesis of multiple inflammatory and autoimmune disorders. (wikipedia.org)
  • vitro
  • Since their recent discovery, HAP1 cells cultured in vitro have been established as a dependable screening tool for targeted genetics screens. (wikipedia.org)
  • These regulatory Th17 cells are generated by TGF-beta plus IL-6 in vitro. (wikipedia.org)
  • line
  • A431 cells are a model human cell line (epidermoid carcinoma) used in biomedical research. (wikipedia.org)
  • HAP1 cells are a cell line used for biomedical and genetic research. (wikipedia.org)
  • HAP1 cells are a near-haploid cell line derived from the KBM-7 cell line. (wikipedia.org)
  • After its discovery, subsequent experiments have resulted in the HAP1 cell line. (wikipedia.org)
  • HAP1 cells have been used to create a new completely haploid cell line. (wikipedia.org)
  • With this technique, experimenters were able to cultivate the first fully haploid human cell line which they termed eHAP. (wikipedia.org)
  • It is a stable B cell line used to express antibodies. (wikipedia.org)
  • They are a suspension cell line and are best cultured in Eagle's minimal essential medium with 10% Fetal bovine serum, 0.01 units/ml of penicillin and 0.1 mg/ml streptomycin incubated in 37 °C + 5% CO2 + 90% relative humidity with a cell density of 5x105 cell per 15 ml. (wikipedia.org)
  • This cell line is usually used to express antibodies since they can result in antibody titers up to 1 mg under optimum conditions. (wikipedia.org)
  • The Jurkat cell line (originally called JM) was established in the late 1970s from the peripheral blood of a 14-year-old boy with T cell leukemia. (wikipedia.org)
  • Different derivatives of the Jurkat cell line that have been mutated to lack certain genes can now be obtained from cell culture banks. (wikipedia.org)
  • The JCaM1.6 cell line is deficient in Lck kinase activity due to the deletion of part of the lck gene (exon 7) from the Lck transcript. (wikipedia.org)
  • The I 2.1 cell line is functionally defective for FADD and the I 9.2 cell line is functionally defective for caspase-8, both defective molecules being essential to apoptosis or necroptosis of cells. (wikipedia.org)
  • Like porcine LLC-PK1 cells, this cell line has the limitation of lacking several enzymes specific to the proximal tubule. (wikipedia.org)
  • proteins
  • The function of a skin cell is to express certain proteins, keratins for example that protect the skin. (nautil.us)
  • This irregular shape that each individual cell takes on can be influenced by the cytoskeleton and specific proteins. (wikipedia.org)
  • adoptive
  • A rapidly emerging immunotherapy approach is called adoptive cell transfer (ACT): collecting and using patients' own immune cells to treat their cancer. (cancer.gov)
  • In the next few years," he said, "I think we're going to see dramatic progress and push the boundaries of what many people thought was possible with these adoptive cell transfer-based treatments. (cancer.gov)
  • CD4+ T cells polarized with IL-23 and IL-6 are pathogenic upon adoptive transfer in type 1 diabetes while cells polarized with TGF-beta and IL-6 are not pathogenic. (wikipedia.org)
  • therapies
  • Over the last two decades, targeted therapies like imatinib (Gleevec®) and trastuzumab (Herceptin®) -drugs that target cancer cells by homing in on specific molecular changes seen primarily in those cells-have also cemented themselves as standard treatments for many cancers. (cancer.gov)
  • In just the last few years, progress with CAR T cells and other ACT approaches has greatly accelerated, with researchers developing a better understanding of how these therapies work in patients and translating that knowledge into improvements in how they are developed and tested. (cancer.gov)
  • A growing number of CAR T-cell therapies are being developed and tested in clinical studies. (cancer.gov)
  • protein
  • Stimulation of A431 cells with phorbol esters induces expression of interleukin 1-related protein IL1H. (wikipedia.org)
  • found
  • The safety and efficacy of nivolumab for treating metastatic renal cell carcinoma is comparable to that found in the CheckMate 025 trial. (renalandurologynews.com)
  • Researchers say it may be possible to slow and even reverse aging by keeping DNA more stably packed together in our cells In a breakthrough discovery, scientists report that they have found the key to keeping cells young. (freerepublic.com)
  • Some enemies will also drop cells when defeated, which can be used to obtain permanent power-ups such as additional health potions or new items that can be bought or found in later runs. (wikipedia.org)
  • It was also found that unlike place cells, the speed cells are independent of visual cues. (wikipedia.org)
  • An Opalski cell is a large (up to 35 μm in diameter) altered glial cell, originated from degenerating astrocytes, with small, eccentric, pyknotic, densely staining nuclei (single or multiple) displaced to the periphery, and fine granular cytoplasm, found in the cortical and subcortical regions (basal ganglia and thalamus) of the brains of people with Wilson disease and acquired hepatolenticular degeneration. (wikipedia.org)
  • expression
  • During further mitotic expansion of such cysts, all cells retain expression of pluripotency markers. (rupress.org)
  • 1995). "Heterologous expression of rat liver microsomal glutathione transferase in simian COS cells and Escherichia coli" (PDF). (wikipedia.org)
  • In a steady state, TGF-beta and AhR ligands induce low expression of IL-22 along with high expression of AhR, c-MAF, IL-10, and IL-21 that might play a protective role in cell regeneration and host microbiome homeostasis. (wikipedia.org)
  • mutations
  • When working in diploid cells, it is difficult to screen for mutations phenotypically, especially when considering recessive mutations. (wikipedia.org)
  • growth
  • At low (picomolar) concentrations EGF promotes cell growth of A431 cells whereas at higher (nanomolar) concentrations it inhibits growth by causing the cells to terminally differentiate. (wikipedia.org)
  • A thick external cell wall influences the direction of growth by impeding expansion towards the outside of the cell and instead promote expansion parallel to the epidermis layer. (wikipedia.org)
  • Growth and Maintenance of Insect cell lines: User Guide (PDF). (wikipedia.org)
  • The spontaneously immortalized cells with stable growth rate were established after 20 to 30 generations in culture, and then named '3T3' cells. (wikipedia.org)
  • 3T3 cells are often used in the cultivation of keratinocytes, with the 3T3 cells secreting growth factors favourable to these kinds of cells. (wikipedia.org)
  • These cells are characterized primarily by uninhibited growth. (wikipedia.org)
  • leukemia
  • Dr. June has led a series of CAR T cell clinical trials, largely in patients with leukemia. (cancer.gov)
  • The cells are sensitive to sarcoma virus and leukemia virus focus formation. (wikipedia.org)
  • therapy
  • There are several types of ACT (see "ACT: TILs, TCRs, and CARs"), but, thus far, the one that has advanced the furthest in clinical development is called CAR T-cell therapy. (cancer.gov)
  • Until recently, the use of CAR T-cell therapy has been restricted to small clinical trials, largely in patients with advanced blood cancers. (cancer.gov)
  • The therapy requires drawing blood from patients and separating out the T cells. (cancer.gov)
  • In a phase Ib study, dual therapy with axitinib and pembrolizumab was well tolerated and demonstrated antitumor activity in treatment-naïve patients with advanced renal cell carcinoma. (renalandurologynews.com)
  • Immunotherapy with atezolizumab plus targeted therapy with bevacizumab improves progression-free survival better than sunitinib in patients with untreated metastatic renal cell carcinoma. (renalandurologynews.com)
  • immunotherapy
  • The different forms of ACT "are still being developed," said Steven Rosenberg, M.D., Ph.D., chief of the Surgery Branch in NCI's Center for Cancer Research (CCR), an immunotherapy pioneer whose lab was the first to report successful cancer treatment with CAR T cells . (cancer.gov)
  • Cycle
  • Cells must first be fixed to arrest them wherever they are in the cell cycle and to keep their structures from degrading. (wikipedia.org)
  • gene
  • For CML to develop an abnormal gene called BCR-ABL is formed, which turns the myeloid cell into a CML cell. (wikipedia.org)
  • In haploid cells, there is only one copy of each gene, so mutated phenotypes are immediately exposed. (wikipedia.org)
  • cancer cells
  • Harald Janovjak, Assistant Professor at IST Austria, together with Michael Grusch, Associate Professor at the Institute of Cancer Research of the Medical University of Vienna, "remote-controlled" the behaviour of cancer cells with light, as reported in EMBO Journal . (medicalnewstoday.com)
  • Chromosomal abnormalities are common in cancer cells. (wikipedia.org)
  • HAP1 cells are malignant neoplastic cells, also known as cancer cells. (wikipedia.org)
  • cellular
  • My hypothesis is that we can induce cellular rejuvenation without changing the function of the cells. (nautil.us)
  • His focus is on extending life spans by intervening at the cellular level, repairing damaged cells and in turn extending life. (freerepublic.com)
  • development
  • They can reprogram themselves to carry out the function of virtually any other type of cell, and play a vital role in early development. (nautil.us)
  • Similar to Th17 cells the Treg17 development depended on the transcription factor Stat3. (wikipedia.org)
  • researchers
  • Nevertheless, researchers caution that, in many respects, it's still early days for CAR T cells and other forms of ACT, including questions about whether they will ever be effective against solid tumors like breast and colorectal cancer. (cancer.gov)
  • Despite repeated incidents like this one, it took the researchers a while to conquer their disbelief, according to Blakeslee's article, "Cells That Read Minds. (scienceblogs.com)
  • Researchers used CRISPR/Cas9 system to delete the portion of Chromosome 15 that is present in HAP1 cells. (wikipedia.org)
  • lineage
  • Following the discovery of interleukin-17 (IL-17) producing T helper (Th17) cells as a distinct lineage of T helper cells it became clear that these cells play an important role in the host defense and participate in the pathogenesis of many inflammatory and autoimmune diseases. (wikipedia.org)
  • diameter
  • They are near haploid, having one copy of almost every chromosome and are smaller than the average human cell, growing to about 11 micrometers in diameter. (wikipedia.org)
  • organized intracellular
  • Here, we show that lumen formation begins on the interior of single cells, with the formation of an apicosome: a highly organized intracellular membrane-bound apical lumenal compartment studded with microvilli and a primary cilium. (rupress.org)