• Airway smooth muscle infiltration by mast cells is a feature of asthma and not eosinophilic bronchitis. (nih.gov)
  • Whether inflammatory cells within the airway smooth muscle release these cytokines is unknown. (nih.gov)
  • In six subjects with asthma, IL-13 expression by cells within the airway smooth muscle was studied. (nih.gov)
  • Ninety-four percent of the cells expressing IL-4 (3H4), 92% of those expressing IL-4 (4D9) and 100% expressing IL-13 in the airway smooth muscle were mast cells. (nih.gov)
  • Fifty-five percent of the mast cells within the airway smooth muscle co-localized to IL-4 (3H4), 29% to IL-4 (4D9) and 17% to IL-13. (nih.gov)
  • In asthma, IL-4+ and IL-13+ cells were present within the airway smooth muscle and were expressed predominantly by mast cells, suggesting that IL-4 and IL-13 may play an important role in mast cell-airway smooth muscle interactions. (nih.gov)
  • A number of COX inhibitors in cultured human airway cells were compared which exclusively express either COX 1 (primary degree cultured human airway smooth muscle (HASM) cells) or COX 2 (A549 pulmonary epithelial cell-line) as measured by Western blotting. (ersjournals.com)
  • studies have shown that the R- and S-enantiomers of racemic albuterol, a β 2 -adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. (scirp.org)
  • By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. (scirp.org)
  • As a kind of well mature pharmaceutical for asthma treatment, it would be very important to distinguish the effect of two different isomers of albuterol on proliferation and migration activities of airway smooth muscle cells. (scirp.org)
  • third, whole tissue culture was also performed to further demonstrate the different effect of R- and S-albuterol on migration of airway smooth muscle cells. (scirp.org)
  • Primary culture of rat airway smooth muscle cells was performed by enzyme digestion. (scirp.org)
  • After removal of blood vessels, connective tissues and cartilage, pure airway smooth muscle tissue was rinsed with PBS twice and cut into small pieces. (scirp.org)
  • Muscle satellite cells are myogenic stem cells whose quiescence, activation, self-renewal and differentiation are influenced by microenvironment oxygen levels. (purdue.edu)
  • Analysis of satellite cell dynamics on myofibers confirms that HIF1α/2α dKO myoblasts exhibit reduced self-renewal but more pronounced myogenic differentiation under hypoxia conditions. (purdue.edu)
  • We characterized T-cell responses including cytokine profiling, kinetics of activation, expansion, differentiation, TCR usage, and signaling of activation induced by Rv3615c compared with other M. tuberculosis -specific antigens. (portlandpress.com)
  • During cardiogenesis, the differentiation into working muscle cells and the conduction system remains a matter of discussion. (medscape.com)
  • In addition, myoblast cell cultures from pre-manifest and manifest HD subjects showed impaired cell differentiation and HTT inclusions similar to those in brain. (bmj.com)
  • Cell and Tissue Research presents regular articles and reviews in the areas of molecular, cell, stem cell biology and tissue engineering. (wikipedia.org)
  • Areas of research frequently published in Cell and Tissue Research include: neurobiology, neuroendocrinology, endocrinology, reproductive biology, skeletal and immune systems, and development. (wikipedia.org)
  • Autophagy (journal) Cell Biology International Cell Cycle (journal) Cell and Tissue Research - incl. (wikipedia.org)
  • The newly identified stem cells are found within populations of satellite cells located between muscle fibers and the surrounding connective tissue that are responsible for the repair and maintenance of skeletal muscles, said Professor Bradley Olwin of CU-Boulder's molecular, cellular and developmental biology department. (phys.org)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Glutamine is regarded as the most abundant amino acid in the body, is mainly synthesized in skeletal muscle 10 , and muscle tissue is the most important site for Gln storage 11 . (nature.com)
  • option to publish open access Cell & Tissue Research homepage, accessed December 3, 2008. (wikipedia.org)
  • Cell & Tissue Research homepage, accessed December 2, 2008. (wikipedia.org)
  • In the future, new heart muscle cells can likely be used to repair heart tissue damaged during a heart attack. (medicalxpress.com)
  • A University of Colorado at Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice, which could have important implications in the treatment of injured, diseased or aging muscle tissue in humans, including the ravages of muscular dystrophy. (phys.org)
  • The stem cell population identified by the CU team within the satellite cells -- dubbed "satellite-SP" cells -- were shown to renew the satellite cell population after injection into injured muscle cells, contributing to recovery of muscle tissue in the laboratory mice. (phys.org)
  • The hope is this new method will allow us to repair damaged or diseased skeletal muscle tissue. (phys.org)
  • In healthy skeletal muscle tissue, the population of satellite cells is constantly maintained, leading the CU-Boulder team to believe that at least some of the satellite cell population in the mouse study included stem cells. (phys.org)
  • For the study, the researchers injected 2,500 satellite-SP cells into a population of satellite cells within injured mouse muscle tissue. (phys.org)
  • They found that 75 percent of the satellite cells that reproduced were derived from the previous satellite-SP cells injected into the tissue. (phys.org)
  • Although the liver has a higher concentration of glycogen than muscle there is more glycogen stored in muscle tissue because muscle tissue is more abundant than liver tissue. (tripod.com)
  • Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
  • The authors begin the paper by noting their desire to find a method for inducing somatic cells of patients to return to a pluripotent state, a state from which the cell can differentiate into any type of tissue but cannot form an entire organism. (asu.edu)
  • However, since there are many different non-muscle cell populations that reside within the tissue, these experiments cannot easily distinguish true myonuclei from those of neighboring mononuclear cells. (frontiersin.org)
  • Skeletal muscle is the largest tissue in the body. (frontiersin.org)
  • In skeletal muscle, like brain a post-mitotic tissue, multiple mitochondrial DNA deletions as well as variable deficits in complex I of the mitochondrial respiratory chain (MRC), abnormal calcium handling, and reduced expression of PGC-1α have been described. (bmj.com)
  • Methods/techniques We used quadriceps muscle tissue from 12-week old R6/2 HD transgenic mice, and near to motor onset pre-manifest HD (n = 20), early onset HD patients (n = 20) and sex and age matched healthy controls (n = 20), as part of the Multi-Tissue Molecular signatures in HD project (MTM-HD). (bmj.com)
  • Constitutive activation of Notch signaling can rescue HIF1α/2α dKO induced inhibition of satellite cell self-renewal. (purdue.edu)
  • The involvement of autophagy in the development of diabetes is corroborated by affecting the physiology and role of pancreatic β cells and the homeostasis of glucose. (frontiersin.org)
  • Lockshin and Williams used this doctoral research as the basis for five articles, with the main title "Programmed Cell Death," that were published between 1964 and 1965 in the Journal of Insect Physiology. (asu.edu)
  • This study was designed to investigate the effects of substances released from non-injured and injured bovine arterial endothelial cells on 125I-low density lipoprotein uptake and degradation by smooth muscle cells in culture. (lu.se)
  • article{e328883f-12c1-4d3a-a8e7-8700ca87f7ac, abstract = {{This study was designed to investigate the effects of substances released from non-injured and injured bovine arterial endothelial cells on 125I-low density lipoprotein uptake and degradation by smooth muscle cells in culture. (lu.se)
  • Evaluation of pulmonary arterial endothelial cells and smooth muscle cells revealed that miR-130/301 targeted PPARγ with distinct consequences. (jci.org)
  • Human vascular smooth muscle cell derived from a skin precursor. (portlandpress.com)
  • describe new approach to studying human vascular smooth muscle cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin (see pages 1801-1814). (portlandpress.com)
  • Damage to the endothelium results in vascular smooth muscle cell proliferation. (aspetjournals.org)
  • In this work, we investigated the effect of l -citrulline on vascular smooth muscle cell proliferation. (aspetjournals.org)
  • These findings suggest that l -citrulline decreases vascular smooth muscle cell proliferation in the A10 cell line by acting on DNA synthesis by mechanisms that involve the ANP receptor. (aspetjournals.org)
  • When muscle fibers are stressed or traumatized, satellite cells divide to make more specialized muscle cells and repair the muscle, said Olwin. (phys.org)
  • Although injected cells will repair the muscle fibers, maintaining the muscle fibers requires additional cell injections. (phys.org)
  • Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
  • The Role of RBC Oxidative Stress in Sickle Cell Disease: From the Molecular Basis to Pathologic Implications. (duke.edu)
  • Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
  • Because carbohydrates play such an important role in producing energy for the body, they are stored in the form of glycogen in both skeletal muscles and in the liver. (tripod.com)
  • Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. (frontiersin.org)
  • It was demonstrated that endothelial cell-released non-dialysable (molecular weight cut off 12-14000) substances significantly stimulated 125I-low density lipoprotein uptake and degradation by smooth muscle cells. (lu.se)
  • Endothelial cell-released dialysable substances and endothelin-1 did not cause this stimulation. (lu.se)
  • However, in endothelial cell-smooth muscle cell co-culture 125I-low. (lu.se)
  • However, in endothelial cell-smooth muscle cell co-culture 125I-low density lipoprotein uptake and degradation by smooth muscle cells were not stimulated. (lu.se)
  • Injury to endothelial cells by lipid-soluble smoke particles or ultraviolet light, which reduced total cellular protein by 15-25%, enhanced the endothelial cell release of the substances stimulating 125I-low density lipoprotein uptake. (lu.se)
  • In endothelial cells, miR-130/301 modulated apelin-miR-424/503-FGF2 signaling, while in smooth muscle cells, miR-130/301 modulated STAT3-miR-204 signaling to promote PH-associated phenotypes. (jci.org)
  • Therefore, smooth muscle and endothelial cell function were assessed in 20 patients with diabetes and compared with 41 age-matched control subjects. (diabetesjournals.org)
  • Therefore, in collaboration with W. Wright, we have developed an approach for the immortalisation of human muscle precursors that allows them to retain their ability to differentiate: this has enabled the generation of immortal cell lines derived from patient cells. (institut-myologie.org)
  • Stem cells are distinguished by their ability to renew themselves through cell division and differentiate into specialized cell types. (phys.org)
  • More important, people found that, during the pathogenesis of asthma, smooth muscle cells could differentiate into the migration phenotype. (scirp.org)
  • Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
  • This research shows how satellite cells can maintain their populations within injured tissues," said Olwin. (phys.org)
  • How the body develops from just a single cell to an individual with millions of cells organised into many different tissues and organ systems. (otago.ac.nz)
  • The immune system is comprised of highly specialized q The findings and conclusions in this report are those of the authors and cells, tissues, and organs that give the human body the do not necessarily represent the views of the Agency for Toxic Substances and Disease Registry. (cdc.gov)
  • The study of tissues and cells under a microscope. (cdc.gov)
  • The increase in 125I-low density lipoprotein uptake and degradation by smooth muscle cells could be dissociated from cell proliferation. (lu.se)
  • Scholars@Duke publication: Smooth muscle cell proliferation in the occluded rat carotid artery: lack of requirement for luminal platelets. (duke.edu)
  • The relationship of intimal smooth muscle cell proliferation in the permanently occluded rat carotid artery to the presence or absence of luminal platelets was examined. (duke.edu)
  • The latter cells had some features of vascular smooth muscle cells and were apparently derived from medial cells which traversed the internal elastic lamina. (duke.edu)
  • After 14 days, identifiable smooth muscle cells emerged as the predominant cell type in a rapidly growing intimal plaque. (duke.edu)
  • Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation. (duke.edu)
  • The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation and pro-inflammatory signaling. (duke.edu)
  • Vascular smooth muscle cells derived from skin-derived precursors from subjects with type-2 diabetes carry persistent signatures of disease even weeks after being removed from the patient. (portlandpress.com)
  • l -Citrulline (10 −8 M) significantly decreased rat aortic (A10 cell line) vascular smooth muscle proliferation. (aspetjournals.org)
  • Immediately after angioplasty, a thin optical fibre inserted into the artery delivered low-power red laser light to the site, killing the smooth muscle cells. (newscientist.com)
  • However, the different effects of R- and S-albuterol on smooth muscle cells proliferation and migration have never been tested. (scirp.org)
  • After rinse with PBS, smooth muscle cell culture media (Cell Application Inc) was mixed and then seeded into 12 well culture plates coating with fibronectin (R & D, Minneapolis). (scirp.org)
  • Human diabetes is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution. (diabetesjournals.org)
  • Alterations of vascular smooth muscle function have been implicated in the development of vascular complications and circulatory dysfunction in diabetes. (diabetesjournals.org)
  • However, little is known about changes in smooth muscle contractility and the intracellular mechanisms contributing to altered responsiveness of blood vessels of diabetic patients. (diabetesjournals.org)
  • In rings from uterine arteries, smooth muscle sensitivity to K+, norepinephrine (NE), and phenylephrine (PE) was enhanced by 1.4-, 2.3-, and 9.7-fold, respectively, and endothelium-dependent relaxation was reduced by 64% in diabetic patients, as compared with control subjects. (diabetesjournals.org)
  • In contrast, subplasmalemmal Ca2+ response, which favors smooth muscle relaxation caused by activation of Ca2+-activated K+ channels, was reduced by 38% in diabetic patients as compared with control subjects, indicating a significant change in the subcellular Ca2+ distribution in vascular smooth muscle cells in diabetic patients. (diabetesjournals.org)
  • In contrast to the altered Ca2+ signaling found in freshly isolated cells from diabetic patients, in cultured smooth muscle cells isolated from control subjects and diabetic patients, no difference in the intracellular Ca2+ signaling to stimulation with either K+ or NE was found. (diabetesjournals.org)
  • Incubation of freshly isolated smooth muscle cells from control subjects with the *O2- -generating system xanthine oxidase/hypoxanthine mimicked the effect of diabetic patients on subcellular Ca2+ distribution in a superoxide dismutase-sensitive manner. (diabetesjournals.org)
  • We conclude that in diabetic subjects, smooth muscle reactivity is increased because of changes in subcellular Ca2+ distribution on cell activation. (diabetesjournals.org)
  • Increased *O2- production may play a crucial role in the alteration of smooth muscle function. (diabetesjournals.org)
  • Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
  • In quiescent cells, centrioles dock at the plasma membrane and act as basal bodies that template the formation of cilia and flagella ( Breslow and Holland, 2019 ). (elifesciences.org)
  • Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
  • The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Cell proliferation deep within an atherosclerotic plaque could be initiated by factors other than platelets, perhaps by products of inflammatory cells. (duke.edu)
  • The study offers an unprecedented, detailed look at the distribution system that rapidly provides energy throughout the cell where it is needed for muscle contraction. (evolutionnews.org)
  • Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides. (institut-myologie.org)
  • 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). (jci.org)
  • Once the sugars reach the bloodstream they are driven into the liver and muscle cells by the action of the hormone insulin. (tripod.com)
  • Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
  • DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)
  • We demonstrate that exercise training targets many of the age-related transcripts and DNA methylation loci to maintain younger methylome and transcriptome profiles, specifically in genes related to muscle structure, metabolism, and mitochondrial function. (lu.se)
  • Expression of muscle growth related genes was quantified with qPCR. (nature.com)
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • The specification model postulates that the primary myocardial cells express either conduction system or working myocyte genes. (medscape.com)
  • Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
  • The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
  • We have undertaken a comparative immunohistochemical study in bronchial biopsies from 14 subjects with asthma, 10 with eosinophilic bronchitis and eight normal controls recruited from two centres. (nih.gov)
  • Percutaneous muscle biopsies from the vastus lateralis were taken before (Pre) and 48 h postexercise. (mcmaster.ca)
  • Here, we studied human pulmonary T-cell responses induced by the M. tuberculosis -specific antigen Rv3615c, a protein with a similar size and sequence homology to ESAT-6 and CFP-10, which induced dominant CD4 + T-cell responses in human tuberculosis (TB) models. (portlandpress.com)
  • Development of the vascular disease pulmonary hypertension (PH) involves disparate molecular pathways that span multiple cell types. (jci.org)
  • In validation of this model, diseased pulmonary vessels and plasma from mammalian models and human PH subjects exhibited upregulation of miR-130/301 expression. (jci.org)
  • Hypoxia inducible factors (HIFs) are central mediators of cellular responses to fluctuations of oxygen, an environmental regulator of stem cell activity. (purdue.edu)
  • Together, HIF1α and HIF2α are dispensable for muscle stem cell function under normoxia, but are required for maintaining satellite cell self-renewal under hypoxic environment. (purdue.edu)
  • A breakthrough in stem cell research. (medicalxpress.com)
  • The findings are published in the latest issue of the journal Stem Cell Research . (medicalxpress.com)
  • A paper on the subject was published in the March 5 issue of the journal Cell Stem Cell . (phys.org)
  • However, the in vivo roles of HIFs in quiescent satellite cells and activated satellite cells (myoblasts) are poorly understood. (purdue.edu)
  • Subjects with type-2 diabetes have fewer skin-derived precursors in their skin. (portlandpress.com)
  • Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
  • You will learn techniques such as immunohistochemistry, cell culture, and gene sequencing, and have access to state-of-the-art equipment such as electron and confocal microscopes, and next-generation sequencing technology. (otago.ac.nz)
  • Our team is working on the molecular and cellular actors involved in human muscle regeneration , in muscle ageing and in muscular dystrophies including oculopharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). (institut-myologie.org)
  • In muscular dystrophy, the loss of a protein called dystrophin causes the muscle to literally tear itself apart, a process that cannot be repaired without cell-based intervention. (phys.org)
  • COX inhibitors have different selectivities for the two COX isoenzymes (COX 1 and COX 2) which vary between purified enzyme and intact cell preparations. (ersjournals.com)
  • Skeletal muscle cells were known to have many mitochondria, but it was not clear how the products of ATP production, called metabolites, became distributed throughout the cell. (evolutionnews.org)
  • Scientists are reporting the first clear evidence that muscle cells distribute energy primarily by the rapid conduction of electrical charges through a vast, interconnected network of mitochondria - the cell's "powerhouse" - in a way that resembles the wire grid that distributes power throughout a city . (evolutionnews.org)
  • For the current experiments, the NIH scientists collaborated in a detailed study of the mitochondria structure, biochemical composition, and function in mouse skeletal muscle cells. (evolutionnews.org)
  • In testing the subjects increased mitochondria, and improved the function of the muscle cells. (anabolicminds.com)
  • However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
  • However, HIF1α/2α dKO in postnatal satellite cells impairs injury-induced muscle repair, accompanied by a reduced number of myoblasts during regeneration. (purdue.edu)
  • Skeletal muscle satellite cells (SC) play an important role in muscle repair following injury. (mcmaster.ca)
  • Previous studies have derived MRF expression from whole muscle homogenates, but little work has examined whether the mRNA expression of these transcripts reflects the pattern of expression in the actual population of satellite cells (SC). (mcmaster.ca)
  • The mRNA expression of these MRF in humans following muscle damage has been predominately measured in whole muscle homogenates. (mcmaster.ca)
  • Gurdon's first experiment in 1958 showed that the nuclei of Xenopus cells maintained their ability to direct normal development when transplanted. (asu.edu)
  • There is a general agreement that hypertrophy is accompanied by the addition of new nuclei from stem cells to help the muscles meet the enhanced synthetic demands of a larger cell. (frontiersin.org)
  • Skeletal muscle is fairly unique in that the mature cells are syncytial and can contain hundreds of nuclei. (frontiersin.org)
  • More precisely we are working on RNA metabolism , muscle regeneration , muscle stem cells , and fibrosis , with the final aim of developing innovative therapeutic approaches. (institut-myologie.org)
  • These cell lines are shared in collaboration with many international teams, either to study physiological or pathophysiological mechanisms, or to test innovative therapeutic approaches. (institut-myologie.org)
  • While it is mainly used by men, some women oocytes and steroid-producing cells of rat and human ovary: molecular analysis and regulation by gonadotropins. (thedollpalace.com)
  • Obestatin signalling counteracts glucocorticoid-induced skeletal muscle atrophy via NEDD4/KLF15 axis. (institut-myologie.org)
  • There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. (frontiersin.org)
  • In "Generation," the authors point to dedifferentiation of somatic cells as an avenue for generating pluripotent stem cells useful for treating specific patients and diseases. (asu.edu)
  • All 50 control subjects were monitored gation to verify their health status and that for somatic illness throughout the investiga- they were not taking any drugs. (who.int)
  • Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
  • The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
  • if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
  • Although encouraging results have been obtained in experimental models by exposing recipient thymus to donor cells before transplantation, donor cells are not typically available at that time, and the donor antigens responsible for the effect are poorly defined. (duke.edu)
  • By 7 days a neointima was formed by macrophages and undifferentiated cells. (duke.edu)
  • Whole cell vaccines against pertussis can induce a hypotonic-hyporesponsive episode or shock-like syndrome (collapse) in children, 1 but this may also occur with diphtheria and tetanus vaccines, acellular pertussis vaccine, and without vaccination. (bmj.com)
  • Our results demonstrate: (1) that recipient muscle cells can be genetically engineered to induce donor-specific unresponsiveness when given intrathymically, and (2) transfected recipient cells expressing only donor MHC class I antigen can induce tolerance to a fully allogeneic donor. (duke.edu)
  • Subjects repeated the text editing task with the mouse in two other locations: a "high" mouse position, which simulated using a keyboard drawer with the mouse on the primary work surface, and "center" mouse position with the mouse between the keyboard and the body, centered with the body's center line. (cdc.gov)
  • A) Degenerate Purkinje's cell with an eosinophilic, intracytoplasmic inclusion body and a Negri body (arrow). (cdc.gov)
  • locally relevant and of potential benefit to athletes or persons suffering from muscle diseases. (sun.ac.za)
  • This platform has generated over 85 different cell lines, from controls or pathological subjects. (institut-myologie.org)
  • Glycogen supercompensation occurs only in muscles that were trained and is maximal at a carbohydrate intake of approximately 25 grams per hour for average adults and possibly 40 grams or more per hour for bodybuilders. (tripod.com)
  • Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). (elifesciences.org)
  • Scholars@Duke publication: Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. (duke.edu)
  • Within this reticulum , we find proteins associated with mitochondrial proton-motive force production preferentially in the cell periphery and proteins that use the proton-motive force for ATP production in the cell interior near contractile and transport ATPases . (evolutionnews.org)
  • By performing cell biological and biochemical experiments using human cells, Moyer and Holland show that PLK4 interacts with a protein called STIL that is found in the central part of the centriole. (elifesciences.org)