Cells pathways cell proliferation. Medical search. Frequent questions

Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
The SignalStain ® Proliferation/Apoptosis IHC Sampler Kit from Cell Signaling Technology allows the researcher to examine paraffin-embedded tissues or cells with antibodies that will detect cellular apoptosis or proliferation. (cellsignal.com)
Each antibody in the SignalStain ® Proliferation/Apoptosis IHC Sampler Kit detects endogenous levels of its target protein and does not cross-react with any related proteins. (cellsignal.com)
Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle through inhibiting apoptosis and promoting cell division (4,5). (cellsignal.com)
In conjunctiva, the immunoreactivity, localized in cytoplasm of epithelial cells generally, may demonstrate VDR legislation of cell development most likely, differentiation, and apoptosis, while in pterygium VDR co-localization in the nucleus and cytoplasm of epithelial cells may suggest choice nuclear pathways where supplement D might exert its antiinflammatory and anti-proliferative results by the legislation of gene appearance. (bibf1120.com)
PFT-μ induces cell cycle arrest and apoptosis in leukemic cells To further evaluate the impact of PFT-μ on leukemic cells we performed cell cycle and apoptosis analyses with the cell lines NALM-6 and KG-1a. (tech-strategy.org)
The effect of PFT-μ on particular apoptosis was dependant on AnnexinV/7-AAD staining after incubation with different concentrations of KP372-1 IC50 PFT-μ for 48?h in NALM-6 KG-1a TOM-1 End up KP372-1 IC50 being-13 K562 and Jurkat cells. (tech-strategy.org)
In accordance with the results from cell cycle analyses induction of apoptosis by PFT-μ was more pronounced in NALM-6 cells as compared with KG-1a. (tech-strategy.org)
In NALM-6 incubation with PFT-μ at 4 5 and 6.5?μ resulted in 34 59 and 80% apoptotic cells above spontaneous apoptosis (11%) respectively. (tech-strategy.org)
KG-1a cells showed a rate of specific apoptosis of 17% (20?μ PFT-μ) 18 (30?μ PFT-μ) and 25% (40?μ PFT-μ) above control (11% Physique 2b). (tech-strategy.org)
This observation was further strengthened by the actual fact that pre-incubation with skillet caspase inhibitor Z-VAD-FMK (50?μ for 1?h) significantly reduced apoptosis after PFT-μ in NALM-6 whereas KG-1a cells weren't rescued by Z-VAD-FMK (data not shown). (tech-strategy.org)
Hence PFT-μ exerted different impacts in cell apoptosis and cycle in both leukemic cell lineages. (tech-strategy.org)
Overexpression and silencing of RASSF7 were performed to measure the impact on HCC cell proliferation, cell cycle and apoptosis. (cellmolbiol.org)
Overexpression of RASSF7 promoted HCC cell proliferation, drived G1-S phase cell cycle transition and inhibited apoptosis. (cellmolbiol.org)
Knockdown of RASSF7 suppressed cell growth, induced G1-S phase cell cycle arrest and cell apoptosis. (cellmolbiol.org)
The aim of this study was to elucidate the role of fucoxanthin on apoptosis via signaling pathway in ovarian cancer cells. (phcog.com)
We established the action potential of fucoxanthin on cell proliferation in addition to apoptosis in A2780 cells, which were measured using reactive oxygen species (ROS) generation and the mitochondrial membrane potential (MMP). (phcog.com)
Our results established that fucoxanthin stimulates apoptosis as confirmed through reduced cell viability, improved production of ROS, and altered MMP in A2780 cells. (phcog.com)
In addition, we uncovered upstream signaling cascade (Akt/mTOR) induced by incubation A2780 cell lines with fucoxanthin that mediated cell apoptosis, migration, and invasion process. (phcog.com)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
The inhibitory effect of MicroRNA-16-5p on the proliferation, invasion, cell cycle and apoptosis of glioma cells was evaluated by the cell proliferation, invasion and flow cytometry. (ijpsonline.com)
The over expression of MicroRNA-16-5p can inhibit the growth and invasion of the glioma cell line, promote the apoptosis and delay the cell cycle. (ijpsonline.com)
Silencing of Chl1 in INS-1 cells was done to assess its impact on the insulin secretion, content, cell viability, and apoptosis. (lu.se)
Cell viability, apoptosis, and proliferation rate were not affected. (lu.se)
Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)
PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)

Recently, T β 4 has have been shown to promote the differentiation of progenitor cell lines to cardiomyocytes [ 8 ]. (oncotarget.com)
In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
These pathways are important for the growth and division (proliferation) and maturation (differentiation) of cells. (medlineplus.gov)
In particular, Sonic Hedgehog appears to be essential for the proliferation and differentiation of cells that ultimately give rise to cartilage and bone. (medlineplus.gov)
Wang C, Yuan X, Yang S. IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. (medlineplus.gov)
We show that loss of Erk1/2 in intestinal epithelial cells results in defects in nutrient absorption, epithelial cell migration, and secretory cell differentiation," the authors wrote. (genengnews.com)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
The differentiation of endometrial stromal cells into decidual cells, termed decidualization, is an integral step in the establishment of pregnancy. (bioone.org)
Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
These growth factors promote cell migration, proliferation, and differentiation, which are essential for wound healing. (thieme-connect.de)
While substantial progress has been made to delineate the developmental pathway of T-cell lineage commitment, still little is known about the relationship between differentiation competence and the remarkable expansion of the earliest (DN1 stage) T-cell progenitors. (lu.se)
To satisfy differentiation kinetics and overall cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
T cell differentiation. (cdc.gov)
Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
Signaling through CysLT1R results in increased proliferation, survival and migration of intestinal epithelial cells, whereas signaling through CysLT2R leads to differentiation of colorectal cancer cells. (lu.se)

Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway. (cellmolbiol.org)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)

Mutations in K-Ras and B-Raf activate the phosphoinositide 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathways. (biomedcentral.com)
Activated PAK1 enhances cell survival and migration via the AKT pathway, and stimulates transformation through the Ras/Raf/ERK/MAPK pathway. (biomedcentral.com)
the changes of proteins related to MAPK/ERK signaling pathway were also detected using western blotting. (biomedcentral.com)
Collectively, RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway. (biomedcentral.com)
RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway, which may serve as a novel therapeutic target for cancers in which MAPK/ERK signaling is a dominant feature. (biomedcentral.com)
Here, we demonstrate that RPL5 promotes COAD cell proliferation and migration via the MAPK/ERK signaling pathway. (biomedcentral.com)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)

Activated hepatic stellate cells (HSCs) have been shown to play a function in angiogenesis and vasculogenesis. (oncotarget.com)
Although its pathogenesis appears multi-factorial, chronic irritation, angiogenesis and uncontrolled proliferation possess a key function in the pathogenesis of pterygium. (bibf1120.com)
29,31-34 Recently, supplement D position continues to be connected with risk for several malignancies inversely, since supplement D inhibits cell angiogenesis and proliferation, activates apoptotic pathways, and exerts pro-differentiative results.35,36 In 1980, Garland37 and Garland reported an inverse association between sunshine publicity and cancer of the colon mortality, hypothesizing for vitamin D a protective function against the chance of cancer of the colon. (bibf1120.com)
This is a critical pathway in angiogenesis, a process that cancer cells use to form new blood vessels, which provide necessary elements to the tumor for tumor survival. (wikipedia.org)
During the healing process, the transforming growth factor β1 (TGF-β1) is the primary growth factor for re-epithelialization, angiogenesis, and fibroblast proliferation. (thieme-connect.de)

Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication (6). (cellsignal.com)
Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA (reviewed in 7). (cellsignal.com)

We report here that IgE sensitization induces HASM cell proliferation, as measured by 3H-thymidine, EdU incorporation, and manual cell counting. (harvard.edu)

These genes are involved in the PI3K-AKT pathway. (biomedcentral.com)
Treatment with 2.5 µM arecoline increased the levels of miR-21-3p, miR-21-5p and miR-1267, upregulated the expression of PI3K-AKT pathway factors, CDK1, CCND1 but decreased RAF1 expression. (biomedcentral.com)
A low concentration arecoline can induce the proliferation and migration of HepG2 cells, with the potential mechanism of action linked to high levels of exosomal miR-21 and miR-1267, activation of the PI3K-AKT pathway, upregulation of CDK1 and CCND1, and downregulation of RAF1. (biomedcentral.com)
Previous studies have demonstrated that IGF-1R activates the phosphoinositide 3- kinase (PI3K)/AKT signaling pathways and promotes glioblastoma cell proliferation and survival by ligand binding [ 10 ]. (jcancer.org)

Our studies indicate that EOPK significantly reduced proliferation and migration of colorectal cancer cells. (biomedcentral.com)

As an upstream signature component of FcεRI signaling, inhibition of spleen tyrosine kinase (Syk) abrogated the IgE-induced HASM proliferation. (harvard.edu)
Inhibition of ZL55 cell proliferation by ADP was completely reversed by inhibiting MEK1/2, or JNK1/2, or PKC-δ, and PKC-α. (unisalento.it)
Conclusions: Our findings indicate that the andrographolide constraints SW-480 cell growth through inhibition of the Notch signaling pathway. (notchgene.com)
Furthermore, pre-treatment of CA rescues the proliferation inhibition induced by a sub-IC 50 dose of paclitaxel (PTX), an anticancer drug. (tmu.edu.tw)

Knockdown of RPL5 significantly inhibited the proliferation and migration of HCT16 and RKO cells, and arrested the cell cycle in G0/G1 phase. (biomedcentral.com)
Meanwhile, triptolide treatment combined with Cav-1 knockdown in PCa cells enhanced the effects of anti-migration and anti-invasion, and those effects were restored following Cav-1-rescued. (nih.gov)
Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. (jcancer.org)
Primary human endometrial stromal cells (HESCs) were subjected to small interfering RNA knockdown of WNK1 followed by in vitro decidualization. (bioone.org)

Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
This is an underappreciated escape pathway for tumor cells. (genengnews.com)
What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)

In conclusion, these findings indicate that FBXO17 is a novel inhibitor of endometrial tumor development and it likely exerts effects via regulation of the Wnt signaling pathway. (medsci.org)
Futhermore, the molecular mechanism of MEK1/2-ERK1/2 signaling pathway regulation by RASSF7 was explored. (cellmolbiol.org)
This study uncovered a new layer of regulation of pro-proliferative genes by menin via the Hedgehog signaling pathway," Hua says. (medindia.net)
AMPK pathways are energy regulation pathways. (springer.com)
The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)

Moreover, the Nogo-A-Δ20 domain promotes neuroblast migration toward the OB through activation of the Rho/ROCK (Rho-associated, coiled-coil containing protein kinase) pathway, without the participation of NgR1. (jneurosci.org)
A study by White et al found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)

In the present study, it was shown that FBXO17, which is a member of the F-box family, is abnormally downregulated in UCEC tissues compared with non-tumor endometrial tissues, and this was significantly associated with the clinical histological grade, as well as the abnormal proliferation of the UCEC cell line, Ishikawa, both in vitro and in vivo . (medsci.org)
EOPK significantly decreased HCT116 cell proliferation and migration, and induced G1 arrest without affecting normal cells. (biomedcentral.com)
The expression of Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver. (oncotarget.com)
In this study, our data show that Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver, and Tβ4 significantly suppressed cell viability and migration of HSCs. (oncotarget.com)
The expression level of RPL5 in colon cancer tissues and cell lines was significantly higher than that in adjacent tissues and NCM460 cells, respectively, and its expression level was higher in HCT116 cells and RKO cells. (biomedcentral.com)
RASSF7 was significantly up-regulated in HCC tissues and cell lines, and correlated with AFP, poor tumor histology and T stage. (cellmolbiol.org)
In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner. (nih.gov)
mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)

PAKs are downstream effectors of the Rho family GTPases, which regulate cell motility and survival. (biomedcentral.com)
Extracellular nucleotides can regulate cell proliferation in both normal and tumorigenic tissues. (unisalento.it)
Here, we studied how extracellular nucleotides regulate the proliferation of ZL55 cells, a mesothelioma-derived cell line obtained from bioptic samples of asbestos-exposed patients. (unisalento.it)
Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)
After activation in the wound area, platelets will release growth factors to regulate cell migration, proliferation, and matrix deposition and reduce the risk of infection from the wound, increasing the quality of healing and tissue repair. (thieme-connect.de)

Further, a recent report on the effects of EOPK indicated that the oil has anti-obesity and hypolipidemic activity in vitro and in vivo , using 3 T3-L1 cells and high fat diet-fed rats [ 16 ]. (biomedcentral.com)
Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
Moreover, linc01023 depletion inhibited glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. (jcancer.org)
Using pharmacological approaches along with in vitro and in vivo experiments, we found that Nogo-A/NgR1 signaling regulates the pace of neuronal neogeneration by reducing NSC proliferation. (jneurosci.org)

The goal of this study was to investigate the anti-cancer mechanism of EOPK in HCT116 colorectal cancer cells. (biomedcentral.com)
This study examines the effect of RPL5 on the progression of colon adenocarcinoma (COAD), including cell proliferation, migration and determines its underlying molecular mechanism using CRC cell lines in vitro. (biomedcentral.com)
Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen that disrupts the morphology and proliferation of gubernaculum testis cells , but the underlying mechanism is unclear. (bvsalud.org)
To explore the role of RASSF7 in hepatocellular carcinoma (HCC) cells proliferation and molecular mechanism. (cellmolbiol.org)
and reveals a potential mechanism of fucoxanthin-mediated Akt/mTOR suppression in human ovarian cancer cell line. (phcog.com)
Therapies aimed at targeting ERK1/2 likely fail because this mechanism is allowing proliferation through a different pathway," noted senior study author Eyal Raz, M.D., professor of medicine at UC San Diego School of Medicine. (genengnews.com)
In this paper, the mechanism of MicroRNA-16-5p in the occurrence and development of glioma was studied by the cell experiment in vitro. (ijpsonline.com)

PAK1 is an important effector of Rac and Cdc42 that regulates cell transformation and tumor proliferation [ 9 ]. (biomedcentral.com)

Taken together, this study provides a novel evidence for clinical significance of RASSF7 as a potential biomarker, and demonstrates that RASSF7- MEK1/2-ERK1/2 signaling pathway might be a novel pathway involved in HCC progression. (cellmolbiol.org)
In one case study, a patient with advanced metastatic vulvar epithelioid sarcoma showed a partial resolution of both lung and pleural metastases when pazopanib was administered, whereas all other therapies had failed MET (mesenchymal to epithelial transition) is another biological pathway that is likely involved in the development and progression of epithelioid sarcoma. (wikipedia.org)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)

Collectively, our data provide mechanisms of a novel function of IgE which may contribute, at least in part, to airway remodeling observed in allergic asthma by directly inducing HASM cell proliferation. (harvard.edu)
Collectively, the study indicates that linc01023 plays an oncogenic role in glioma through activation of IGF1R/AKT signal pathway, and it could be a candidate therapeutic target. (jcancer.org)

The activation of P2Y1 receptor by ADP leads to activation of intracellular transduction pathways involving [Ca(2+) ]i , PKC-δ/PKC-α, and MAPKs, ERK1/2 and JNK1/2. (unisalento.it)
The results demonstrated that U-73122 impaired DES-evoked intracellular Ca2+ mobilization in gubernaculum testis cells and inhibited DES-induced proliferation of gubernaculum testis cells . (bvsalud.org)
Andrographolide plus intracellular ROS and induced G0 / G1 phase cell cycle arrest in SW480 colon cancer cells. (notchgene.com)
PFT-μ decreases intracellular concentrations of AKT and ERK1/2 in NALM-6 cells Following we performed intracellular staining and fluorescence-activated cell sorting analyses of AKT p-AKT ERK1/2 and p-ERK1/2 kinases in NALM-6 cells to judge whether PFT-μ impacts these two main signaling kinases or their phosphorylation position. (tech-strategy.org)

Studies have shown that various signaling pathways serve crucial roles in the tumorigenesis of UCEC, amongst which the Wnt/β-catenin pathway is of great interest due to its crucial role in cell proliferation and the huge potential as a therapeutic target. (medsci.org)
Besides, the results suggested that FBXO17 may inhibit the Wnt/β-catenin signaling pathway and influence the expression of adhesion molecules, such as E-cadherin and N-cadherin in Ishikawa cells. (medsci.org)
Herein, we investigated the potential role of Tβ4 in liver fibrosis by describing the effects of Tβ4, and we discuss the possible signaling pathway regulated by Tβ4. (oncotarget.com)
Recently, Notch signaling pathway has gained attention as a potential therapeutic target for chemotherapeutic intervention. (notchgene.com)
The purpose of this study was to determine the effect of andrographolide in aberrantly activated Notch signaling in SW-480 cells in vitro. (notchgene.com)
c-MET is a tyrosine kinase oncogene, and its signaling pathway has been implicated in a variety of malignancies, including many cancers. (wikipedia.org)
citation needed] The Sonic hedgehog and Notch signaling pathways are also suspected to be up-regulated in epithelioid sarcoma. (wikipedia.org)
Our study suggested that the pro-survival effect of CA on PTX-treated lung cancer cells is mediated through a NF-κB signaling pathway. (tmu.edu.tw)
These cell structures play central roles in many different chemical signaling pathways, including a series of reactions called the Sonic Hedgehog pathway. (medlineplus.gov)
Researchers speculate that these changes in IFT alter certain signaling pathways, including the Sonic Hedgehog pathway, which may underlie the abnormalities of bone growth characteristic of asphyxiating thoracic dystrophy. (medlineplus.gov)
These signaling pathways are widely expressed and known to drive cancer growth in one-third of patients with colorectal cancer (CRC). (genengnews.com)
A research team led by Xianxin Hua, MD, PhD, associate professor of Cancer Biology at the Abramson Family Cancer Research Institute, report in Cancer Research that menin suppresses signaling in the much-studied Hedgehog pathway in endocrine organs. (medindia.net)
Menin mutations lead to increased Hedgehog signaling and cell proliferation. (medindia.net)
The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
GSEA showed that the insulin-signaling pathway was influenced in Chl1 -silenced cells. (lu.se)
Silencing of Chl1 impairs β-cell function by disrupting the activity of key signaling pathways of importance for insulin biosynthesis and secretion. (lu.se)

Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation. (cellmolbiol.org)

To assess the effects of EOPK on cell migration, we performed a wound-healing assay. (biomedcentral.com)
The potential cytostatic andrografolida on SW-480 cells was evaluated by 3- (4,5-dimethylthiazol-2-yl) -2, 5-diphenyl tetrazolium bromide (MTT) assay, assessment of morphology and colony formation test. (notchgene.com)
MTT assay showed a dose and time dependent cytoxicity of andrographolide on SW-480 cells. (notchgene.com)
The growth assay showed that CA moderately promoted the proliferation of the lung cancer cells. (tmu.edu.tw)

Researchers still did not exactly understand how menin mutations lead to MEN1 syndrome, and more importantly, what molecular pathways might be dysregulated by menin mutations and thus can be targeted to improve therapy against this type of cancer. (medindia.net)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)

AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)

Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (3). (cellsignal.com)

Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)

Metabolic adaptations of cancer cells. (hindawi.com)
Scientists have identified that pancreatic cancer cells growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer. (medindia.net)

IgE was recently shown to induce HASM cell proliferation but the detailed mechanisms remain unknown. (harvard.edu)
Here we explore potential mechanisms how the proliferation and contractility of gubernaculum testis cells are regulated by diethylstilbestrol . (bvsalud.org)
Here, we investigated the effect of arecoline on the proliferation and migration of human HepG2 hepatoma cells and its potential oncogenic mechanisms. (biomedcentral.com)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
However, intestinal epithelial cell proliferation is not impeded, implying compensatory mechanisms. (genengnews.com)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. (nih.gov)
Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy. (nih.gov)
Glioma, the vast majority of intracranial malignant tumors, is characterized by rapid proliferation and aggressive invasion [ 1 ]. (jcancer.org)

An international research team lead by scientists at the University of California San Diego School of Medicine uncovered some surprising results while investigating a potential therapeutic target for the ERK1 and two pathways. (genengnews.com)

Moreover, TBHQ could partially reverse the inhibitory effect of siRPL5 on the proliferation and migration of colon cancer cells. (biomedcentral.com)
The nucleotide potency profile and the blockade of the ADP-mediated inhibitory effect by the phospholipase C inhibitor U-73122 suggest that P2Y1 receptor controls ZL55 cell proliferation. (unisalento.it)

In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)

Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
Chen C, Song G, Xiang J, Zhang H, Zhao S, Zhan Y. AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. (cellmolbiol.org)
As this tumor suppressor is commonly inactivated in epithelioid sarcoma, cell division can fail to appropriately halt, resulting in unregulated cellular growth and the formation of cancer tumors. (wikipedia.org)
We performed Kyoto Encyclopedia of Genes and Genomes (KEGG) and hub target genes analysis to illuminate potential biomarkers and related pathways in arecoline-induced cancer. (biomedcentral.com)
First, fucoxanthin exhibited obvious cytotoxicity against A2780 human ovarian cancer cells. (phcog.com)
Here we used two human lung cancer cell lines, A549 and H1299, to clarify the role of CA in cancer cell proliferation. (tmu.edu.tw)
In turn, as a result of research into the abnormal cancer cell, the basic understanding of the cell has greatly improved. (medscape.com)
Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
The ERK pathway plays a critical role in embryonic development and tissue repair because it instructs cells to multiply and start dividing, but when overactivated cancer growth often occurs. (genengnews.com)
If you block one pathway, cancer cells usually mutate and find another pathway that ultimately allows for a recurrence of cancer growth," remarked co-lead study author Koji Taniguchi, M.D., Ph.D., senior researcher at the Keio University School of Medicine in Tokyo. (genengnews.com)
ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways. (nih.gov)
Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin. (medindia.net)
We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. (lu.se)
In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
The ratio between the IC50 values for MCF-10A and JIMT-1 cells, as a measure for the selectivity of a compound to kill cancer cells, was calculated, and found to vary between just over 1 to more than 10. (lu.se)
This offers one of the most challenging paradoxes in cancer biology: what is required of a cell to not only survive massive genetic damage but also outcompete neighboring cells and present as a malignant tumor? (lu.se)
Загальні відомості про терапію злоякісних новоутворень Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. (lu.se)
Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks of cancer, including proliferation and cell adhesion. (lu.se)

RASSF7 Hepatocellular carcinoma Proliferation Cell cycle MEK1/2-ERK1/2 pathway. (cellmolbiol.org)
Genetic deletion of Erk1/2 or pharmacological targeting of MEK1/2 results in supraphysiological activity of the ERK5 pathway. (genengnews.com)

The findings from this study were published recently in Nature Communications in an article entitled "ERK5 Signalling Rescues Intestinal Epithelial Turnover and Tumour Cell Proliferation upon ERK1/2 Abrogation. (genengnews.com)

SMARCB1 is a core protein subunit of the 15 subunit SWI/SNF (or BAF) complex involved in regulating the nucleosome architecture of our genome and has been shown to be a potent tumor suppressor gene, meaning that its primary role is to control cell division and to even halt division under appropriate circumstances (i.e. signals to over-replicate). (wikipedia.org)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The IFT80 gene provides instructions for making a protein that is part of a group (complex) called IFT complex B. This complex is found in cell structures known as cilia. (medlineplus.gov)

For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)

Our findings provide the first evidence that PLC-Ca2+ -CREB signalling pathway mediates the nongenomic effects of diethylstilbestrol on gubernaculum testis cells . (bvsalud.org)
These findings indicate that PPARγ plays a critical role in the control of B cell response and imply a role in diseases in which B cell hyperreactivity is involved, such as arthritis and autoimmunity. (jci.org)
The researchers were excited by their findings but urged caution at over interpretation of their initial findings and suggested that other classes of inhibitors be tested in combination with ERK5 inhibitors in human CRC cells in preclinical mouse models before any patient trial can begin. (genengnews.com)

Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
Immunofluorescent staining of intestinal epithelium tissue shows cell growth (green). (genengnews.com)

and downregulation of Bcl-2 antiapoptotic in SW-480 treated cells. (notchgene.com)

Acitvated HSCs trigger the expression of α-smooth muscle actin (α-SMA) and production of abnormal ECM, along with enhanced proliferation and migration [ 4 - 5 ]. (oncotarget.com)
This, in turn, creates a clonal population of a single abnormal cell. (medscape.com)
A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)

cell cycle phase distribution was evaluated Annexin V-FITC / PI staining. (notchgene.com)
In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
Antimetabolites such as fluorouracil and methotrexate are cell cycle-specific and have a nonlinear dose-response relationship. (msdmanuals.com)
Continuous infusion may increase cell kill with some cell cycle-specific drugs (eg, fluorouracil). (msdmanuals.com)

Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)

To evaluate cytotoxicity of PFT-μ in non-malignant cells we analyzed BMSC samples of four AML patients as well as PB MNC (n=6) and CD34-positive cell samples (n=5) from healthy donors. (tech-strategy.org)
LncRNAs have been proved to be involved in the promotion of glioma cell malignant development. (jcancer.org)

In this study, we confirm linc01023 is up-regulated in glioma tissues and cell lines. (jcancer.org)

This material is considered to stimulate the intrinsic pathway of healing. (thieme-connect.de)

In the current study, we profiled linc01023 expressions in glioma tissues and cells. (jcancer.org)
Compared with the normal tissues, the expression of MicroRNA-16-5precursor was low in glioma tissues, which was consistent with that in the Uppsala87 and Uppsala251 cell lines. (ijpsonline.com)
We have demonstrated the MicroRNA-873-5p-p53/ Bcl-2 Associated X-protein regulatory pathway in the development of glioma, which provides a theoretical basis for the development of the alternative strategies for the clinical treatment of glioma. (ijpsonline.com)

The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)

Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
In a normal mouse model (left), cell growth is controlled, but in a mouse model with the ERK1/2 pathway blocked (right) increased cell proliferation and loss of organization occurred. (genengnews.com)
There was more cell growth and loss of organization within the cells. (genengnews.com)
The exciting part of this new study is investigators found that treating both ERK1/2 and the compensatory pathway ERK5 concomitantly with a combination of drug inhibitors halted CRC growth more effectively in both mouse models and human CRC cell lines. (genengnews.com)
This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)

Anatomy42

Organisms13

Diseases13

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes56

Disciplines and Occupations1

Information Science3

Apoptosis29

Differentiation15

MTOR signali4

MAPK9

Angiogenesis5

Proteins2

Induces1

PI3K4

Reduced proliferation and migration1

Inhibition4

Knockdown4

Tumor cells3

Regulation5

Protein kinase2

Significantly8

Regulate5

Vitro and in vivo4

Mechanism7

Regulates cell1

Progression3

Collectively2

Intracellular4

Signaling16

Liver cancer1

Assay4

Molecular2

Inhibit1

Apoptotic1

Biosynthesis1

Metabolic2

Mechanisms6

Oncotarget1

Invasion3

Therapeutic target1

Inhibitory effect2

Metabolism2

Cancer25

MEK12

Turnover1

Gene4

Airway1

Findings3

Intestinal2

Downregulation1

Abnormal3

Cycle4

Involves1

Malignant2

Tissues and cell lines1

Stimulate1

Glioma3

Molecules1

Growth5