Cells neutrophil infiltration. Medical search. Frequent questions

These results indicate that HBO improves ischemic wound healing by downregulation of HIF-1alpha and subsequent target gene expression with attenuation of cell apoptosis and reduction of inflammation. (nih.gov)
Pulmonary inflammation was assessed via bronchoalveolar lavage fluid (BALF) cell and protein quantification and inflammatory cytokine/chemokine expression was determined by electrochemiluminescence. (cdc.gov)
RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. (jci.org)
Mitochondria have recently emerged as key drivers of inflammation associated with cell death. (nature.com)
In this review, we discuss how mitochondria can initiate inflammation during cell death highlighting parallels with bacterial activation of inflammation. (nature.com)
Moreover, we discuss the roles of mitochondrial inflammation during cell death and how these processes may potentially be harnessed therapeutically, for instance to improve cancer treatment. (nature.com)
Apoptotic caspase activity inhibits cell death-associated inflammation. (nature.com)
Mitochondrial-driven inflammation can enhance the immunogenicity of cell death. (nature.com)
Is mitochondrial-driven inflammation during cell death driven by bacterial-like DAMPs? (nature.com)
What physiological functions has mitochondrial inflammation during cell death? (nature.com)
Interleukin (IL)17-producing Th17 cells, which are different from Th1 and Th2 cells, have been described as serving critical roles in inflammation and autoimmune diseases, as well as in cancer development ( 8 - 11 ). (spandidos-publications.com)
Neutrophils play an essential role in the host defense and in inflammation, but the latter may trigger and sustain the pathogenesis of a range of acute and chronic diseases. (go.jp)
The recruitment of neutrophils in airway inflammation may account for the generation of IL-8. (go.jp)
To evaluate the effectiveness of green tea polyphenols in the modulation of airway inflammation through the blocking of neutrophil chemokine production, nasal mucosal fibroblasts and A549 bronchial epithelial cells were analyzed for the production of IL-8. (go.jp)
In addition, using immunohistochemical staining and quantification of terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL)-positive and activated caspase-3-positive cell death after intraperitoneal LPS challenges, we addressed the hypothesis that this exaggerated inflammation exacerbates the neurodegenerative process. (jneurosci.org)
Together, these proposals comprise the "microglial priming hypothesis," which predicts that microglia, primed by an existing pathology such as synapse, axon, or neuronal cell body degeneration or by amyloid deposition can be stimulated to an aggressive state of inflammation by secondary influences, such as infection and injury, and during this window of activation can exacerbate neuronal death. (jneurosci.org)
This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)
These data suggest that intrauterine LPS induces parturition directly, independent of myometrial inflammatory cell infiltration, and that fetal demise occurs without fetal inflammation. (imperial.ac.uk)
Major physical trauma triggers the release of damage- and pathogen-associated molecular patterns, cytokine expression, neutrophil-mediated inflammation, and physiological barrier disruption. (uni-ulm.de)
We have previously demonstrated that increased release of small extracellular nanovesicles (sEVs, exosomes) from endothelial cells after thorax trauma (TxT) propagates local and systemic inflammation. (uni-ulm.de)
Pharmacological inhibition of sEV-biogenesis in mice after TxT significantly normalized plasma-sEV concentrations, reversed adverse molecular signatures, impaired neutrophil infiltration, systemic inflammation, barrier destabilization and secondary acute kidney injury. (uni-ulm.de)
Thus, we want to test the hypothesis that inhibiting sEV-secretion or -uptake by endothelial cells/neutrophils might be a promising strategy to attenuate aberrant inflammation after severe trauma. (uni-ulm.de)
Thorax trauma (TxT) drives the release of pro-inflammatory small extracellular vesicles (sEVs) from endothelial cells, which systemically propagate endothelial inflammation, cytokine release, neutrophil activation, endothelial barrier disruption and secondary organ damage in kidneys (trauma-related acute kidney injury, TRAKI). (uni-ulm.de)
Likewise, dexamethasone can reduce cerebral cell apoptosis and inhibit inflammation [ 10 ,] and deferoxamine (DFX) provides new therapy target [ 11 ]. (karger.com)
Previous work by the MIT/MGH and Rutgers team, along with independent research, has demonstrated a link between liver inflammation and the hepatic gap junctions that enable direct intercellular communication between coupled cells in the liver. (genengnews.com)
Cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can be generated by inflammatory and nonimmune cells in response to inflammation, tissue injury, microbial invasion, and immunological reactions ( Dinarello, 1994 ). (jneurosci.org)
Syrina is a pharmacist and her research in cell pathology focuses on neutrophils recruitment in colorectal cancers microenvironment and in cancer related inflammation. (lu.se)

Vascular endothelial growth factor, cyclooxygenase-2, and neutrophil infiltration were reduced in ischemic wounds treated with HBO. (nih.gov)
Serum bioactivity of whole and exosome-depleted fractions was assessed in mouse brain endothelial cells via serum cumulative inflammatory potential (SCIP) assay. (cdc.gov)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
In the analysis of immune infiltration, ATF2 was negatively correlated with T cells but positively correlated with neutrophils and endothelial cells. (hindawi.com)
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. (cancerindex.org)
These effects were mediated by systemic transfer of transcripts for endothelial cell adhesion molecules, such as ICAM-1 and cytokines, like IL6 or CXCL8 by sEVs to the endothelium. (uni-ulm.de)
Besides, we will generate targeted, therapeutic sEVs with siRNAs against cytokines to impair sEV-loading of pro-inflammatory transcripts in ICAM-1-positive endothelial and lung alveolar cells. (uni-ulm.de)
Project A06 seeks to disrupt these adverse events by identifying clinically approved drugs that block sEV secretion or uptake for endothelial cells and neutrophils. (uni-ulm.de)
It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)

The following cells were identified: mast cells (AA1:tryptase), eosinophils (EG1:stored cationic protein and EG2: secretory form of cationic protein), monocytes/macrophages (CD68), neutrophils (elastase), CD3+ and CD8+ T cells (CD3 polyclonal Ab and CD8+ mAb, respectively). (nih.gov)
Treatment was associated with the early appearance of CD4 cells, activated dendritic cells and macrophages, with later infiltration by CD8 T cells. (nih.gov)
Dendritic cells continually increased with time, while macrophages reached a maximum at 1 week and then declined slightly. (nih.gov)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. (who.int)

Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
Methods We stimulated purified monocytes and whole peripheral blood mononuclear cells (PBMCs) from patients with GPA, patients with MPA or healthy controls with PR3 or MPO and visualised MGC and granuloma-like structure formation using light, confocal and electron microscopy, as well as measuring the cell cytokine production. (bmj.com)
prior to labor, myometrial neutrophils and monocytes numbers were greater in PBS-injected mice, but this was not associated with an earlier onset of labor. (imperial.ac.uk)

MWCNT exposure significantly increased macrophage and neutrophil infiltration in BALF. (cdc.gov)
Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. (bmj.com)

The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. (spandidos-publications.com)

RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. (who.int)
Lactate dehydrogenase (LDH) activity, inflammatory cells, and total protein concentration were analyzed in bronchoalveolar lavage fluid (BALF). (lu.se)
We observed a significant increase in IFN-γ-producing CD8 + T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor , a species that is not typically associated with invasive, disseminated disease. (cdc.gov)

We hypothesize that neutrophil recruitment could be exploited as a therapeutic approach to alleviate oral cancer pain in female mice. (frontiersin.org)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)

During the course of hepatocyte necrosis, an intense accumulation of neutrophils is often observed within the liver microenvironment. (mdpi.com)
the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions. (bvsalud.org)

The numbers of EG1- and EG2-positive eosinophils infiltrating the airway wall of the larger airways were greater in fatal asthma than in mild-moderate asthma (78.2 versus 22.8 cells/mm2, p = 0.012 and 138.1 versus 31.7 cells/mm2, p = 0.022). (nih.gov)
The presence of more than 10% of eosinophils in the cell population in the nasal secretion supports the diagnosis. (medscape.com)

The latter mediates aseptic abruption-related neutrophil infiltration. (scirp.org)

Imiquimod is presumed to clear basal cell carcinoma (BCC) through apoptosis mediated by cytokines and lymphocytes, with erosion often observed correlating with complete clearance. (nih.gov)
CD4 and CD8 T lymphocytes play an import role in the inflammatory response, as these cells may manage the profile of cytokines produced against an infectious agent 4 . (bvsalud.org)
Lymphocytes and plasma cells mixed with neutrophils are the predominant infiltrating inflammatory cells. (msdmanuals.com)

De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
Studies have clearly shown that tissue neutrophil numbers need to be tightly regulated for optimal CDI outcomes: while excessive colonic neutrophilia is associated with severe CDI, neutrophil depletion also results in worse outcomes. (frontiersin.org)
C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
RR genotype) was associated with higher CXCR2 expression and more tissue neutrophils. (frontiersin.org)
and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
However, despite a key role for neutrophils in disease pathogenesis, the underlying biological mechanisms that regulate systemic and tissue neutrophil numbers after CDI remain poorly defined. (frontiersin.org)
Infiltration of neutrophils occurs as a response to chemoattractant molecules by resident tissue cells. (go.jp)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
Our results indicate that IL-8 overexpression in corneal tissue causes ulcer formation in the cornea through chemoattraction of neutrophils, suggesting the aetiological role of IL-8 in some types of corneal ulcers. (bmj.com)
The local action of these released peptides are known to increase tissue blood flow, capillary permeability, and inflammatory cell activities ( Holzer, 1988 ). (jneurosci.org)
Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)
Her research involves methods as tissue microarray (TMA) of colon cancer patients for immunohistochemistry (IHC) and Western blot, qPCR, transfection, luciferase assay, immunofluorescens on colon cancer cell lines. (lu.se)

Flow cytometry showed that LPS induced a dramatic systemic inflammatory response provoking a rapid and marked leucocyte infiltration into the maternal lung and liver in association with increased cytokine levels. (imperial.ac.uk)
Detected in spleen, lung and muscle, probably as a result of leucocyte infiltration in these tissues. (lu.se)

It has been confirmed that naïve (uncommitted) CD4 + T cells can be induced to different specific lineages according to the local cytokine, including towards T helper (Th)1, Th2, Th17 and T regulatory (Treg) cells ( 7 ). (spandidos-publications.com)
To achieve this, we assessed proinflammatory cytokine expression, inflammatory cell infiltration, and expression of effector enzymes such as cyclooxygenase 2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) after intracerebral and intraperitoneal LPS challenges. (jneurosci.org)

Neutrophils are key first-responders in the innate immune response to C. difficile infection (CDI) and play a central role in disease pathogenesis. (frontiersin.org)
This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. (jci.org)
Considering these facts, it could be concluded that pro-inflammatory Th17 cells may have extensive effects on LSCC pathogenesis and anti-tumor response. (spandidos-publications.com)

With just a blood sample from a patient, a promising technology has the potential to accurately diagnose non-small cell lung cancer (NSCLC ), the most-common form of the disease, more than 90 percent of the time. (nih.gov)
RESULTS: BALB/c and C57Bl/6J mice showed infiltration of neutrophils to the lung, and an increase in total protein concentration and LDH activity in response to dsRNA administration. (lu.se)
Airway IFN-γ + CD8 + T-cells were decreased and lung germination was eliminated in mice that aspirated A. fumigatus conidia that were formaldehyde-fixed or heat-inactivated. (cdc.gov)

Unlike the development of squamous cell carcinoma, the development of sarcomas is unrelated to smoking and alcohol use. (medscape.com)
We hypothesize that a neutrophil-mediated endogenous analgesic mechanism is responsible for sex differences in nociception secondary to oral squamous cell carcinoma (SCC). (frontiersin.org)
The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)

We previously demonstrated that male mice with carcinogen-induced oral SCC exhibit less nociceptive behavior and a higher concentration of neutrophils in the cancer microenvironment compared to female mice with oral SCC. (frontiersin.org)
We found that recombinant G-CSF (rG-CSF, 5 μg/mouse, intraperitoneal) significantly increased circulating Ly6G + neutrophils in the blood of male and female mice within 24 h of administration. (frontiersin.org)
In an oral cancer supernatant mouse model, rG-CSF treatment increased cancer-recruited Ly6G + neutrophil infiltration and abolished orofacial nociceptive behavior evoked in response to oral cancer supernatant in both male and female mice. (frontiersin.org)
Chronic rG-CSF treatment (2.5 μg/mouse, every 72 h) increased the HSC-3 recruited Ly6G + neutrophils, increased β-endorphin protein content in the tongue and attenuated nociceptive behavior in female mice with HSC-3 tumors. (frontiersin.org)
Using conventionally raised and germ-free Ern2-/- mice, we found that ERN2 was required for microbiota-induced goblet cell maturation and mucus barrier assembly in the colon. (jci.org)
Mice lacking Ern2 had a dysbiotic microbial community that failed to induce goblet cell development and increased susceptibility to colitis when transferred into germ-free wild type mice. (jci.org)
We show that, using the ME7 model of prion disease, intracerebral challenge with LPS results in dramatic interleukin-1β (IL-1β) expression, neutrophil infiltration, and inducible nitric oxide synthase expression in the brain parenchyma of prion-diseased mice compared with the same challenge in normal mice. (jneurosci.org)
Remarkably, Ager AHA/AHA mice phenocopied Ager −/− mice in two different pathophysiological processes, namely bone remodeling and neutrophil-mediated liver injury, which demonstrates that HS-induced RAGE oligomerization is essential for RAGE signaling. (elifesciences.org)
Finally, we have performed RNA-seq analysis of neutrophils and lungs and found that while Ager −/− mice had a broad alteration of transcriptome in both tissues compared to wild-type mice, the changes of transcriptome in Ager AHA/AHA mice were much more restricted. (elifesciences.org)
The spatial patterns of liver injury in the TAA-treated wild-type mice led the authors to postulate that gap junction communication between cells might promote the propagation and amplification of an injury signal after TAA treatment. (genengnews.com)
Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)

Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
Results: Light microscopy analysis revealed a decreased expression of GATA-3-positive cells when bone loss progressed. (bvsalud.org)

Furthermore, the proliferation of Th17 cells and Th17‑associated cytokines, including interleukin (IL)17, IL23 and RAR‑related orphan receptor γt, was analyzed by reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
It was further demonstrated that Th17 cells could be induced and expanded in the tumor microenvironment through cytokines produced by the tumor cells. (spandidos-publications.com)
Production of IL-8 after stimulation by proinflammatory cytokines in both nasal fibroblasts and bronchial epithelial cells was significantly blocked by pretreatment with green tea polyphenols. (go.jp)
Progression of periodontal lesions is caused by dysregulation of molecules (cytokines) released by specific cell populations 5 . (bvsalud.org)
They can be distinguished based on the profile of cytokines produced: Th1 cells produce characteristic cytokines such as IL-2, IFN-γ, TNF-β, IL-12, while active Th2 cells secrete IL-4, IL-5, IL-6, IL-10 and IL-136. (bvsalud.org)

In addition to Th1 and Th2 cells, Th17, Treg and T Fh cells have also been described 7 , Treg cells are associated with reduction of clinical scores of disease in soft and hard tissues 8 . (bvsalud.org)
These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. (lu.se)

Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)

This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)

Neutrophils isolated from the cancer-induced inflammatory microenvironment contain β-endorphin protein and are identified by the Ly6G + immune marker. (frontiersin.org)
In addition, the LSCC microenvironment was identified as a strong Th17-cell inducer. (spandidos-publications.com)
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
It´s still not clear what role the infiltration of neutrophils in colorectal cancer have and how many types of neutrophils exist that interact with cancer and its effect on CRC microenvironment. (lu.se)
Now, she is interested in the interaction between the immune cells (mainly mast cells) present in the colon cancer microenvironment and colon cancer cells. (lu.se)

We have tested the hypothesis that airway infiltration by inflammatory cells reflects the severity of asthma by comparing the inflammatory cell infiltrates in fatal severe asthma and in subjects with mild to moderate asthma who died of unrelated causes. (nih.gov)

Because cancer cells within a tumor can vary greatly, a single biopsy taken at a single site in the tumor may miss cells with PD-L1. (nih.gov)
Histopathology of biopsy specimen showed some granuloma with central neutrophils infiltration and adjacent multinucleated giant cells and inflammatory cell infiltration. (jpgmonline.com)

In vivo , it regulates the proinflammatory effects of IL-22 ( e.g. neutrophil infiltration) but not of IL-10 (7). (rndsystems.com)

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
Displayed on the surface of a cancer cell, PD-L1 can bind to a protein found on immune cells with the similar designation of PD-1. (nih.gov)
BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. (lu.se)

PBMCs stimulated by PR3 formed granuloma-like structures with central MGC surrounded by T cells. (bmj.com)
Although the structure of the granulomas and multinucleated giant cells in granulomatosis with polyangiitis (GPA) is known, little is established about what drove granuloma formation and why it is infrequently found in patients with myeloperoxidase-antineutrophil cytoplasm antibodies. (bmj.com)

Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. (rndsystems.com)

Many of the pro-inflammatory pathways activated during cell death occur upon mitochondrial outer membrane permeabilization (MOMP), the pivotal commitment point to cell death during mitochondrial apoptosis. (nature.com)
Caspases, while dispensable for cell death during mitochondrial apoptosis, inhibit activation of pro-inflammatory pathways after MOMP. (nature.com)
Animal experiments demonstrated that fingolimod could reduce edema, cell apoptosis and cerebra atrophy and show neuroprotective function in ICH rats [ 8 ]. (karger.com)
Thus any modification of ECM components can be transmitted via integrins and impact on cell movement during development and proliferation, differentiation, apoptosis. (springer.com)

T cells can participate in the inflammatory response of IDD by highly expressing gamma interferon (IFN- γ ) [ 10 , 11 ]. (hindawi.com)
Intrauterine LPS provokes a marked local and systemic inflammatory response but with limited inflammatory cell infiltration into the myometrium or placenta. (imperial.ac.uk)
Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization. (lu.se)

During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). (scirp.org)
Decidual cell-derived thrombin weakens the amniotic membrane and lowers decidual cell-expressed progesterone receptor levels by increasing phospho-ERK1/2 signaling. (scirp.org)
The mechanism of exercise-induced myopathy could be the cell membrane damage by lipid peroxidation and DNA fragmentation in the working muscle cells by free radicals generation. (scielo.org.ar)
ECM components (i.e., fibronectin or collagens) directly interact with membrane receptors (i.e., integrins), particularly, by influencing cell behavior. (springer.com)

In the current study, we used LPS to mimic aspects of central or systemic infection and the ME7 model of murine prion disease to model chronic neurodegeneration to address the hypothesis that microglial cells, activated by chronic neurodegeneration, are primed to produce greater proinflammatory responses to subsequent central and systemic inflammatory challenges. (jneurosci.org)

Histopathologically, epidermal acantholysis and neutrophil infiltration predominate, hence the synonyms intraepidermal neutrophilic (IEN) IgA dermatosis, intraepidermal IgA pustulosis, IgA herpetiform pemphigus, and intercellular IgA vesiculopustular dermatosis have been used to describe this group of diseases. (medscape.com)

We infer that rG-CSF-induced Ly6G + neutrophils drive an endogenous analgesic mechanism. (frontiersin.org)
however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. (jci.org)
One of the reasons for this is the acquisition of Gem resistance (Gem‑R). To elucidate the mechanism of Gem‑R, two Gem‑R PaCa cell lines were established from AsPC‑1 and MIA PaCa‑2 cells. (cancerindex.org)

The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. (nature.com)
IL-22BP is critical for limiting IL-22 induced epithelial cell proliferation during wound healing, and its deficiency can enable uncontrolled proliferation and enhance tumor development (12). (rndsystems.com)

The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Neutrophils are one of the most common inflammatory mediators in tumors which secretes a large amount of leukotrienes. (lu.se)

Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a similar clinical presentation, one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. (jci.org)

We then evaluated the efficacy of chronic rG-CSF administration to attenuate oral cancer-induced nociception using a tongue xenograft cancer model with the HSC-3 human oral cancer cell line. (frontiersin.org)

In mouse embryos, cells seem prepatterned to become certain cell lineage because the first cleavage plane has been related with further embryonic-abembryonic axis at the blastocyst stage. (bioone.org)
However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. (medscape.com)

Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells. (spandidos-publications.com)
13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
Mononuclear cells and neutrophils infiltrate the entire mucosa to the level of the muscularis, but exudate or crypt abscesses seldom result, as might be expected by such infiltration. (msdmanuals.com)

neutrophils through the dermis and sub- cutis. (who.int)

In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
This study is to explore the biomarkers in IDD and to explore the role of immune cell infiltration in IDD. (hindawi.com)
The SNHG5/miR-299-5p/ATF2 can be used as biomarker of IDD, and infiltration of immune cells plays an important role in the pathological development of IDD. (hindawi.com)
They carry RNA and proteins (including PD-L1) throughout the body and are known to play a role in communication between cells. (nih.gov)
It has been shown to induce an intense myometrial inflammatory cell infiltration, but the role of LPS-induced inflammatory cell activation in labor onset and fetal demise is unclear. (imperial.ac.uk)
Neutrophils play a vital role in protecting against infection, so the duration and severity of neutropenia directly correlate with the total incidence of all infections, including those that are life threatening. (medscape.com)

From these data, we conclude that neutrophil-mediated endogenous opioids warrant further investigation as a potential strategy for oral cancer pain treatment. (frontiersin.org)

Epithelial cells lining mucosal surfaces of the gastrointestinal and respiratory tracts uniquely express ERN2/IRE1β, a paralogue of the most evolutionarily conserved endoplasmic reticulum stress sensor ERN1/IRE1α. (jci.org)
Both nasal mucosal fibroblasts and bronchial epithelial cells produced significant amounts of IL-8 through stimulation of IL-1β. (go.jp)

Finally, the infiltration of immune cells in the data were analyzed by MCPcounter analysis package. (hindawi.com)
At the same time, the nucleus pulposus cells release Fas ligand (FasL) tumor necrosis factor to destroy the infiltrating immune cells and maintain immune isolation [ 14 , 15 ]. (hindawi.com)
When the body's immune system detects a developing tumor, it activates various immune cells that work together to kill the suspicious cells. (nih.gov)
The binding of the two proteins keeps immune cells from killing tumor cells. (nih.gov)

Results In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. (bmj.com)
Aim: To evaluate the involvement of Th2 cells in different periods of the active phase of experimental periodontal disease and expression of the R1 subunit of the receptor for IFN-γ during the early and advanced progression of the disease. (bvsalud.org)
This signal together with the T Cell Receptor (TCR) induces the expression of GATA-3. (bvsalud.org)

The objective was to determine the cellular immune response early in the course of treatment in order to examine whether cell mediated immunity could be responsible for imiquimod mediated regression of BCC. (nih.gov)

Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
To achieve this, cells of in vitro produced bovine embryos were traced from the 2-cell stage to the blastocyst stage. (bioone.org)
To test whether Cx32 is required to propagate an oxidative stress signal to neighboring cells, the team generated an in vitro co-culture system. (genengnews.com)
Human fibroblast monocultures were found to be insufficient to fully replicate in vivo fibrosis outcomes suggesting in vitro predictive potential depends upon more advanced cell culture in vitro models. (cdc.gov)

Inhibiting gap junctions in liver cells could provide a feasible strategy to preventing drug-induced liver injury (DILI), investigators claim. (genengnews.com)

Overview of Acid Secretion Acid is secreted by parietal cells in the proximal two thirds (body) of the stomach. (msdmanuals.com)

Here, we investigated the biological mechanisms that regulate neutrophil CXCR2 expression after CDI, and the influence of host genetics on this process. (frontiersin.org)
It was demonstrated that expression of interleukin‑8 (IL‑8) mRNA was significantly upregulated in Gem‑R PaCa cells by cDNA microarray and RT‑qPCR analyses. (cancerindex.org)
IFN-γ R1 was detected at an early stage during the active phase of disease, but the expression of positive cells remained unaltered during the remaining period of the study. (bvsalud.org)
Expression increases throughout myelocyte differentiation and peaks in the mature myelomonocytic cells. (lu.se)
INF-gamma increases expression in neutrophils. (lu.se)
Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines. (lu.se)

EVs are tiny molecular containers released by cells. (nih.gov)
Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)

Anatomy36

Organisms15

Diseases50

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes29

Disciplines and Occupations1

Health Care1

Inflammation27

Endothelial15

Macrophages6

Monocytes3

Macrophage2

Studied using immunohistoch1

Bronchoalveolar lavag3

Recruitment2

Accumulation4

Eosinophils2

Mediates1

Lymphocytes3

Tissue15

Leucocyte infiltration2

Cytokine2

Pathogenesis3

Lung3

Squamous Cell Carc3

Mice11

Bone5

Cytokines5

Tissues2

Matrix metalloproteinases1

Chemokine1

Microenvironment5

Tested the hypothesis1

Biopsy2

Regulates1

Protein4

Granuloma2

Colorectal1

Apoptosis4

Inflammatory response3

Membrane4

Proinflammatory1

Neutrophilic1

Mechanism3

Proliferation2

Tumors4

Immunohistochemistry1

Chronic1

Lineage2

Mononuclear cells3

Dermis1

Role6

Endogenous1

Epithelial2

Immune cells4

Receptor3

Cellular1

Vitro4

Liver injury1

Secretion1

Expression6

Molecular2