• membrane
  • They make their entrance into the cytoplasm either from outside the cell through the cell membrane via calcium channels (such as calcium-binding proteins or voltage-gated calcium channels), or from some internal calcium storages such as the endoplasmic reticulum and mitochondria. (wikipedia.org)
  • In addition, the plasma membrane Ca2+ ATPase (PMCA) obtains energy to pump calcium out of the cell by hydrolysing adenosine triphosphate (ATP). (wikipedia.org)
  • Each pre-synaptic cell can have from 10 to 100 ribbons tethered at the membrane, or a total number of 1000-10000 vesicles in close proximity to active zones. (wikipedia.org)
  • zebrafish
  • Using the minnow-sized zebrafish in his research, Drew is working with Dr. Brian McDermott and other researchers at Case Western Reserve University School of Medicine to learn more about how hair cells play a role in hearing. (prweb.com)
  • A frame from a timelapse video shows three pairs of hair cells (green) in a neuromast of the lateral line of a zebrafish larva. (rockefeller.edu)
  • Synapse
  • Synapse formation by each hair cell of the zebrafish's lateral line occurs during a particular interval after the cell's birth. (rockefeller.edu)
  • This interpretation has recently been questioned at the inner hair cell ribbon synapse, where it has been instead proposed that exocytosis is described by uniquantal (i.e., univesicular) release shaped by a flickering vesicle fusion pore. (wikipedia.org)
  • Information is conveyed from photoreceptor cells to bipolar cells via the release of the neurotransmitter glutamate at the ribbon synapse. (wikipedia.org)
  • Parkinson's
  • A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parson's lab at King's College London, learning new cell migration assays and analysing fibroblasts cultured from individuals with Parkinson's. (biologists.org)
  • Parkinson's disease is the second most common neurodegenerative disease, in which the death of dopamine-producing cells in the substantia nigra of the midbrain leads to impaired motor function, perhaps best characterised by tremor. (wikipedia.org)
  • dermal
  • To manufacture RCH-01, dermal sheath cup cells are isolated from a small punch biopsy taken from the back of a subject's scalp. (belgraviacentre.com)
  • induce
  • It is vitally important to regulate this calcium gradient, not least because high levels of calcium are toxic to the cell, and can induce apoptosis. (wikipedia.org)
  • calcium ions
  • Calcium ions (Ca2+) play a vital role in the physiology and biochemistry of organisms and the cell. (wikipedia.org)
  • The influx of calcium ions into the cell can initiate a myriad of calcium-dependent processes including muscle contraction, gene expression, and secretion. (wikipedia.org)
  • patch-clamp
  • Whole-cell patch-clamp recordings demonstrate that these transient PCDH15/PCDH15 links mediate mechanotransduction currents of normal amplitude but abnormal Ca(2+)-dependent decay (adaptation). (nih.gov)
  • researchers
  • First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. (biologists.org)
  • Importantly, when the researchers treated macrophages with a Wnt inhibitor drug, the activation of hair growth was delayed, demonstrating a role for Wnts from macrophages in promoting hair growth. (india.com)
  • afferent nerve
  • During the same period projections emerge from the cellular soma, extending toward a specific subpopulation of mature hair cells and interacting with polarity-specific afferent nerve terminals. (rockefeller.edu)
  • The hair cell at the lower left, which formed recently as the sister of the cell at the lower right, extends a projection (red arrowhead) toward a growth cone (teal arrowhead) from an afferent nerve fiber (magenta). (rockefeller.edu)
  • This results from the specialized mechanoreceptor cells that are superimposed upon the afferent nerve fibers. (wikipedia.org)
  • Afferent nerve endings without mechanoreceptor cells are called free nerve endings. (wikipedia.org)
  • genetic
  • RepliCel's technique involves re-activating existing hair follicles in people with the genetic hair loss conditions Male Pattern Baldness and Female Pattern Hair Loss . (belgraviacentre.com)
  • Rounding out the scientific bases of this book, chapter six covers genetic aspects of hair cell derived hearing loss unique to Usher Syndrome. (audiology.org)
  • restore
  • Organix Renewing Moroccan Argan Oil instantly penetrates the hair shaft to restore shine, softness and strength. (bizrate.com)
  • This research success marks a major breakthrough toward medicine's eventual ability to restore missing hair cells and lost hearing of patients. (thefreelibrary.com)
  • Although hair cells can regenerate disrupted tip links and restore hearing, the molecular details of this process are unknown. (nih.gov)
  • apoptosis
  • They observed that when skin cells are dormant, a fraction of macrophages die naturally due to a normal process called apoptosis. (india.com)
  • organisms
  • All organisms, and apparently all cell types, sense and respond to mechanical stimuli. (wikipedia.org)
  • In specialized cells of the higher organisms, other types of MSCs are probably the basis of the senses of hearing and touch and sense the stress needed for muscular coordination. (wikipedia.org)
  • PCDH15
  • Immature mouse cochleae and UB/OC-1 cells were used in this work to address whether specific variants of PCDH15 and VLGR1 are being selectively transported to opposite poles of the hair cells. (biomedsearch.com)
  • mechanisms
  • Once we have a stronger understanding of the cellular mechanisms behind cancer cells' ability to thrive, we will have a better chance of interrupting them. (medicalnewstoday.com)
  • influx
  • For example, the sodium-calcium exchanger uses energy from the electrochemical gradient of sodium by coupling the influx of sodium into cell (and down its concentration gradient) with the transport of calcium out of the cell. (wikipedia.org)
  • density
  • The goals of the trial will be to ascertain safety, as well as test the efficacy of the product based on hair fibre thickness and density. (belgraviacentre.com)
  • In clinical trials, after injections are performed, subjects return to the clinic at regular intervals for assessment of total, terminal and vellus hair density and cumulative hair thickness, as well as for safety and data collection. (belgraviacentre.com)
  • Hair cells lack an arciform density so the anchor of this ribbon is considered to be invisible by electron microscope. (wikipedia.org)
  • cellular
  • Within a typical cell, the intracellular concentration of ionized calcium is roughly 100 nM, but is subject to increases of 10- to 100-fold during various cellular functions. (wikipedia.org)
  • structure
  • Moroccan argan oil has a centuries-old history of providing natural Vitamin E and antioxidants while renewing hair's cell structure. (bizrate.com)
  • specific
  • The method involves extracting hair from the scalp, identifying specific cell populations and then replicating them in a lab before they are implanted back into the areas of the scalp where they are needed. (belgraviacentre.com)
  • Although
  • Although this chapter is of significant value to the student of cochlear physiology, it is helpful in educating the clinical audiologist regarding type I hair cells and afferents. (audiology.org)
  • Although the core of this book is about hair cell mechanics, it is in the final two chapters that the reader will discover the most clinically relevant information. (audiology.org)