Cells epididymis. Medical search. Frequent questions

Detailed histopathological examination of testis and epididymis were performed, as well. (europa.eu)
However, in the 200 and 800 mg/kg groups the relative and absolute weights of testis and epididymis were significantly decreased.The results of sperm analysesshowedsignificantlyreduced ofsperm motility, viability, survivability and the number of sperms in the left epididymis in the group treated with 50 mg/kg or more of the test chemical compared with controls. (europa.eu)
To investigate the presence of Coumestrol-Estrogen Receptor complexes by fluorescence in testis and epididymis, its effect in the ER expression by immunostain in the same tissues and the effect of this binding in the testis histological characteristics. (nel.edu)

The epididymis serves as an interconnection between the multiple efferent ducts at the rear of a testicle (proximally), and the vas deferens (distally). (wikipedia.org)
Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
During their passage through the epididymis to the vas deferens, sperm acquire their motility. (jci.org)
Testes, seminal vesicles, epididymis + vas deferens. (jax.org)
Three distinctive types of neoplasm were induced in hamsters by a combination of oestrogen and testosterone: a tumour of the uterine endometrium, a tumour of the vas deferens-epididymis and a basal-cell epithelioma of the flank. (inchem.org)
Duct system , which includes the epididymis and vas deferens through which the sperm-containing fluid semen travels. (michaelshealth.com)
A coiled tube at the back of each testicle that stores sperm cells while they mature and carries them to the vas deferens (the tube that carries sperm from the testicle to the urethra). (cancer.ca)
Neural stimulation induces contraction and forces sperm from the epididymis into the vas deferens. (histologyguide.com)
The visceral layer of the tunica vaginalis testis is closely applied to the testis, epididymis, and ductus deferens. (medscape.com)

Sperm in most mammalian species including rat, mice and human are kept completely quiescent (motionless) and viable for up to a few weeks in the cauda epididymis before ejaculation. (bioscientifica.com)
The molecular mechanisms that suppress sperm motility but increase cell survival during storage in cauda epididymis are not known. (bioscientifica.com)
Angiotensin-converting enzyme 2 is also localized in the clear cells of the cauda epididymis that are postulated to have an important immune function. (nih.gov)

Persistence of the cranial end of the mesonephric duct will leave behind a remnant called the appendix of the epididymis. (wikipedia.org)

The head of the epididymis receives spermatozoa via the efferent ducts of the mediastinium of the testis at the superior pole of the testis. (wikipedia.org)
Near the top of the testis is the head of the epididymis, which stores sperm until it is ready to undergo maturation. (healthline.com)

These parameters correlated with elevated pro-inflammatory cytokines and myeloperoxidase activity in testes, as well as increase in oxidative stress in both testes and epididymis. (cdc.gov)
An image depicting the testes and epididymis can be seen below. (medscape.com)

Spermatozoa formed in the testis enter the caput epididymis, progress to the corpus, and finally reach the cauda region, where they are stored. (wikipedia.org)
Sperm entering the caput epididymis are incomplete-they lack the ability to swim forward (motility) and to fertilize an egg. (wikipedia.org)
Immobilin is predominantly secreted into the proximal caput epididymis prior to the acquisition of the potential for sperm motility. (wikipedia.org)

Microfilariae were found in peripheral blood smears of 38 out of 294 (12.92%) tested camels, while 20 out of 125 camels (13.89%) harbored D. evansi adult worms in at least one region in their testicle, epididymis, spermatic cord, lung and heart. (scialert.net)
The tunica vaginalis testis (a remnant of the processus vaginalis) envelopes the testis in a double layer, except at the superior and posterior borders where the spermatic cord and epididymis adhere to the testes. (medscape.com)

The epididymal head overhangs the upper pole of the testis, receives the seminal fluid from the ducts of the testis (which pierce the upper portion of the mediastinum), then allows the passage of the sperm into the distal portion of the epididymis. (medscape.com)
Additionally, we found ZIKV RNA in seminal leukocytes and epithelial cells. (cdc.gov)

The epididymis is invested completely by the tunica vaginalis (which is continuous with the tunica vaginalis covering the testis). (wikipedia.org)
Partially surrounding and separating the epididymis from the testis is a thin sheet of tissue referred to as the tunica vaginalis. (healthline.com)

1296 The epididymis is covered by a two layered pseudostratified epithelium. (wikipedia.org)
The epithelium is separated by a basement membrane from the connective tissue wall which has smooth muscle cells. (wikipedia.org)
The major cell types in the epithelium are: Principal cells: columnar cells that, with the basal cells, form the majority of the epithelium. (wikipedia.org)
Human epididymis protein 4 (HE4) was first identified in the epithelium of the distal epididymis and originally predicted to be a protease inhibitor involved in sperm maturation. (nature.com)
In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
Immunohistochemical analysis showed morbillivirus antigen in the bronchiolar epithelium, type 2 pneumocytes, and alveolar multinucleate cells. (cdc.gov)

Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
Its primary function is the storage, maturation and transport of sperm cells. (wikipedia.org)
During their transit in the epididymis, sperm undergo maturation processes necessary for them to acquire motility and fertility. (wikipedia.org)
In addition to its secretory role in ensuring functional maturation and survival of spermatozoa, the epididymis has a complex immune function. (biorxiv.org)

The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
The incidences of leukaemia and of liver-cell and breast tumours in untreated mice of some strains were decreased by testosterone treatment, but the incidence of mammary tumours was increased by neonatal treatment of females of a mammary-tumour-virus-bearing strain. (inchem.org)
The tumour suppressor miR-34c targets MET in prostate cancer cells. (lu.se)

Because sperm are initially non-motile as they leave the seminiferous tubules, large volumes of fluid are secreted to propel them to the epididymis. (wikipedia.org)
This absorption creates a fluid current that moves the immobile sperm from the seminiferous tubules to the epididymis. (wikipedia.org)
We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr −/− .Leiden) mice, and studied the morphological structure of the testes and histologically examined the proportion of Sertoli cells, spermatocytes and spermatids in the seminiferous tubules. (nature.com)
The histopathological examination of the gonads revealed atrophy of seminiferous tubule of testis and the epididymis in the two highest dose groups (200 and 800 mg/kg). (europa.eu)
Immotile sperm flow from the lumen of the seminiferous tubules into the epididymis via the rete testis. (jci.org)
B ) Histological cross section through an adult mouse testis depicting seminiferous tubules, the peritubular myoid cells, and the interstitium (space between tubules). (jci.org)
The seminiferous tubules are lined with germ cells that produce sperm and nutrient fluid. (medscape.com)

The development of adult Leydig cell population was also analyzed 65 days postpartum. (frontiersin.org)
For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development. (frontiersin.org)
In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
Late-stage pubertal development of Leydig cells is mainly involved in the transition of immature Leydig cells to adult Leydig cells. (frontiersin.org)
Fluorescence signals in testis interstitial Leydig cells and epididymus indicating ER-coumestrol complexes were detected at the same points to those Immunohystochemically detected ER. (nel.edu)
The receptor is also expressed at high levels in the human testis, where it is found in both Sertoli and Leydig cells. (nih.gov)
Intestinal testicular Leydig cells and germinal cells counts were elevated significantly in mice treated with Orchis anatolica plant when compared with the other two groups. (degruyter.com)
The Leydig cells of the testes respond to LH by producing between 5 and 10 mg of testosterone daily. (msdmanuals.com)

A retrospective study reported that patient age, white blood cell count, and laterality are key factors distinguishing testicular torsion from acute scrotum. (medscape.com)

Pathscan intracellular signaling array provided the preliminary picture of cell signaling in quiescent and motile rat sperm, indicating upregulation of cell-survival pathways in quiescent sperm, which were downregulated during motility activation. (bioscientifica.com)
Data suggest that sperm motility and survival are inversely complementary and critically regulated by intracellular cell signaling. (bioscientifica.com)
Aberrant cell signaling in caudal sperm may affect cell survival (sperm concentration) and motility of ejaculated sperm. (bioscientifica.com)
To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. (bioone.org)
Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. (bioone.org)

Apical cells: predominantly found in the head region Clear cells: predominant in the tail region Intraepithelial lymphocytes: distributed throughout the tissue. (wikipedia.org)
In the embryo, the epididymis develops from tissue that once formed the mesonephros, a primitive kidney found in many aquatic vertebrates. (wikipedia.org)
The walls of the epididymis are lined in pseudostratified columnar epithelial tissue, meaning that the arrangement of the cells gives the appearance of two layers, although it is only one. (healthline.com)

Human epididymis protein 4 promotes P-glycoprotein-mediated chemoresistance in ovarian cancer cells through interactions with Annexin II. (uni-muenchen.de)
As an example, cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) have been detected in the serum of ovarian cancer patients. (biomedcentral.com)
BMMSCs additionally considerably improved the expression stage of microtubule-associated protein 1 gentle chain 3 (LC3)-II in each DCD donor livers and ROS-induced injured IAR-20 cells, together with upregulating the expression of ferritin. (nerc-bess.net)

Observamos que en el miembro superior izquierdo, el 29,7% de los ramos del nervio mediano se originaban en el tercio medio de la mitad distal del antebrazo y en el 30.3% penetraban en el tercio proximal de la mitad proximal del antebrazo. (scielo.cl)
En igual proporciones proximal y distal al músculo extensor largo del pulgar se originan los ramos digitales colaterales. (scielo.cl)

Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
Testicular dynamics parameters recorded in both testes and caudae epididymides were found to be increased only in Orchis anatolica treated mice. (degruyter.com)

Two such appendages are the appendix testis, a remnant of the paramesonephric (müllerian) duct, and the appendix epididymis, a remnant of the mesonephric (wolffian) duct. (medscape.com)

The reproductive organs of mammals produce the gametes (sperm and egg cells), help them fertilize and then support the developing embryo. (wikibooks.org)

The epididymis is a long, coiled tube that stores sperm and transports it from the testes. (healthline.com)

At diagnosis, 1-2% are bilateral and 90-95% of cases are germ cell tumours (GCT) [ 6 ]. (uroweb.org)

The epithelial cells of proximal tubules perform the functions of both copper uptake from the primary urine and release to the blood. (researchgate.net)
Pudimos observar en todos los casos que el RSNR se dividía proximal al PER en un ramo volar (R1) y un ramo dorsal. (scielo.cl)

Developmental cell 46(4): 481-494, August 2018. (upenn.edu)

Intraepithelial macrophages The stereocilia of the epididymis are long cytoplasmic projections that have an actin filament backbone. (wikipedia.org)

The virus infects Sertoli cells in the testis and causes inflammation leading to structural damage and breakdown of the blood-testis barrier (BTB) in mice. (nih.gov)
If, however, the baby is genetically male, with both an X and a Y chromosome, and all goes as planned, around day 51 the Y, or male designating chromosome, signals the gonad's Sertoli cells to blast the female organs with an anti-feminine secretion called AFH. (oneradionetwork.com)
In males, estradiol is the main inhibitor of LH production, whereas both estradiol and inhibin B, a peptide produced by Sertoli cells of the testes, inhibit production of FSH. (msdmanuals.com)
In the presence of testosterone , FSH stimulates the Sertoli cells and induces spermatogenesis. (msdmanuals.com)
In spermatogenesis, each germinal cell (spermatogonium), located adjacent to the Sertoli cells, undergoes differentiation into 16 primary spermatocytes, each of which generates 4 spermatids. (msdmanuals.com)

However, the exposure of these cells to excessive levels of oxidative stress by too high levels of ROS or too low levels of antioxidative protection will render these cells dysfunctional thereby failing the fertilization process and causing couples to be infertile. (hindawi.com)

PL: epididymides /ɛpɪdɪˈdɪmədiːz/ or /ɛpɪˈdɪdəmɪdiːz/) is an elongated tubular structure attached to the posterior side of each one of the two male reproductive glands, the testes. (wikipedia.org)
The epididymis is situated posterior and somewhat lateral to the testis. (wikipedia.org)

The epididymis secretes immobilin, a large glycoprotein that is responsible for the creating of the viscoelastic luminal environment that serves to mechanically immobilize spermatozoa until ejaculation. (wikipedia.org)
On the one hand, reactive oxygen species (ROS) are mandatory mediators for essential cellular functions including the function of germ cells (oocytes and spermatozoa) and thereby the fertilization process. (hindawi.com)

On the other hand, this lipid membrane makes the sperm cell sensitive to oxidative damage caused by reactive oxygen species (ROS)( 2 2 Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms ofmale infertility: role of antioxidants. (scielo.br)
GPx is part of the membrane defense system, protecting the integrity of the sperm cell from oxidative damage( 3 3 Drevet JR. The antioxidant glutathione peroxidase family andspermatozoa: a complex story. (scielo.br)
Hydrogen peroxide was used to induce an oxidative stress mannequin of hepatocyte IAR-20 cells to guage the protecting results of BMMSCs in vitro. (nerc-bess.net)

However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)

and the unique differentiation of haploid cells (spermiogenesis) (Figure 1 ). (jci.org)

tall columnar cells (~75 to 80 µm) with numerous modified, long microvilli called stereocilia extend from their luminal surface. (histologyguide.com)

Long considered an accessory tubule of the male reproductive system, the epididymis is proving to be a key determinant of male fertility. (biorxiv.org)
Therefore, it becomes essential to investigate possible effects of emerging viruses on reproductive tissues and cells to better understand potential impacts on fertility that may be sex specific. (nih.gov)

In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)
The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)
The CAISMOV24 line was assessed for cell growth, production of soluble biomarkers, expression of surface molecules and screened for typical mutations found in serous ovarian carcinoma. (biomedcentral.com)
Additionally, CAISMOV24 cell line was characterized as a low-grade serous ovarian carcinoma, which still resembles its primary malignant cells. (biomedcentral.com)

From this point forward, the steps and cell types of spermatogenesis are conserved between mice and humans. (jci.org)

Cell lines from various tumor types have been developed for use as a tumor model for controlled laboratory studies. (biomedcentral.com)

Giant cell formation in the testis, which is usually accompanies germinal celldegeneration/atrophy was observed at the dose of 50 mg/kg and above. (europa.eu)

BACKGROUND To enhance the standard of liver grafts from extended-criteria donors donated after circulatory dying (DCD), this examine explored whether or not bone marrow mesenchymal stem cells (BMMSCs) mixed with normothermic machine perfusion (NMP) have protecting results on DCD donor livers and the results of ferroptosis on this process. (nerc-bess.net)

Basal cells: shorter, pyramid-shaped cells which contact the basal lamina but taper off before their apical surfaces reach the lumen. (wikipedia.org)
Basal Cells - small, round stem cells resting on the basement membrane. (histologyguide.com)

However, these techniques have to be carried out very carefully as they, if applied wrongly, bear risks of generating ROS damaging the germ cells and preventing fertilization. (hindawi.com)

These membrane extensions increase the surface area of the cell, allowing for greater absorption and secretion. (wikipedia.org)
These cells are equipped on their apical and basal membrane with copper transporters CTR1 and ATP7A. (researchgate.net)

The lab utilizes a combination of state-of-the-art genomic, molecular biology, and assisted reproduction techniques across multiple model systems including mice, embryonic stem cells, and C. elegans to understand these questions. (upenn.edu)

two oval-shaped organs that make the hormone testosterone and create and store millions of sperm cells. (michaelshealth.com)
CAIS is caused by several mutations in the androgen receptor (AR) that result in a suppressed response of target cells to testosterone and dihydrotestosterone (DHT) 6 . (bvsalud.org)

The reproductive systems of mammalian males contain a component called the epididymis. (microscopyu.com)

In the caput (head) region these cells have long stereocilia that are tuft-like extensions that project into the lumen. (wikipedia.org)
The stereocilia in the epididymis are non-motile. (wikipedia.org)
It has been shown that epithelial sodium channel ENaC that allows the flow of Na+ ions into the cell is localized on stereocilia. (wikipedia.org)

Anatomy23

Organisms4

Diseases7

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes10

Disciplines and Occupations1

Testis and epididymis3

Deferens9

Cauda epididymis3

Appendix of the epi1

Head of the epididymis2

Testes and epididymis2

Caput epididymis3

Spermatic cord2

Seminal2

Tunica vaginalis2

Epithelium6

Maturation4

Tumour3

Seminiferous7

Leydig11

Scrotum1

Motility5

Tissue3

Protein3

Distal2

Testicular2

Mesonephric1

Embryo1

Stores sperm1

Tumours1

Proximal2

20181

Cytoplasmic1

Sertoli5

Excessive levels of oxidative stress1

Posterior2

Spermatozoa2

Oxidative3

Lung1

Haploid cells1

Columnar cells1

Fertility2

Ovarian4

Spermatogenesis1

Tumor1

Germinal1

Bone Marrow1

Basal cells2

Germ cells1

Membrane2

Stem cells1

Testosterone2

Males1

Stereocilia3