• mammalian
  • The information obtained from yeast studies can then be used to inform more directed studies in mammalian models, such as mice or human cell lines. (omrf.org)
  • tumor
  • We are exploring details of its function in cancer cells as part of a collaboration with colleague Gary Gorbsky to better understand how it might be targeted to prevent tumor cell growth. (omrf.org)
  • These results suggest that a senescence gene or genes, which may be located on the Chinese hamster X chromosome, can be regulated by DNA methylation, and that escape from senescence and possibly loss of tumor suppressor gene activity can occur by epigenetic mechanisms. (sciencemag.org)
  • This suggests that chromosome instability and aneuploidy may play a critical role in tumor development and progression ( Sen, 2000 ). (biologists.org)
  • cellular
  • This system has allowed us to describe the cellular processes that are used to correctly partition the error-prone chromosomes in most meioses. (omrf.org)
  • The integrity of the cell and of its genome and the correct accomplishment of cellular processes depend on the existence of control points in the cell cycle. (biologists.org)
  • discovery
  • Ever since their discovery, these chromosomes have captivated researchers because of their obvious involvement in fundamental aspects of an organism's life, such as sex determination, sexual reproduction and sexual conflicts. (lu.se)
  • human
  • The idea of morphological reduction of W is also enhanced by our perspective of the gradual shortening of human Y chromosome [ 5 ], although there are examples of Y becoming larger than X in non-human species [ 2 ]. (royalsocietypublishing.org)
  • The improper partitioning of chromosomes is responsible for a many human maladies. (omrf.org)
  • In addition, we have recently determined that the spindle checkpoint is especially important for the segregation of error-prone meiotic chromosomes and that the human spindle checkpoint protein, BubR1, can participate in this process in yeast. (omrf.org)
  • Number of germ cells and somatic cells in human fetal ovaries during the first weeks after sex differentiation. (warwick.ac.uk)
  • mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • events
  • We propose a model in which ObgE is required to license chromosome segregation and subsequent cell cycle events. (wiley.com)
  • These control mechanisms, called `checkpoints', inhibit the transition to the next cell cycle phase if the events of the previous phase have not been correctly executed. (biologists.org)
  • content
  • Depletion of ObgE also results in cell filamentation, with polyploid DNA content. (wiley.com)
  • early
  • At early passages of the A9/CX donor cells, the hamster X chromosome was highly active, inducing senescence in 100% of the colonies obtained after its transfer into the nickel-transformed cells. (sciencemag.org)
  • fundamental
  • This lack of detailed knowledge about sex chromosome evolution compromises our understanding of fundamental biological questions (e.g. the evolution of sexual conflicts) as well as more practical ones (e.g. about sex-linked genetic diseases). (lu.se)
  • move
  • In the 'extrusion-capture' model, replication through an anchored replisome provides the force to move daughter chromosomes to the poles ( Lemon and Grossman, 2001 ). (wiley.com)
  • origin
  • Cells lacking ObgE continue to initiate replication, with a normal ratio of the origin to terminus. (wiley.com)
  • After replication at mid-cell, the origin region ( oriC ) is rapidly segregated outward. (wiley.com)
  • cause
  • Depletion of ObgE did not cause lethality, and cells recovered fully after expression of ObgE was restored. (wiley.com)