• Cycle
  • One important gene family involved in such control is the p21/p27/p57 class of negative cell cycle regulators. (biologists.org)
  • This mutant, called rr31 , is a fully dominant, maternal-effect, gain-of-function mutation in the cdc-25.1 cell cycle phosphatase that sensitizes the intestinal lineage to an extra cell division. (biologists.org)
  • This coordination is executed through regulating both positive and negative regulatory components of the basal cell cycle machinery. (biologists.org)
  • The cell cycle machinery is well conserved among eukaryotes and complex mechanisms ensure that cell cycle progression occurs in a timely and precise sequence. (biologists.org)
  • Cyclin-dependent kinases (Cdks) drive progression through the different cell cycle phases (reviewed by Nigg, 2001 ). (biologists.org)
  • These developmental signals converge on many of the same key cell cycle components described above. (biologists.org)
  • addition
  • In addition, we showed that the cdc-25.1(gf) requires cyclin E. The extra cell division defect was shown to be restricted to the E lineage and the E fate is necessary and sufficient to sensitize cells to this mutation. (biologists.org)
  • provides
  • However, in more complex multicellular organisms, larger families of Cdks and cyclins exist, and their elaborate regulation provides cell-type and functional diversity. (biologists.org)
  • To ensure ease of data interpretation when the numbers of apoptotic cells are low, CardioTACS provides Nuclear Fast Red Counterstain which provides superb contrast to the TACS Blue Label in apoptotic cells. (selectscience.net)