• syndrome
  • A clue may come from the fact that the syndrome is also a major complication of treatment of metastatic cancer with interleukin-2 alone or in combination with lymphokine-activated killer cells (4). (annals.org)
  • monoclonal
  • The patient had IgG κ monoclonal gammopathy in association with not only a slight increase in plasma cells in the bone marrow but also several punched out lesions in the skull, indicating multiple myeloma. (go.jp)
  • Pharmaceuticals, including the chemotherapy medication gemcitabine, as well as certain interleukins and monoclonal antibodies, can also cause capillary leaks. (wikipedia.org)
  • secondary
  • In a Phase 2 confirmatory multicenter single-arm trial (BLAST), adult patients with B-cell precursor ALL with minimal residual disease (MRD) who received BLINCYTO monotherapy demonstrated clinically meaningful relapse-free survival (RFS), as measured in the key secondary endpoint (abstract #680). (amgen.com)
  • fluid
  • Mechanisms of capillary leakage - The vascular endothelium is a semi-permeable barrier that controls the passage of fluid and macromolecules between the intravascular and interstitial spaces. (uptodate.com)
  • patients
  • Other presentations demonstrate BLINCYTO ' s potential in a high risk subpopulation of patients with relapsed or refractory Philadelphia chromosome-positive (Ph+) B-precursor ALL (abstract #679) and confirm BLINCYTO's efficacy in a subset of patients with relapsed or refractory Philadelphia chromosome-negative (Ph-) ALL after an allogeneic hematopoietic stem cell transplantation (alloHSCT), who typically have poor outcomes with current therapies (abstract #861). (amgen.com)
  • separate
  • It is characterized by self-reversing episodes during which the endothelial cells which line the capillaries, usually of the extremities, separate for one to three days, causing a leakage of plasma mainly into the muscle compartments of the arms and legs. (wikipedia.org)