• Red blood cells (RBCs) are an important component of clots and have been shown to have procoagulant functions in vivo and in vitro. (unc.edu)
  • [ 2 , 3 ] These parameters allow laboratories to detect potential causes of erroneous results, such as hyperlipidemia or hemolysis (both in vivo and in vitro), so the correct results can be reported. (medscape.com)
  • Together with S. Recktenwald (A5), we plan to compare wall shear stress distributions between in vivo and in vitro models and collaborate on aspects of non-Newtonian rheology. (uni-saarland.de)
  • The basis of hematology testing is the complete blood count (CBC) that provides information on blood components: hemoglobin, hematocrit, red blood cells, white blood cells, reticulocytes, platelets. (kaloramainformation.com)
  • The menu of hematology tests includes: CBC + 5-Part Differential (or 3-part Differential), Manual Differential/Review, Hematocrit, Hemoglobin (Automated, Manual), Sedimentation Rate, Reticulocyte Count, white blood cell (WBC) count, platelet count and analysis, and red blood cell count (RBC). (kaloramainformation.com)
  • Both mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) reflect the average hemoglobin content of red blood cells in slightly different ways (see "Description" in Background). (medscape.com)
  • Although MCH expresses the average content (mass, weight) of hemoglobin per red cell, MCHC expresses the average weight of hemoglobin per unit volume of red cell (see also "Understanding MCH and MCHC Using a River Tubing Analogy" in Background). (medscape.com)
  • MCH, MCHC, and MCV are parts of red cell indices (parameters reflecting size and hemoglobin content of red cells) that have traditionally been used to aid in the differential diagnosis of anemia. (medscape.com)
  • [ 3 ] Although MCH can be used to determine if an anemia is hypo-, normo-, or hyperchromic, the mean corpuscular volume (MCV) has to be considered along with the MCH since cell volume (MCV) affects the content of hemoglobin present per cell (MCH), and MCH can decrease or increase in parallel to the MCV. (medscape.com)
  • It is also increased in homozygous sickle cell or hemoglobin C disease . (medscape.com)
  • [ 6 ] or in other words, the ratio of hemoglobin mass to the volume of red cells. (medscape.com)
  • Blood samples were collected for assessing: red blood cells, hemoglobin, hematocrit and leukocyte formula. (bvsalud.org)
  • This will manifest as a high mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC) so these results are often cancelled. (eclinpath.com)
  • Exposure to AZT was toxic to the bone marrow, resulting in significant changes in the peripheral blood (decreased hematocrit values, erythrocyte counts, and hemoglobin concentrations, and increased mean cell volume and mean cell hemoglobin) and bone marrow (erythroid hypoplasia) characteristic of a dose- and time-dependent, minimal to moderate, poorly regenerative macrocytic anemia. (nih.gov)
  • Prior to offering testosterone therapy, clinicians should measure hemoglobin and hematocrit and inform patients regarding the increased risk of polycythemia. (surfinglion.com)
  • Anemia describes a diminished circulating red cell mass, expressed as grams of hemoglobin per 100 cc of whole blood. (medscape.com)
  • The XE-2100 counts and sizes red blood cells (RBC) and platelets (PLT) using electronic resistance detection enhanced by hydrodynamic focusing. (crlcorp.com)
  • 4. Experiments involving measurement of cyclic GMP levels, electrochemical detection of NO and electron paramagnetic resonance of haemoglobin in red blood cells, indicated that scavenging of NO generated from S-nitrosothiols by haemoglobin was responsible for the lack of effect of S-nitrosothiols on platelets in whole blood. (uhi.ac.uk)
  • Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodium falciparum revolutionized research on this important parasite. (nature.com)
  • The development of a protocol for the routine continuous in vitro culture of Plasmodium falciparum in 1976 1 released malaria researcher from the reliance on in vivo observations. (nature.com)
  • Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum . (nature.com)
  • Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. (biomedcentral.com)
  • All the synthesised compounds were screened for their in vitro antimalarial activities against chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7) and antimicrobial activity against Gram positive bacteria i.e. (biomedcentral.com)
  • Clear broth extract was incubated with in vitro cultures of Plasmodium falciparum asexual or mature sexual stage cultures and assayed for parasite viability after 72 hours. (bmj.com)
  • Complex vegetable and/or meat broths have substantial in vitro antimalarial activity. (bmj.com)
  • This finding suggests that decreasing hematocrit or diminishing platelet function could be effective methods for lowering arterial thrombosis risk in high-risk patients. (unc.edu)
  • Abbott Diagnostics, Beckman Coulter/Danaher, Siemens Healthineers and Horiba offer specialized platelet, red blood cell and white blood cell analysis and automatic slide makers/stainers. (kaloramainformation.com)
  • 1. S-Nitrosothiols are nitric oxide (NO) donor drugs that have been shown to inhibit platelet aggregation in platelet rich plasma (PRP) in vitro and to inhibit platelet activation in vivo. (uhi.ac.uk)
  • The aim of this study was to compare the platelet effects of a novel S-nitrosated glyco-amino acid, RIG200, with an established S-nitrosothiol, S-nitrosoglutathione (GSNO) in PRP, and to investigate the effects of cell-free haemoglobin and red blood cells on S-nitrosothiol-mediated inhibition of platelet aggregation. (uhi.ac.uk)
  • 2. The effects of GSNO and RIG200 in collagen (2.5 microg ml(-1))-induced platelet aggregation in PRP and whole blood were investigated in vitro. (uhi.ac.uk)
  • 5. These studies suggest that scavenging of NO by haemoglobin in blood might limit the therapeutic application of S-nitrosothiols as anti-platelet agents. (uhi.ac.uk)
  • Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
  • our group already reported one compound luteolin as a potent antimalarial lead compound against P. falciparum using in silico and in vitro analysis [ 16 ]. (springeropen.com)
  • Protection against P. falciparum malaria was also demonstrated in clinical trials using attenuated sporozoites (the stage transmitted by Anopheles mosquitoes during blood feeding) as the drug product (Sanaria´s PfSPZ) 7 , 8 . (nature.com)
  • However, liver stage vaccines offer no or very little protection against the subsequent asexual blood stages that cause most of the pathology associated with P. falciparum malaria, including anaemia, hypoglycaemia, vaso-occlusive events and the syndromes associated with maternal and cerebral malaria 10 . (nature.com)
  • Efforts to develop a blood stage vaccine have been sobering, in spite of encouraging immune-epidemiological studies showing that residents from malaria endemic areas are able to attain, with time and after repeated exposure to P. falciparum infections, a strain-transcending antigenic memory that protects against clinical disease 11 . (nature.com)
  • Controlled reactive professional phagocytic leukocytes in immunodeficient mice allowed for sizeable human blood chimerism and injected huRBCs acted as bona fide host cells for P. falciparum . (frontiersin.org)
  • A human blood chimeric mouse could serve to harmonize in vitro P. falciparum cultivation and in vivo studies carried out in rodent animal models. (frontiersin.org)
  • Introduction of several mouse strains with genetic immune deficiencies has greatly benefited the development of a small laboratory animal model ( 7 - 15 ) to study the asexual blood stage infection of P. falciparum . (frontiersin.org)
  • Sera samples from malaria immune participants (n = 105) in a therapeutic efficacy study were assessed for in vitro growth inhibitory activity against the 3D7 strain of P. falciparum using a fluorescent-based growth inhibition assay (GIA). (biomedcentral.com)
  • Growth inhibition assays (GIA) assesses the functional activity of sera to reduce/inhibit red blood cell (RBC) invasion and/or intra-RBC growth of P. falciparum in vitro [ 11 ]. (biomedcentral.com)
  • 50% in vitro growth inhibition against P. falciparum asexual blood stages, with 2 having comparable inhibition to that seen with dihydroartemisinin, a leading antimalarial. (bmj.com)
  • Decreased spurious results may be seen by centrifugation methods when excess EDTA, hypernatremia, or in vitro hemolysis is present, or by automated methods when clotting, agglutination, hemolysis, or RBC microcytosis is evident. (medscape.com)
  • No blood hemolysis was evidenced by the in vitro test with the administration of diclofenac vesicles. (bvsalud.org)
  • An in vitro blood test of the final prototype has been conducted with hemolysis test rig. (ku.edu.tr)
  • The in vitro test result demonstrates satisfying performance regarding the hemolysis index, pHb generation, hematocrit level, etc. in the range of clinically available LVADs. (ku.edu.tr)
  • Hematocrit may be used as a cutoff to determine transfusion requirements. (medscape.com)
  • Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit. (semcs.net)
  • Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
  • Any licensed independent practitioner can order a blood transfusion and obtain consent to do so. (medscape.com)
  • In spite of widespread use, data supporting specific practice paradigms for whole blood and component therapy transfusion are lacking, the notable exception being in the primary treatment of hemorrhagic shock. (medscape.com)
  • Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
  • [ 1 ] Massive transfusion protocols (MTPs) should be institutionally monitored by a blood utilization committee that can track initiation, cessation, component wastage, storage of blood products outside of the blood bank, transport standards, and compliance with applicable Food and Drug Administration (FDA) standards. (medscape.com)
  • The history of blood transfusion originated with William Harvey's discovery of blood circulation in 1628. (medscape.com)
  • The earliest known blood transfusions occurred in 1665, and the first human blood transfusion was performed by Dr. Philip Syng Physick in 1795. (medscape.com)
  • The first transfusion of human blood for the treatment of hemorrhage was performed by Dr. James Blundell in London in 1818. (medscape.com)
  • Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)
  • The most widespread use of whole blood transfusion is the US military buddy transfusion system. (medscape.com)
  • [ 2 ] Additionally, whole blood transfusion in civilian pre-hospital settings and in the trauma bay is seeing a resurgence in some regions. (medscape.com)
  • Blood transfusion treatment of anaemia. (bvsalud.org)
  • past history of blood transfusion or drug and potassium of 4.2 mmol/L. (who.int)
  • died despite blood transfusion and 2 preschool children. (who.int)
  • in vivo: In a murine MPN model, CYT387 normalizes white cell counts, hematocrit, spleen size, and restores physiologic levels of inflammatory cytokines. (aksci.com)
  • Blood and spleen samples were collected at day 0, day 14, day 21 and day 28 for preparation of serum and cell cultures respectively. (biomedcentral.com)
  • However, for P. vivax , the most widely distributed and difficult to treat malaria parasite, a strict preference for reticulocytes thwarts efforts to maintain it in vitro. (nature.com)
  • Broths were then tested for their ability to arrest malaria parasite asexual growth or sexual stage development in vitro. (bmj.com)
  • Conclusions This screening approach succeeded in finding broths with activity against malaria parasite in vitro growth, arising from complex vegetable and/or meat-based broths. (bmj.com)
  • Demonstration of Borrelia in peripheral blood is the definitive method of diagnosis but requires a high degree of experience ( 11 ). (cdc.gov)
  • Hematology is the study of peripheral blood and bone marrow cells in order to diagnose various diseases of the blood including leukemias, anemia and autoimmune diseases. (kaloramainformation.com)
  • An elevated RDW will provide a clue for heterogenous red cell size (anisocytosis) and/or the presence of two red cell populations, and peripheral blood smear review can help confirm the above findings. (medscape.com)
  • However, research on P. vivax remains severely hampered because, to date, attempts to maintain this parasite in routine in vitro blood cultures have been hindered by the strict restriction to invasion of reticulocytes, a minor short-lived fraction of peripheral blood. (nature.com)
  • Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, mouse bone marrow erythrocytes, and mouse peripheral blood erythrocytes. (nih.gov)
  • In addition, CYT387 has been shown to inhibit erythroid colony growth in vitro from JAK2V617F-positive PV patients with similar potency with IC50 of 2µ-4 µM. (aksci.com)
  • As a result, current indications for the use of whole blood are generally few. (medscape.com)
  • These findings Trenaver for sale highlight will include any savings with spinal cord injury: relationship the increase of haemoglobin and hematocrit. (showyou.com)
  • obtained from the father of the child for Laboratory investigations showed publication of this case report and any haemoglobin of 4 g/dL, haematocrit accompanying images. (who.int)
  • 3. Neither compound inhibited aggregation in whole blood, even at concentrations of 100 microM. (uhi.ac.uk)
  • These might identify bacteria or measure the concentrations of certain molecules in the blood, for example. (elifesciences.org)
  • METHODS: In our in vitro investigations different concentrations of ASA and MET solutions were added to blood. (semcs.net)
  • RESULTS: Epinephrine-induced aggregation was completely inhibited in all ASA and MET concentrations in vitro. (semcs.net)
  • Each group of 95 animals was composed of a core group of 50 animals for evaluation of carcinogenic response, a group of 30 animals for evaluation of hematology and bone marrow cellularity, and a group of 15 animals from which blood was drawn for determination of plasma AZT concentrations at week 54. (nih.gov)
  • An uncertainty factor of 3 for animal to human extrapolation because in vitro data show that human red blood cells are much less sensitive to the hemolytic effects of the 2-BUTOXYETHANOL metabolite, 2-butoxyacetic acid. (cdc.gov)
  • The majority of reported in vitro to in vivo extrapolation (IVIVE) data have historically focused on CYP3A, leaving the assessment of other CYP isoforms insubstantial. (aspetjournals.org)
  • The Sysmex XE-2100 is a quantitative automated hematology analyzer for in vitro diagnostic use in determining 25 hematological parameters. (crlcorp.com)
  • Incorporation of laser excitation and fluorescence detection into the hematology analyzer has grown the instruments' cell discrimination abilities to include blood cell components that required labor intensive and inexact manual methods. (kaloramainformation.com)
  • The remaining WBC nuclei and intact BASO are differentiated by cell size and internal structure. (crlcorp.com)
  • The vasopressin (VP) magnocellular neurosecretory cells (MNCs) in the supraoptic and paraventricular (PVN) nuclei are regulated by estrogen and exhibit robust expression of estrogen receptor (ER)-β. (jneurosci.org)
  • Systemic vasopressin (VP) and oxytocin (OT) are chiefly produced by magnocellular neurosecretory cells (MNCs) in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. (jneurosci.org)
  • Furthermore, CYT387 also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba/F3-MPLW515L cells, CHRF-288-11 cells and Ba/F3-TEL-JAK2 cells with IC50 of 200 nM, 1 nM and 700 nM, respectively. (aksci.com)
  • The RBC rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, and also other haematological disorders and diseases that affect RBC deformation more directly, such as, hereditary spherocytosis, sickle cell anemia, and malaria [4,10]. (webmedcentral.com)
  • Therefore, MCV together with red cell distribution width (RDW) have become the two most useful parameters in classifying anemias, while MCH and MCHC do not add significant, clinically relevant information. (medscape.com)
  • Product name]PT1000 blood gas analyzer [Intended use] It is used in conjunction with the blood gas determination kit manufactured by our company to quantitatively detect the following substances in human whole blood samples in vitro: Acidity and alkalinity (pH), partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), sodium ion (Na+), potassium ion (K+), calcium ion (Ca++), glucose (Glu), lactic acid (Lac), hematocrit (Hct) parameters. (eindiabusiness.com)
  • Blood parameters of treated mice up to 90 days were not statistically different from those of control mice. (who.int)
  • 1500 mg/kg per day for 90 days did not harmful to the environment than synthetic produce any signs of toxicity, mortality, insecticides, new evidence indicates that changes in tissue weight, pathology or se- these products may pose a risk to certain rum and blood parameters [ 8 ]. (who.int)
  • Blood cultures using Columbia agar were drawn but must be incubated at 25-28°C and take up to 2-4 weeks to become positive. (uab.edu)
  • However, the MCHC, as measured by a multichannel analyzer nowadays, is not affected by plasma trapping, which typically results in slightly increased hematocrit. (medscape.com)
  • Furthermore, many thousands of blood cells can be measured in a few minutes - fast enough to be suitable as a diagnostic test. (elifesciences.org)
  • 95% of the red blood cells contained small pleomorphic coccobacilli intracellularly which are diagnostic of acute bartonellosis. (uab.edu)
  • A search of the University of Washington Drug-Drug Interaction Database was conducted to identify a clinically relevant weak, moderate, and strong inhibitor for selective substrates of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6, resulting in 18 inhibitors for in vitro characterization against 119 clinical interaction studies. (aspetjournals.org)
  • Following careful assessment of various culture conditions, we describe here the robust continuous cultivation of the blood stages of P. cynomolgi lines derived from the Berok strain. (nature.com)
  • Whole blood tube with lavender closure and EDTA potassium salt additive. (medscape.com)
  • The research material is probiotic capsules used as a food supplement, which contain 4 different strains of lactobacilli with a total germ count of 10E9 microbial cells. (who.int)
  • Based on in vitro tests, the strains selected for the study prevent the growth of bacteria associated with genitourinary tract infections, and their antibiotic sensitivity profile meets the requirements of the European Food Safety Authority. (who.int)
  • White blood cells, or leukocytes, are the immune system's primary defensive against infection and disease. (kaloramainformation.com)
  • Their oral administration did not produce sizeable modifications in the percentages of the leukocyte formula elements, of some blood constants useful for evaluating the hepatic and renal function, respectively, and of some markers of oxidative stress and immune system activity, which suggests a good biocompatibility in mice. (bvsalud.org)
  • Here, we show that the vaccine, termed SumayaVac-1 , elicited both a humoral and cellular immune response as well as a recall T cell memory. (nature.com)
  • The reduction in the residual innate immune effectors (mainly cells of monocytes and macrophages lineage) and co-administration of huRBCs supplied with decomplemented human serum through an intravenous route led to the development of a reproducible humanized mouse. (frontiersin.org)
  • CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. (aksci.com)
  • Therefore, measuring the level of white blood cells in blood enables clinicians to easily detect and monitor various conditions. (kaloramainformation.com)
  • Osmotic challenges were monitored by serum measures, including osmolality and hematocrit. (ajnr.org)
  • Blood film for malaria is shown in Image B. (uab.edu)
  • In vitro studies in rats showed that a hemotoxic dose of divicine of 1.5 mM, when added to a suspension of red blood cells, resulted in a rapid decline in cellular glutathione, formation of echinocytes and damage to the membrane skeleton. (wikipedia.org)
  • Epidemiologic studies in humans have suggested an association between increased numbers of circulating RBCs (elevated hematocrit) and risk of thrombosis. (unc.edu)
  • This approach takes previous results of mechanical studies on specifically isolated blood cells to the level of application directly in blood and adds a functional dimension to conventional blood analysis. (elifesciences.org)
  • Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
  • In vitro studies show that the virus can infect various cell types such as endothelial cells and B-lymphocytes 15 . (bvsalud.org)
  • Hematocrit may indicate that a patient has anemia, erythrocytosis, or changes in plasma volume. (medscape.com)
  • The anemia is due to red-cell lysis and not autoimmune in nature as the Coombs test is uniformly negative. (uab.edu)
  • In the United Kingdom testing in vitro and after approximately 100 mg to 200 differences in the ratio of carbon isotopes in different compounds. (showyou.com)
  • Change in hematocrit during trauma assessment predicts bleeding even with ongoing fluid resuscitation. (medscape.com)
  • Rodrigues RO, Faustino V, Pinto E, Pinho D, Lima R. Red Blood Cells deformability index assessment in a hyperbolic microchannel: the diamide and glutaraldehyde effect. (webmedcentral.com)
  • What is lacking to advance initial blood diagnostics is an unbiased and quick functional assessment of blood that can narrow down the diagnosis and generate specific hypotheses. (elifesciences.org)
  • We investigated their in vitro hemocompatibility and in vivo biocompatibility in rats. (bvsalud.org)
  • 03:33 the only cells in that colony. (yale.edu)
  • Red blood cells have a high capability for metabolism of lisdexamfetamine as in vitro data demonstrated substantial hydrolysis happens even at low hematocrit levels. (monroestcharles.us)
  • While substantial progress has been made towards liver stage vaccines, the development of a blood stage vaccine is lagging behind. (nature.com)
  • Constant rocking may cause PLT clumping and alter white cell membranes, resulting in false interpretive messages. (crlcorp.com)
  • In 2008, a cluster of polycythemia vera, a rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. (cdc.gov)
  • In 2004, four cases of a rare blood cancer called polycythemia vera (PV) were found in people living on the same rural road near the borough of Tamaqua in northeast Pennsylvania. (cdc.gov)
  • The red blood cells (RBCs) are the major component of the blood and contain a lot of physiological and clinical information. (webmedcentral.com)
  • A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. (elifesciences.org)
  • Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (semcs.net)
  • The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. (semcs.net)
  • Testosterone insufficiency should be clearly demonstrated by clinical features (regression of secondary sexual characteristics, change in body composition, asthenia, reduced libido, erectile dysfunction etc.) and confirmed by 2 separate blood testosterone measurements. (medicines.org.uk)
  • Glipizide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. (nih.gov)
  • The mechanism by which glipizide lowers blood glucose during long-term administration has not been clearly established. (nih.gov)
  • Hematocrit may be measured directly by centrifugation or indirectly by automated methods. (medscape.com)
  • Ces travaux suggèrent ainsi qu'il est possible de localiser la concentration de médiateurs périphériques en profondeur dans des tissus, à l'aide d'un faisceau ultrasonore. (umontreal.ca)
  • Both methionine-lysine-bradykinin and labradimil increased the blood half-life of Gd-DTPA sufficiently enough to increase significantly the tumor tissue Gd-DTPA area under the time-concentration curve. (biomedcentral.com)
  • WBC count and differential are all evaluated using flow cytometry with a semiconductor laser exploiting the differences in cell size. (crlcorp.com)
  • The differential cell placement is then enhanced using Adaptive Cluster Analysis. (crlcorp.com)
  • Metabolically stable bradykinin B2 agonists, methionine-lysine-bradykinin and labradimil, had differential effects on the transvascular flow rate of Gd-DTPA across the blood-brain tumor barrier. (biomedcentral.com)
  • The most active extract(s) was further screened for cytotoxicity potential against murine macrophage RAW264.7 cell line using MTT assay. (springeropen.com)
  • From the in vitro study, the hydro-alcoholic extract of C. maxima (Burm. (springeropen.com)
  • Our study revitalizes MSP1 FL as a relevant blood stage vaccine candidate and warrants further evaluation of SumayaVac-1 in a phase II efficacy trial. (nature.com)
  • Hematocrit is the fraction of whole blood composed of red blood cells. (medscape.com)
  • Here, we define the conditions under which P. cynomolgi can be adapted to long term in vitro culture to yield parasites that share many of the morphological and phenotypic features of P. vivax . (nature.com)
  • We show that the in vitro-cultured P. cynomolgi (from ex vivo or cryopreserved stocks) retain the key characteristics that these parasites share with P. vivax . (nature.com)
  • Therefore, C9-M and C9-C (Rescued phenotype of wild-type growth by genetic complementation) parasites ( 26 ) showed the attenuation in PF13_0027 knock-out parasites (C9-M) growth, which in turn resulted in the irregular cell cycle. (frontiersin.org)
  • In vitro antiplasmodial IC 50 value of the most potent compound 5d was found to be 4.40 nM which is even less than all the three reference drugs chloroquine (18.7 nM), pyrimethamine (11 nM) and artimisinin (6 nM). (biomedcentral.com)
  • Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
  • Red blood cells (RBCs) deformability can be defined as the ability of the cells to deform when subjected to certain flow conditions. (webmedcentral.com)
  • In this work, a microfluidic system composed of a microchannel with a hyperbolic-shaped contraction was used to investigate the effect of both diamide and glutaraldehyde on the cell deformation index (DI) of human and ovine RBCs. (webmedcentral.com)
  • For example, the RBCs change to an ellipsoid shape when submitted to shear stress and elongate significantly to pass through the smallest capillaries of the microcirculation [8, 9], even when they are smaller than the relaxed discoid cells [10]. (webmedcentral.com)
  • Hence, the main objective of the present paper is to measure RBCs deformability index (DI) in a hyperbolic microchannel and examine the effect of both diamide and glutaraldehyde on the cell deformation of human and ovine RBC. (webmedcentral.com)
  • This NSG mouse, depleted with γ-chain of the IL-2 receptor, has been shown to better tolerate a variety of human transplanted cells ( 17 - 24 ). (frontiersin.org)
  • Trypsin digest and tandem mass spectroscopic analysis of proteins from one of the clusters, using the NCBI human trypsin-specific database (ftp://ftp.ncbi.nlm.nih.gov/blast/db/FASTA/nr.gz), yielded partial or complete sequences including a peptide in cord blood plasma with a predicted molecular mass of approximately 4 kDa. (nihvp.org)
  • Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
  • However, such screening strategies are precluded for P. vivax because of the limited availability of infected blood from patients, an obstacle that would be circumvented should in vitro-cultured P. cynomolgi be available. (nature.com)
  • En effet, les traitements anti-cancer s'accompagnent généralement de toxicités systémiques importantes et/ou ne sont efficaces que chez des sous-groupes de patients. (umontreal.ca)
  • In vitro effects of hCH(177-191) peptide and its analogues (0. (surfinglion.com)
  • PV is a myeloproliferative neoplasm (MPN) of the bone marrow characterized by an overproduction of erythrocytes and often other blood cells. (cdc.gov)
  • Three pigs weighing 77-92 kg have been used to assess the anatomical fitting and blood-handling characteristics during the acute experiments up to 6 hours. (ku.edu.tr)
  • Western blot (pending) and PCR are most useful for diagnosis of the chronic eruptive form of the disease (see below) where blood films are usually negative but are generally unnecessary in the acute form where, on average, over 60% of erythrocytes have intracellular bacteria. (uab.edu)
  • The parasite was probably discovered by Giuseppe Franchini, an Italian scientist, while examining blood specimens of monkeys [ 8 ]. (biomedcentral.com)