• murine
  • CR1 and CR2 on murine B cells form complexes with a co-accessory activation complex containing CD19, CD81, and the fragilis/Ifitm (murine equivalents of LEU13) proteins. (wikipedia.org)
  • Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was demonstrated by them to be present on murine thymocytes, on T lymphocytes, and on neuronal cells. (wikipedia.org)
  • There have been some reports of Thy1 monoclonal antibodies cross reacting with some cytoskeletal elements: anti Thy-1.2 with actin in marsupial, murine, and human cells and anti Thy-1.1 with vimentin, and were suggested to be due to sequence homology by studies done more than 20 years back. (wikipedia.org)
  • Decay
  • decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55. (ox.ac.uk)
  • Decay-accelerating factor (DAF or CD55) Factor H (fH) Other soluble complement regulators that do not belong to the RCA/CCP family are Complement Factor I and C1 inhibitor. (wikipedia.org)
  • follicular dendr
  • CR1, a surface protein produced primarily by follicular dendritic cells, appears to be critical for generation of appropriately activated B cells of the germinal centre and for mature antibody responses to bacterial infection. (wikipedia.org)
  • antibodies
  • CD97 antibodies and lack of CD97 or CD55 in mice reduced synovial inflammation and joint damage in collagen- and K/BxN serum transfer-induced arthritis. (wikipedia.org)
  • The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane. (wikipedia.org)
  • These receptors, which we now call "antibodies," were called by Ehrlich "amboceptors" to emphasise their bifunctional binding capacity: They recognise and bind to a specific antigen, but they also recognise and bind to the heat-labile antimicrobial component of fresh serum. (wikipedia.org)
  • The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). (wikipedia.org)
  • human
  • We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. (ox.ac.uk)
  • Every cell in the human body is protected by one or more of the membrane-associated RCA proteins, CR1, DAF or MCP. (wikipedia.org)
  • Xenotransplantation of human tumor cells into immunocompromised mice is a research technique frequently used in pre-clinical oncology research. (wikipedia.org)
  • The human homolog was isolated in 1980 as a 25kDa protein (p25) of T-lymphoblastoid cell line MOLT-3 binding with anti-monkey-thymocyte antisera. (wikipedia.org)
  • interaction
  • The expression of CD97 on macrophage and the abundant presence of its ligand CD55 on fibroblast-like synovial cells suggest that the CD97-CD55 interaction is involved in the recruitment and/or retention of macrophages into the synovial tissue in rheumatoid arthritis. (wikipedia.org)
  • Interaction of DAF with cell-associated C4b of the classical and lectin pathways interferes with the conversion of C2 to C2b, thereby preventing formation of the C4b2b C3-convertase, and interaction of DAF with C3b of the alternative pathway interferes with the conversion of factor B to Bb by factor D, thereby preventing formation of the C3bBb C3 convertase of the alternative pathway. (wikipedia.org)
  • anchor
  • The structure of the sugar residues in the GPI anchor and their associated esterified structures (e.g. additional fatty acids and alcohols) also can be cell type and species specific. (wikipedia.org)
  • mice
  • Mice lacking CD97 or its ligand CD55 have twice as many granulocytes as wild-type mice possibly due to enhanced granulopoiesis. (wikipedia.org)
  • The discovery of Thy-1 in mice and humans led to the subsequent discovery of many other T cell markers, which is very significant to the field of immunology since T cells (along with B cells) are the major cellular components of the adaptive immune response. (wikipedia.org)
  • tissue
  • In brain tissue, CD97 is undetectable in normal white matter, and expression of CD55 is fairly restricted to the endothelium. (wikipedia.org)
  • glycoproteins
  • A variety of GPI-linked cell-surface glycoproteins are composed of one or more copies of a conserved domain of about 100 amino-acid residues. (wikipedia.org)
  • Upon
  • Upon immunisation with an antigen, more of these receptors are formed, and they are then shed from the cells to circulate in the blood. (wikipedia.org)
  • species
  • Xenotransplantation (xenos- from the Greek meaning "foreign"), is the transplantation of living cells, tissues or organs from one species to another. (wikipedia.org)
  • Certain procedures, some of which are being investigated in early clinical trials, aim to use cells or tissues from other species to treat life-threatening and debilitating illnesses such as cancer, diabetes, liver failure and Parkinson's disease. (wikipedia.org)
  • differentiation
  • It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in thymocytes (precursors of T cells in the thymus). (wikipedia.org)
  • The composition of Thy-1 carbohydrate moieties varies considerably between different tissues or even among cells of the same lineage at different stages of differentiation: e.g., galactosamine only in brain Thy-1, sialic acid in thymic Thy-1 in far excess than brain Thy-1, that too increasing in parallel with T cell maturation. (wikipedia.org)
  • variety
  • Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. (wikipedia.org)
  • domains
  • N-glycosylation of CD97 within the EGF domains is crucial for CD55 binding. (wikipedia.org)
  • Since then, other CCP domains have been solved either by NMR-spectroscopy (also relaxation studies, e.g. module 2 and 3 from CD55 (pdb:1nwv)) or by X-ray diffraction (also with co-crystallized partner, e.g. (wikipedia.org)
  • cancer
  • a plasma membrane component) and lysophosphatidic acid (LPA) use heterodimeric LPAR1-CD97 to drive Gi/o protein-phospholipase C-inositol 1,4,5-trisphosphate signaling and induce [Ca2+] in breast cancer cells. (wikipedia.org)