This Human Sodium/hydrogen exchanger 1 (SLC9A1) ELISA Kit employs a two-site sandwich ELISA to quantitate SLC9A1 in samples. (abbkine.com)
Human Sodium/hydrogen exchanger 1 (SLC9A1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SLC9A1. (abbkine.com)
Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaffolding.Here, we identify the human Na(+)/H(+) exchanger 1 (hNHE1) as a membrane scaffold protein for ERK2 and show direct hNHE1-ERK1/2 interaction in cellular contexts. (ox.ac.uk)
Exchangers4
Na+/H+ exchangers-1-6 (Na+/H+ antiporters, NHE-1-6) are integral membrane proteins that are expressed in most mammalian tissues where they regulate intracellular pH and cell volume. (thermofisher.com)
The strict exchange of protons for sodium ions across cell membranes by Na +/ H + exchangers is a fundamental mechanism for cell homeostasis. (elsevierpure.com)
Sodium-hydrogen exchangers (Na + /H + exchangers, NHE) are ATP-independent membrane glycoprotein transporters that are involved in the regulation of intracellular pH, cell volume and the cellular response to hormones and mitogens. (tocris.com)
Sodium/hydrogen exchangers or sodium/proton antiports are a family of transporters that maintain cellular pH by utilising the sodium gradient across the plasma membrane to extrude protons produced by metabolism, in a stoichiometry of 1 Na + (in) : 1 H + (out). (guidetopharmacology.org)
Ions4
NHEs mediate the secondary active extrusion of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+). (thermofisher.com)
A family of plasma membrane exchange glycoprotein antiporters that transport sodium ions and protons across lipid bilayers. (nih.gov)
Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (childrensmercy.org)
Solute carrie1
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. (utsouthwestern.edu)
NHE12
NHE1, the most well characterized NHE isoform, mediates transepithelial transport in secretory parotid acinar cells and may also mediate ammonium reabsorption in the kidney. (tocris.com)
Transgenic NHE1 overexpression results in salt-sensitive hypertension in rodents, whilst NHE1 activity in peripheral blood mononuclear cells (PBMCs) from hypertensive patients is directly correlated with increased blood pressure. (tocris.com)
ATPase4
In this cell, CO 2 + H 2 O are converted to H + and HCO 3 - by a reaction catalyzed by carbonic anhydrase (CA) . H + are secreted into the lumen of the stomach by the H + /K + -ATPase, whereas K + recycle back into the parietal cell (not shown for simplicity). (abdominalkey.com)
Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in this website by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles. (childrensmercy.org)
Proteins1
Arabidopsis Intracellular NHX-Type Sodium-Proton Antiporters are essential pertaining to Seed starting Storage space Health proteins Control. (signalingmolecule.com)
Epithelial cells4
MIM 309845) (ERM) protein family are highly concentrated in the apical aspect of polarized epithelial cells. (wikipedia.org)
Some people with the Liddle phenotype have Liddle syndrome, which involves a genetic mutation resulting in upregulation of the epithelial sodium channel (ENaC), located in the apical membrane of polarized epithelial cells in the late distal tubule and collecting duct of the kidney. (worldsbest.rehab)
Unlike the other NHE isoforms, NHE3 is recycled between apical membranes and the endosomal compartment of epithelial cells where it has a significant involvement in renal and intestinal Na + absorption. (tocris.com)
We have produced continuous cell lines using retroviral transduction of SV40 large T antigen into epithelial cells removed from the lumen of liver cysts from four female patients with autosomal dominant polycystic kidney disease (ADPKD). (elsevierpure.com)
Transporters1
The transporters mediate the simultaneous efflux of a hydrogen ion and the influx of a sodium ion across the plasma membrane, the driving force being the inwardly directed electrochemical Na + gradient. (tocris.com)
Intracellular pH5
They have critical functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens. (nih.gov)
Because the human Na + -H + antiporter (NHE-1) possesses a C-terminal consensus sequence for carboxyl methylation, we examined the role of protein carboxyl methylation in the regulation of intracellular pH homeostasis. (elsevierpure.com)
The effect of AFC on both basal intracellular pH (pH(i)) and on the kinetic properties of the Na + -H + antiporter was characterized. (elsevierpure.com)
Our data indicate that inhibition of carboxyl methylation reduces basal pH(i) and alters the kinetic properties of the Na + -H + antiporter in human platelets, suggesting that carboxyl methylation is implicated in the regulation of intracellular pH homeostasis. (elsevierpure.com)
LCDE cells exhibit intracellular pH regulatory pathways that, with one exception, are similar to those found in normal intrahepatic biliary epithelium. (elsevierpure.com)
Protein3
In this report, we discuss the significance of protein interactions to HCO 3 - secretion in pancreatic duct cells. (elsevierpure.com)
These findings reveal that protein complexes in the plasma membrane of pancreatic duct cells are highly organized for efficient HCO 3 - secretion. (elsevierpure.com)
This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. (utsouthwestern.edu)
Glutamate1
2005). Sodium ion pumps and hydrogen production in glutamate fermenting anaerobic bacteria. (tcdb.org)
Excretion3
Amiloride blocks the epithelial sodium channel (ENaC) in the late distal tubule, connecting tubule, and collecting duct of the nephron, which both reduces absorption of sodium ion from the lumen of the nephron and reduces excretion of potassium ion into the lumen. (worldsbest.rehab)
Because Liddle phenotype usually involves an upregulation of ENaC channels, leading to retention of sodium and water and to hypokalemia, amiloride is useful as an ENaC channel inhibitor due to its promotion of sodium excretion and its potassium-sparing effects, restoring potassium to normal levels. (worldsbest.rehab)
Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. (yale.edu)
Pumps1
Upon release, histamine acts on H 2 receptors expressed on the basolateral membrane of parietal cells, leading to increased intracellular cAMP levels and activated proton pumps on parietal cells. (drugbank.com)
Kidneys4
A large input of NaHCO 3 cannot maintain metabolic alkalosis because the kidneys will readily excrete sodium (Na + ) and HCO 3 − or potential HCO 3 − (citrate) very quickly, unless reduced kidney function is present. (abdominalkey.com)
NHE3 is highly expressed in the intestine and kidneys and regulate sodium movements in those tissues. (guidetopharmacology.org)
Loss of tubular function prevents the kidneys from excreting hydrogencations (H + ) and thereby causes metabolic acidosis. (medscape.com)
Loss of tubular function prevents the kidneys from excreting hydrogencations (H+) and thereby causes metabolic acidosis. (medscape.com)
Regulate1
Neuroendocrine cells called enterochromaffin-like (ECL) cells lie close to the parietal cells and regulate the basal secretion of histamine. (drugbank.com)
Reabsorption1
When there is a reduction in effective arterial blood volume, reabsorption of sodium predominates over the kidney's ability to maintain acid-base balance. (abdominalkey.com)
Parietal cells1
Histamine acts as a local hormone that stimulates the acid output by parietal cells via a paracrine mechanism. (drugbank.com)
Amiloride1
Excluding NHE-1, which is ubiquitously expressed, the NHE isoforms 2-6 have distinct tissue- and cell type-dependent expression, and inhibitiory characteristics by amiloride analogs. (thermofisher.com)
Physiological1
However, evaluating the precise effects of dR on neuronal functions in cultured cells under physiological conditions over a long period of time is difficult. (nature.com)
Regulation2
The antiporter is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. (abbkine.com)
Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets. (tocris.com)
Activity1
Alkali-treated collagen retained the triple helical conformation and the ligand activity for the cell adhesion via alpha2beta1 integrin. (lookformedical.com)
Concentration1
this leads to increased intracellular Ca 2+ concentration, driving vascular smooth muscle cell contraction. (tocris.com)
Fluid1
Prospective studies involving very low birth weight (VLBW) infants (BW ≤1500 g) and extremely low birth weight (ELBW) infants (BW ≤1000 g) demonstrated a consistent pattern of fluid and sodium balance despite varying intakes of sodium and water over the first five to seven days of life [ 3,4 ]. (medilib.ir)
Nucleus2
SV40 large T antigen is localized to the cell nucleus. (elsevierpure.com)
Virus-specific DNA sequences were found in the nucleus of infected Vero cells at early times in the synthesis of the viral DNA, forming dense foci localized in proximity to the nuclear membrane. (lookformedical.com)
Exchange1
In a chronic mechanism, CFTR increases the luminal expression of Na + /H + exchange in pancreatic duct cells. (elsevierpure.com)
Metabolic1
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. (tocris.com)
Positive1
LCDE cells maintain their epithelial appearance and are positive for the biliary-specific markers cytokeratin 7 and 19 and γ-glutamyl transpeptidase while being negative for hepatocyte markers. (elsevierpure.com)
Bacterial1
In addition, unique biochemical properties such as broad substrate specificity, participation of novel coenzymes in the methanogenesis pathways and the presence of unique lipids in their cell wall set these organisms apart from the bacterial and eukaryotic branches of life [ 28 ]. (biomedcentral.com)