• We tested this novel hypothesis in over 6,000 HCT from 8/8 HLA-matched UD reported to the European Group for Blood and Marrow Transplantation (EBMT), to demonstrate that HLA-DPB1 non-TPHE mismatches were associated with worse relapse-free survival and overall survival than TPHE mismatches, present in 21.7% of single HLA-DPB1 disparate pairs. (haematologica.org)
  • Median (95% CI) relapse-free survival (RFS) censored and not censored at subsequent alloSCT were both 11.6 (2.7-20.5) and 11.7 months (2.8-20.5), respectively. (gilead.com)
  • Duration of remission and relapse-free survival, overall survival, minimal residual disease (MRD) negativity rate, and alloSCT rate were assessed as secondary endpoints. (gilead.com)
  • They conducted a phase 2, multicenter trial to analyze if post-transplant eprenetapopt plus Vidaza improved relapse-free survival (which is the length of time following completion of primary treatment that a patient survives without signs or symptoms of that cancer). (curetoday.com)
  • Based on prior results, the study investigators determined that a one-year relapse-free survival rate of 50% or greater would be considered successful. (curetoday.com)
  • Of the different cells isolated from the submandibular gland, this specific population, Lin - CD24 + c-Kit + Sca1 + , possessed the highest capacity for proliferation, self renewal, and differentiation during serial passage in vitro. (jci.org)
  • We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
  • Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
  • Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
  • Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
  • We have conducted extensive in vitro studies to confirm its efficacy in supporting stem cell viability, proliferation and new tissue deposition. (ca.gov)
  • These scaffolds combine the injectability and cell encapsulation of conventional hydrogels with macroporosity, which facilitates nutrient transfer, cell survival, proliferation, and tissue formation. (ca.gov)
  • We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
  • Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
  • This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
  • However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)
  • Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
  • MTT analysis, PI/Annexin V staining, transwell and metabolic flux assays were performed to examine the effects of C1QBP on proliferation, apoptosis, migration, invasion, and oxidative phosphorylation of HCC cells. (jcancer.org)
  • Loss-of-function assays showed that proliferation, migration and invasion of HCC cells were mitigated while cell apoptosis was augmented upon the loos of C1QBP. (jcancer.org)
  • Molecular Cell paper provides evidence that FOXO3a triggers transcription of HIF1 target gene, which in turn inhibits HIF-1 induced apoptosis. (genengnews.com)
  • HIF-1 induced apoptosis in normal and breast cancer cells was inhibited due to FOXO3a stimulating the transcription of the HIF1 target gene, CITED2, according to Dr. Mak. (genengnews.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. (cshlpress.com)
  • Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
  • Complement C11 binding protein (C1QBP, also named p32 and HABP1) is a multifunctional protein which plays a pivotal role in diverse cellular processes such autophagy and cell apoptosis [ 7 , 8 ]. (jcancer.org)
  • To discover miR-BARTs that can inhibit apoptosis, I individually expressed miR-BARTs in the EBV- GaCa cell line AGS, and identified five miR-BARTs that conferred this phenotype. (duke.edu)
  • Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)
  • Following compromise of the UPS, the overexpression of proteasome activator PA28 can specifically recover proteasome function and improve cell viability in both HD model and patient cells. (science20.com)
  • PA28γ also improved cell viability in mutant huntingtin-expressing striatal neurons exposed to pathological stressors, such as the excitotoxin quinolinic acid and the reversible proteasome inhibitor MG132. (science20.com)
  • Methods: This article focuses on recent research development that addresses the viability issues of stem cells. (benthamscience.com)
  • Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)
  • The idea is to disrupt every gene and screen to see if it's required for cell viability in culture. (blogspot.com)
  • We analyzed cell viability at 96 hr after siRNA transfection with two orthogonal statistical methods and identified 55 survival genes that encoded proteases, kinases, and transferases. (aspetjournals.org)
  • More work is also needed to understand how to protect the microbiome during intensive cancer treatments such as stem cell transplantation, he added. (cancer.gov)
  • Previous studies from single hospitals have shown that people undergoing allogeneic stem-cell transplantation often have disruptions in their gut microbiome, including an increase in numbers of potentially disease-causing species of bacteria and an overall loss of diversity. (cancer.gov)
  • The researchers collected almost 9,000 fecal samples from about 1,350 people undergoing allogeneic stem-cell transplantation, both before and after the procedure. (cancer.gov)
  • They then looked for associations between diversity of the gut microbiome and survival following transplantation, as well as the incidence of graft-versus-host disease. (cancer.gov)
  • The long-term goal of this grant is to accelerate clinical translation of stem cell-based therapy for regenerative medicine by enhancing cell delivery, survival, and integration, thus improving therapeutic outcomes, substantially reducing the number of cells needed for transplantation, and reducing the associated time and cost to produce these cells. (ca.gov)
  • However, the majority of transplanted cells die shortly after transplantation, which greatly diminishes the efficacy of stem cell-based therapies. (ca.gov)
  • Relapse and graft- versus -host disease (GvHD) are the main impediments to the clinical success of allogeneic hematopoietic cell transplantation (HCT) in curing malignant blood disorders. (haematologica.org)
  • p = 0.001) and higher in those who received autologous hematopoietic stem cell transplantation. (scielo.br)
  • Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. (scielo.br)
  • Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
  • ZUMA-3 is an ongoing international multicenter (US, Canada, Europe), single arm, open label, registrational Phase 1/2 study of Tecartus in adult patients (≥18 years old) with ALL whose disease is refractory to or has relapsed following standard systemic therapy or hematopoietic stem cell transplantation. (gilead.com)
  • The findings support future studies of assessing the safety and efficacy of the novel drug-chemotherapy combination as a maintenance strategy following stem cell transplantation across a range of blood cancers, according to the study authors. (curetoday.com)
  • Maintenance treatment with eprenetapopt, a novel drug, plus the chemotherapy Vidaza (azacitidine) following allogeneic hematopoietic stem cell transplantation was associated with improved survival outcomes in a group of patients with TP53-mutant, high-risk acute myeloid leukemia and myelodysplastic syndromes, according to new study findings. (curetoday.com)
  • A total of 84 patients were screened to determine if they were eligible for an allogeneic hematopoietic stem cell transplantation. (curetoday.com)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • Because Merkel cell carcinoma is quick to spread, patients should promptly report any unusual symptoms to a physician to accelerate the diagnostic process. (moffitt.org)
  • Patients with localized Merkel cell carcinoma have a 78% survival rate while those whose cancer has spread to the lymph nodes or other nearby structures have a 52% survival rate. (moffitt.org)
  • There are so many variables in play locally, including how we treat our patients, and environmental and genetic influences on the microbiome that vary across geographical regions," said Steven Pavletic, M.D., a stem-cell transplant specialist at NCI's Center for Cancer Research , who was not involved in the study. (cancer.gov)
  • Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from radiation therapy. (jci.org)
  • CHICAGO -- An immunotherapy drug improved survival in patients with advanced nonsquamous non-small cell lung cancer (NSCLC), a researcher said here. (medpagetoday.com)
  • An immunotherapy drug (nivolumab, known as Opdivo) improved survival in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) compared with docetaxel. (medpagetoday.com)
  • After a minimum of 13.2 months of follow-up, Paz-Ares said, the 12-month overall survival rate for patients getting nivolumab was 51%, compared with 39% for docetaxel. (medpagetoday.com)
  • The main study endpoint was safety and tolerability in a group of patients, 75% of whom had previous systemic therapy for their disease, but they also looked at anti-tumor response rates and overall survival. (medpagetoday.com)
  • The aim of this study was to evaluate whether radioactive iodine therapy after total thyroidectomy improves prognosis and survival in patients with HCC. (thyroid.org)
  • In this large SEER-based study, patients with HCC who underwent total thyroidectomy had overall an excellent cancer-specific survival. (thyroid.org)
  • However, there was no difference in cancerspecific survival noted between patients who received and those who did not receive radioactive iodine therapy after total thyroidectomy. (thyroid.org)
  • BACKGROUND--The relationship between cell types in bronchoalveolar lavage (BAL) fluid and the clinical course of patients with idiopathic pulmonary fibrosis (IPF) has been the subject of several studies. (bmj.com)
  • The aim of this study was to investigate the relationship between the absolute and relative cell numbers in BAL fluid from patients with IPF and their survival. (bmj.com)
  • CONCLUSIONS--Although this study has restrictions, these findings suggest a negative relationship between the absolute numbers and percentages of eosinophils in BAL fluid samples and survival in patients with IPF. (bmj.com)
  • A personalized immunotherapy (AGS-003) nearly doubled expected progression-free survival and overall survival when added to standard sunitinib (Sutent) in patients with unfavorable-risk metastatic renal cell carcinoma, according to results from a single-arm phase II study. (urologytimes.com)
  • The results support an ongoing phase III study of the approach in which patients with metastatic clear-cell RCC are being randomized to personalized immunotherapy plus sunitinib or sunitinib alone, with overall survival as the primary endpoint, said first author Asim Amin, MD, PhD. (urologytimes.com)
  • At the Genitourinary Cancers Symposium in Orlando, FL, Dr. Amin described long-term survival in 21 patients with intermediate- or poor-risk metastatic RCC who were treated with autologous dendritic cell immunotherapy in combination with sunitinib. (urologytimes.com)
  • When analyzed by baseline Heng risk status, the median progression-free survival was 19.4 months for intermediate-risk patients and 5.8 months for subjects with poor-risk features at baseline. (urologytimes.com)
  • The ongoing phase III ADAPT (The Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma) study is using this approach to personalized immunotherapy, with the goal of randomizing 450 patients. (urologytimes.com)
  • Our work provides a synthesis of previous algorithms, mechanistically based on HLA-DPB1 immunopeptidome divergence 5 and expression by residual leukemia cells, 6 , 7 respectively, into a new and integrative model for intelligent mismatching in UD-HCT, to improve survival for future patients. (haematologica.org)
  • We retrospectively analyzed clinical characteristics, response to treatment and survival of 282 patients with active newly-diagnosed multiple myeloma, comparing results between patients younger and older than 65 years. (scielo.br)
  • Outcome and survival of myeloma patients diagnosed 2008-2015. (scielo.br)
  • The aims of the present study were to describe clinical features at diagnosis, response to treatment and survival in 282 patients with active newly-diagnosed MM (NDMM) and compare outcomes between patients younger and older than 65 years. (scielo.br)
  • Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
  • The continued durable response and significant improvement in survival indicated by these new data can potentially establish a new standard of care for adult patients living with this aggressive form of leukemia. (gilead.com)
  • Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. (frontiersin.org)
  • The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
  • Bioinformatic approaches were employed for checking the expression of C1QBP in HCC patient samples and the association between C1QBP mRNA expression and survival rates of patients with HCC or the promoter methylation of C1QBP . (jcancer.org)
  • C1QBP is correlated with a poor prognosis of HCC patients and promotes the survival, migration and invasion of HCC cells. (jcancer.org)
  • Although patients with HCC have been benefiting from the development of various effective therapeutic approaches, the five-year survival rate is still rather low (around 12% as reported in China) [ 2 ]. (jcancer.org)
  • We don't know so much about how and why memory killer cells are formed in the skin and what it means for cancer patients," says Professor Yenan Bryceson at the Department of Medicine (Huddinge), Karolinska Institutet. (technologynetworks.com)
  • The researchers then went on to study tumour samples from melanoma patients and found that those with a higher rate of survival also had a larger accumulation of epidermal memory killer cells. (technologynetworks.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The case- fatality rate for pediatric patients in this outbreak was lower than for adults, but the reasons for this increased survival were unknown. (cdc.gov)
  • The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with Ebola virus disease. (cdc.gov)
  • In this study, we used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from the Gulu outbreak to identify biomarkers that had age-specific associations with survival, hemorrhagic manifestations, or both. (cdc.gov)
  • There are, however, no firm data on the survival of patients with sickle-cell anaemia on the African continent. (who.int)
  • By comparison, in a pivotal trial, treatment with sunitinib yielded a median overall survival of 20.7 months for intermediate-risk and 5.3 months for poor-risk subjects. (urologytimes.com)
  • After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
  • Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
  • Sandwalk: How many human protein-coding genes are essential for cell survival? (blogspot.com)
  • We would like to know how many of those genes are essential for the survival of an individual and for long-term survival of the species. (blogspot.com)
  • The ability to knock out human genes using CRISPR technology has opened to door to testing for essential genes in tissue culture cells. (blogspot.com)
  • Each group identified between 1500 and 2000 protein-coding genes that are essential in their chosen cell lines. (blogspot.com)
  • By looking only at genes that are essential for cell survival, they are ignoring all those genes that are specifically required in other cell types. (blogspot.com)
  • These are the genes activated by heat shock and other forms of stress and they churn out a lot of HSP70 chaperone in order to save the cells. (blogspot.com)
  • Target identification and validation remain difficult steps in the drug discovery process, and uncovering the core genes and pathways that are fundamental for cancer cell survival may facilitate this process. (aspetjournals.org)
  • Therefore, we implemented a short interfering RNA (siRNA) screen with 16,560 siRNAs targeting 5,520 unique druggable human genes aimed at identifying these survival genes in the T98G glioma cell line because glioblastoma represents a challenging form of cancer for chemotherapy. (aspetjournals.org)
  • Interestingly, 22% (12/55) of the survival genes were constituents of the 20S and 26S proteasome subunits. (aspetjournals.org)
  • Biological networks were built with the other survival genes using a protein-protein interaction network, which identified clusters of cellular processes, including protein ubiquitination, purine and pyrimidine metabolism, nucleotide excision repair, and NF-κB signaling. (aspetjournals.org)
  • The results of this study should broaden our understanding of the core genes and pathways that regulate cell survival, and we highlight the potential significance of proteasome inhibition, through either small molecule inhibition or RNA interference. (aspetjournals.org)
  • Although drugs, for example a MEK inhibitor Refametinib [ 5 ], targeting key driver genes involved in HCC progression are being utilized for the clinical intervene, chemotherapy-resistance and the following cancer recurrence or metastasis still hinder the improvement of patient survival rates. (jcancer.org)
  • To identify pro-apoptotic genes targeted by the five anti-apoptotic miRNAs, I validated one previously published target and identified nine novel targets by performing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. (duke.edu)
  • On the other hand, in order to identify miR-BARTs that can activate the Wnt signaling pathway, I analyzed the PAR-CLIP data set of C666 cells and discovered nine anti-Wnt signaling targets of miR-BARTs, including seven novel genes and two pro-apoptotic genes identified above. (duke.edu)
  • After knocking out specific genes, they could also demonstrate which genes are required for the maturation of memory killer cells in tissue. (technologynetworks.com)
  • Sickle-cell anaemia is a common genetic condition due to a haemoglobin disorder - inheritance of mutant haemoglobin genes from both parents. (who.int)
  • About 5% of the world's population carries genes responsible for haemoglobinopathies and each year about 300 000 infants are born with major haemoglobin disorders - in more than 200 000 cases sickle-cell anaemia in Africa. (who.int)
  • Although a single abnormal gene may protect against malaria, inheritance of two abnormal genes leads to sickle-cell anaemia and confers no such protection, and malaria is a major cause of ill-health and death in children with sickle-cell anaemia. (who.int)
  • The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the excess adiposity generated by a Western diet, and a compelling explanation for the promotion of tumour growth by high-fructose corn syrup. (nature.com)
  • Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells. (frontiersin.org)
  • In an allogeneic stem cell transplant, the blood-forming stem cells in a patient's bone marrow are destroyed using high doses of chemotherapy or radiation therapy. (cancer.gov)
  • Combination with other treatment modalities such as chemotherapy may overcome immunoresistance of cancer cells. (uni-muenchen.de)
  • Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
  • Of note, an allogeneic hematopoietic stem cell transplant is a procedure where a patient with cancer receives healthy blood-forming stem cells from a donor to replace their own stem cells that have been damaged by other cancer treatments such as radiation or chemotherapy. (curetoday.com)
  • For the overall study population, median progression-free survival was 11.2 months and the final median overall survival was 30.2 months. (urologytimes.com)
  • The estimated median overall survival is 39.5 months for intermediate- and 9.1 months for poor-risk subjects. (urologytimes.com)
  • Results from the analysis showed a median overall survival (OS) of 26 months and demonstrated that responses remained durable in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) with a consistent safety profile observed since the two-year analysis. (gilead.com)
  • Additionally, the median overall survival (time from treatment to death of any cause) was 20.6 months at a median follow-up of 17 months. (curetoday.com)
  • In the United States of America median survival was estimated in 1994 to be 42 years for men and 48 years for women, whereas comparable figures for Jamaica published in 2001 suggested 53 years for men and 58.5 years for women. (who.int)
  • In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF- κ B, and requires GHS-R1a. (hindawi.com)
  • Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
  • In a new NCI-funded study, researchers found that, in people with blood cancers who had received an allogeneic hematopoietic stem cell transplant, the health of their gut bacteria was linked with their survival. (cancer.gov)
  • Overall CR rate (CR + CRi), CR, and subsequent allogeneic stem cell transplant (alloSCT) rates remained unchanged since the prior data cut at 71%, 56%, and 20%, respectively. (gilead.com)
  • Disease relapse is the primary reason why allogeneic hematopoietic stem cell transplants fail, according to the study authors, who noted that novel strategies for stem cell transplant to reduce the risk for disease relapse are severely needed. (curetoday.com)
  • Currently, maintenance strategies (which are used to reduce the risk for disease recurrence) are not standard of care in allogeneic (hematopoietic stem cell transplant) for (acute myeloid leukemia and myelodysplastic syndromes)," the study authors wrote. (curetoday.com)
  • It's difficult to assess the true Merkel cell carcinoma survival rate due to the rarity of the disease. (moffitt.org)
  • Because a virus may play a role in the development of Merkel cell carcinoma, researchers believe that the cancer might respond favorably to treatments that utilize the body's immune system. (moffitt.org)
  • New drugs that target hormone-producing cells also show promise in the treatment of Merkel cell carcinoma. (moffitt.org)
  • The five-year survival rate for Merkel cell carcinoma is improving. (moffitt.org)
  • At Moffitt Cancer Center, our expert oncologists take a comprehensive approach to Merkel cell carcinoma treatment. (moffitt.org)
  • And, behind the scenes, our dedicated researchers are continually evaluating new treatments that could ultimately improve the Merkel cell carcinoma survival rate. (moffitt.org)
  • Wang X et al 2022 Radioactive iodine therapy does not improve cancer-specific survival in Hürthle cell carcinoma of the thyroid. (thyroid.org)
  • Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model. (uni-muenchen.de)
  • We have previously shown that gemcitabine sensitizes human pancreatic carcinoma cells against CTL-mediated lysis. (uni-muenchen.de)
  • Methods: Bone marrow-derived DC from C57BL/6 mice were loaded with UV-irradiated, syngeneic Panc02 carcinoma cells and were administered subcutaneously. (uni-muenchen.de)
  • In EBV latently infected epithelial cells, such as nasopharyngeal carcinoma (NPC) and gastric carcinoma (GaCa) cells, viral protein expression is low. (duke.edu)
  • Immunological adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene. (the-scientist.com)
  • In the May Nature Immunology Thomas Mitchell and colleagues from the National Jewish Medical and Research Center , Denver show that adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene. (the-scientist.com)
  • The memory killer cells have been shown to respond to immunotherapy, a Nobel Prize-winning cancer therapy involving the tweaking/activation of the immune system. (technologynetworks.com)
  • Finding out how these cells develop enables us to contribute to the development of more efficacious immunotherapy for diseases like melanoma. (technologynetworks.com)
  • The researchers now aim to harness their findings to optimise the immunotherapy-induced T-cell response to make it even better at eliminating cancer cells in tissues. (technologynetworks.com)
  • Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
  • Our results reveal a pro-survival role for FOXO3a in normal cells and cancer cells that are adapting to hypoxic stress," explains Dr. Mak. (genengnews.com)
  • Researchers at the University of Washington (UW) have found that nematode worms live longer if their genetic make-up permits their cells to turn on the hypoxic response under normal oxygen conditions. (sciencedaily.com)
  • They found that these worms, which were able to turn on the hypoxic response under normal oxygen conditions, lived about 30 percent longer than worms whose cells made VHL-1. (sciencedaily.com)
  • Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on tumor growth depending on whether or not the tumor cells have enough oxygen. (genengnews.com)
  • The hope is that those dendritic cells will then express the patient's own tumor antigens to the T cells. (urologytimes.com)
  • Background: Tumor-specific cytotoxic T lymphocytes (CTL) can be activated in vivo by vaccination with dendritic cells (DC). (uni-muenchen.de)
  • For prophylactic vaccination, mice were vaccinated three times in weekly intervals prior to tumor challenge with Panc02 cells. (uni-muenchen.de)
  • Combination of the two strategies significantly increased survival of tumor-bearing mice (50 % at day 58 after tumor challenge). (uni-muenchen.de)
  • Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal cancer (mCRC).Initial analyses identified marker-defined subsets of PC, including cells expressing PDGFR-β or α-SMA or both markers. (lu.se)
  • Perivascular PDGFR-α and -β remained independent factors for survival in multivariate analyses.Overall, our study identified host vasculature and oncogenic status as determinants of tumor perivascular features. (lu.se)
  • A biochemical pathway that keeps cells alive when oxygen is low has now been showed to play a role in longevity and resistance against some diseases of old age. (sciencedaily.com)
  • They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components. (cshlpress.com)
  • Discussion: Activation of the PI3K/AKT pathway decreases the concentration of apoptotic factors, while the HIF pathway protects stem cells against the micro-environment of tissue (hypoxia). (benthamscience.com)
  • Concomitant with the reduction of HH pathway activity, Tctn2 mutants exhibited increased cell death in the neurectoderm and facial ectoderm, culminating in a collapse of the facial midline. (elifesciences.org)
  • Enhancing HH signaling by decreasing the gene dosage of a negative regulator of the pathway, Ptch1 , decreased cell death and rescued the midface defect in both Tctn2 and Cc2d2a mutants. (elifesciences.org)
  • The primary study outcome was cancer-specific survival (CSS), calculated as the time from the initial diagnosis to death from thyroid cancer, last follow-up or 12/31/2018, the first occurring event being chosen for each patient. (thyroid.org)
  • There is increasing evidence that malaria not only influences outcome but also changes the manifestations of sickle-cell anaemia in Africa. (who.int)
  • That is electroporated into the patient's own dendritic cells. (urologytimes.com)
  • In the next report period, we will focus on measuring the functional improvement by monitoring stem cell survival using BLI and fat volume retention using micro-CT imaging over time. (ca.gov)
  • Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)
  • The efficiency of transplanted stem cells reduces due to conditions like hypoxia, inflammation, nutrient deprivation, immunogenicity, extracellular matrix loss on delivery and mechanical stress. (benthamscience.com)
  • DAPI negative, single living cells were first separated with epithelial marker CD24 and hematopoietic and endothelial lineage marker CD45/31. (jci.org)
  • 95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. (duke.edu)
  • It is likely that miR-BARTs play a crucial role in EBV-infected epithelial cells, however a comprehensive understanding of miR-BARTs is currently lacking. (duke.edu)
  • Bronchiolar epithelial hyperplasia, alveolar septal thickening, and alveolar septal infiltration by inflammatory cells were seen in the lungs of ozone exposed hamsters. (cdc.gov)
  • Multimeric alpha-lactalbumin killed all transformed, embryonic, and lymphoid cells tested but spared mature epithelial elements. (lu.se)
  • D ) Quantification of salisphere number to seeding-cell number of each population at D7 and D14 in vitro. (jci.org)
  • The linear quadratic model is now most often used to describe the cell survival curve, assuming that there are two mechanisms to cell death by radiation: A single lethal event or an accumulation of harmful but non-lethal events. (wikipedia.org)
  • The mechanisms by which cell death occurs are genetically encoded and carefully controlled. (cshlpress.com)
  • Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. (cshlpress.com)
  • We determined how this intervention altered cell survival after exposure to toxins known to simulate pathological mechanisms in HD. (science20.com)
  • This process can potentially eliminate some cancers derived from cells in the bone marrow, such as leukemia and lymphoma. (cancer.gov)
  • Hürthle-cell cancer (HCC) is a rare type of thyroid cancer, representing 3-5% of all thyroid cancers. (thyroid.org)
  • Despite the great promise stem cells hold for regenerative medicine, the efficacy of stem cell-based therapies is greatly limited by poor cell engraftment and survival. (ca.gov)
  • Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)
  • Sickle-cell anaemia is particularly common among people whose ancestors come from sub-Saharan Africa, India, Saudi Arabia and Mediterranean countries, and migration raised the frequency of the gene in the American continent. (who.int)
  • Toxic protein aggregations, he explained, are seen in the brain cells of those with Alzheimer's disease, Huntington's disease, and several other degenerative conditions that afflict the elderly. (sciencedaily.com)
  • The mammalian target of rapamycin complex 2 (mTORC2) has been implicated in the regulation of cell survival by phosphorylating the protein kinase Akt. (bl.uk)
  • Taken together, the results presented in this study show a key role of the scaffold protein Sin1 in regulating neuronal survival. (bl.uk)
  • In Huntington's disease (HD) the disease provoking mutation in the huntingtin gene eventually causes the cell to build up intranuclear and cellular inclusions of protein-aggregates, made up primarily of huntingtin. (science20.com)
  • One cellular organelle with a central role of clearing such protein build up in the cell is the ubiquitin proteasome system (UPS). (science20.com)
  • The manuscript shows that cellular changes due to expression of huntingtin protein with longer CAG repeats can reduce the ubiquitin proteasome system (UPS) function in Huntington¡¦s disease cells. (science20.com)
  • We determined how to enhance UPS function and influence catalytic protein degradation and cell survival in HD. (science20.com)
  • mRNA of ghrelin receptors(GHS-R1a and GHS-R1b), as well as, protein levels of GHS-R1a, were expressed abundantly in A2780 cells. (hindawi.com)
  • AG treatment did not affect the mRNA and protein levels of GHS-R1a and GHS-R1b in both control and Cis-treated cells. (hindawi.com)
  • In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
  • Aifantis, I. Regulation of stem cell function by protein ubiquitylation. (benthamscience.com)
  • Stem cells from a donor, called a graft , are then infused to replace the destroyed cells, produce new marrow, and rebuild the recipient's immune system. (cancer.gov)
  • It also carries risks of potential harms, including infection, graft-versus-host disease (where certain immune cells from the donor attack the normal tissue of the transplant recipient), and death. (cancer.gov)
  • Alloreactive donor T cells are important mediators of both relapse control by graft- versus -leukemia (GvL) effects, and of GvHD. (haematologica.org)
  • 1 In unrelated donor (UD)-HCT, frequent human leukocyte antigen (HLA)-DPB1 disparity is the target of T-cell alloreactivity, contributing to both leukemia control and GvHD. (haematologica.org)
  • Alloreactive donor T cells recognizing patient-specific genetic polymorphisms, including mismatched HLA allotypes, play a major role in both beneficial GvL and severe GvHD after UD-HCT. (haematologica.org)
  • The requirement of Sin1 in cell survival, and in particular in neuronal survival, has not been established due to the early embryonic lethality of mice with a targeted deletion of the Sin1 gene. (bl.uk)
  • Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
  • Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
  • Multiplacenta derived stem cell/cytokine treatment increases survival time in a mouse model with radiation-induced bone marrow damage. (stembook.org)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • The key finding, he told reporters at the annual meeting of the American Society of Clinical Oncology, is that the drug extended overall survival compared with docetaxel. (medpagetoday.com)
  • In spite of the big improvement in the clinical field for OC therapy, an overlall low survival and high recurrence rates still exist and were attributed to the poor screening approach, inadequate therapeutic options, and development of drug resistance [ 3 , 4 ]. (hindawi.com)
  • Most data regarding the impact of age on survival mainly come from clinical trials developed before the current therapy choices were in use. (scielo.br)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)
  • Association studies implied specific oncogenic mutations in malignant cells as determinants of PC status. (lu.se)
  • Cancer and neurodegeneration are detrimental conditions associated with an inappropriate regulation of cell survival and cell death, causing compromised cells to evade death or excessive death of healthy neurons. (bl.uk)
  • Researchers at Karolinska Institutet in Sweden and the University of Copenhagen in Denmark have now identified how these cells are formed, and shown that high levels of memory killer cells in cancer tissue correlate with a better survival rate in people with melanoma. (technologynetworks.com)
  • Meanwhile, we will also start assessing the efficacy of µRB-based scaffolds for supporting stem cell engraftment and bone regeneration in a murine cranial defect model. (ca.gov)
  • To overcome this major bottleneck, the goal of this proposal is to validate the efficacy of novel microribbon (µRB)-based scaffolds for cell delivery. (ca.gov)
  • In preliminary studies, our µRB-based scaffolds markedly enhanced the survival of human stem cells and accelerated bone repair in vivo. (ca.gov)
  • Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
  • SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite, a Gilead Company (Nasdaq: GILD), today announced the three-year follow-up results from the pivotal ZUMA-3 study of the CAR T-cell therapy Tecartus ® (brexucabtagene autoleucel). (gilead.com)
  • Here we show that dietary fructose improves the survival of intestinal cells and increases intestinal villus length in several mouse models. (nature.com)
  • Thus, here we propose to validate the efficacy of µRB-like hydrogels with tunable stiffness and macroporosity as cell-delivery matrices that enhance the engraftment and survival of stem cells for both soft and hard tissue reconstruction using relevant animal models in vivo. (ca.gov)
  • Stem cell-based therapies hold great promise for treating tissue loss and enhancing tissue regeneration, often via direct injection of cells at the target site. (ca.gov)
  • Certain immune T cells called tissue-resident memory cells are formed locally in the skin and other tissue, and protect against infections that they have encountered before. (technologynetworks.com)
  • Germ cells (eggs and sperm) and stem cells contain an enzyme, telomerase, that restores telomere length. (cdc.gov)
  • Here, we identified and characterized a stem cell population from adult murine submandibular glands. (jci.org)
  • Not only do these worms live longer, the researchers noted, their cells are relatively free from the toxic proteins that accumulate and clump together as an animal ages. (sciencedaily.com)
  • They also found that animals lacking VHL-1 were resistant to the toxic proteins known to cause Alzheimer's and Huntington's diseases, and that their cells accumulated less of an age-pigment called lipofuscin. (sciencedaily.com)
  • To function, each living cell needs both to build new and to degrade old or damaged proteins. (science20.com)
  • To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins. (science20.com)
  • Some of them express proteins that enable them to kill infected cells. (technologynetworks.com)
  • The researchers isolated T cells from the skin and blood of healthy volunteers and used advanced techniques to examine gene activity and expression of different proteins. (technologynetworks.com)
  • Our results demonstrate that M. tb Ppiases are immunogenic proteins that can possibly modulate host immune response and enhance persistence of the pathogen within the host by subverting host cell generated stresses. (bvsalud.org)
  • Telomeres provide a buffer that grows shorter every time a cell divides. (cdc.gov)
  • Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases. (cshlpress.com)
  • These "memory killer cells" can also contribute to the inflammatory skin disorders vitiligo and psoriasis. (technologynetworks.com)
  • Treatment of THP-1 cells with increasing concentrations of rPpiA, induced secretion of pro-inflammatory cytokines TNF-α and IL-6 . (bvsalud.org)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
  • Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • Administration of GDNF improved saliva production and enriched the number of functional acini in submandibular glands of irradiated animals and enhanced salisphere formation in cultured salivary stem cells, but did not accelerate growth of head and neck cancer cells. (jci.org)
  • The aim of the present study was to evaluate the influence of Ang II on human endometrial cancer cells. (spandidos-publications.com)
  • Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. (hindawi.com)
  • Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
  • these abnormal chromosomes are often observed in cancer cells. (cdc.gov)
  • Although it is normally inactive in most other cells in the body, telomerase is activated in cancer cells, making them "immortal. (cdc.gov)
  • Furthermore, heterologous expression of M. tb PpiA and PpiB in Mycobacterium smegmatis increased bacterial survival in THP-1 cells as compared to those transformed with the vector control . (bvsalud.org)
  • While investigating the effect of human milk on bacterial adherence to a human lung cancer cell line, we were surprised to discover that the milk killed the cells. (lu.se)