Cells antimetabolites antineoplastic. Medical search. Frequent questions

Fludarabine causes the death of cancer cells by interfering with their growth and reproduction. (pharmachoice.com)
Fludara (fludarabine) is a cancer medication used to treat B-cell chronic lymphocytic leukemia (CLL). (rxlist.com)
FLUDARA (fludarabine) FOR INJECTION should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. (rxlist.com)

As an analog of deoxycytidine, this antimetabolite medication includes into human being DNA and as a result gets rid of leukemic cells by interfering with DNA and RNA activity [1]. (ampkpathway.com)

It is a purine nucleoside antimetabolite . (bionity.com)

Classic antimetabolite anticancer drug with chemical structure similar to endogenous intermediates or building blocks of DNA or RNA synthesis. (medscape.com)
4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
Various types of anticancer medications kill cancer cells in different ways. (lls.org)
Appropriately, autophagy can either promote cell loss of life or serve as a success system in leukemic cells treated with different anticancer medicines [20], [21]. (ampkpathway.com)

As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)
Gemcitabine 200 Mg is an anti-cancer ('antineoplastic' or 'cytotoxic') chemotherapy drug. (oncology-drugs.net)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)

Fluorouracil is a pyrimidine antimetabolite. (medscape.com)
Fluorouracil Cream USP is topical preparations containing the fluorinated pyrimidine 5-fluorouracil, an antineoplastic antimetabolite. (nih.gov)

DNA-repair enzyme inhibitors attack the cancer cell proteins (enzymes) that normally repair damage to DNA. (lls.org)
Histone deacetylase inhibitors attack cancer cells by targeting the proteins that support DNA in the cell nucleus. (lls.org)
JAK inhibitors block the enzymes JAK1, JAK2, JAK3 and tyrosine kinase 2, which play a role in the cell-signaling process that leads to the inflammatory and immune responses seen in certain diseases. (lls.org)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)

The present study investigated the role of autophagy, a cellular self-digestion process, in the cytotoxicity of antileukemic medication cytarabine towards human being leukemic cell lines (REH, HL-60, MOLT-4) and peripheral blood vessels mononuclear cells from leukemic patients. (ampkpathway.com)
Intro Cytarabine (cytosine arabinoside, arabinofuranosyl cytidine) is usually ICAM4 a chemotherapeutic medication utilized only or in mixture with additional antineoplastic brokers to deal with different forms of leukemia. (ampkpathway.com)

These agents inhibit cell growth and proliferation. (medscape.com)
Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
Platinum compounds inhibit cell growth and proliferation. (medscape.com)
Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
Cell viability, proliferation, DNA damage response and apoptosis were investigated using immunofluorescence staining and immunoblotting. (bmj.com)
Results Gemcitabine treatment caused DNA damage, cellular stress, inhibited proliferation and activated cell cycle check-point sensors and induced apoptosis as shown by increased expression of g-histone H2AX, p-JNK, Chk-1/Chk-2, cleaved forms of PARP and caspase-3 in the asynchronous cells in a dose dependent manner. (bmj.com)
As a result, the proliferation and in vitro AMH and oestrogen production of the cells were decreased at post-exposure 24h. (bmj.com)
In the cells synchronized at S phase gemcitabine significantly inhibited DNA synthesis and blocked their proliferation. (bmj.com)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Загальні відомості про злоякісні новоутворення Cancer is an unregulated proliferation of cells. (msdmanuals.com)
ASS1 loss secondary to epigenetic silencing was accompanied by increased tumor cell proliferation and invasion, consistent with a tumor-suppressor role for ASS1. (ox.ac.uk)

Renal cell carcinoma is responsible for 80%-85% of all primary renal neoplasms. (lecturio.com)

Broadly, most chemotherapeutic drugs work by impairing mitosis ( cell division ), effectively targeting fast-dividing cells . (wikidoc.org)
With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)

Introduction/Background We aimed to compare gemcitabine vs. cisplatin in terms of DNA damage response, viability/apoptosis of malignant granulosa cells. (bmj.com)
Exposure of the cells to gemcitabine at G2/M transition abolished the progression of mitosis, caused mitotic arrest and failure to exit mitosis as evidenced by the inhibition of Cyclin B degradation and absence of de-phosphorylation of cdc-2 at Tyr 15 residue. (bmj.com)
Conclusion These results may suggest that anti-metabolite chemotherapy drug gemcitabine might have anti-neoplastic actions on granulosa cell tumour. (bmj.com)
Gemcitabine fights cancer by preventing the growth of cancer cells, which eventually results in their destruction. (rxhealthmed.ca)
The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. (ox.ac.uk)
Gemcitabine is classified as an antimetabolite. (oncology-drugs.net)

Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
Apoptosis: cell death 3. (studylib.net)
Nevertheless, in particular circumstances, autophagy can also stimulate apoptosis [18] or function as an option cell-death path (designed cell loss of life type II) [19]. (ampkpathway.com)
Furthermore, medicinal and hereditary inhibition of autophagy sensitive leukemic cells to cytarabine-induced apoptosis. (ampkpathway.com)

Mitoxantrone - a synthetic anthracycline analogue (anthraquinone) that can intercalate DNA, thereby preventing cell division. (wikipedia.org)
Anthracycline antineoplastics inhibit DNA and RNA synthesis by steric obstruction. (medscape.com)
Doxorubicin is an anthracycline antineoplastic that causes DNA strand breakage through effects on topoisomerase II and direct intercalation into DNA, which causes DNA polymerase inhibition. (medscape.com)

Capecitabine fights cancer by killing cancer cells and preventing their growth. (mediresource.com)

Suppresses mRNA expression of Th2 cytokines (interleukins 4 and 13) in peripheral blood mononuclear cells. (medscape.com)

Furthermore, the genetics, biology, and therapeutic implications of ASS1 loss were investigated in urothelial cancer cells. (ox.ac.uk)

Hydroxyurea fights cancer by preventing the growth of cancer cells, which eventually results in their destruction. (medbroadcast.com)

Fluorouracil is an antineoplastic anti-metabolite. (pharmacycode.com)
Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency which provokes unbalanced growth and death of the cell. (nih.gov)
The effects of DNA and RNA deprivation are most marked on those cells which grow more rapidly and take up fluorouracil at a more rapid rate. (nih.gov)

Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
7. Drugs that exert their influence during any phase of the cell cycle are called Cell cycle nonspecific (CCNS) drugs and include Alkylating agents, hormones and anti-tumor antibiotics. (studylib.net)
Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
DNA-damaging agents (antineoplastics) and alkylating agents react with DNA to change it chemically and keep it from allowing cell growth. (lls.org)
Hypomethylating (demethylating) agents interfere with cancer cell duplication by slowing or reversing hypermethylation. (lls.org)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
Antiangiogenic agents as second-line therapy for advanced non-small cell lung cancer. (jscimedcentral.com)
Aggarwal C, Somaiah N, Simon G. Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed? (jscimedcentral.com)

They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. (illumina.com)
When the cancer cell uses an antimetabolite instead of the natural substances, it can't produce normal DNA or RNA and the cell dies. (lls.org)

Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
Unfortunately, scientists have yet to identify specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib ). (wikidoc.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
Methodology Malignant granulosa tumour cell lines (COV434 and KGN) were used for the experiments. (bmj.com)

Pemetrexed disrupts the folate-dependant metabolic processes important for cell replication, inhibits the enzymes involved in folate metabolism and DNA synthesis, and inhibits protein synthesis. (medscape.com)
Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
Methylation is a critical part of cell growth and replication. (lls.org)

As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)

In the cell, cobalamin acts as a coenzyme in several reactions, including the synthesis of methionine from homocysteine during the reduction of dihydrofolate to tetrahydrofolate and the conversion of methylmalonyl CoA to succinyl CoA. (medscape.com)
5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
At two stages in the biosynthesis of purines and at one stage in the synthesis of pyrimidines, one-carbon transfer reactions occur which require specific coenzymes synthesized in the cell from tetrahydrofolic acid. (illumina.com)
ADI-PEG20 was synthetically lethal in ASS1-methylated bladder cells and its exposure was associated with a marked reduction in intracellular levels of thymidine, due to suppression of both uptake and de novo synthesis. (ox.ac.uk)
Antitumor antibiotics prevent cell division by either binding to DNA to prevent the cells from duplicating or inhibiting RNA synthesis. (lls.org)

This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Antimitotics damage cancer cells by blocking a process called mitosis (cell division), which prevents cancer cells from dividing and multiplying. (lls.org)

Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)
Efudex is classed as an antineoplastic antimetabolite, a chemotherapy drug. (nicerx.com)
The cellular kinetics of particular cancers is an important consideration in the design of antineoplastic drug regimens and may influence the dosing schedules and timing intervals of treatment. (msdmanuals.com)
Drug therapy can speed up cancer cell death. (lls.org)
However, many conventional and investigational drug therapies combine drugs that attack cancer cells at different points in their growth cycles. (lls.org)
This approach often makes therapy more effective and reduces the chance that the cancer cells will become resistant to a particular drug. (lls.org)
Chemotherapy is an aggressive form of a chemical drug meant to shrink the tumour size and obliterate the rapidly growing cells in a body. (medigence.com)
6-mercaptopurine (6-MP) is an antimetabolite antineoplastic chemotherapy drug. (omeka.net)

Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
Thrombopoiesis takes place primarily in the bone marrow through a series of cell differentiation and is influenced by several cytokines. (lecturio.com)

The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)
Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). (biomedcentral.com)
All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)
ARA-C reduced EWS/FLI protein abundance and accordingly diminished cell viability and transformation and abrogated tumor growth in a xenograft model. (broadinstitute.org)

Hydroxyurea belongs to the group of cancer-fighting medications known as antineoplastics , and specifically to the group of antineoplastics known as antimetabolites . (medbroadcast.com)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)

12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 1 Define the following terms: 1. (studylib.net)
12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key excretion of cellular breakdown products and to reduce the risk of hemorrhagic cystitis. (studylib.net)
12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 3 greater, brimmed hats, and lightweight, long-sleeved shirts). (studylib.net)

Drugs affect "younger" tumors (i.e. more differentiated) more effectively, because mechanisms regulating cell growth are usually still preserved. (wikidoc.org)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)

The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
EPO-secreting tumors EPO-secreting tumors Polycythemia Vera , such as renal cell carcinoma Renal cell carcinoma Renal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. (lecturio.com)

Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions. (medscape.com)

It is usually used to treat certain types of cancers of the skin on the head and neck (excluding the lip) known as squamous cell carcinomas . (medbroadcast.com)
In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. (pharmacycode.com)
The diagnosis should be established prior to treatment, since this method has not been proven effective in other types of basal cell carcinomas. (nih.gov)

Analyzing the pivotal trial that compared sunitinib and IFN-a in renal cell carcinoma, using a method that assesses tumor regression and growth. (jscimedcentral.com)

A cell line derived from cultured tumor cells. (lookformedical.com)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)

FCM, or FMC in the context of chemotherapy is an acronym for a chemotherapy regimen that is used in the treatment of indolent B cell non-Hodgkin's lymphomas. (wikipedia.org)
The addition of monoclonal antibodies like rituximab to chemotherapy regimens has increased treatment outcomes for patients with indolent B cell non-Hodgkin's lymphomas, including chronic lymphocytic leukemia. (wikipedia.org)
Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen . (wikidoc.org)
In developing a treatment approach, we identified a novel targeted antimetabolite strategy to exploit arginine deprivation with pegylated arginine deiminase (ADI-PEG20) as a therapeutic. (ox.ac.uk)

A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)

Luvica is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. (acteropharma.com)

Low permeability of cytarabine across the cell membrane layer, want for natural service through phosphorylation and quick deamination into sedentary 1-d-arabinofuranosyluracil need high cytarabine dosages in purchase to accomplish acceptable antileukemic impact [2]. (ampkpathway.com)

It acts throughout the entire cell cycle and by direct intercalating into DNA triggers DNA breakage by topoisomerase II, causing subsequent cytocydal activity. (medscape.com)

Megaloblastic changes affect all 3 hematopoietic cell lines. (medscape.com)
Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)

Oncozar is a prescription medicine used to treat the symptoms of cancer such as Pancreatic Cancer, Non-Small Cell Lung Cancer, Breast Cancer and Ovarian Cancer. (acteropharma.com)

When treating these types of cancers, hydroxyurea is usually used at the same time as radiation therapy, as these two methods work together to kill cancer cells more effectively. (medbroadcast.com)
As well as interfering with the genetic material DNA of cancer cells, hydroxyurea can interfere with some of your normal cells. (medbroadcast.com)
It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (biomedcentral.com)
Consistently, the essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer. (biomedcentral.com)
It is used to treat cancer by preventing the activity of a special group of proteins which are known to be involved in the growth and spread of cancer cells. (acteropharma.com)
It works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing. (acteropharma.com)
Monoclonal antibodies target proteins on the surface of cancer cells. (acteropharma.com)
Blocking these proteins can slow down growth of cancer cells and delay the progression of cancer. (acteropharma.com)
Evrolia reduces the blood supply to the tumour and slows down the growth and spread of cancer cells. (acteropharma.com)
Cancer (CA): group of diseases in which abnormal cells grow out of control and can spread to other areas of the body 2. (studylib.net)
8. The growth factor and doubling time are two factors that play a major role in the response of cancer cells to anti-cancer drugs. (studylib.net)
14. Alkylating drugs damage cell DNA strands the preventing reproduction of cancer cells. (studylib.net)
Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)
Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
Cancer cells can grow too fast or fail to die quickly. (lls.org)
Sometimes cancer cells may be resistant to the initial drugs used or can become resistant to the drugs after a period. (lls.org)
Antimetabolites mimic the building blocks of DNA or RNA that cancer cells need to survive and grow. (lls.org)
Some enzymes can prevent cancer cells from surviving. (lls.org)
Without this repair process, the cancer cell is much more susceptible to damage and cannot grow. (lls.org)
This process sometimes speeds up in cancer cells. (lls.org)
It is designed to lowering the cancer cells in the body and is aimed towards enhancing the patient's quality of life. (medigence.com)
This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). (broadinstitute.org)

This means that other fast dividing cells such as those responsible for hair growth and for replacement of the intestinal epithelium (lining) are also often affected. (wikidoc.org)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)
The model is fitted to growth curves for a range of cell lines and derived values of OCR are validated using clinical measurement. (ox.ac.uk)
Palbociclib works by blocking proteins called cyclin-dependent kinase 4 and 6, which regulate cell growth and division. (acteropharma.com)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
The method may further comprise administering to the subject a cell growth inhibitor. (justia.com)
Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)

Nevertheless, to the greatest of our understanding, no research therefore much offers looked into the capability of cytarabine to induce autophagic response in malignancy cells, or the feasible part of cytarabine-triggered autophagy in rules of malignancy cell loss of life. (ampkpathway.com)
In the present research, we demonstrate that cytarabine induce autophagy in leukemic cell lines and main leukemic cells, but not really healthful leukocytes, by suppressing the primary unfavorable autophagy regulator, mammalian focus on of rapamycin (mTOR) [4]. (ampkpathway.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

The most common side effects are stomach problems (including vomiting, diarrhea, and nausea ), and effects on blood cells (including low red blood cells count, low white blood cell count, low platelet count, fever , and infection. (bionity.com)
Decreased progression of disease and improved rate of conversion from bring transfusion dependent to independent of red blood cell and platelet transfusions. (unboundmedicine.com)

However, the thickness of the epithelial cell layer of experimental samples was significantly lower than in control samples. (bvsalud.org)

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia. (ox.ac.uk)
To prevent the undesirable results and improve level of sensitivity of leukemia cells, cytarabine offers been mixed with different brokers able of modulating its balance, lipophilicity or apoptotic response of malignancy cells [2]. (ampkpathway.com)
Components and Strategies Cell tradition Human being lymphoblastic leukemia cell collection REH (ATCC CRL-8286) was acquired from American Type Tradition Collection (Manassas, Veterans administration), while human being promyelocytic leukemia cell collection HL-60 (ECACC 98070106) was bought from the Western Collection of Pet Cell Ethnicities (Salisbury, UK). (ampkpathway.com)

It treats scaly overgrowths of the skin (actinic keratosis or solar keratosis) and is also used to treat superficial basal cell carcinoma. (nicerx.com)

Methotrexate selectively affects the most rapidly dividing cells (neoplastic and psoriatic cells). (illumina.com)
The drugs used in chemotherapy destroy rapidly dividing cells in the body or slow cell division nonspecifically. (bvsalud.org)
has more effect on rapidly replicating cells. (unboundmedicine.com)

Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. (biomedcentral.com)

In this case, your doctor may prescribe different drugs to target and kill the cancerous cells. (lls.org)

Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
Clofarabine can stop the bone marrow from making enough red blood cells , white blood cells , and platelets . (bionity.com)

Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
However, such an effect was not observed in the cells synchronized and treated with cisplatin at G2/M. (bmj.com)

Cytotoxicity can occur at any stage of the cell cycle, but cell is most vulnerable to action of these drugs in G1 and S phase. (medscape.com)
Oncozar belongs to a class of drugs called Antineoplastics, Antimetabolite. (acteropharma.com)
Many antineoplastic drugs, such as antimetabolites, are most effective when cells are actively dividing. (msdmanuals.com)
Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)

Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)

Anatomy3

Diseases3

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes6

Fludarabine3

Deoxycytidine1

Purine1

Anticancer4

Cytotoxic4

Pyrimidine2

Inhibitors4

Medication2

Proliferation11

Neoplasms1

Chemotherapeutic5

Gemcitabine6

Apoptosis6

Anthracycline3

Capecitabine1

Mononuclear cells1

Urothelial1

Fights cancer1

Fluorouracil3

Agents8

Substances2

Malignant7

Replication3

Chemotherapy affects cell division1

Synthesis5

Mitosis2

Drug8

Differentiation2

Mantle cell lymphomas1

Viability4

Medications2

Pharmacology3

Mechanisms2

Tumors4

Reactions1

Carcinomas3

Renal cell carc1

Line2

Treatment5

Peripheral1

Chronic1

Membrane1

Topoisomerase1

Hematopoietic cell2

Pancreatic Cancer1

Cancer31

Growth9

Induce2

Vitro1

Platelet2

Experimental1

Leukemia3

Basal1

Rapidly3

Tumor cell1

Cancerous cells1

Bone4

Cisplatin2

Drugs4

SIGNAL TRANSDUCTION1