Cells antigens cd5. Medical search. Frequent questions

This proposal seeks to develop for the first time in humans a novel CD5 knocked out (KO) anti-CD5 chimeric antigen receptor T cell (CART) product for patients with relapsed or refractory T-cell lymphomas. (lls.org)
The present project seeks to translate this discovery into a first-in-human clinical trial to evaluate the feasibility, toxicity, and efficacy of CD5-deleted anti-CD5 chimeric antigen receptor CART for T-cell lymphoma. (lls.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). (exbio.cz)
CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. (exbio.cz)
In thymocytes and B1a cells it seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. (exbio.cz)
CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction. (thermofisher.com)
It is a member of the scavenger receptor superfamily found on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-CLL), and peripheral blood dendritic cells. (biolegend.com)
CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions upon binding to ligands such as CD72. (biolegend.com)
The results suggest that the novel protein is a macrophage-specific membrane receptor with a role in host defense, as it shows postnatal expression in macrophages, which are considered responsible for the binding of bacterial antigens and phagocytosis. (embl.de)
The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. (embl.de)
The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. (arigobio.cn)
May act as a receptor in regulating T-cell proliferation. (arigobio.cn)
3. Stimulation of CD5 Enhances Signal Transduction by the T cell Antigen Receptor. (exalpha.com)
Occasional lymphocytes expressed CD4, CD5, CD8 and CD30, while staining for the B-cell marker CD20 and for CD56, activin receptor-like kinase 1 (Alk1) and T-cell receptor alpha/beta (TCR alpha/beta) was consistently negative. (upmc.edu)
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). (exbio.cz)
Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (ox.ac.uk)
The lymphocyte receptor CD5 influences cell activation by modifying the strength of the intracellular response initiated by antigen engagement. (ox.ac.uk)
Regulation through CD5 involves the interaction of one or more of its three scavenger receptor cysteine-rich domains present in the extracellular region. (ox.ac.uk)
The cells are then modified with a synthetic receptor and then re-infused into the body for treatment of cancers. (medika.life)
This method builds upon the basics of CAR T: the use of T cells with a synthetically engineered receptor to target and kill specific cells. (medika.life)
T cells must be extracted from the blood, then genetically modified with a new receptor and expanded to great numbers. (medika.life)
The team adapted mRNA delivery technology seen in current COVID-19 vaccines and applied it to basic Chimeric Antigen Receptor design. (medika.life)
The mRNA does not integrate into the T cell genome, allowing for temporary transcription of the mRNA and transient expression of the new receptor. (medika.life)
The authors adopted a strategy to introduce the chimeric receptor to T cells in the body rather than extracting and purifying them outside the body. (medika.life)
Additionally NKp46 high NK cells expressed elevated levels of the chemokine receptor CXCR3 on mRNA level. (biomedcentral.com)
Nevertheless, a recent study from our group with newly developed monoclonal antibodies (mAbs) against the activating receptor NKp46 enabled a more comprehensive insight into the phenotype of porcine NK cells and putative subsets [ 20 ]. (biomedcentral.com)
Using a T cell transfer colitis model, we demonstrate a key role for T cell-specific IL-1 receptor (IL-1R) signals in the accumulation and survival of pathogenic CD4(+) T cells in the colon. (ox.ac.uk)
The first area of research, representing a long-term project in the lab, involves characterization of the role of T cell antigen receptor (TCR) signals, and in particular, individual TCR signal transducing subunits and signal transducing motifs in T cell development. (nih.gov)
We describe improved responses in T-ALL patients during a Phase I dose study (NCT03081910) of autologous CD5-directed chimeric antigen receptor T cell (CD5 CAR T) following the addition of tyrosine kinase inhibitors during manufacturing. (march.bio)
We describe a Phase I dose escalation study (NCT03081910) of autologous CD5-directed chimeric antigen receptor T cell (CD5 CAR T) therapy for relapsed or refractory (r/r) T-cell leukemia and lymphoma. (march.bio)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. (bvsalud.org)

Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. (bdbiosciences.com)
67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. (exbio.cz)
Raman C: CD5, an important regulator of lymphocyte selection and immune tolerance. (exbio.cz)
Total viable cells in the lymphocyte gate were used for analysis, as determined by LIVE/DEAD Blue (Product # L34962). (thermofisher.com)
Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. (southernbiotech.com)
The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (embl.de)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)

Monoclonal Antibodies and T Cell Hybridomas: Perspectives and Technical News. (bdbiosciences.com)
Human T-cell antigens deﬁned by monoclonal antibodies: The 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. (bdbiosciences.com)
Warnke RA, Levy R. Detection of T and B cell antigens with hybridoma monoclonal antibodies: a biotinavidin-horseradish peroxidase method. (bdbiosciences.com)
CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. (exbio.cz)
Western blotting analysis of human CD5 using mouse monoclonal antibodies MEM-32, CRIS1, and L17F12 on laurylmaltoside lysates of Jurkat cells and of K562 cells (negative control) under non-reducing conditions. (exbio.cz)
COS cells transfected with the CD6 clone express a 90-kD protein that reacts with all available anti-CD6 monoclonal antibodies. (embl.de)
The team then decorated the lipid nanoparticle surface with CD5 targeting antibodies to direct lipid uptake. (medika.life)
Phenotypical analyses with newly developed monoclonal antibodies (mAbs) against porcine NKp46 recently revealed that in blood NKp46 - and NKp46 + cells with NK phenotype exist with comparable cytotoxic properties. (biomedcentral.com)

The mouse monoclonal antibody CRIS1 reacts with an extracellular epitope of CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). (exbio.cz)
CD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1. (biolegend.com)
CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. (southernbiotech.com)
The isolation, characterization, and expression of a full-length cDNA encoding the human T cell glycoprotein CD6 is described. (embl.de)
The antibody MEM-98 reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells. (exbio.cz)

Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
By immunostains, the lymphocytes are predominantly T cells, and plasma cells are polyclonal, expressing both kappa and lambda light chains. (cap.org)
However, these neoplasms have a distinct nodular appearance without abundant lymphocytes and plasma cells typically seen in Hashimoto thyroiditis. (cap.org)
positive control: peripheral blood lymphocytes (PBL), Jurkat human leukemia T-cell line, HPB human leukemia T-cell line, MOLT-4 human leukemia T-cell line. (exbio.cz)
CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. (exbio.cz)
Human peripheral blood lymphocytes were stained with purified CD5 (UCHT2) (solid line) or purified mouse IgG1, κ (dashed line), followed by anti-mouse IgG PE. (biolegend.com)
To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with focal bone marrow involvement, particularly low grade malignant B cell lymphoma of lymphoplasmacytic immunocytoma subtype, which frequently exhibits increased mast cell (MC) numbers. (bmj.com)
50%), compact MC infiltrates are accompanied by perifocal clusters of lymphocytes containing a mixture of B and T cells. (bmj.com)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation of CD5CD23 B-cell lymphocytes. (haematologica.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
Identicication of CD20 PE human B cells associated approximately 10% of peripheral blood lymphocytes. (nordicmubio.com)
4. Surface Immunoglobulin Ligands and Cytokines Differentially Affect Proliferation and Antibody Production by Human CD5+ and CD5- B Lymphocytes. (nordicmubio.com)
For IHC analysis, anti-human CD5 monoclonal mouse antibody to identify T lymphocytes, CD20 monoclonal mouse antibody for the identification of mature B lymphocytes and HLA-DR antigen (alpha-chain) monoclonal mouse antibody for the identification of the major histocompatibility complex type II were previously validated for both species by Western-blotting technique. (ulpgc.es)
T-test method applied to quantitative evaluation of IHC positive cells showed a significant relationship between the number of (expression) of CD20 stained lymphocytes and normal and hypoplastic lymph nodes, respectively. (ulpgc.es)
A simple linear regression was calculated to predict if the amount of OCs could influence the number of inflammatory cell subpopulations and a moderate negative correlation was found between the presence of high quantity of contaminants and the number of T lymphocytes. (ulpgc.es)

The CD5 antibody, clone L17F12, is derived from the hybridization of NS-1/Ag4 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with human T-acute lymphoblastic leukemia (ALL) cells. (bdbiosciences.com)
The CD5 antibody is composed of mouse IgG2a heavy chains and kappa light chains. (bdbiosciences.com)
Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-CD5 monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. (exbio.cz)
The following product was used in this experiment: CD5 Monoclonal Antibody (53-7.3), NovaFluor™ Red 725, eBioscience™ from Thermo Fisher Scientific, catalog # M026T03R05, RRID AB_2926168. (thermofisher.com)
C57BL/6 mouse splenocytes were unstained (left) or stained with 0.2 µg of CD5 Monoclonal Antibody, NovaFluor Red 725 (Product # M026T03R05) (right). (thermofisher.com)
All cells were co-stained with CD45R (B220) Monoclonal Antibody, eFluor 450 (Product # 48-0452-82). (thermofisher.com)
Description: The 53-7.3 monoclonal antibody reacts with mouse CD5, a 67 kDa protein expressed by a majority of thymocytes, mature T cells and a subset of B cells. (thermofisher.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Whenever possible, we recommend adding CellBlox Blocking Buffer to antibody cocktails/master mixes prior to combining with cells. (thermofisher.com)
Purified Anti-Mouse CD5 antibody for use in flow cytometry assays. (southernbiotech.com)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
Western blot: 10 µg of Jurkat cell lysate stained with ARG66751 anti-CD5 antibody [SQab20184] at 1:1000 dilution. (arigobio.cn)
The tissue section was stained with ARG66751 anti-CD5 antibody [SQab20184] at 18°C - 25°C for 30 minutes. (arigobio.cn)
1. Anti-DNA Antibody Production by CD5+ and CD5- B Cells of Patients with Systemic Lupus Erythematosus. (exalpha.com)
Some RVA and most, if not all, RVC strains are extremely difficult to adapt to cell culture, and serological assays are unavailable to measurement of the immune response and antibody levels in response to natural planned exposure (NPE) protocols. (porkcheckoff.org)

He underwent a repeat kidney biopsy which demonstrated MN with 20% interstitial infiltrate that was PAX5, CD23, CD20 and CD5 stain positive consistent with clonal B-cell lymphoproliferation with features of CLL. (asn-online.org)
CD20=Derived from the hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with the LB lymphoblastoid cell line. (nordicmubio.com)

Nevertheless, the needle has not moved for most other malignancies, in particular T cell lymphomas that have a very poor prognosis with current therapies. (lls.org)
However, one challenge of targeting T cell lymphomas using CAR-T cell immunotherapy is that most targets expressed in tumor cells, like CD5, are also expressed by the CAR-T cells themselves, leading to the potential reduction of the CAR-T anti-tumor effect. (lls.org)
Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
Plasmablastic lymphoma was first reported in 1997, when a series of sixteen diffuse large B-cell lymphomas with unique immunohistochemistry were presented in HIV-positive patients with predominant involvement of the oral cavity [ 3 ]. (hindawi.com)
Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
In particular, it is correlated with chronic lymphocytic leukemia/small lymphocytic lymphomas, mantle cell lymphoma, as well as a subset of diffuse large B cell lymphomas. (abeomics.com)
Distinction between atypical lymphoid proliferations rich in Reed-Sternberg-like cells (reactive immunoblasts) and classic Hodgkin lymphomas. (medscape.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

It has been identified as the major ligand of the B-cell antigen CD72. (southernbiotech.com)
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. (exbio.cz)
By comparing amino acid sequences of V H n and V H a Ig, we identified a putative V H ligand binding site for a bacterial or endogenous B cell superantigen. (silverchair.com)
Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)
The B-cell-specific molecule CD72 is a natural ligand for CD5. (bvsalud.org)

It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. (southernbiotech.com)
Macrophage scavenger receptors are integral membrane proteins whose ability to bind and degrade modified LDL has implicated them in the process of atherosclerotic foam cell formation. (embl.de)
On the other hand, other ligands, such as HLA, bind to inhibitory receptors NKG2A and killer immunoglobulin-like receptors (KIR) to inhibit NK cells, providing a form of protection for self-cells from innate immunity. (molcells.org)
Thus, the overall response of an NK cell depends on the balance of stimulating these different receptors. (molcells.org)
Coinhibitory receptors play an important role in the prevention of autoimmune diseases, such as systemic lupus erythematosus (SLE), by limiting T cell activation. (cnrs.fr)

For the 2021 Leukemia Lymphoma Society Translational Research Program, we assembled a group of investigators from different but complementary disciplines, including the Principal Investigator (Dr. Ruella - CART translational research) and clinical lead (Dr. Barta, lymphoma clinical trials) and collaborators (Drs. Lim, Hwang, Siegel, and June) to tackle the issue of the treatment of relapsed or refractory T cell lymphoma. (lls.org)
CART immunotherapy has been very successful in certain cancers, such as B-cell leukemia and lymphoma. (lls.org)
This proposal seeks to develop a novel approach for patients with relapsed or refractory T cell lymphoma by developing a novel CAR-T cell immunotherapy to recognize the tumor-associated target CD5. (lls.org)
Indeed, this novel CAR-T cell product (CD5-deleted CART5) showed increased anti-tumor effect against T cell lymphoma in the laboratory. (lls.org)
We will treat patients with relapsed and refractory T cell lymphoma to define the safety and feasibility of this therapy. (lls.org)
This study will significantly impact the field of cancer immunotherapies by developing a novel potent anti-T-cell lymphoma immunotherapy. (lls.org)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Warnke R, Miller R, Grogan T, Pederson M, Dilley J, Levy R. Immunologic phenotype in 30 patients with diffuse large-cell lymphoma. (bdbiosciences.com)
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
Large, monomorphic, multinucleated neoplastic cells containing abundant cytoplasm and scattered pleomorphic cells were also noted, leading to the diagnosis of tibial plasmablastic lymphoma. (hindawi.com)
Initially considered a variation of diffuse large B-cell lymphoma (DLBCL), PBL was later classified as a distinctive mature B-cell lymphoma and separated from the class of DLBCL by WHO [ 1 ]. (hindawi.com)
We report 3 fatal cases of adult T-cell leukemia/lymphoma caused by human T-cell lymphotropic virus type 1 Australo-Melanesian subtype c. (cdc.gov)
Among HTLV-1 carriers in these regions, adult T-cell leukemia/lymphoma (ATLL) will ultimately develop in 1%-5% ( 2 ). (cdc.gov)
In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
2 Bcl-2 (B-cell lymphoma-2) family of antiapoptotic (bcl-2, bcl-xl, bcl-w and mcl-1) and proapoptotic (bax, bak and bok) proteins are critical regulators of apoptosis in CLL. (haematologica.org)
Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
Lymphoma b cell. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (cdc.gov)
About 2 to 10% of CLL cases develop into diffuse large B-cell lymphoma (called Richter's transformation). (msdmanuals.com)

Los anticuerpos específicos de los antígenos CD5 fomentan la activación de los linfocitos T mediada por los receptores de los linfocitos T. La molécula CD72 específica de los linfocitos B es un ligando natural de CD5. (bvsalud.org)

The expression of CD5 by a small subset of B cells characterizes a developmentally and functionally distinct lineage of B cells called B-1 cells. (thermofisher.com)
Identification of human helper/inducer T cells expressing the 67,000 M.W. surface antigen, 85% peripheral blood lyymphocytes that form rosettes with sheep red blood cells (E+), and a small subset of B cells. (exalpha.com)
Furthermore, cross-linking of NKp46 by NKp46-specific mAbs led to a superior CD107a expression in the NKp46 high NK cells, thus indicating a higher cytolytic capacity of this subset. (biomedcentral.com)
Therefore porcine splenic NKp46 high NK cells represent a highly activated subset of NK cells and may play a profound role in the immune surveillance of this organ. (biomedcentral.com)
CD3 - CD8α + NKp46 - NK cells show phenotypic and functional properties of NK cells although they produce reduced levels of IFN-γ compared to the NKp46 + subset after in vitro stimulation. (biomedcentral.com)
These data indicate, therefore, that a subset of this polyclonal B cell population is capable of making cognate interactions with T cells within this unique environment, and provide the first insights into the dynamics of B cells within an inflammatory site. (ox.ac.uk)
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. (bvsalud.org)

Expression of the activation marker CD30 may be seen in occasional tumor cells. (webpathology.com)
Unlike primary NK cells, those prepared from iPSCs can be prepared with a homogeneous quality and are easily modified to exert a desired response to tumor cells. (molcells.org)
Furthermore, T cells and NK cells complement each other in that certain immune suppression mechanisms taken by tumor cells that are effective against T cells, such as the downregulation of human leukocyte antigens (HLA), have proven to be stimulatory for NK cells. (molcells.org)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. (exbio.cz)
About 30% to 40% of PTCL, NOS, express markers of cytotoxic T-cells such as T-cell intracellular antigen-1 (TIA-1). (webpathology.com)
Immunohistochemically, the vast majority of the infiltrating cells stained positive for CD3 (Figure 6 ) and over half of them were positive for CD2 and T-cell intracellular antigen 1 (TIA1). (upmc.edu)
Finally, we demonstrated that defective BTLA function can be corrected by restoring intracellular trafficking and by normalizing the lipid metabolism in lupus CD4+ T cells. (cnrs.fr)

CD23 was positive in 16% of the cases (all CD5 negative and all CD40 positive). (aacrjournals.org)
The lymphocytic clusters in SM contained nearly equal numbers of mature T and B cells, the latter with no coexpression of aberrant antigens, such as CD5 or CD23. (bmj.com)

BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD5-UNLB (SB Cat. (southernbiotech.com)

In the current study it is shown that this NKp46 high phenotype was correlated with an increased expression of CD16 and CD27 compared to the CD8α + NKp46 - and NKp46 + NK-cell subsets in spleen and blood. (biomedcentral.com)
In the mouse likewise CD27 and CD11b (Mac-1) are used to dissect NK cells into functionally and developmentally different subsets [ 9 ]. (biomedcentral.com)

Recombinant full length protein of Human CD5 (extracellular). (arigobio.cn)
We describe a case of MN in association with CLL successfully treated with acalabrutinib and propose a novel antigen EGF-containing fibulin-like extracellular matrix protein (EFEMP2) as a possible target antigen in this disease. (asn-online.org)

Human Leu T-cell differentiation antigens: quantitative expression on normal lymphoid cells and cell lines. (bdbiosciences.com)
Summary of T-cell studies performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)

Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells. (exbio.cz)
Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. (exbio.cz)
Nine of these proteins were identified as potential immunotherapeutic targets, including five that were validated by FCM, confirming their expression on the cell surface of primary MM patient cells. (bmj.com)
Cluster of differentiation 5 (CD5) is expressed in high levels on the surface of T cells, while controversy surrounds the expression levels and role of CD5 in B cells. (abeomics.com)
CD5 demonstrates positive expression in thymic carcinomas, and is not as sensitive as CD3. (abeomics.com)
6. In Vivo and In Vitro Expression of Myeloid Antigens on B-lineage Acute Lymphoblastic Leukemia Cells. (nordicmubio.com)
Additionally, a third NK cell population with elevated NKp46 expression levels was identified in high frequencies in spleen and liver, pointing towards a special role of NK cells with this phenotype. (biomedcentral.com)
In infected mice, there was a small increase in mIgM(lo)mIgD(+) mature B2 cells, but no enrichment of B cells with regulatory phenotype or function compared to the naïve hepatic B cell population, as assessed by CD1d and CD5 expression and by IL-10 production. (ox.ac.uk)
We investigated BTLA expression on various T cell subsets, and we did not observe significant variations of BTLA expression between lupus patients and healthy controls. (cnrs.fr)
However, associations between the expression of PD-L1 and infiltration of B cells (a major immunoregulatory cell) remain unknown. (cancer-genetics.org)
Therefore, we investigated the role of infiltrating B cells in LUAD progression and its correlation with PD-L1 expression. (cancer-genetics.org)
The Cancer Genome Atlas (TCGA) LUAD data set was used to explore associations among B-cell infiltration, PD-L1 expression, clinical outcome, and gene landscape. (cancer-genetics.org)
To achieve project objectives, VP7 sequences of G5 RVA and G6 RVC (sequenced from the feedback material) were cloned into pcDNA3.1(+) mammalian expression vector with a CD5 secretory signal for efficient secretion into the culture media. (porkcheckoff.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

Peripheral blood examination revealed lymphocytosis (22.4 × 10 9 /L) with atypical lymphoid cells. (cdc.gov)
Lymphoid cells concerned with humoral immunity. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
2. Characteristics of CD11c+ CD5+ Chronic B cell Leukemias and the Identification of Novel Peripheral Blood B cell Subsets with Chronic Lymphoid Leukemia Immunophenotypes. (exalpha.com)
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. (ox.ac.uk)
We show that IL-1β promotes innate immune pathology in Helicobacter hepaticus-triggered intestinal inflammation by augmenting the recruitment of granulocytes and the accumulation and activation of innate lymphoid cells (ILCs). (ox.ac.uk)

Phenotypic and functional characterization of human Leu-1 (CD5) B cells. (bdbiosciences.com)
Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc. (exbio.cz)
The frequency of CD5 + B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5 + B cells suggest that they may represent a distinct lineage, known as B-1 cells. (southernbiotech.com)

Background Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow. (bmj.com)
These T cells target either CD19 or BCMA, two antigens found on malignant B cells. (medika.life)
In chronic lymphocytic leukemia, CD5+ B cells undergo malignant transformation. (msdmanuals.com)

5. Evidence for Differential Responsiveness of Human CD5+ and CD5- B cell Subsets to T cell Independent Mitogens. (exalpha.com)
Functional analyses revealed that splenic NKp46 high NK cells produced much higher levels of Interferon-γ and Tumor Necrosis Factor-α upon stimulation with cytokines or phorbol-12-myristate-13-acetate/Ionomycin compared to the other two subsets. (biomedcentral.com)
A considerable number of phenotypically and functionally different NK-cell subsets have been identified up to date [ 5 ]. (biomedcentral.com)
Despite these hints on important functions of porcine NK cells in vivo, so far no investigations on the existence of functionally differing NK-cell subsets have been reported. (biomedcentral.com)
In contrast, NKp46 in the pig was shown to divide porcine CD3 - CD8α + NK cells into NKp46 - and NKp46 + subsets in blood and all organs tested [ 20 ]. (biomedcentral.com)

Besides their role as cytotoxic cells through the production of perforin and granzymes, NK cells are potent producers of cytokines like Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α [ 3 ] and thus play important roles in immunomodulation and the defence against viral, parasitic and bacterial pathogens [ 4 ]. (biomedcentral.com)

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Flow cytometry and nucleotide sequence analyses revealed that the V H n to V H a repertoire shift did not occur, demonstrating the requirement for interactions between GALT and intestinal microflora in the selective expansion of V H a B cells. (silverchair.com)
Flow cytometry is an important methodology for the diagnosis of chronic B-cell lymphoproliferative diseases (B-CLPD), however, sometimes the cytometrist does not find sufficient elements for the exact definition of the pathological entity involved. (bvsalud.org)
The results emphasize that even though flow cytometry is important for the characterization of B-CLPD, sometimes the cytometrist needs to include the category "other chronic B-cell lymphoproliferative diseases not classified by flow cytometry" in the report to induce the prescriber to request additional complementary exams. (bvsalud.org)
In co-cultures of either the murine pre-B cell line J13, fetal liver cells, or adult peritoneal or bone marrow cells with ST2 mouse bone marrow stromal cells in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), the development of CD5+ macrophages was demonstrated by immunohistochemical staining and flow cytometry. (jax.org)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Microscopic examination revealed a diffuse mononuclear cell infiltrate with variable cell density infiltrating the neuropil rather than growing in sheets. (upmc.edu)

May bind bacterial antigens in the protein MARCO. (embl.de)
Transfected COS cells synthesized a native trimeric plasma membrane protein that bound labeled bacteria and acetylated LDL, but not yeast or Ficoll. (embl.de)
Although CD5+ macrophages were not present in the peritoneal cavities of normal mice, approximately 30% of the peritoneal macrophages in viable motheaten (mev/mev) mice, deficient in SHP-1 protein tyrosine phosphatase, expressed cell surface CD5 and B220, markers for B cells. (jax.org)

Therefore, antigen binding and stimulation could contribute to clonal selection and expansion as well as disease promotion. (nih.gov)
It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)
Furthermore, we found an impaired capacity of BTLA to inhibit T cell activation in SLE due to a poor BTLA recruitment to the immunological synapse following T cell stimulation. (cnrs.fr)

The researchers used whole-exome sequencing to detect the presence of clonal hematopoiesis of indeterminate potential in peripheral blood cells and associated that discovery with coronary heart disease using samples from 4 case-control studies that together enrolled 4,726 participants with coronary heart disease and 3,529 controls. (ascopost.com)

Osorio LM, De Santiago A, Aguilar-Santelises M, Mellstedt H, Jondal M: CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM. (exbio.cz)

Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)

CD5 is intended for in vitro diagnostic use in the identification of cells expressing CD5 antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)

It arises in a hematopoietic stem cell and is characterized by the chromosomal translocation t(9;22)(q34.1;q11.2), which results in the formation of the Philadelphia ( Ph ) chromosome , containing the BCR-ABL1 fusion gene . (cancer.gov)
In this review, we examine the manufacturing and gene engineering of NK cells generated from iPSCs (iPS-NK) for ACT. (molcells.org)
Synthetic mRNA is inserted into the cell with a retrovirus, a virus commonly used in gene therapy to permanently change other cells' genomes. (medika.life)

Most B cells in neonatal Alicia rabbits express V H n allotype immunoglobulin (Ig)M. Within weeks, the number of V H n B cells decreases, whereas V H a allotype B cells increase in number and become predominant. (silverchair.com)

The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. (exbio.cz)
Serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule (sVCAM)-1 were measured by ELISA. (hku.hk)

CAR-T cell immunotherapy is a novel type of cancer therapy that includes the engineering of patient's own immune cells (CAR-T cells) to recognize and fight cancer. (lls.org)
Then, we will test this novel CD5-deleted CART5 immunotherapy product in a first-in-human clinical trial. (lls.org)
The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)

CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. (exbio.cz)
Zimmerman AW, Joosten B, Torensma R, Parnes JR, van Leeuwen FN, Figdor CG: Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. (exbio.cz)

Hürthle cell neoplasms of the thyroid show a distinct nodule or nodules that are comprised mostly of large oncocytes with distinct cell borders, deeply eosinophilic and granular cytoplasm, and a large nucleus with prominent nucleolus. (cap.org)
As a part of a diagnostic panel, its utility lies predominantly as a marker for T cells, with over 70% of T cell neoplasms expressing CD5. (abeomics.com)

In the peritoneal cavity of GM-CSF-treated mice, the percentages of hematopoietic progenitor cells doubly positive for CD5 and CD34 or c-kit and of macrophage precursor cells doubly positive for CD5 and ER-MP58 or ER-MP20 were increased significantly during the development of CD5+ macrophages and CD5 B cells, suggesting that CD5+ macrophages and B cells may share a bipotential progenitor in vivo. (jax.org)

Chronic lymphocytic leukemia (CLL) represents the outgrowth of a CD5(+) B cell. (nih.gov)
Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells. (exbio.cz)
Immunophenotypes in Classical B-cell Chronic Lymphocytic Leukemia. (nordicmubio.com)
author = {Matthieu Sawaf and Hélène Dumortier and Fanny Monneaux}, doi = {10.1155/2016/5767106}, issn = {2314-7156}, year = {2016}, date = {2016-01-01}, journal = {Journal of Immunology Research}, volume = {2016}, pages = {5767106}, abstract = {Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. (cnrs.fr)

RNA blot hybridization analysis indicates that CD6 transcripts are predominantly restricted to cells in the T lineage. (embl.de)
Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)

The patient was seropositive for HTLV-1 by Western blot and positive for hepatitis B surface antigen. (cdc.gov)
A better understanding of the MM cell surface proteome could facilitate development of new directed therapies and assist in stratification and monitoring of patient outcomes. (bmj.com)
Methods In this study, we first used a mass spectrometry (MS)-based discovery-driven cell surface capture (CSC) approach to map the cell surface N -glycoproteome of MM cell lines. (bmj.com)
Results We identified 696 MM cell surface N -glycoproteins by CSC, and developed 73 targeted MS detection assays. (bmj.com)

The role of circulating bone marrow derived endothelial progenitor cells (EPCs) for vascular repair in scleroderma (SSc) remains unclear. (hku.hk)

CD5 also has value as a prognostic indicator, being associated with poor prognosis in acute T cell lymphoblastic leukemia. (abeomics.com)

Anatomy32

Organisms9

Diseases4

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes31

Disciplines and Occupations1

Information Science3

Health Care1

Receptor33

Lymphocyte7

Antibodies8

Glycoprotein5

Lymphocytes21

Antibody15

CD202

Lymphomas9

Ligand5

Receptors5

Lymphoma29

CD721

Subset7

Tumor cells4

Intracellular4

CD232

Mouse CD51

CD272

Extracellular2

Differentiation antigens2

Expression14

Lymphoid7

Phenotypic3

Malignant3

Subsets5

Cytotoxic1

Flow cytometry6

Diffuse1

Protein3

Stimulation3

Clonal1

Modulates1

Autologous2

Vitro2

Gene3

Immunoglobulin1

Molecule2

Immunotherapy4

Proliferation2

Neoplasms2

CD341

Chronic4

Lineage3

Surface4

Progenitor cells1

Leukemia1