• For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. (wikipedia.org)
  • INTRODUCTION: Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy individuals, are reportedly associated with increased mortality. (bvsalud.org)
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)
  • In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. (wikipedia.org)
  • RESULTS: Six factors, namely red blood cell count, human major compatibility complex, mean platelet volume, albumin/globulin ratio (ALB/GLB), prealbumin, and bicarbonate radical, were chosen with the aim of constructing the diagnostic nomogram using ML methods. (bvsalud.org)
  • HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. (wikipedia.org)
  • In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
  • In addition, validation cohort included 147 cases with HLA-B27 positivity whereas 236 with HLA-B27 negativity. (bvsalud.org)
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • METHODS: This study screened totally 1503 patients who underwent HLA-B27 examination, liver/kidney function tests, and complete blood routine examination in First Affiliated Hospital of Guangxi Medical University. (bvsalud.org)
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • Life expectancy was analysed in 377 axSpA patients having available pelvic radiographs and HLA-B27 status, comparing with matched Swiss population data. (bvsalud.org)
  • BACKGROUND: HLA-B27 positivity is normal in patients undergoing rheumatic diseases. (bvsalud.org)
  • OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)
  • HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. (wikipedia.org)
  • In a proof-of-concept analysis integrating transcriptomics and immunopeptidomics data, we showed that hundreds of IRIS-predicted TCR targets are presented by human leukocyte antigen (HLA) molecules. (bvsalud.org)
  • However, among HLA-DR3-positive patients and controls, carriage of HLA-DR3 without microsatellite and single-nucleotide polymorphism alleles of the 8.1AH (HLA-A1, B8, DRB3*0101, DRB1*0301, DQB1*0201) was marginally less common in patients. (nih.gov)
  • Patients showed no increase in carriage of the 18.2AH (HLA-A30, B18, DRB3*0202, DRB1*0301, DQB1*0201) or HLA-DR3 without the central MHC of the 8.1AH, further arguing against HLA-DRB1 as the direct cause of susceptibility. (nih.gov)
  • [ 75 ] Type 1 diabetes occurs in ~18% of these patients, and development of diabetes is influenced by the dominantly protective HLA allele DQB1*0602 and insulin gene polymorphisms. (medscape.com)
  • Previous studies of sporadic inclusion body myositis (sIBM) have shown a strong association with HLA-DR3 and other components of the 8.1 ancestral haplotype (AH) (HLA-A1, B8, DR3), where the susceptibility locus has been mapped to the central major histocompatibility complex (MHC) region between HLA-DR and C4. (nih.gov)
  • If HLAs bind none of the peptides produced by a pathogen, then there is no way for the immune system to tell that a cell is infected. (wikipedia.org)
  • This is a significant decrease and is almost certainly a result of the abnormally efficient binding of HLA-A*02 to peptides originating from EBV. (wikipedia.org)
  • This high affinity increases the probability of CD8+ t-cell recognition of EBV peptides held by HLA-A*02 complexes. (wikipedia.org)
  • We describe Isoform peptides from RNA splicing for Immunotherapy target Screening (IRIS), a computational platform capable of discovering AS-derived tumor antigens (TAs) for T cell receptor (TCR) and chimeric antigen receptor T cell (CAR-T) therapies. (bvsalud.org)
  • Seven TCRs transduced into human peripheral blood mononuclear cells (PBMCs) showed high activity against individual IRIS-predicted epitopes, providing strong evidence of isolated TCRs reactive to AS-derived peptides. (bvsalud.org)
  • Neoantigens are peptides derived from non-synonymous mutations presented by human leukocyte antigens (HLAs), which are recognized by antitumour T cells1-14. (bvsalud.org)
  • In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. (wikipedia.org)
  • HLAs serve as the primary link between the immune system and interior of cells. (wikipedia.org)
  • This prevents the HLAs from being expressed on the cell surface and then functioning properly. (wikipedia.org)
  • HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. (wikipedia.org)
  • [ 72 ] The AIRE gene has a major role in enhancing the expression of peripheral antigens such as insulin within the thymic medullary epithelial cells. (medscape.com)
  • [ 73 , 74 ] Tiny amounts of "peripheral" (i.e., not in the thymus) antigens such as insulin, antigens expressed within the thymus, are associated with negative selection of autoreactive T cells and protection from autoimmunity. (medscape.com)
  • Here, the association with HLA-DR3 and other genes in the central MHC and class II region was further investigated in a group of 42 sIBM patients and in an ethnically similar control group (n = 214), using single-nucleotide polymorphisms and microsatellite screening. (nih.gov)
  • The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. (wikipedia.org)
  • To validate the immunogenicity and T cell recognition of IRIS-predicted TCR epitopes, we performed in vitro T cell priming in combination with single-cell TCR sequencing. (bvsalud.org)
  • Upon loading onto major histocompatibility complex (MHC) molecules, they can trigger recognition by T cells. (bvsalud.org)
  • Whereas a subset of peptide positions are presented to the T cell receptor for recognition, others are responsible for anchoring to the MHC, making these positional considerations critical for predicting T cell responses. (bvsalud.org)
  • The purpose of this study is to characterize the molecular and cell biology of the tumor cells in lymphoma. (stanford.edu)
  • Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (stanford.edu)
  • Analysis of 923 tumor samples shows that 6 to 38% of neoantigen candidates are potentially misclassified and can be rescued using allele-specific knowledge of anchor positions. (bvsalud.org)
  • HLA-A*02 is globally common, but particular variants of the allele can be separated by geographic prominence. (wikipedia.org)
  • From 2,939 NEPC-associated AS events, IRIS predicted 1,651 epitopes from 808 events as potential TCR targets for two common HLA types (A*02:01 and A*03:01). (bvsalud.org)
  • We computationally predicted anchor positions for different peptide lengths for 328 common HLA alleles and identified unique anchoring patterns among them. (bvsalud.org)
  • This syndrome clearly demonstrates the crucial role played by regulatory T cells and that most humans would develop type 1 diabetes unless pathogenic T cells are held in check. (medscape.com)
  • Our study illustrates the contribution of AS to the TA repertoire of cancer cells and demonstrates the utility of IRIS for discovering AS-derived TAs and expanding cancer immunotherapies. (bvsalud.org)
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • One selected TCR showed efficient cytotoxicity against target cells expressing the target peptide. (bvsalud.org)
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)
  • Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). (wikipedia.org)