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  • HSCT
  • A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. (bmj.com)
  • 1 In the past 25 years, nearly a thousand patients with these types of storage disorders, including mucopolysaccharidosis (MPS) type I (Hurler syndrome), other MPS, adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD), Krabbe disease, and others have received allogeneic hematopoietic stem cell transplantation (HSCT) with bone marrow from matched or mismatched related donors who were either carriers or noncarriers of the disease, resulting in clinical benefit in many of them. (bloodjournal.org)
  • cord blood
  • http://www.medisteminc.com ), reported positive safety data in 114 patients who were treated by doctors at Nanshan Affiliated Hospital of Guangdong Medical College (Shenzhen Nanshan Hospital) in Shenzhen using Beike's proprietary cord blood stem cell transplantation protocol. (news-medical.net)
  • study
  • This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets. (news-medical.net)
  • tissue
  • Billingham RE and Brent L (1954) Quantitative studies of tissue transplantation immunity. (springer.com)
  • A lab technician examines the surface of the sample tissue cells to identify the proteins that give everyone his or her own unique tissue type, called human leukocyte antigens (HLAs). (lls.org)
  • As a result, many researchers have focused on adult stem cells , or stem cells isolated from adult humans that can be transplanted into damaged tissue. (wikipedia.org)
  • Once these MSCs are ready for re-implanation, they are usually transferred with growth factors to allow for continued cell growth and engraftment to the damaged tissue. (wikipedia.org)
  • The National Organ, Tissue and Cell Transplantation Policy is a policy that was formulated by the Surgical and Emergency Services Unit of the Medical Services Development Section, Medical Development Division of the Malaysian Ministry of Health in June 2007. (wikipedia.org)
  • It is also responsible for getting more people to pledge and at the same time act as the registrar for organ, tissue and cells donation in Malaysia. (wikipedia.org)
  • Research into new treatments for spinal cord injuries includes stem cell implantation, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (wikipedia.org)
  • The damage can also be divided into primary and secondary injury: the cell death that occurs immediately in the original injury, and biochemical cascades that are initiated by the original insult and cause further tissue damage. (wikipedia.org)
  • An advantage of using teleost fish over other animals, such as pigs, in the studies of diabetes mellitus is that its endocrine cells are separated from the pancreatic exocrine tissue and can be easily isolated and harvested. (wikipedia.org)
  • chronic
  • 1991) Kidney allograft tolerance in primates without chronic immunosuppression-the role of veto cells. (springer.com)
  • Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. (springer.com)
  • Since there is an enhanced and more durable CD4 cell count recovery when ART is initiated earlier, early HIV treatment may mitigate the downstream effects of chronic inflammation [26, (natap.org)
  • chemotherapy
  • In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • When used to treat cancers such as non-Hodgkin's lymphoma and multiple myeloma, high-dose chemotherapy also destroys normal cells such as the HSCs and HPCs in the bone marrow. (nih.gov)
  • To replenish the lost cells, HSCs and HPCs are routinely harvested from a donor's or patient's blood, and then transplanted back into the patient at the conclusion of the chemotherapy procedure to repopulate the bone marrow. (nih.gov)
  • patient's body
  • Using the derived predictive formula, we illustrated bone marrow volume depending on the platelet count to obtain 2.3×10 8 nucleated cell count per patient's body weight. (go.jp)
  • progenitor cells
  • A recent study conducted in mice, baboons, and human volunteers has shown that a non-steroidal anti-inflammatory drug approved by the U.S. Food and Drug Administration (FDA), called meloxicam, significantly increased the number of blood (hematopoietic) stem cells (HSCs) and their descendent hematopoietic progenitor cells (HPCs) entering the circulation from the bone marrow, where they typically reside until needed. (nih.gov)
  • The levels of HSCs and HPCs normally found in blood are very low, and strategies have been devised to mobilize HSCs and progenitor cells out of the bone marrow and into the circulation. (nih.gov)
  • Dr. Khay-Yong Saw and his team evaluated the quality of the repair knee cartilage after arthroscopic microdrilling (also microfracture) surgery followed by post-operative injections of autologous peripheral blood progenitor cells (PBPC) in combination with hyaluronic acid(HA). (wikipedia.org)
  • organ
  • Many approaches which have proven successful in rodent models of solid organ or cellular transplantation have not translated well to large animals or humans. (springer.com)
  • Its main objective is to spread correct information and increase awareness on organ donation and transplantation in Malaysia. (wikipedia.org)
  • The NTRC also collaborate with various NGOs, religious bodies, students' association, corporate bodies as well as the media to spread information on organ donation and transplantation to the public. (wikipedia.org)
  • mesenchymal stem
  • Recent research demonstrates that articular cartilage may be able to be repaired via percutaneous introduction of mesenchymal stem cells (MSC's). (wikipedia.org)
  • As an example, a PubMed search for the year 1999 reveals about 90 papers published under the MESH heading of "Mesenchymal Stem Cells", the same search ran for the year 2007 reveals more than 4,000 entries. (wikipedia.org)
  • Until recently, the use of cultured mesenchymal stem cells to regenerate cartilage has been primarily in research with animal models. (wikipedia.org)
  • While the use of cultured mesenchymal stem cells has shown promising results, a more recent study using uncultured MSC's has resulted in full thickness, histologically confirmed hyaline cartilage regrowth. (wikipedia.org)
  • Infection
  • Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells. (springer.com)
  • Common applications of BLI include in vivo studies of infection (with bioluminescent pathogens), cancer progression (using a bioluminescent cancer cell line), and reconstitution kinetics (using bioluminescent stem cells). (wikipedia.org)
  • severe
  • There are also occasional settings in which transplantation can be performed without any preparation, primarily in children with severe combined immunodeficiency who lack T cell function [ 1 ]. (uptodate.com)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • Survival
  • The hematopoietic niche of the bone marrow supports the survival and self-renewal of HSCs and HPCs, yet prevents the ill-timed release of these cells into the circulation. (nih.gov)
  • The researchers performed in-depth analysis of the effects of labeling on the stem cells, including its effects on cell proliferation, differentiation, survival and electrophysiology. (photonics.com)
  • embryonic
  • The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells. (wikipedia.org)
  • lesion
  • The knee microfracture surgery technique popularized by Steadman relies on the release of these cells into a cartilage lesion to initiate fibrocartilage repair in osteochondral defects. (wikipedia.org)
  • renal
  • Cardiac arrest Cytokine release syndrome Tumor lysis syndrome, causing acute renal failure Infections Hepatitis B reactivation Other viral infections Progressive multifocal leukoencephalopathy (PML) Immune toxicity, with depletion of B cells in 70% to 80% of lymphoma patients Pulmonary toxicity Bowel obstruction and perforation Two patients with systemic lupus erythematosus died of progressive multifocal leukoencephalopathy (PML) after being treated with rituximab. (wikipedia.org)
  • In renal transplant recipients, such cells may be found in up to 40 percent of cases. (wikipedia.org)
  • Decoy cells are clinically relevant since they may be used as a prognostic marker for clinical conditions such as polyomavirus BK-induced nephropathy in renal transplant recipients, and haemorrhagic cystitis in haematopoietic stem cell transplant recipients. (wikipedia.org)
  • Several publications have tried to use decoy cells as a prognostic marker for polyomavirus-associated diseases such as polyomavirus BK-associated nephropathy (BKVAN), a condition occurring only in immunocompromised individuals and especially in renal transplant recipients. (wikipedia.org)
  • diseases
  • Granulysin has been implicated in a myriad of diseases including infection, cancer, transplantation, autoimmunity, skin and reproductive maladies. (wikipedia.org)
  • Rituximab destroys both normal and malignant B cells that have CD20 on their surfaces and is therefore used to treat diseases which are characterized by having too many B cells, overactive B cells, or dysfunctional B cells. (wikipedia.org)
  • Creating female sperm was first raised as a possibility in a patent filed in 1991 by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes (to correct genetic diseases). (wikipedia.org)
  • liver
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • lymphoma
  • Intensive chemoradiotherapy, with or without additional local radiotherapy, and unpurged autologous marrow transplantation was given to 68 patients with progressive non-Hodgkin's lymphoma. (uni-bonn.de)
  • Intensive chemoradiotherapy and autologous marrow transplantation produces durable remissions in some patients with progressive non-Hodgkin's lymphoma. (uni-bonn.de)
  • However, improved conditioning regimens will also be needed, and measures to reduce occult lymphoma stem cell contamination with the autograft may also be required to increase the likelihood of cure in some patients. (uni-bonn.de)
  • Cutaneous T cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system. (wikipedia.org)
  • A point-based algorithm for the diagnosis for early forms of cutaneous T cell lymphoma was proposed by The International Society for Cutaneous Lymphomas in 2005. (wikipedia.org)
  • Cutaneous T-cell lymphoma may be divided into the several subtypes. (wikipedia.org)
  • There is some evidence of a relationship with human T-lymphotropic virus (HTLV) with the adult T-cell leukemia/lymphoma subtype. (wikipedia.org)
  • Elorac, Inc. Announces Orphan Drug Designation for Novel Topical Treatment for Pruritus in Cutaneous T-cell Lymphoma (CTCL) website Turgeon, Mary Louise (2005). (wikipedia.org)
  • tissues
  • Combining two-photon microscopy with fluorescent tracers, we successfully visualized the engrafted tissues at the single cell level in live mice over several months. (jove.com)
  • Imaging using confocal/two-photon hybrid microscopy enables simultaneous high resolution assessment of uniquely marked cells and their progeny in conjunction with structural components of the tissues. (jove.com)
  • A lipid storage disorder (or lipidosis) can be any one of a group of inherited metabolic disorders in which harmful amounts of fats or lipids accumulate in some of the body's cells and tissues. (wikipedia.org)
  • When these cells or tissues are subjected to inflammatory, fibrotic, and other insults, they commonly reduce their expression of LECT2. (wikipedia.org)
  • germ cells
  • In addition, post-meiotic germ cells undergo a dramatic morphological reshaping process as well as a global epigenetic reconfiguration of the germ line chromatin-the histone-to-protamine switch. (jove.com)
  • Procedure
  • If created, a "female sperm" cell could fertilize an egg cell, a procedure that, among other potential applications, might enable female same-sex couples to produce a child that would be the biological offspring of its two mothers. (wikipedia.org)
  • inflammatory
  • 9kD granulysin is also a chemoattractant for T lymphocytes, monocytes, and other inflammatory cells and activates the expression of a number of cytokines, including RANTES, MCP-1, MCP-3, MIP-1α, IL-10, IL-1, IL-6 and IFNα. (wikipedia.org)
  • 100 E) per cytospin smear was semiquantitatively determined, along with analysis of inflammatory cells (neutrophil granulocytes) and fungi. (wikipedia.org)
  • chromosome
  • An analogy, then, is that a cell from a woman has complete Y chromosome deficiency. (wikipedia.org)
  • While many genes on the Y chromosome have backups (homologues) on other chromosomes, a few genes such as RBMY on the Y chromosome do not have such backups, and their effects must be compensated for to convert cells from a woman into sperm. (wikipedia.org)
  • Blood
  • CD34+ cells may be isolated from blood samples using immunomagnetic or immunofluorescent methods. (wikipedia.org)
  • Of all cancers involving the same class of blood cell, 2% of cases are cutaneous T cell lymphomas. (wikipedia.org)
  • The Singapore Cord Blood Bank (Abbreviation: SCBB) is Singapore's only public cord blood bank that collects, processes and stores donated umbilical cord blood for use in stem cell transplants. (wikipedia.org)
  • The expressed mission of the SCBB is to provide placental cord blood units of high safety and quality, through the practice of internationally accredited techniques of collection, processing, banking and disposition, in order to support cord blood transplantations and related research in Singapore and around the world. (wikipedia.org)
  • organs
  • Here we report a novel mouse model that allows long-term single cell imaging of many organs. (jove.com)
  • In usual circumstances, when foreign cells (such as cells or organs from other people, or infectious bacteria) are put into a human body, its immune system will reject such cells or organs. (wikipedia.org)
  • vivo
  • The heterodimer also stimulated cAMP production and thymidine incorporation by cultured thyroid cells and increased serum thyroxine levels in TSH-suppressed rats in vivo. (jci.org)
  • human
  • Her son, the Sage of the Six Paths, was born with the ability to produce chakra by combining physical energy (身体エネルギー, shintai enerugī), drawn from the trillions of cells that make up the human body, and mental energy (精神エネルギー, seishin enerugī), gained through experience and meditation. (wikipedia.org)
  • Leukocyte cell-derived chemotaxin-2 (LECT2) is a protein first described in 1996 as a chemotactic factor for neutrophils, i.e. it stimulated human neutrophils to move directionally in an in vitro assay system. (wikipedia.org)
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • In 2007, a patent application was filed on methods for creating human female sperm using artificial or natural Y chromosomes and testicular transplantation. (wikipedia.org)
  • proteins
  • Genetic combinatorial marking using lentiviral vectors encoding fluorescent proteins (FPs) enabled cell fate mapping through advanced microscopy imaging. (jove.com)
  • Inside cells under normal conditions, lysosomes convert, or metabolize, lipids and proteins into smaller components to provide energy for the body. (wikipedia.org)
  • Thus
  • Thus, because of their CD34+ expression, such undifferentiated cells can be sorted out. (wikipedia.org)
  • Thus, a woman's cells will remain in the man's testicles long enough to be converted into sperm. (wikipedia.org)
  • However
  • However, its expression in these cells is extremely low or undetectable even though these cells express very high levels of LECT2 mRNA. (wikipedia.org)
  • vascular
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • initially
  • The cancerous T cells in the body initially migrate to the skin, causing various lesions to appear. (wikipedia.org)
  • Key to successful creation of female sperm (and male eggs) will be inducing male epigenetic markings for female cells that initially have female markings, with techniques for doing so disclosed in the patent application. (wikipedia.org)
  • circumstances
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • presence
  • By phase-contrast microscopy, decoy cells show the same abnormalities described for stained specimens, namely, enlargement of the nucleus with a ground-glass or vesicular appearance, altered chromatin, enlarged nucleoli, the presence of a halo, and at times also cytoplasmic vacuoles. (wikipedia.org)
  • several
  • Several viruses mediated the emergence of decoy cells, amongst which cytomegalovirus and polyomavirus. (wikipedia.org)
  • disease
  • Higher Karnofsky scores (P less than .01, Mann-Whitney U test) and less resistant disease status at transplantation (P = .04, chi 2 test) were significant when calculations were limited to complete responses. (uni-bonn.de)
  • For this reason DQ3 serotyping is a poor method of typing for transplantation or disease association prediction or study. (wikipedia.org)
  • The viruses that induce the emergence of decoy cells, may causes disease, but again mainly in immunocompromised individuals. (wikipedia.org)