• proliferation
  • Cell proliferation was evaluated by a novel flow cytometric technique which allows direct identification of phenotype of the proliferating cells within complex cell populations. (unipi.it)
  • In order to explore if the T cell proliferation was associated with particular TCR V usage we subsequently analysed TCR Va/VB expression upon in vitro stimulation with M tuberculosis. (unipi.it)
  • Conclusions We conclude that for B-cell tumors with features suggesting a possible c-MYC translocation, such as intermediate to large cell size and high proliferation rate, the presence of VpreB3 should prompt subsequent confirmatory genetic testing, whereas the absence of VpreB3 is virtually always associated with wildtype c-MYC alleles. (haematologica.org)
  • Clinical studies also document that the oral consumption of a tea component, L-theanine, enhances gammadelta T cell proliferation and interferon-gamma secretion. (umassmed.edu)
  • subsets
  • According to the type of TCR heterodimer, T cells can be phenotypically divided into alpha-beta+ or gamma-delta+ subsets. (unipi.it)
  • When mature they are divided into functionally distinct subsets that obey their own (mostly unknown) rules and that have countless direct and indirect effects on healthy tissues and immune cells, on pathogens and tissues enduring infections and the host responses to them. (wikipedia.org)
  • However, the various subsets may also be considered part of the innate immunity where a restricted TCR may be used as a pattern recognition receptor. (wikipedia.org)
  • stem
  • Finally, significant differences were observed in the V beta usage by CD4 or CD8 single-positive T cells that matured from genetically identical stem cells in different thymic environments. (rupress.org)
  • Recovery of thymopoiesis after allogeneic hematopoietic stem cell transplantation is considered pivotal for full immune competence. (haematologica.org)
  • A detailed survey of all post-engraftment infectious complications, non-relapse mortality and overall survival during long-term follow-up was performed in 83 recipients of allogeneic stem cell grafts after myeloablative conditioning. (haematologica.org)
  • These results indicate that patients, who fail to recover thymopoiesis after allogeneic hematopoietic stem cell transplantation are at very high risk for severe infections and adverse clinical outcome. (haematologica.org)
  • human
  • In many human inflammatory/autoimmune diseases significant expansions of ab+ and gd+ T cells have been described. (unipi.it)
  • Design and Methods Here, we used a novel antibody to investigate the normal expression pattern of VpreB3 protein in human hematolymphoid tissues, and determine whether VpreB3 can serve as a useful diagnostic biomarker for select B-cell lymphomas. (haematologica.org)
  • Thymic selection in SCID-hu thymus induces changes in V beta usage by the single-positive CD4+ or CD8+ T cells comparable with those previously reported for single-positive cells present in a normal human thymus. (rupress.org)
  • For example, according to this paradigm, large numbers of (human) Vγ9/Vδ2 T cells respond within hours to common molecules produced by microbes, and highly restricted intraepithelial Vδ1 T cells will respond to stressed epithelial cells bearing sentinels of danger. (wikipedia.org)
  • mature
  • Recent profiling studies unexpectedly revealed abundant transcripts of one member of the VpreB family, VpreB3, in a subset of mature B-cells and Burkitt lymphoma. (haematologica.org)
  • suggest
  • Such similarity in expanded T cell populations might suggest a mycobacterial involvement in the pathogenesis of sarcoidosis. (unipi.it)
  • healthy
  • Expansion of CD4+Va2.3+ T cells with preference to short CDR3-lengths was recorded in HLA-DR17(3)+ healthy individuals. (unipi.it)
  • common
  • This group of T cells is usually much less common than αβ T cells, but are at their highest abundance in the gut mucosa, within a population of lymphocytes known as intraepithelial lymphocytes (IELs). (wikipedia.org)
  • study
  • In our study, significant oligoclonal expansions of peripheral blood T cells were recorded in BD patients. (unipi.it)
  • A recent clinical study demonstrated that ingesting a fruit and vegetable juice concentrate increased the number of circulating gammadelta T cells. (umassmed.edu)