• proliferation
  • Cell proliferation was evaluated by a novel flow cytometric technique which allows direct identification of phenotype of the proliferating cells within complex cell populations. (unipi.it)
  • In order to explore if the T cell proliferation was associated with particular TCR V usage we subsequently analysed TCR Va/VB expression upon in vitro stimulation with M tuberculosis. (unipi.it)
  • Conclusions We conclude that for B-cell tumors with features suggesting a possible c-MYC translocation, such as intermediate to large cell size and high proliferation rate, the presence of VpreB3 should prompt subsequent confirmatory genetic testing, whereas the absence of VpreB3 is virtually always associated with wildtype c-MYC alleles. (haematologica.org)
  • Clinical studies also document that the oral consumption of a tea component, L-theanine, enhances gammadelta T cell proliferation and interferon-gamma secretion. (umassmed.edu)
  • proliferative
  • To investigate the interactions between T-cells and an infectious agent, we then explored, by use of an in vifro infection model, the proliferative response of human peripheral blood T cells from healthy adults upon stimulation with mycobacteria. (unipi.it)
  • Although limited, research demonstrates that nutrients and bioactive food components can influence gammadelta T cell cytotoxicity, cytokine secretion, and proliferative capacity, and the results are nonetheless intriguing. (umassmed.edu)
  • stem
  • Finally, significant differences were observed in the V beta usage by CD4 or CD8 single-positive T cells that matured from genetically identical stem cells in different thymic environments. (rupress.org)
  • Recovery of thymopoiesis after allogeneic hematopoietic stem cell transplantation is considered pivotal for full immune competence. (haematologica.org)
  • A detailed survey of all post-engraftment infectious complications, non-relapse mortality and overall survival during long-term follow-up was performed in 83 recipients of allogeneic stem cell grafts after myeloablative conditioning. (haematologica.org)
  • These results indicate that patients, who fail to recover thymopoiesis after allogeneic hematopoietic stem cell transplantation are at very high risk for severe infections and adverse clinical outcome. (haematologica.org)
  • type
  • According to the type of TCR heterodimer, T cells can be phenotypically divided into alpha-beta+ or gamma-delta+ subsets. (unipi.it)
  • role
  • Most of the immunological studies suggest a central role for T cells in the pathogenesis of BD. (unipi.it)
  • and Milner, John A., "Bioactive food components that enhance gammadelta T cell function may play a role in cancer prevention" (2007). (umassmed.edu)
  • impact
  • Adoptive transfer and TCRdelta-/- knock out mice models should be used more extensively to determine the physiological impact of the number and activity of these cells as a function of dietary component exposures. (umassmed.edu)
  • mature
  • Recent profiling studies unexpectedly revealed abundant transcripts of one member of the VpreB family, VpreB3, in a subset of mature B-cells and Burkitt lymphoma. (haematologica.org)
  • human
  • In many human inflammatory/autoimmune diseases significant expansions of ab+ and gd+ T cells have been described. (unipi.it)
  • Design and Methods Here, we used a novel antibody to investigate the normal expression pattern of VpreB3 protein in human hematolymphoid tissues, and determine whether VpreB3 can serve as a useful diagnostic biomarker for select B-cell lymphomas. (haematologica.org)
  • Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. (rupress.org)
  • Thymic selection in SCID-hu thymus induces changes in V beta usage by the single-positive CD4+ or CD8+ T cells comparable with those previously reported for single-positive cells present in a normal human thymus. (rupress.org)
  • suggest
  • Such similarity in expanded T cell populations might suggest a mycobacterial involvement in the pathogenesis of sarcoidosis. (unipi.it)
  • study
  • In our study, significant oligoclonal expansions of peripheral blood T cells were recorded in BD patients. (unipi.it)
  • A recent clinical study demonstrated that ingesting a fruit and vegetable juice concentrate increased the number of circulating gammadelta T cells. (umassmed.edu)