• tissues
  • A tumor composed of cells derived from hemopoietic tissues of the bone marrow. (thefreedictionary.com)
  • miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. (wikipedia.org)
  • Maintenance of these levels results from a balance between production of eosinophils by bone marrow eosinophil precursor cells termed CFU-Eos and the emigration of circulating eosinophils out of the blood through post-capillary venules into tissues. (wikipedia.org)
  • The biological samples can be different cells/tissues within the same individual, the same cell/tissue at different times, cells/tissues from different individuals, even different alleles in the same cell. (wikipedia.org)
  • A neoplasm can be caused by an abnormal proliferation of tissues, which can be caused by genetic mutations. (wikipedia.org)
  • This, however, changes once neoangiogenesis begins and endothelial cells become active in places like tumor vessels, inflamed tissues, skin with psoriasis, vascular injury and during embryogenesis. (wikipedia.org)
  • Other cells in which endoglin is expressed consist of monocytes, especially those transitioning into macrophages, low expression in normal smooth muscle cells, high expression vascular smooth muscle cells and in kidney and liver tissues undergoing fibrosis. (wikipedia.org)
  • It has been found on endothelial cells in all tissues, activated macrophages, activated monocytes, lymphoblasts fibroblasts, and smooth muscle cells. (wikipedia.org)
  • myeloid
  • solid mass -extramedullary myeloid tumor (granulocytic sarcoma): malignancy of hematopoietic cells, from myeloid cells or precursors (granulocytes, monocytes) presents as solid mass -many prefer one type of manifestation, these types of disease manifestations are not exclusive-often overlap -overlap of CLL and SLL: same biologic disease, but differs if blood and marrow (CLL) vs. enlarged lymph node due to growth (SLL). (brainscape.com)
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • tissue
  • microscopic appearance of malignant cells -histologic growth pattern of cells in marrow, ln, other tissue -presence/absence of malignant cells in blood/marrow -relative amt. (brainscape.com)
  • Tissue culture has been an invaluable tool to study many aspects of cell function, from normal development to disease. (jove.com)
  • Conventional cell culture methods rely on the ability of cells either to attach to a solid substratum of a tissue culture dish or to grow in suspension in liquid medium. (jove.com)
  • Such failure has been attributed to the absence of the appropriate extracellular matrix components of the tissue microenvironment from the standard systems where tissue culture plastic is used as a surface for cell growth. (jove.com)
  • Extracellular matrix is an integral component of the tissue microenvironment and its presence is crucial for the maintenance of physiological functions such as cell polarization, survival, and proliferation. (jove.com)
  • Here we present a 3-dimensional tissue culture method where primary bone marrow cells are grown in extracellular matrix formulated to recapitulate the microenvironment of the human bone (rBM system). (jove.com)
  • Embedded in the extracellular matrix, cells are supplied with nutrients through the medium supplemented with human plasma, thus providing a comprehensive system where cell survival and proliferation can be sustained for up to 30 days while maintaining the cellular composition of the primary tissue. (jove.com)
  • These agents serve to orchestrate robust immune and inflammatory responses that destroy invading microbes, foreign tissue, and malignant cells. (wikipedia.org)
  • Not all types of neoplasms cause a tumorous overgrowth of tissue, however (such as leukemia or carcinoma in situ). (wikipedia.org)
  • The main cellular component of this tissue is the adipocyte, or fat cell. (wikipedia.org)
  • immunoglobulin
  • The CD79a/b heterodimer associates non-covalently with the immunoglobulin heavy chain through its transmembrane region, thus forming the BCR along with the immunoglobulin light chain and the pre-BCR when associated with the surrogate light chain in developing B cells. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • systemic
  • Systemic amyloidosis is a fatal disorder caused by pathological extracellular deposits of amyloid fibrils that are always coated with the normal plasma protein, serum amyloid P component (SAP). (readbyqxmd.com)
  • Epidermis List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes Odom, Richard B. (wikipedia.org)
  • Angioimmunoblastic T-cell lymphoma (AITL, sometimes misspelled AILT) (formerly known as "angioimmunoblastic lymphadenopathy with dysproteinemia") is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. (wikipedia.org)
  • clinical
  • Most importantly for chiropractors, the leading clinical symptoms of MM are related to bone neoplasm and may mimic pain of musculoskeletal origin. (chiro.org)
  • Chronic lymphocytic leukemia (CLL) is an indolent B-cell lymphoma with a variable clinical course. (hindawi.com)
  • Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos acanthoma," and "Pale cell acanthoma") is a benign clinical and histological lesion initially described as neoplastic, which some authors now regard as a reactive dermatosis. (wikipedia.org)
  • Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. (wikipedia.org)
  • survival
  • In this study, Ran et al showed that the frequency of ALDH bright cells at diagnosis predicted the failure to achieve complete remission at the end of the first cycle of chemotherapy, and was the strongest prognostic marker affecting overall survival in the multivariate model. (iseh.org)
  • Mantle cell lymphoma (MCL), a subtype of B-cell non-Hodgkin's lymphoma, has a chemoresistant nature, and thus a very poor prognosis with a median survival of less than 3 years. (iseh.org)
  • More specifically, BM stromal cells (SCs) are known to interact with MM cells to promote MM cell survival and proliferation. (jove.com)
  • The fundamental driver of these hypereosinophilic (or uncommonly eosinophilic) disorders is the mutation which increases the proliferation, survival, and further mutation of cells descendant from the originally mutated cell. (wikipedia.org)
  • peripheral
  • Similarly, humans with homozygous splice variants in CD79A predicted to result in loss of the transmembrane region and a truncated or absent protein display agammaglobulinemia and no peripheral B cells. (wikipedia.org)
  • commonly
  • Recently, it has been shown that the most commonly studied alkylphospholipids inhibit proliferation by inducing apoptosis in malignant cells while leaving normal cells unaffected. (biomedsearch.com)
  • While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media. (wikipedia.org)
  • Malignant neoplasms are commonly called cancer. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • The overproduced Ig's, termed myeloma proteins, commonly circulate in blood, may accumulate in urine, and are the hallmarks of plasma cell dyscrasias including their most malignant forms viz. (wikipedia.org)
  • proliferative
  • 10 g/dL), and lytic b one lesions (CRAB features) that can be attributed to the plasma cell proliferative disorder ( 7 ). (aacrjournals.org)
  • Synthetic alkylphospholipids, compounds with aliphatic side chains that are ether linked to a glycerol backbone, are structurally derived from platelet-activating factor and represent a new class of drugs with anti-proliferative properties in tumour cells. (biomedsearch.com)
  • Apart from its anti-proliferative effect, Ino-C2-PAF strongly reduces cell motility via its inhibitory effect on the phosphorylation of the cytosolic tyrosine kinases FAK and Src. (biomedsearch.com)
  • precursors
  • These cells are progeny of a small pool of immature committed erythroid precursors (BFU-e) that retain the ability to produce HbF. (wikipedia.org)
  • Radiotherapy
  • Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy. (wikipedia.org)
  • protein
  • Moreover, cells can be isolated from the rBM and subsequently used for in vivo transplantation, cell sorting, flow cytometry, and nucleic acid and protein analysis. (jove.com)
  • Genetic deletion of the transmembrane exon of CD79A results in loss of CD79a protein and a complete block of B cell development at the pro to pre B cell transition. (wikipedia.org)
  • The CD79a protein is present on the surface of B-cells throughout their life cycle, and is absent on all other healthy cells, making it a highly reliable marker for B-cells in immunohistochemistry. (wikipedia.org)
  • Development of Sertoli cells is directed by the testis-determining factor protein. (wikipedia.org)
  • inhibin and activins - secreted after puberty, and work together to regulate FSH secretion androgen binding protein (also called testosterone binding globulin) - increases testosterone concentration in the seminiferous tubules to stimulate spermatogenesis estradiol - aromatase from Sertoli cells convert testosterone to 17 beta estradiol to direct spermatogenesis glial cell line-derived neurotrophic factor (GDNF) - has been demonstrated to function in promoting undifferentiating spermatogonia, which ensures stem cell self-renewal during the perinatal period. (wikipedia.org)
  • transferrin - a blood plasma protein for iron ion delivery The occluding junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. (wikipedia.org)
  • These include proteins of the FoxO family, which stimulate cell cycle progression, and protein kinase D, which enhances glucose metabolism. (wikipedia.org)
  • The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. (wikipedia.org)
  • ELMO also binds the activated form of the small G protein RhoG and this has been shown to promote DOCK-dependent signalling by helping recruit the ELMO-DOCK complex to areas of high substrate availability (usually the plasma membrane). (wikipedia.org)
  • keratinocytes
  • Clear cell acanthoma is characterized by a sharply demarcated psoriasiform epidermal hyperplasia composed of a proliferation of slightly enlarged keratinocytes, and basal cells with pale-staining glycogen-rich cytoplasm, mild spongiosis and scattered neutrophils, which may form small intraepidermal microabscesses. (wikipedia.org)
  • genome
  • The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals. (wikipedia.org)
  • The src gene was taken up by RSV and incorporated into its genome conferring it with the advantage of being able to stimulate uncontrolled mitosis of host cells, providing abundant cells for fresh infection. (wikipedia.org)
  • The RNA genome of RSV contains an extremely long 3' UTR that ranges between 5-7 kb in length which would usually direct it toward nonsense mediated decay (NMD) within the eukaryotic host cell. (wikipedia.org)
  • Fusion occurs when the virus fuses together with the target cell membrane and releases its genome into the cell. (wikipedia.org)
  • The researchers found that the cancer cells experienced lower methylation rates than the healthy cells, but only in gene poor regions of the genome. (wikipedia.org)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • behavior
  • The rBM system allows for direct, in-matrix real time visualization of the cell behavior and evaluation of preclinical efficacy of novel therapeutics. (jove.com)
  • therapeutic
  • Taken together, our study demonstrates for the first time a role for Eos in the pathology of MM and suggests that therapeutic strategies targeting these cells may be beneficial. (jove.com)
  • increases
  • The src gene is not essential for RSV proliferation but it greatly increases virulence when present. (wikipedia.org)
  • Sickle-cell disease (increases production of fetal hemoglobin that then reduces the tendency of sickle cells to sickle, as well as reducing white blood cells that contribute to the general inflammatory state in sickle cell patients. (wikipedia.org)
  • In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. (wikipedia.org)
  • The precise mechanism of action is not yet clear, but it appears that hydroxycarbamide increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma globin gene expression and subsequent gamma chain synthesis necessary for fetal hemoglobin (HbF) production (which does not polymerize and deform red blood cells like the mutated HbS, responsible for sickle cell disease). (wikipedia.org)
  • tumors
  • Vascular tumors (formed from blood vessels) are thus looked at as being amalgams of a solid skeleton formed by sticky cells and an organic liquid filling the spaces in which cells can grow. (wikipedia.org)
  • Tumor Characteristics: Tumors with a high cell turnover rate, rapid growth rate, and high tumor bulk tend to be more associated with the development of tumor lysis syndrome. (wikipedia.org)
  • hormones
  • Sertoli cells control the entry and exit of nutrients, hormones and other chemicals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site. (wikipedia.org)
  • tumour progression
  • Signalling pathways under the control of the FAK/Src complex are normally required for both migration and proliferation and play a prominent role in tumour progression. (biomedsearch.com)
  • Dock4 was discovered as a gene product which was disrupted during tumour progression in a murine cancer model-derived osteosarcoma cell line. (wikipedia.org)
  • migration
  • Dock4 undergoes RhoG/ELMO-dependent recruitment to the plasma membrane and promotes migration in fibroblasts. (wikipedia.org)
  • More recently, a role has been described for Dock4 as part of the Wnt signalling pathway which regulates cell proliferation and migration. (wikipedia.org)
  • Dock4 dependent Rac activation regulates reorganisation of the cytoskeleton and leads to the formation of membrane protrusions (e.g. lamellipodia) which are a crucial step in neuronal development and cell migration. (wikipedia.org)
  • multiple
  • plasma cell myeloma multiple myeloma . (thefreedictionary.com)
  • Multiple immortal cell lines have been created and grown using such approaches, however, these methods frequently fail when primary cells need to be grown ex vivo . (jove.com)
  • The occurrence of CD79A thus coincides with the evolution of B cell receptors with greater diversity generated by recombination of multiple V, D, and J elements in bony fish contrasting the single V, D and J elements found in shark. (wikipedia.org)
  • CD79a plays multiple and diverse roles in B cell development and function. (wikipedia.org)
  • gene
  • The selection committee has identified the following areas as key to the 2012 meeting program: developmental biology (both mammalian and other animal models), ES/iPS cells, epigenetics, leukemia/lymphoma, microenvironment, novel tools/approaches in hematology, transcriptional/translational control of hematopoiesis and transplantation/gene therapy/regenerative medicine. (iseh.org)
  • RSV has four genes: gag - encodes capsid proteins pol - encodes reverse transcriptase env - encodes the envelope gene src - encodes a tyrosine kinase that attaches phosphate groups to the amino acid tyrosine in host cell proteins. (wikipedia.org)
  • malignancy
  • BCR functions are required for normal antibody production, and defects in BCR signal transduction may lead to immunodeficency, and B-cell malignancy. (wikipedia.org)
  • tumor cells
  • They also participate in transplant rejection, Graft-versus-host disease, and the killing of tumor cells. (wikipedia.org)
  • Tumor lysis syndrome (TLS) is a group of metabolic abnormalities that can occur as a complication during the treatment of cancer, where large amounts of tumor cells are killed off (lysed) at the same time by the treatment, releasing their contents into the bloodstream. (wikipedia.org)
  • High turnover of tumor cells leads to spill of potassium into the blood. (wikipedia.org)
  • One suggestion for the reason of this is that the high cell turnover rate leads to high uric acid levels through nucleobase turnover but the tumor reuses the released phosphate for growth of new tumor cells. (wikipedia.org)
  • In post-chemotherapy TLS, tumor cells are destroyed and no new tumor cells are being synthesized. (wikipedia.org)
  • lesion
  • This lesion is also known as a plasma cell granuloma, myofibroblastoma, inflammatory myofibroblastic tumor, and xanthomatous pseudotumor, and it occurs as the result of an inflammatory myofibroblastic proliferation and a pseudosarcomatous fibroinflammatory process. (thefreedictionary.com)
  • progression
  • Because of the apical progression of the spermatogonia (sperm stem cells), the occluding junctions must be dynamically reformed and broken to allow the immunoidentical spermatogonia to cross through the blood-testis barrier so they can become immunologically unique. (wikipedia.org)
  • secrete
  • Sertoli cells secrete the following substances: anti-Müllerian hormone (AMH) - secreted during the early stages of fetal life. (wikipedia.org)
  • basal
  • about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum. (wikipedia.org)
  • proteins
  • Gag proteins are necessary for virion assembly and mature virus infection of the host cell. (wikipedia.org)
  • This repair likely employs the process of non-homologous end joining involving XRCC1 and PARP1 proteins that are expressed in Sertoli cells. (wikipedia.org)
  • Dock4 also contains a DHR2 domain (also known as Docker2 or CZH2) which is conserved among DOCK family proteins and mediates GEF-dependent functions, and a DHR1 domain (CZH1/Docker1) which has been shown to bind PtdIns(3,4,5)P3, an important step in recruitment to the plasma membrane. (wikipedia.org)
  • DOCK family proteins contribute to cell signalling by activating G proteins of the Rho family, such as Rac and Cdc42. (wikipedia.org)
  • ITAM
  • In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM. (wikipedia.org)
  • However, the presence of both the CD79a and CD79b ITAM tyrosines were required for normal T cell dependent antibody responses. (wikipedia.org)
  • The CD79a cytoplasmic domain further contains a non-ITAM tyrosine distal of the CD79a ITAM (human CD79a Tyr210, mouse CD79a Tyr204) that can bind BLNK and Nck once phosphorylated, and is critical for BCR mediated B cell proliferation and B1 cell development. (wikipedia.org)
  • Each member of the dimer spans the plasma membrane and has a cytoplasmic tail bearing an immunoreceptor tyrosine-based activation motif (ITAM). (wikipedia.org)
  • mutation
  • Compared to spermatocytes, the mutation frequency is about 5 to 10-fold higher in Sertoli cells. (wikipedia.org)
  • This may reflect the need for greater efficiency of DNA repair and mutation avoidance in the germ line than in somatic cells. (wikipedia.org)
  • The exact mechanism and extent to which it regulates cancer-associated signalling pathways is poorly understood thus far although a mutation in Dock4 which affects its GEF specificity has been reported to promote detachment and invasion of cancer cells. (wikipedia.org)
  • infiltrate
  • The Epstein-Barr virus (EBV) is observed in the majority of cases, and the virus has been found in the reactive B-cells that comprise part of the polymorphous infiltrate of this disease and in the neoplastic T-cells. (wikipedia.org)
  • occurs
  • Translocation of germ cells from the base to the lumen of the seminiferous tubules occurs by conformational changes in the lateral margins of the Sertoli cells. (wikipedia.org)
  • stem cells
  • Presenting to the ISEH audience is advantageous to advancing your ideas and quality hard work in the field of hematology and stem cells. (iseh.org)
  • The existence of leukemia stem cells (LSCs) was first documented in AML using xenotransplant assays. (iseh.org)
  • pathways
  • Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane. (biomedsearch.com)
  • Instead, they are incorporated into cell membranes, where they accumulate and interfere with lipid metabolism and lipid-dependent signalling pathways. (biomedsearch.com)
  • These cleaved products include the matrix (MA), capsid (CA), and nucleocapsid (NC), which are able to enter other pathways to infect new cells. (wikipedia.org)