• medial
  • Anatomically, the axons of SBCs cross the midline in the dorsal component of the trapezoid body and typically innervate the medial superior olive (MSO) on both sides, the ipsilateral lateral superior olive (LSO), and the contralateral ventral nucleus of the lateral lemniscus (VNLL). (kuleuven.be)
  • In contrast, GBC axons travel in the ventral component of the trapezoid body, never innervate the MSO, rarely innervate the ipsilateral LSO, and always innervate the contralateral medial nucleus of the trapezoid body. (kuleuven.be)
  • lateral
  • An increased number of cells in the lateral aspects of the dorsal raphe is characteristic of humans and other primates. (wikipedia.org)
  • The nucleus raphes dorsalis have been known to project to the lateral hypothalamus, along with the locus coeruleus and the tuberomammillary nucleus. (wikipedia.org)
  • The neurotransmitters of these three aforementioned nuclei, which project to the lateral hypothalamus, are serotonin, norepinephrine and histamine respectively. (wikipedia.org)
  • axons
  • In an attempt to clarify these details, we have physiologically characterized and anatomically labeled individual axons of the spherical bushy cell (SBC) class of the cat AVCN. (kuleuven.be)
  • Ten percent of the axons from the nucleus raphe dorsalis of the rat have been shown to project to the amygdala, while only medium cells seem to project to the caudate and putamen and olfactory bulb. (wikipedia.org)
  • protein
  • We have developed a novel method, MCLIP ( Membrane protein Cross-Link ImmunoPrecipitation ), which takes advantage of a cell permeable crosslinker to enable effective detection and analysis of specific interactions of NE proteins in live cells using Western blot. (diva-portal.org)
  • Using MCLIP we show that, in U2OS cells, the integral inner nuclear membrane protein Samp1 interacts with Lamin B1, the LINC (Linker of nucleoskeleton and cytoskeleton) complex protein, Sun1 and the soluble small GTPase Ran. (diva-portal.org)
  • We also, show that MCLIP is suitable to coprecipitate protein interactions in different stages of the cell cycle. (diva-portal.org)
  • activity
  • A muscle relaxant, known as Mephenesin, reduces to activity of the dorsal nucleus, as well as microinjections of carbachol (which induces atonia while awake). (wikipedia.org)
  • Studies
  • Some studies have suggested that the dorsal raphe may be decreased in size in people with depression and, paradoxically, an increased cell density in those who commit suicide. (wikipedia.org)
  • Effect
  • The dorsal raphe nucleus is rich in pre-synaptic serotonin 5-HT1A autoreceptors, and it's believed that the action of the selective serotonin reuptake inhibitors (SSRIs) in this region is responsible for the latency of their antidepressant effect. (wikipedia.org)