Loading...



  • medial
  • Anatomically, the axons of SBCs cross the midline in the dorsal component of the trapezoid body and typically innervate the medial superior olive (MSO) on both sides, the ipsilateral lateral superior olive (LSO), and the contralateral ventral nucleus of the lateral lemniscus (VNLL). (kuleuven.be)
  • In contrast, GBC axons travel in the ventral component of the trapezoid body, never innervate the MSO, rarely innervate the ipsilateral LSO, and always innervate the contralateral medial nucleus of the trapezoid body. (kuleuven.be)
  • oocytes
  • 2006. Evaluation of the embryonic preimplantation potential of human adult somatic cells via an embryo interspecies bioassay using bovine oocytes. (koreascience.or.kr)
  • Recently, I was involved with a scientific group in Yonago, Japan in the development of ROSNI during which immature spermatozoa (spermatids) were harvested from the testes of infertile men and their nuclei were transferred into nucleated oocytes and electrofusion was applied and pregnancies were achieved. (zavos.org)
  • lateral
  • An increased number of cells in the lateral aspects of the dorsal raphe is characteristic of humans and other primates. (wikipedia.org)
  • The nucleus raphes dorsalis have been known to project to the lateral hypothalamus, along with the locus coeruleus and the tuberomammillary nucleus. (wikipedia.org)
  • The neurotransmitters of these three aforementioned nuclei, which project to the lateral hypothalamus, are serotonin, norepinephrine and histamine respectively. (wikipedia.org)
  • axons
  • In an attempt to clarify these details, we have physiologically characterized and anatomically labeled individual axons of the spherical bushy cell (SBC) class of the cat AVCN. (kuleuven.be)
  • Ten percent of the axons from the nucleus raphe dorsalis of the rat have been shown to project to the amygdala, while only medium cells seem to project to the caudate and putamen and olfactory bulb. (wikipedia.org)
  • vitro
  • 2007. Cell cycle analysis and interspecies nuclear transfer of in vitro cultured skin fibroblasts of the Siberian tiger (Panthera tigris Altaica). (koreascience.or.kr)
  • The results show that the previously detected in vitro interaction between Samp1 and Emerin also takes place in live cells. (diva-portal.org)
  • I have also received extensive training in the areas of gamete physiology, manipulation, cell culture and in-vitro gamete manipulation. (zavos.org)
  • activity
  • A muscle relaxant, known as Mephenesin, reduces to activity of the dorsal nucleus, as well as microinjections of carbachol (which induces atonia while awake). (wikipedia.org)
  • Effect
  • 2008. Effect of epigenetic modifications of donor somatic cells on the subsequent chromatin remodeling of cloned bovine embryos. (koreascience.or.kr)
  • The dorsal raphe nucleus is rich in pre-synaptic serotonin 5-HT1A autoreceptors, and it's believed that the action of the selective serotonin reuptake inhibitors (SSRIs) in this region is responsible for the latency of their antidepressant effect. (wikipedia.org)
  • size
  • Some studies have suggested that the dorsal raphe may be decreased in size in people with depression and, paradoxically, an increased cell density in those who commit suicide. (wikipedia.org)
  • Actin
  • The analysis suggests that the pressure difference across the nuclear envelope, which is influenced by changes in cell volume and regulated by microtubules and actin filaments, is a major factor determining nuclear morphology. (biologists.org)
  • Cytoskeletal motors also directly influence the nuclear shape: microtubule motors apply an overall compressive pressure, whereas actin stress fibers apply compressive forces on the nucleus. (biologists.org)
  • structures
  • Researchers have published a cellular delivery method of nanoparticles called quantum dots which could be used as molecular probes for simultaneous imaging and manipulation of single biomolecules in the nucleus and for observation of subnuclear structures and events in the Oct. 4 edition of Small . (healthimaging.com)
  • The round structures are the nuclei, the control centres of the individual cells. (sciencephoto.com)
  • mRNA
  • Nucleus acts as the site for gene transcription and it is here that mRNA is formed and undergoes post-transcriptional modification before being sent to the cytoplasm for translation (for making the proteins). (enotes.com)
  • chromatin
  • When a cell is exposed to ionizing radiation, its chromatin can be damaged with DSB, triggering the DDR which starts with the MRN complex recruiting ATM kinase to the exposed H2AX histones on the damaged DNA. (wikipedia.org)
  • molecules
  • For example, up to 200,000 different small molecules might be made in plants, although not all these will be present in the same species, or in a single cell. (wikipedia.org)
  • The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complexes (NPCs). (wikipedia.org)
  • alterations
  • this has been associated with decreasing amounts of satellite cells, but also to alterations in their activation, proliferation, and/or differentiation. (hindawi.com)
  • We demonstrated that in satellite cells the RNA pathways undergo alterations during aging, possibly hampering their responsiveness to muscle damage. (hindawi.com)
  • Alterations in nuclear morphology are closely associated with essential cell functions, such as cell motility and polarization, and correlate with a wide range of human diseases, including cancer, muscular dystrophy, dilated cardiomyopathy and progeria. (biologists.org)
  • cytosol
  • Although water forms the large majority of the cytosol, its structure and properties within cells is not well understood. (wikipedia.org)
  • The term "cytosol" was first introduced in 1965 by H. A. Lardy, and initially referred to the liquid that was produced by breaking cells apart and pelleting all the insoluble components by ultracentrifugation. (wikipedia.org)
  • The term cytosol is now used to refer to the liquid phase of the cytoplasm in an intact cell. (wikipedia.org)
  • Due to the possibility of confusion between the use of the word "cytosol" to refer to both extracts of cells and the soluble part of the cytoplasm in intact cells, the phrase "aqueous cytoplasm" has been used to describe the liquid contents of the cytoplasm of living cells. (wikipedia.org)
  • The proportion of cell volume that is cytosol varies: for example while this compartment forms the bulk of cell structure in bacteria, in plant cells the main compartment is the large central vacuole. (wikipedia.org)
  • Most of the cytosol is water, which makes up about 70% of the total volume of a typical cell. (wikipedia.org)
  • genes
  • The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expression-the nucleus is, therefore, the control center of the cell. (wikipedia.org)
  • When we refer to "expression regulation," we are talking about the fact that not all genes are expressed in the cell at the same time. (wikibooks.org)
  • macromolecules
  • The classic view of water in cells is that about 5% of this water is strongly bound in by solutes or macromolecules as water of solvation, while the majority has the same structure as pure water. (wikipedia.org)
  • outer
  • Brown was studying orchids under microscope when he observed an opaque area, which he called the "areola" or "nucleus", in the cells of the flower's outer layer. (wikipedia.org)
  • In addition, examples of specialized primary cilia can be found in human sensory organs such as the eye and the nose: The outer segment of the rod photoreceptor cell in the human eye is connected to its cell body with a specialized non-motile cilium. (wikipedia.org)
  • regulation
  • He is currently a Professor at Cold Spring Harbor Laboratory (CSHL) and head of the Gene Regulation and Cell Proliferation program of the CSHL Cancer Center. (wikipedia.org)
  • penetrate
  • Yu worked with fellow mechanical science and engineering professor Ning Wang, PhD, and postdoctoral researcher Kyungsuk Yum, PhD, to develop a controlled delivery and release method that uses a cargo-carrying nanoneedle (serving also as a nanoscale electrode) to penetrate into the nucleus of a living cell. (healthimaging.com)
  • differentiation
  • Cancerous cells lose that differentiation. (wikipedia.org)
  • The current scientific understanding of primary cilia views them as "sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. (wikipedia.org)
  • gene expression
  • David L. Spector (born (1952-12-06)December 6, 1952, in New York City) is a cell and molecular biologist best recognized for his research on gene expression and nuclear dynamics. (wikipedia.org)
  • bind
  • Mutations that affect tRNA's structure inhibit its ability to bind to exportin-t, and consequentially, to be exported, providing the cell with another quality control step. (wikipedia.org)
  • RIF1 has been shown to bind to RNA in the nucleus. (wikipedia.org)
  • interacts
  • Now in the nucleus, the Ran-GDP interacts with a guanine nucleotide exchange factor (GEF) which replaces the GDP with GTP, resulting again in Ran-GTP, and beginning the cycle anew. (wikipedia.org)
  • smooth
  • Smooth muscle cells. (istockphoto.com)
  • Here, we demonstrate that when an adherent cell is detached from its substratum, the nucleus undergoes a large volumetric reduction accompanied by a morphological transition from an almost smooth to a heavily folded surface. (biologists.org)
  • cargo
  • To rapidly release the attached cargo inside the nucleus, the researchers applied a small external electrical potential through the nanoneedle. (healthimaging.com)
  • Once inside the nucleus, interaction with Ran-GTP causes a conformational change in the importin that causes it to dissociate from its cargo. (wikipedia.org)
  • in the nucleus, the exportin binds the cargo and Ran-GTP and diffuses through the pore to the cytoplasm, where the complex dissociates. (wikipedia.org)
  • Exportin-t binds directly to its tRNA cargo in the nucleus, a process promoted by the presence of RanGTP. (wikipedia.org)
  • nanoscale
  • Our ultimate goal is to develop a nanoscale delivery system that can drop off its payload - in this case nanoparticles with other agents attached - into a cell to enhance the effectiveness of a drug treatment," Vo-Dinh said. (medica-tradefair.com)
  • processes
  • Both the processes of mitosis and meiosis divide the cell nucleus and its contents. (reference.com)
  • these differences in ion levels are important in processes such as osmoregulation, cell signaling, and the generation of action potentials in excitable cells such as endocrine, nerve and muscle cells. (wikipedia.org)
  • adaptive immune system One of two main immunity strategies found in vertebrates that inhibits or eliminates pathogens through the actions of highly specialized systemic cells and processes. (wikipedia.org)
  • mechanical
  • One of the most promising applications of quantum dots is molecular imaging in living cells, according to Min-Feng Yu, PhD, associate professor of mechanical science and engineering, University of Illinois at Urbana-Champaign, and colleagues. (healthimaging.com)
  • However, the mechanical forces influencing the shape of the nucleus in live cells are not fully understood. (biologists.org)
  • organisms
  • First, it reproduces both by cell division (splitting one cell into two) and by conjugation, in which two organisms temporarily join in order to swap DNA. (wikipedia.org)
  • photoreceptor
  • This also turned out to be a misnomer: arrestin-1 expresses at comparable very high levels in both rod and cone photoreceptor cells. (wikipedia.org)
  • Imaging
  • Basic Methods in Microscopy, Live Cell Imaging: A Laboratory Manual), and a treatise of The Nucleus, that are used in laboratories throughout the world. (wikipedia.org)
  • binds
  • Ran-GTP binds GAP and hydrolyzes GTP, and the resulting Ran-GDP complex is restored to the nucleus where it exchanges its bound ligand for GTP. (wikipedia.org)
  • receptors
  • Breast cancer cells may or may not have many different types of receptors, the three most important in the present classification being: estrogen receptor (ER), progesterone receptor (PR), and HER2/neu. (wikipedia.org)
  • describe
  • Pathologists describe cells as well differentiated (low-grade), moderately differentiated (intermediate-grade), and poorly differentiated (high-grade) as the cells progressively lose the features seen in normal breast cells. (wikipedia.org)
  • control
  • The nucleus is designed to govern and control everything that happens within the entire cell, which includes the process of cell division. (reference.com)
  • The larger, called the "macronucleus", carries out the normal work of the cell by transcribing DNA into RNA, which is used to control the cell's functions. (wikipedia.org)
  • Human
  • while human cytosolic pH ranges between 7.0 - 7.4, and is usually higher if a cell is growing. (wikipedia.org)
  • Knock out MDC1 mice cells and silenced human cells were radiosensitive, failed to initiate Intra-S phase and G2/M checkpoints, failed to produce ionizing radiation-induced foci had poor phosphorylation by the DRR kinases (ATM, CHK1, CHK2), defects in homologous recombination. (wikipedia.org)
  • Human cells with silenced MDC1 also displayed random plasmid integration, reduced apoptosis, and slowed mitosis. (wikipedia.org)
  • division
  • Franz Meyen was a strong opponent of this view, having already described cells multiplying by division and believing that many cells would have no nuclei. (wikipedia.org)
  • Both mitosis and meiosis are types of cell division that share many similarities, and both share the same basic stages of prophase, metaphase, anaphase and. (reference.com)
  • Cell division becomes uncontrolled. (wikipedia.org)
  • The smaller "micronucleus" is used only for reproducing the organism by cell division and by conjugation. (wikipedia.org)
  • It is spread by cell division of Halofolliculina corallasia, which produces a pair of worm-like larvae that settle on undamaged coral just ahead of the black band. (wikipedia.org)
  • progressively
  • these saw that a 20% reduction in the amount of water in a cell inhibits metabolism, with metabolism decreasing progressively as the cell dries out and all metabolic activity halting when the water level reaches 70% below normal. (wikipedia.org)
  • enters
  • Between 1877 and 1878, Oscar Hertwig published several studies on the fertilization of sea urchin eggs, showing that the nucleus of the sperm enters the oocyte and fuses with its nucleus. (wikipedia.org)
  • What Type of Cell Enters the G0 Phase? (reference.com)
  • motility
  • In most species bi-directional motility called intraflagellar transport (IFT) plays an essential role in moving these building materials from the cell body to the assembly site. (wikipedia.org)
  • medial
  • Anatomically, the axons of SBCs cross the midline in the dorsal component of the trapezoid body and typically innervate the medial superior olive (MSO) on both sides, the ipsilateral lateral superior olive (LSO), and the contralateral ventral nucleus of the lateral lemniscus (VNLL). (kuleuven.be)
  • In contrast, GBC axons travel in the ventral component of the trapezoid body, never innervate the MSO, rarely innervate the ipsilateral LSO, and always innervate the contralateral medial nucleus of the trapezoid body. (kuleuven.be)
  • lateral
  • An increased number of cells in the lateral aspects of the dorsal raphe is characteristic of humans and other primates. (wikipedia.org)
  • The nucleus raphes dorsalis have been known to project to the lateral hypothalamus, along with the locus coeruleus and the tuberomammillary nucleus. (wikipedia.org)
  • The neurotransmitters of these three aforementioned nuclei, which project to the lateral hypothalamus, are serotonin, norepinephrine and histamine respectively. (wikipedia.org)
  • axons
  • In an attempt to clarify these details, we have physiologically characterized and anatomically labeled individual axons of the spherical bushy cell (SBC) class of the cat AVCN. (kuleuven.be)
  • Ten percent of the axons from the nucleus raphe dorsalis of the rat have been shown to project to the amygdala, while only medium cells seem to project to the caudate and putamen and olfactory bulb. (wikipedia.org)
  • vitro
  • 2007. Cell cycle analysis and interspecies nuclear transfer of in vitro cultured skin fibroblasts of the Siberian tiger (Panthera tigris Altaica). (koreascience.or.kr)
  • I have also received extensive training in the areas of gamete physiology, manipulation, cell culture and in-vitro gamete manipulation. (zavos.org)
  • activity
  • A muscle relaxant, known as Mephenesin, reduces to activity of the dorsal nucleus, as well as microinjections of carbachol (which induces atonia while awake). (wikipedia.org)
  • Effect
  • The dorsal raphe nucleus is rich in pre-synaptic serotonin 5-HT1A autoreceptors, and it's believed that the action of the selective serotonin reuptake inhibitors (SSRIs) in this region is responsible for the latency of their antidepressant effect. (wikipedia.org)
  • size
  • Some studies have suggested that the dorsal raphe may be decreased in size in people with depression and, paradoxically, an increased cell density in those who commit suicide. (wikipedia.org)