• mechanism
  • The retinoblastoma protein: Rb) inhibits both cell division and apoptosis, but the mechanism by which Rb alternatively regulates these divergent outcomes remains poorly understood. (wustl.edu)
  • cycle
  • The dynamic exchange of centrosome-associated γ-tubulin occurs throughout the cell cycle, including mitosis, and it does not require microtubules. (rupress.org)
  • One possibility is that the centrosome grows gradually during the cell cycle, recruiting both structural and functional elements that are then maintained in an inactive form until needed (e.g. (rupress.org)
  • The stress-regulated mitogen activated protein kinase: MAPK) p38 also phosphorylates Rb, but it does so in a cell cycle-independent manner that is associated with apoptosis rather than with cell division. (wustl.edu)
  • p38 bypasses the cell cycle-associated hierarchical phosphorylation and directly phosphorylates Rb on Ser567, which is not phosphorylated during the normal cell cycle. (wustl.edu)
  • different
  • These findings provide a mechanistic explanation for how Rb regulates cell division and apoptosis through different kinases, and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53. (wustl.edu)
  • Inter-sex variation in synaptonemal complex lengths largely determine the different recombination rates in male and female germ cells. (warwick.ac.uk)