Cell differentiation gata3 transcription factor. Medical search. Frequent questions

Recent data also suggest that the potential of cDC2s to induce pure Th2 immunity or a mixed Th2/Th17 type of response is tightly regulated by cell intrinsic mechanisms, including fine tuning of TLR signalling pathways and metabolic programming (Sinclair et al. (icem2012.org)
In addition to Th1 and Th2 cells, Th17, Treg and T Fh cells have also been described 7 , Treg cells are associated with reduction of clinical scores of disease in soft and hard tissues 8 . (bvsalud.org)
Usually, protective and destructive roles are assigned to the Th1 and Th17 3,9-11 cells, while Th2 and Treg cells are more involved in processes that reduce the destruction of the periodontium 10 . (bvsalud.org)
Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). (cdc.gov)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
After being activated through their T-cell receptor (TCR) in a particular cytokine milieu, naive CD4 T cells differentiate into distinct Th lineages, including Th1, Th2, and Th17 cells, which are indispensable for different types of immunity to various microorganisms. (nih.gov)
Similarly, unnecessary activation of Th1, Th17 or Th2 cells by harmless environmental- or self-antigens can cause organ-specific autoimmune diseases or allergic inflammatory diseases. (nih.gov)
In addition, our results suggest that fish activate an adaptive immune response visible through the stimulation of T-helper cells, Th17, with congruent reduction of Th2 and T-regulatory cells. (biomedcentral.com)
Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103 + CD11b + cDC2s and alters characteristics of CD103 − CD11b + cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt + Th17 cells and type 3 Rorγt + regulatory T cells. (life-science-alliance.org)
Although the exact roles of Rorγt + type 3 Treg cells have not yet been unraveled, they are involved in suppressing exaggerated Th2 responses ( Ohnmacht et al, 2015 ), Th17 and Th1 responses ( Sefik et al, 2015 ). (life-science-alliance.org)
We showed that conditional deletion of rictor, an essential subunit of mTORC2, impaired differentiation into T helper 1 (Th1) and Th2 cells without diversion into FoxP3(+) status or substantial effect on Th17 cell differentiation. (omicsdi.org)
The combination of these two agonists enhanced the expression of cytokines for Th1 and Th17 responses and suppressed the expression of cytokines for Th2 response in these cells. (ijbs.com)
Western blot analysis was used to estimate the protein expression levels of specific transcription factors for T helper cells (Th1, Th2 and Th17) and key molecules of the Janus-activated kinase (Jak)/signal transducer and activator of transcription (Stat3) signaling pathway. (researcher-app.com)
McGeachy, M. J. & Cua, D. J. Th17 cell differentiation: The long and winding road. (nature.com)
Littman, D. R. & Rudensky, A. Y. Th17 and regulatory T cells in mediating and restraining inflammation. (nature.com)

Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. (nih.gov)
Thus, GATA-2 and GATA-3 regulate adipocyte differentiation through molecular control of the preadipocyte-adipocyte transition. (nih.gov)
Although adipocyte differentiation starts early in fetal stages, the increase in adipose cell number and size is maintained along early postnatal growth and later development [ 6 ]. (biomedcentral.com)
In the early stage of adipocyte differentiation, ERK1/2 promotes adipocyte differentiation by promoting the expression of C/EBPα and PPARγ. (cusabio.com)
In the late stage of adipocyte differentiation, activated ERK1/2 phosphorylates PPARγ to inactivate it and inhibit adipocyte differentiation. (cusabio.com)
JNK signaling pathway also plays an important role in regulating adipocyte differentiation. (cusabio.com)
In addition, the ERK5/BMK1 pathway, an atypical MAPK pathway, is involved in the regulation of adipocyte differentiation and fat metabolism. (cusabio.com)
Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. (harvard.edu)

CD4+ T cells are generally treated as having a pre-defined role as helper T cells within the immune system. (wikipedia.org)
T cells require antigens to be processed into short fragments which form linear epitopes on MHC Class II (in the case of helper T cells because they express CD4) or MHC class I (in the case of cytotoxic T cells which express CD8). (wikipedia.org)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

Among immune cells, Foxp3 + regulatory T cells (Treg cells) are potent inhibitors of cancer immunity, and their presence within solid tumors is generally associated with a poor prognosis. (mdpi.com)
These cells express the master regulator transcription factor (TFs) Foxp3. (encyclopedia.pub)
To identify and study Th and ILC subsets at a finer level, multi-color "reporter" mice reflecting the expression of key transcription factors, such as T-bet, GATA3, RORγ t and Foxp3, are being prepared through cross-breeding after generation of single reporter mouse strains using BAC transgenic or knock-in strategies. (nih.gov)
On the other hand, Foxp3 + iTreg cells can be divided into Rorγt − Foxp3 + iTreg and Rorγt + Foxp3 + Treg, the latter is designated as type 3 Treg ( Park & Eberl, 2018 ). (life-science-alliance.org)
Zhang, F. P., Meng, G. X. & Strober, W. Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17-producing T cells. (nature.com)

They aid the activity of other immune cells by releasing cytokines. (wikipedia.org)
Th cells contain and release cytokines to aid other immune cells. (wikipedia.org)
Cytokines are small protein mediators that alter the behavior of target cells that express receptors for those cytokines. (wikipedia.org)
CD4 + T cell subsets exert diverse functions due to their expression of characteristic cytokines. (rndsystems.com)
Intracellular markers include transcription factors that control CD4 + T cell differentiation as well as signature cytokines as they traffic through secretory organelles. (rndsystems.com)
The culture medium from CD4 + T cell differentiation procedures should be analyzed to confirm that the cells are secreting cytokines relevant to the desired cell subset. (rndsystems.com)
CD4 and CD8 T lymphocytes play an import role in the inflammatory response, as these cells may manage the profile of cytokines produced against an infectious agent 4 . (bvsalud.org)
Progression of periodontal lesions is caused by dysregulation of molecules (cytokines) released by specific cell populations 5 . (bvsalud.org)
They can be distinguished based on the profile of cytokines produced: Th1 cells produce characteristic cytokines such as IL-2, IFN-γ, TNF-β, IL-12, while active Th2 cells secrete IL-4, IL-5, IL-6, IL-10 and IL-136. (bvsalud.org)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
Different T cells secrete various cytokines to exert their activity. (encyclopedia.pub)
Signature transcription factors and cytokines designated to different cell types are shown. (encyclopedia.pub)
CTLs) that produce cytokines and cytotoxic enzymes (perforin, granzyme B) that eliminate pathogens or target cells (including pathogen-infected host cells and tumor cells) and can develop into memory T cells ( Figure 1 ) [ 12 ] . (encyclopedia.pub)
Finally, a number of biologics that target CD4 + T cell differentiation into inflammatory subsets or their byproducts (i.e., cytokines) have shown efficacy in treating patients with IBD ( 5 - 7 ). (frontiersin.org)
Given the importance of CD4 + Th cells in the disease process, this review will focus on how Th cells differentiate in the inflamed intestinal tract during IBD and how the Th lineage-specific cytokines and transcription factors (TFs) contribute to disease. (frontiersin.org)
This differentiation program can be profoundly influenced based on the cytokines present in the environment in which they are initiated. (frontiersin.org)
Distinct subsets of ILCs are capable of producing similar sets of characteristic effector cytokines as produced by Th cells. (nih.gov)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)
ILC2 secrete 'T H 2-like' cytokines under the control of the transcription factors GATA-3 and RORa. (pasteur.fr)
ILC3 includes several phenotypically distinct cells that express and require the transcription factor RORgt in order to produce notably the cytokines IL-17 and IL-22. (pasteur.fr)
Furthermore, SR1001 inhibited the expression of cytokines when added to differentiated murine or human T H 17 cells. (nature.com)
This was accompanied by enhanced gene expression of proinflammatory cytokines and chemokines, as well as more recruited inflammatory cells into the intestine. (biomedcentral.com)
Activation of myofibroblasts occurs in response to different stimuli, including growth factors such as transforming growth factor beta (TGF-β) and platelet-derived growth factor (PDGF), pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-13 and IL-17, as well as CC chemokines like CCL2, CCL3 and CCL4, and lipid mediators released by immune and non-immune cells [ 6 ]. (biomedcentral.com)
In this article we will focus on the physical and functional interrelationship between cytokine signaling pathway-activated transcription factors (TFs) and steroid receptors in different cell models, where the signals triggered by cytokines and steroid hormones have major roles: (1) the ligand-dependent-activated glucocorticoid receptor (GR) influence the genetic program that specifies lineage commitment in T helper (Th) cell differentiation. (conicet.gov.ar)

Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)
In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3. (biolegend.com)
In addition, transforming growth factor and bone morphogenetic protein BMP-2 induce Runx2 /Cbfa1 transcriptional expression via the p38 MAPK pathway. (cusabio.com)
Among them, Runx2 is a key target gene affecting osteogenic activity, and Cbfa1 regulates the differentiation of MSCs into osteoblasts at the transcriptional level. (cusabio.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
Transcriptional regulation of innate lymphoid cell fate. (pasteur.fr)

These are defined by the presence of a lineage-determining (or lineage-specifying) transcription factor (also called master regulator, though the term has been criticized for being too reductive). (wikipedia.org)
The loss of function in a lineage specifying transcription factor results in the absence of the corresponding class of helper T cell which can be devastating for the health of the host. (wikipedia.org)
Immature SP thymocytes undergo further differentiation to generate either MHC Class II restricted CD4 SP helper or MHC Class I restricted CD8 SP cytotoxic lineage cells [ 1 ] . (encyclopedia.pub)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
Lineage-specific genes found in mice studies may serve as new biomarkers for identifying human T-cell subsets and/or targets for treating specific human diseases. (nih.gov)
A network of super enhancer(SE) driven transcription factors(TFs) underlies lineage identity and their dysregulation leads to cancer. (nih.gov)
T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. (nature.com)

Following cell differentiation, flow cytometry can be used to verify the expression of established cell surface or intracellular markers of CD4 + T cell subsets. (rndsystems.com)
Many subsets of CD4 + T cells have been identified as players in perpetuating chronic intestinal inflammation. (frontiersin.org)
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. (omicsdi.org)
Collectively, the data uncover vital mTOR-PKC and mTOR-Akt connections in T cell differentiation and reveal distinct pathways by which mTORC2 regulates development of Th1 and Th2 cell subsets. (omicsdi.org)
The T-cell subsets were assessed using a fluorescence-activated cell sorter (FACS). (researcher-app.com)

The colony formation assay was used to identify the effects of AKBA on cell proliferation. (boswellia.org)
MAPK can cause the activation of transcription factors in the nucleus, participate in the process of signal transmission from the cell surface to the nucleus, and regulate cell proliferation and differentiation. (cusabio.com)
This pathway can also affect the proliferation and differentiation of red blood cells. (cusabio.com)
Studies have shown that ERK signaling pathway is also involved in signal transduction of osteoblast differentiation and proliferation. (cusabio.com)
Mammalian target of rapamycin (mTOR) plays a range of crucial roles in cell survival, growth, proliferation, metabolism, and morphology. (omicsdi.org)
Protein kinase C (PKC) is involved in a wide array of cellular processes such as cell proliferation, differentiation and apoptosis. (omicsdi.org)
Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). (omicsdi.org)
Long noncoding RNA (lncRNAs) are vital noncoding RNAs (ncRNAs) that regulate fat accumulation, including the processes of proliferation, differentiation, and hypertrophy of adipocytes [ 6 , 7 ]. (animbiosci.org)
Morphine has been shown to negatively impact macrophage function by impairing the proliferation of macrophage progenitor cells, inhibiting cytokine secretion leading to decreased chemotaxis, hindering the ability of macrophages to directly phagocytize pathogens, and inhibiting nitric oxide production. (uspharmacist.com)

They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils. (wikipedia.org)
Professional antigen-presenting cells are primarily dendritic cells, macrophages and B cells, although dendritic cells are the only cell group that expresses MHC Class II constitutively (at all times). (wikipedia.org)
however, follicular dendritic cells may acquire MHC Class II proteins via exosomes that become attached to them). (wikipedia.org)
Acquired immune responses are initiated by activation of CD4 + helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). (life-science-alliance.org)
Conventional dendritic cells (cDCs) are specialized antigen-presenting cells of the immune system. (life-science-alliance.org)
Based on the 7 immune infiltration algorithm, we found that Neutrophils, Myeloid dendritic cells, M2 macrophages, Cancer-associated fibroblasts, etc., were more concentrated in the high-risk group. (biomedcentral.com)
In dendritic cells, CpG-2722 and 2'3'-c-di-AM(PS)2 showed a cooperative effect on inducing expression of molecules critical for T cell activation. (ijbs.com)
and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
Immunobiology of dendritic cells. (scriptiebank.be)
11,12 Dendritic cells are essential to the innate immune system through their presentation of foreign antigens to T-cells. (uspharmacist.com)

The MAPK signaling pathway activates transcription factors and regulates gene expression through a cascade reaction (MAPKKK-MAPKK-MAPK). (cusabio.com)
MEK can phosphorylate and activate ERK, which is transferred into the nucleus and regulates gene expression by activating other kinases or transcription factors. (cusabio.com)
Inhibition of the p38 MARK pathway down-regulates the activity of protein kinase C ( PKC ), which plays an important role in osteogenic differentiation of cells. (cusabio.com)
The p38 signaling pathway regulates the differentiation direction of stem cells, which may be related to the regulation of the stability of p53 protein [3] [4] . (cusabio.com)
Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation. (omicsdi.org)
Like other proteins of the GATA family (GATA1-6), GATA3 is a transcription factor that regulates various cellular programs during embryogenesis and differentiation in several organ systems, including parathyroid gland, kidney, breast epithelium, urothelium, and the nervous system. (ms-validatedantibodies.com)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)

Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
Lymphocytes, CD4 T cells in particular, play a central role in orchestrating adaptive immune responses. (nih.gov)
Recently, additional innate lymphocytes have been discovered named innate lymphoid cells (ILCs) in both humans and mice ( 1-8 ). (pasteur.fr)
ILC1 consists of NK cells and other interferon-g producing innate lymphocytes characterized by expression of the transcription factors T-bet and/Eomes. (pasteur.fr)
These results indicate that DGBX can regulate the differentiation of T lymphocytes, resulting in immunosuppressive and hematogenic functions on AA mice. (researcher-app.com)
Weak to moderate GATA3 positivity of a fraction of lymphocytes. (ms-validatedantibodies.com)
Moderate GATA3 positivity of a significant fraction of lymphocytes. (ms-validatedantibodies.com)
TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)

GATA-3-deficient embryonic stem cells exhibit an enhanced capacity to differentiate into adipocytes, and defective GATA-2 and GATA-3 expression is associated with obesity. (nih.gov)
For example, humans are derived from fertilized eggs, and this process involves the differentiation of embryonic stem cells. (cusabio.com)
Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)
Here we extend those findings to humans using only genetically unmodified human naive embryonic stem cells (cultured in human enhanced naive stem cell medium conditions) 4 . (nature.com)
These include embryonic disc and bilaminar disc formation, epiblast lumenogenesis, polarized amniogenesis, anterior-posterior symmetry breaking, primordial germ-cell specification, polarized yolk sac with visceral and parietal endoderm formation, extra-embryonic mesoderm expansion that defines a chorionic cavity and a connecting stalk, and a trophoblast-surrounding compartment demonstrating syncytium and lacunae formation. (nature.com)
Much of this process relies on the morphogenesis of the extra-embryonic tissues and the effect this has on the organization of embryonic cells. (nature.com)

Maturation of RTE in SLO results in the generation of mature naive T cells (naïve meaning they have never been exposed to the antigen that they are programmed to respond to), but naive T cells now lack or have downregulated (reduced) expression of the RTE-related surface markers, such as CD31, PTK7, Complement Receptor 1 and 2 (CR1, CR2) and the production of interleukin 8 (IL-8). (wikipedia.org)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
SR1001 inhibited the development of murine T H 17 cells, as demonstrated by inhibition of interleukin-17A gene expression and protein production. (nature.com)

CD80/86-CD28 interaction and others), these signals initiate a program of cell division and differentiation. (frontiersin.org)

These agents inhibit cell growth and differentiation. (medscape.com)
Estrogens are important regulators of growth and differentiation in (range, 0 -9 fmol/mg protein, median 0.7). (lu.se)

We examined a panel of prolactin-induced tumors for characteristics relevant to clinical tumors: histotype, ERα/progesterone receptor (PR) expression and estrogen responsiveness, Activating Protein 1 (AP-1) components, and phosphorylation of signal transducer and activator of transcription 5 (Stat5), extracellular signal regulated kinase (ERK) 1/2 and AKT. (biomedcentral.com)

Surprisingly, Akt re-activation was not sufficient to rescue cell survival or invasion, and modestly increased branching of mTORC2-impaired mammary epithelial cells (MECs) in culture and in vivo. (omicsdi.org)
Strong GATA3 positivity in all epithelial cells. (ms-validatedantibodies.com)
Moderate to strong GATA3 positivity of a epithelial cells. (ms-validatedantibodies.com)
Variable (weak to strong) GATA3 positivity in squamous epithelial cells. (ms-validatedantibodies.com)
Weak to moderate GATA3 positivity in epithelial cells including hair follicles. (ms-validatedantibodies.com)
Expression of markers of myofibroblast activation was determined in TGF-β1-stimulated human intestinal epithelial cells (IECs). (biomedcentral.com)
LF82 also potentiated TGF-β1-stimulated epithelial-mesenchymal transition and myofibroblast activation in IECs, by further inducing gene expression of the main mesenchymal cell markers FN1 and VIM and downregulating the IEC marker OCLN . (biomedcentral.com)
These cells not only derive from resident mesenchymal cells (fibroblasts and smooth muscle cells) but can also originate from epithelial and endothelial cells via epithelial/endothelial transition, as well as from stellate cells, pericytes and bone marrow stem cells [ 5 ]. (biomedcentral.com)

Of note, only a very small minority of T cells egresses from the thymus (estimates commonly range from 1-5% but some experts feel even this is generous). (wikipedia.org)
CD4+ T cells have TCRs with an affinity for Class II MHC, and CD4 is involved in determining MHC affinity during maturation in the thymus. (wikipedia.org)
Naïve human CD4 + T cells, which are now considered to be a heterogeneous population, can be subcategorized based on CD31 (also known as PECAM1) expression, into the youngest (recent thymus emigrant) naïve T cells (CD31 + ) and more established "mature" naïve T cells (CD31 − ) [ 2 ] [ 3 ] . (encyclopedia.pub)

Th9 cells protect against helminth infection, promote CTL and NK cell mediated anti-tumor immunity, and contribute to chronic inflammation in allergic asthma, ulcerative colitis, psoriasis, autoimmunity, and tuberculosis. (rndsystems.com)
2016). Thus, mice lacking B cells had less TFH cells and an increase Tedalinab in TRM cells, explaining why B cell deficient mice had increased airway inflammation when challenged with HDM inhalation long after the priming period (Hondowicz et al. (icem2012.org)
1- 5 Moreover, we have previously shown that the Th1 cell response in fetal gut explants results in villous atrophy and crypt cell hyperplasia, 6, 7 thus supporting the role of local Th1 cell inflammation in promoting CD associated tissue damage. (bmj.com)
Fractions of Suppress LTA, LTC, Cyclooxygenase-2 Activities and mRNA in HL-60 Cells and Reduce Lung Inflammation in BALB/c Mice. (boswellia.org)
Inflammatory bowel disease is a complex set of diseases that includes Crohn's disease (CD) and ulcerative colitis (UC), each with multiple bacterial, immune, and non-immune cell types contributing to inflammation. (frontiersin.org)
Much of the remainder of the discussion focuses on the different ways in which, in the longer term, the chronic inflammatory process influences maturation, differentiation, and function of effector T cells at sites of inflammation. (biomedcentral.com)
I conclude by speculating about how our understanding of T-cell activation in chronic inflammation may influence future therapy, and discuss this in the context of the prevailing view that in a susceptible host, chronic inflammatory disease occurs through a failure of regulatory T cells to downregulate the inflammatory process. (biomedcentral.com)
ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. (pasteur.fr)
Sustained inflammation and chronic wound healing response often lead to intestinal fibrosis, a condition defined by an excessive accumulation of extracellular matrix (ECM) proteins produced by activated myofibroblasts, which are alpha smooth muscle actin (α-SMA)-expressing cells. (biomedcentral.com)
As a result, there is a reduction of cellular debris clearance (autophagy), decreased the pool of stem cells, increase in inflammation and cellular senescence. (geresdengle.com)
Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation. (geresdengle.com)

Interestingly, the ILCs also express many key transcription factors that are found in Th cells, suggesting that a given transcription factor may regulate one particular type of immune response in different immune cells. (nih.gov)
For example, hematopoietic stem cells differentiate into various immune cells. (cusabio.com)
Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
Substantial cells are divided into immune cells and non-immune cells. (biomedcentral.com)
The infiltrating immune cells in the TME constitute the main body of TIME. (biomedcentral.com)
2 Previous studies have evaluated the opioid receptors on a wide array of immune cells. (uspharmacist.com)

The ERK-MAPK signaling pathway plays a role in the differentiation of mesenchymal stem cells (MSCs) into adipocytes [1] [2] . (cusabio.com)
p38 pathway plays a very important role in the osteogenic differentiation of mesenchymal stem cells (MSCs). (cusabio.com)

Like all T cells, they express the T cell receptor-CD3 complex. (wikipedia.org)
The T cell receptor (TCR) consists of both constant and variable regions. (wikipedia.org)
B cells can induce Th2 and TFH responses and elicit help from CD4+ T cells in an MHC-II dependent manner, but using T cell antigen receptor Tedalinab (TCR) transgenic Tedalinab 1-DER mice that react to the type 2 antigen Der p 1 of the house dust mite (Dullaers et al. (icem2012.org)
Aim: To evaluate the involvement of Th2 cells in different periods of the active phase of experimental periodontal disease and expression of the R1 subunit of the receptor for IFN-γ during the early and advanced progression of the disease. (bvsalud.org)
This signal together with the T Cell Receptor (TCR) induces the expression of GATA-3. (bvsalud.org)
T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)
Recently, a class of innate lymphoid cells (ILCs), whose development requires signaling through the IL-2 receptor (IL-2R) common γ chain and IL-7Rα , has been discovered. (nih.gov)
The main process of this pathway: the growth factor activates the receptor by binding to the tyrosine kinase receptor, and the activated tyrosine kinase receptor activates the Ras protein, then the Ras protein phosphorylates the Raf, and the activated Raf phosphorylates the downstream MEK. (cusabio.com)
Dr. Mak was recognized for his seminal work to clone the T cell receptor. (cancerresearch.org)
The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17 + T helper cells. (nature.com)
Manel, N., Unutmaz, D. & Littman, D. R. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. (nature.com)
More importantly, there is no full cure is available up to now despite majority of children with asthma can alleviate the asthmatic symptoms and obtain adequate asthma control via avoidance of triggering factors, rational management and/or medication, such as short-acting inhaled β2-receptor agonists [ 4 , 5 ]. (researchsquare.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

GATA-3 acts as a master regulator of Th2 differentiation 12-13 . (bvsalud.org)
Inhibition of SOX11 led to 30% decreased cell growth without evidence of differentiation indicating SOX11 may be a key regulator of self-renewal. (nih.gov)
In a cohort of 498 NB patients, SOX11 is overexpressed in HR cases and associated with poor prognosis(p=6.582e-09), whereas SOX4 is overexpressed in more differentiated low-risk cases and is associated with good prognosis(p=6.188e-17), implicating SOX4 as a regulator of NB differentiation. (nih.gov)

Current knowledge about the most aggressive forms of BC points to the role of specific cells with stem properties located within BC, the so-called "BC stem cells" (BCSCs). (wjgnet.com)
Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)
Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)
The mechanism of action is similar to that of endogenous erythropoietin, which interacts with stem cells to increase red blood cell production. (medscape.com)

Several studies have clearly demonstrated that distinct cytokine activated signalling and transcription factors regulate the commitment of a naïve T cell along the Th1 or T helper cell type 2 (Th2) phenotype, as well as maintenance of the polarised phenotype. (bmj.com)
After encountering antigen, naïve CD4 + T cells differentiate into CD4 + effector T cells, which can take the form of well-defined subgroups that express distinct cytokine profiles: T helper 1 (Th-1), Th-2, Th-9, T follicular helper (Tfh) cells, and Th-17 cells ( Figure 1 ) [ 4 ] . (encyclopedia.pub)
Fate-mapping experiments to address T-cell plasticity and stability are being performed using reporter mice in which inducible-Cre expression is under the control of cytokine or transcription factor locus. (nih.gov)
Indeed, there are now compelling data to suggest that chronic cytokine activation may contribute substantially to the phenotype and effector function of synovial T cells. (biomedcentral.com)
On the basis of these data, it is proposed that T-cell survival and effector responses are driven by antigen-independent, cytokine-dependent mechanisms, and that therapeutic strategies that seek to restore T-cell homeostasis rather than further depress T-cell function should be explored in the future. (biomedcentral.com)
This process of differentiation is characterised by a distinctive pattern of cytokine production and is important because its outcome dictates the host response to foreign pathogens such as Listeria monocytogenes infection or to parasitic infestation [ 2 ]. (biomedcentral.com)
CpG-2722 and 2'3'-c-di-AM(PS)2 have distinct cytokine inducing profiles in different cell populations. (ijbs.com)

If the antigen expresses appropriate molecular patterns (sometimes known as signal 0), it can induce maturation of the dendritic cell which results in enhanced expression of costimulatory molecules needed to activate T cells (see signal 2) and MHC Class II. (wikipedia.org)
Many important questions remain however regarding factors which induce and maintain Th1 cell polarisation in CD. (bmj.com)
JNK can change the mRNA level of osteocalcin , so the activation of JNK can induce osteoblast differentiation. (cusabio.com)
We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. (life-science-alliance.org)
However, retinoids (RA) can arrest NB growth and induce neural differentiation. (nih.gov)

For example, when an antigen-presenting cell displays a peptide antigen on MHC class II proteins, a CD4+ cell will aid those cells through a combination of cell to cell interactions (e.g. (wikipedia.org)
Class II MHC proteins are generally only found on the surface of professional antigen-presenting cells (APCs). (wikipedia.org)
The 2022 William B. Coley Award for Distinguished Research in Basic Immunology was shared by Drs. Vishva Dixit, Judy Lieberman, Feng Shao, and Hao Wu in recognition of the importance of their discoveries regarding gasdermins, the proteins that rip open cell membranes during an inflammatory form of cell death called pyroptosis. (cancerresearch.org)
GATA3 gene at 10p14 consists of 8 exons and codes for GATA3, variant 1, and GATA3, variant 2, proteins of 48 KDa that which differ in one amino acid and may have identical functions. (ms-validatedantibodies.com)

T cell differentiation is a tightly regulated process. (encyclopedia.pub)
Differentiation of Th cells is tightly regulated by the networks of specific transcription factors. (nih.gov)

T helper type 9 (Th9) cells constitute one subset of CD4 + effector T cells and are characterized by the secretion of IL-9, IL-10, and IL-21. (rndsystems.com)
Precisely how effector T cells initiate and promote the inflammatory process in RA, however, remains far from clear. (biomedcentral.com)

p38 MAPK can be activated by a variety of extracellular stress responses, including ultraviolet, radiation and proinflammatory factors. (cusabio.com)
T cell differentiation is also directly linked to pyruvate metabolism, with inhibition of pyruvate oxidation by PDKs promoting proinflammatory T cell polarization. (molcells.org)

CD4+ cells are mature Th cells that express the surface protein CD4. (wikipedia.org)
Mature Th cells express the surface protein CD4 and are referred to as CD4+ T cells. (wikipedia.org)
mTORC2 promoted phosphorylation of protein kinase B (PKB, or Akt) and PKC, Akt activity, and nuclear NF-kappaB transcription factors in response to T cell activation. (omicsdi.org)
Utilizing Rictor knock-out cells, immunoprecipitation and mass spectrometry, a novel Rictor associated protein, heterogeneous nuclear ribonucleoprotein M (hnRNP M), was identified. (omicsdi.org)
GATA3 is frequently found mutated in breast cancer, and downregulation of the protein has been linked to poor prognosis of the disease. (ms-validatedantibodies.com)
Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2). (stanford.edu)
Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)
Especially significant is the removal of old damaged protein aggregates, which are detrimental to the functioning of the cell. (geresdengle.com)
Another study that compared a pair of twins with discordant HIV infection status showed that several other genes are also differentially methylated, including insulin-like growth factor binding protein 6 ( IGFBP6 ) [ 19 ]. (biomedcentral.com)
This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)
It is an erythropoiesis-stimulating protein closely related to erythropoietin, a primary growth factor produced in kidney that stimulates the development of erythroid progenitor cells. (medscape.com)

These cells primarily produce interferon (IFN)-γ and tumor necrosis factor (TNF) that, respectively, activate macrophages and direct cytotoxic CD8 + T cell responses, that in turn promote elimination of intracellular pathogens such as viruses and bacteria ( 8 ). (frontiersin.org)

In this review, we summarize the current knowledge on the different intracellular pathways involved in the programming of Treg cell homeostasis and functions in cancer. (mdpi.com)
The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)
Studies reveal that chronic exposure of T cells to TNF uncouples TCR signal transduction pathways by impairing the assembly and stability of the TCR/CD3 complex at the cell surface. (biomedcentral.com)

A weak cytoplasmic GATA3 staining can occur in goblet cells of respiratory epithelium (probably non-specific staining). (ms-validatedantibodies.com)
A weak cytoplasmic GATA3 staining can occur in gastric glands (probably non-specific staining). (ms-validatedantibodies.com)

In order to differentiate into Th1 or Th2 cells, CD4 T cells must become antigen-activated. (bvsalud.org)
while p38 kinase inhibited cell develop into ectodermal cells and eventually differentiate into neural cells. (cusabio.com)
Meanwhile, the ureteric bud secretes Wnt-9b and fibroblast growth factor 9 (FGF9), which differentiate the metanephric mesenchyme into pretubular aggregates. (j-organoid.org)

We also discussed the epigenetic modifications associated with T cell differentiation related to cancer. (encyclopedia.pub)
ChIPseq will be applied to assess genome-wide epigenetic modifications and DNA binding sites for key transcription factors in different cell types. (nih.gov)
On the other hand, environmental factors have been reported to modulate epigenetic modifications and thereby affect gene expression and phenotype [ 11 , 12 ]. (researchsquare.com)

Treg= regulatory T cells). (encyclopedia.pub)
Other CD4 T cells include follicular T cells (Tfh) and regulatory T cells (Treg). (nih.gov)
Tfh cells are critical for promoting antibody responses, whereas Treg cells, which consist of naturally occurring regulatory T cells (nTregs) and inducible regulatory T cells (iTregs), are involved in maintaining immune tolerance and lymphocyte homeostasis. (nih.gov)

These tumors were distinct from mouse mammary tumor virus (MMTV)-neu tumors, and contained elevated transcripts for factors associated with luminal/alveolar expansion and differentiation, suggesting that they arose from physiologic targets of prolactin. (biomedcentral.com)
their evolution from distinct cell lineages. (lu.se)

Differentiation into Th1 depends on the presence of IFN-γ and IL-12, which bind to receptors on the surface of CD4 T cells 5 . (bvsalud.org)
Our data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically T H 17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases. (nature.com)

Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. (nih.gov)
Results: Light microscopy analysis revealed a decreased expression of GATA-3-positive cells when bone loss progressed. (bvsalud.org)
T-bet and STAT-4, two Th1 promoting transcription factors, and STAT-6 and GATA-3, transcription factors which govern T helper cell type 2 (Th2) cell polarisation, were examined in duodenal biopsies by western blotting. (bmj.com)
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. (semanticscholar.org)
GATA3 is characterized by two conserved zinc finger domains, which bind DNA at the nucleotide sequence GATA. (ms-validatedantibodies.com)

TCF1 is essential for survival of CD4+CD8+ double positive thymocytes and differentiation of T cells in the periphery. (biolegend.com)

At the Molecular and Cellular Immunoregulation Section (MCIS), the functions of known key transcription factors, including GATA3 and T-bet, and novel, potentially critical transcription factors during Th and ILC differentiation/development are being investigated with various genetically modified mice including conditional knockout strains. (nih.gov)
Adjuvants formulated with a TLR9 agonist, CpG-2722, with various cyclic dinucleotides (CDNs) that are STING agonists increased germinal center B cell response and elicited humoral immune responses in immunized mice. (ijbs.com)

TCF1 is the first identified member of the T-cell-specific transcription factor family. (biolegend.com)
An immunohistochemical investigation of the gingival tissue was performed to detect the presence of the Th2 specific transcription factor (GATA3). (bvsalud.org)

Thus, understanding how Treg cell identity is controlled, is of utmost importance for the development of novel anti-cancer therapies. (mdpi.com)

Deletion of TCF1 causes massive apoptosis of double positive thymocyte, suggesting that TCF1 is required for thymocyte survival during T cell development. (biolegend.com)
Acetyl-11-Keto-β-Boswellic Acid Exerts the Anti-Cancer Effects via Cell Cycle Arrest, Apoptosis Induction and Autophagy Suppression in Non-Small Cell Lung Cancer Cells. (boswellia.org)
Potential roles of AKBA in regulating the cell cycle, apoptosis, and autophagy in A549 were evaluated by flow cytometry, Western blotting, reverse transcription-polymerase chain reaction (PCR) and immunofluorescence (IF). (boswellia.org)
In A549 cells, AKBA suppressed the clone formation, arrested the cell cycle at the G/G phase, induced cellular apoptosis. (boswellia.org)
AKBA exerts the anti-cancer effects via cell cycle arrest, apoptosis induction, and autophagy suppression in NSCLC cells. (boswellia.org)
2) glucocorticoid (GC) antagonism on the TCR-induced T cell apoptosis. (conicet.gov.ar)

In situ was performed to determine gene expression within the cochlea, and immunohistochemistry was performed to label neurons as well as cell death within the cochlea. (wmich.edu)
Peak evaluation is complex, as gene expression regulation involves interactions between combinatorial transcription factor binding sites and chromatin states. (biomedcentral.com)

During an immune response, professional antigen-presenting cells (APCs) endocytose antigens (typically bacteria or viruses), which undergo processing, then travel from the infection site to the lymph nodes. (wikipedia.org)
This chapter aims to explore this theme in more depth, beginning with an outline of the molecular events that dictate the differentiation of T helper (Th) cells at the outset of adaptive immune responses in regional lymph nodes. (biomedcentral.com)
In the bladder carcinoma case, pathological analysis of fine-needle aspiration biopsy specimen of the metastatic cervical lymph node showed atypical cells with slight squamous differentiation. (biomedcentral.com)
We longitudinally analyzed genome-wide DNA methylation changes in CD4 + T cells from lymph node and blood, using arrays. (biomedcentral.com)
Altered DNA methylation was confirmed in blood and lymph node CD4 + T cells in viremic macaques but was notably absent from SIV controller macaques. (biomedcentral.com)

A role of GATA3 has also been demonstrated for tumor development and progression. (ms-validatedantibodies.com)

In general, mature naive T cells are stimulated by professional antigen presenting cells to acquire an effector module. (wikipedia.org)

This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)
Therefore, diverse cellular compartments orchestrated by multiple environment-driving factors make the mechanisms underlying asthma extraordinary complex and unclear, particularly with respect to long noncoding RNAs (lncRNAs). (researchsquare.com)
Clearing old cellular debris, through a process called autophagy , greatly enhances the youthful functioning of the cell. (geresdengle.com)
Opioids have considerable effects on cellular function across many immune cell lineages, affecting both the innate and adaptive immune systems. (uspharmacist.com)

An entire functional mammary gland may comprise the progeny from a single cell. (semanticscholar.org)
We used genetic disruption of Rictor to impair mTORC2 activity in mouse mammary epithelia, which decreased Akt phosphorylation, ductal length, secondary branching, cell motility, and cell survival. (omicsdi.org)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Yet, CD4 + T cells are also known to be the main drivers of inflammatory bowel disease (IBD) when this balance is perturbed. (frontiersin.org)
Critical factors in the differentiation of effector Th cells during inflammatory bowel disease (IBD). (frontiersin.org)
The strong association between specific alleles encoded within the MHC class II region and the development of rheumatoid arthritis (RA) has provided the best evidence to date that CD4 + T cells play a role in the pathogenesis of this chronic inflammatory disease. (biomedcentral.com)
However, the results of detailed phenotypic and functional analyses of chronically activated T cells derived from inflamed joints are difficult to reconcile with traditional models of cartilage-antigen-driven inflammatory disease in patients with RA. (biomedcentral.com)
Pyruvate metabolism also plays an important role in immune cell activation and function, dysregulation of which also leads to insulin resistance and inflammatory disease. (molcells.org)

However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. (bmj.com)
This study aims to explore the roles and molecular mechanisms of AKBA on cell behavior in non-small cell lung cancer (NSCLC) cells. (boswellia.org)
Transcription factors and regulatory mechanisms are proposed for these altered biological functions. (biomedcentral.com)

When Gata3 was conditionally knocked out and reduced in its expression, fewer neurons appear to have formed compared to the mutant and the neurons that do form lack normal projection patterns. (wmich.edu)
IFN-γ R1 was detected at an early stage during the active phase of disease, but the expression of positive cells remained unaltered during the remaining period of the study. (bvsalud.org)
To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact factors . (biomedcentral.com)
In addition, the expression of these factors may not be mutually exclusive, in some cases resulting in massive heterogeneity of CD4 T cells. (nih.gov)
Complementation with active Akt restored only T-bet transcription factor expression and Th1 cell differentiation, whereas activated PKC-theta reverted only GATA3 transcription factor and the Th2 cell defect of mTORC2 mutant cells. (omicsdi.org)
Osr1 -expressing cell clusters spatially regulate Six2 expression, which in turn induces the cap mesenchymal population. (j-organoid.org)
The interstitial stroma, another subcompartment of the metanephric nephron, is characterized by the expression of the transcription factor forkhead box D1 ( Foxd1 ). (j-organoid.org)

It plays an important role in T cell development and differentiation. (biolegend.com)
Overview of T cell development and differentiation. (encyclopedia.pub)
His work has served as the bedrock for the development of T cell therapies and CAR-T therapy, offering hope and new possibilities in the realm of cancer treatment. (cancerresearch.org)
One cluster(n=254) decreasing with RA included TFs like MYCN, GATA3, ID2, SOX11, known to be involved in stem cell development and differentiation. (nih.gov)
A key role has been identified in T cell development, where GATA3 is the downstream of Notch in differentiation of T-helper cells and important for allergic and humoral immune responses. (ms-validatedantibodies.com)
On day E10.5 of murine development, the metanephric mesenchyme secretes glial cell line-derived neurotrophic factor (GDNF). (j-organoid.org)

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. (wikipedia.org)
To better understand the role of Gata3 in spiral ganglion neurons of the inner ear, a Neurod1-cre model was used to conditionally knock out Gata3 at E9-E9.5, the timepoint when neuroblasts first begin to delaminate from the otic placode. (wmich.edu)
We consider the origin of syncytin, its normal role in human placentogenesis and data regarding its relevance in cell-cell fusion. (ecancer.org)
Recent studies have shown that epigenetics plays a significant role at all stages of the differentiation process. (encyclopedia.pub)
Over the last few decades, understanding of how each subset of Th cells plays a role has dramatically increased. (frontiersin.org)
In these studies, CD4 + T cell-depleting and blocking antibodies caused remission from disease in a number of CD and UC patients examined, suggesting a prominent role of CD4 + T cells in propagating disease ( 1 , 2 ). (frontiersin.org)
Furthermore, hnRNP M also plays a critical role in muscle differentiation because knock-down of either hnRNP M or Rictor in C2C12 myoblasts reduced differentiation. (omicsdi.org)
This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)

We report three cases of malignant infradiaphragmatic tumor diagnosed following an initial finding of left supraclavicular node metastasis after surgery for tongue squamous cell carcinoma (follow-up period, range 18-62 months). (biomedcentral.com)
Hematoxylin-eosin staining of the bladder lesion did not identify a clear glandular or squamous component, and we could not make a definitive diagnosis of whether the lesion was poorly differentiated squamous cell carcinoma, adenocarcinoma, or high-grade urothelial carcinoma. (biomedcentral.com)
Patients with oral squamous cell carcinoma and those with other types of head and neck cancer are at higher risk of second primary cancer than patients with cancers at most other sites [ 3 ]. (biomedcentral.com)

The Warburg effect shows that a unique metabolic phenotype was identified for cancer cells, featuring that compared to normal tissues, they are characterized by a high rate of glycolytic metabolism. (biomedcentral.com)
Tissues and Cells. (lu.se)

The paucity of murine models of this "luminal" tumor subtype has hindered studies of factors that promote their pathogenesis and modulate responsiveness to estrogen-directed therapeutics. (biomedcentral.com)

We observe several master transcription regulators (e.g. (biomedcentral.com)

A complete understanding of how transcription factor complexes are regulated and how they precisely control heterogeneity, plasticity, and stability of Th cells and ILCs has great implication in designing strategies to treat a broad range of immune-related diseases, including chronic bacterial and viral infections such as HIV, autoimmune diseases, allergic diseases, and cancers. (nih.gov)

MAMs and MQCs have also been intensively studied in macrophage and T cell immunity. (molcells.org)

Anatomy29

Organisms11

Diseases1

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes68

Disciplines and Occupations1

Information Science4

Th1715

Adipocyte differentiation8

Helper T cel4

Foxp35

Cytokines25

Transcriptional7

Lineage7

Subsets5

Proliferation9

Dendritic cells10

Regulates7

Lymphocytes9

Embryonic6

Interleukin4

Division and differentiation1

Growth and differentiation2

Signal transducer and activator of transcription1

Epithelial8

Thymus3

Inflammation11

Immune cells6

Mesenchymal stem2

Receptor13

Regulator3

Stem Cells4

Cytokine7

Induce5

Proteins4

Tightly regulated2

Effector T cel2

Proinflammatory2

Protein13

Macrophages1

Pathways3

Cytoplasmic2

Differentiate3

Epigenetic modifications3

Regulatory T cel3

Distinct2

Receptors2

GATA5

Thymocytes1

Mice2

Specific transcription2

Treg1

Apoptosis6

Gene Expression2

Lymph5

Progression1

Antigen-prese1

Cellular4

Mammary3

Inflammatory5

Mechanisms3

Expression8

Development6

Role8

Squamous3

Tissues2

Luminal1

Regulators1

Allergic1

Immunity1