Medical search (cell death • FAQ)

autophagy
Recently, matrine has been reported to induce autophagy and autophagic cell death in cancer cells, although the underlying mechanisms have yet to be elucidated. (bjmu.edu.cn)
Here, we describe an Atg7- and Atg3-independent autophagy pathway that facilitates programmed reduction of cell size during intestine cell death. (umassmed.edu)
Although multiple components of the core autophagy pathways, including Atg8, are required for autophagy and cells to shrink in the midgut of the intestine, loss of either Atg7 or Atg3 function does not influence these cellular processes. (umassmed.edu)
Rather, Uba1, the E1 enzyme used in ubiquitylation, is required for autophagy and reduction of cell size. (umassmed.edu)
Our data reveal that distinct autophagy programs are used by different cells within an animal, and disclose an unappreciated role for ubiquitin activation in autophagy. (umassmed.edu)