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  • EXPRESSION
  • Expression of cell adhesion molecules [intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)] and the influx of leukocytes in the kidney assessed the immunologic status of the kidney. (ox.ac.uk)
  • Regardless of hemodynamic status, a progressive inflammatory activation by cell adhesion molecule expression and an influx of leukocytes could be observed in kidneys of brain-dead rats compared with nonbrain-dead controls. (ox.ac.uk)
  • Increased expression of p53, c-myc and inducible nitric oxide (NO) synthase (iNOS) mRNA were observed by polymerase chain reaction (PCR) in the treated cells compared with the untreated ones. (unicampania.it)
  • The increase in iNOS gene expression was associated with overproduction of NO. Moreover, the addition of 1 mmol L)1 N-monomethyl-Larginine, a structural analogue of arginine, reduced nitrite levels by about 70% in cells treated with captopril or pemphigus serum. (unicampania.it)
  • activation
  • Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys. (ox.ac.uk)
  • receptors
  • The team, from the Cancer Research UK Centre at the UCL Cancer Institute, found that mutations in the KRAS gene interferes with protective self-destruct switches, known as TRAIL receptors, which usually help to kill potentially cancerous cells. (ucl.ac.uk)
  • It occurs as a result of repeated stimulation of specific T-cell receptors (TCR) and it helps to maintain the periphery immune tolerance. (wikipedia.org)
  • On the cell surface they have an immunostimulatory effect, based on their interaction with number of antigen-presenting cell (APC) surface receptors like CD91 and CD40 and also facilitate crosspresentation of antigens derived from tumour cells on MHC class I molecule, which than leads to the CD8+ T cell response. (wikipedia.org)
  • Not much is known about the regulation of Fas and other death receptors. (wikipedia.org)
  • gene
  • The mesenchymal-like cells that result from this "switch" exhibit mutations in the KRAS gene , which plays an important role in controlling cell division. (medicalnewstoday.com)
  • These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. (wikipedia.org)
  • This new fusion gene, BCR-ABL, encodes an unregulated, cytoplasm-targeted tyrosine kinase that allows the cells to proliferate without being regulated by cytokines. (wikipedia.org)
  • This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. (wikipedia.org)
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • macrophages
  • Another indicator of cell death is acid hydrolysis which is released from digestion during phagocytosis of dead cells by macrophages or neighboring cells, and the inta-vital dye isa marker of secondary phagocytosis. (wikipedia.org)
  • PD-1 is expressed on the surface of activated T cells, B cells, and macrophages, suggesting that compared to CTLA-4, PD-1 more broadly negatively regulates immune responses. (wikipedia.org)
  • induces
  • Triggering PD-1, expressed on monocytes and up-regulated upon monocytes activation, by its ligand PD-L1 induces IL-10 production which inhibits CD4 T-cell function. (wikipedia.org)
  • regulates
  • The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. (wikipedia.org)
  • proteins
  • Understanding the way cell death proteins work and what they look like is crucial to finding new ways to treat disease," Dr Czabotar said. (medicalnewstoday.com)
  • Knowing the structure of these proteins and how they work in the cell is essential in designing new treatments to fight disease. (medicalnewstoday.com)
  • caspase
  • Irrespective of caspase activity, MOMP can lead to cell death by causing a progressive decline in mitochondrial function. (sciencemag.org)
  • As a consequence RIP1 forms a cytosolic complex with the adaptor molecule FADD and caspase 8, which leads to cell death. (wikipedia.org)
  • immune
  • It is considered a vital component of various processes of life including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy, embryonic development and chemical-induced cell death. (wikipedia.org)
  • The immune system consists of specialized cells that work together to fight off bacteria, fungi and viruses. (wikipedia.org)
  • Patients with RD have a genetic defect that affects the T cells and at least one other type of immune cell. (wikipedia.org)
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged bone marrow or defective immune system. (wikipedia.org)
  • Patients who suffer from RD will now have more stem cells that can differentiate into immune cells. (wikipedia.org)
  • Disease
  • Deregulation of cell death mechanisms in the skin can lead to diseases such as cancer, necrolysis and graft-versus-host disease. (springer.com)
  • According to data from the Centers for Disease Control and Prevention (CDC), lung cancer is the leading cause of cancer-related death in the United States. (medicalnewstoday.com)
  • This may be the result of the natural process of old cells dying and being replaced by new ones, or may result from such factors as disease, localized injury, or the death of the organism of which the cells are part. (wikipedia.org)
  • Dr. Strasser and colleagues were the first to discover that abnormalities in cell death can cause cancer and autoimmune disease, including the discovery that BCL-2 collaborates with the MYC oncogene in tumorigenesis. (sciencemag.org)
  • survival
  • Thymic selection is associated with extensive cell death, and only a very small proportion of thymocytes are selected for survival and export to the extrathymic environment. (springer.com)
  • It has got a critical role in controlling β-cell survival under endoplasmatic reticulum (ER) stress. (wikipedia.org)
  • cytosol
  • In case of dividing cells, cIAP1 is released into the cytosol early in mitosis, then reaccumulated in nucleus in late anaphase and in telophase. (wikipedia.org)
  • oncosis
  • Oncosis refers to a series of cellular reactions following injury that precedes cell death. (wikipedia.org)
  • First, the cell becomes committed to oncosis as a result of damage incurred to the plasma membrane through toxicity or ischemia, resulting in the leak of ions and water due to ATP depletion. (wikipedia.org)
  • The lack of ion transport at the cell membrane leads to an accumulation of sodium and chloride ions within the cell with a concurrent water influx, contributing to the hallmark cellular swelling of oncosis. (wikipedia.org)
  • therapies
  • Cell death based therapies Fri July 7, AM L. DAVID TOMEI LXR Biotechnologies, Inc Richard Heyman Ligand Pharmaceuticals, Inc. Luc Montagnier Departiment SIDA et Retrovirus Terri Finkel National Jewish Center Charles Alton Morgan Receptagen Corporation J-L Ameisen, Inst. (bio.net)
  • inhibitor
  • A collaboration between WEHI (including the Strasser group), Genentech, and AbbVie led to development of the BCL-2 inhibitor venetoclax, approved for treatment of refractory chronic lymphocytic leukemia, while a similar collaboration with Servier yielded the first potent and selective inhibitor of cell-death inhibitor MCL-1, currently in clinical trials. (sciencemag.org)
  • One such inhibitor is imatinib mesylate, which occupies the tyrosine kinase domain and inhibits BCR-ABL's influence on the cell cycle. (wikipedia.org)
  • 1995
  • First Gordon Conference on Cell Death Colby-Sawyer North, Lebanon NH July 2-7, 1995 The first Gordon Conference on Cell Death will take place in the pleasant New England town of Lebanon, New Hampshire over the period including the Fourth of July. (bio.net)
  • effector
  • Consistent with a role in negatively regulating CD8+ T cell responses, using an LCMV viral vector model of chronic infection, Rafi Ahmed's group showed that the PD-1-PD-L1 interaction inhibits activation, expansion and acquisition of effector functions of virus specific CD8+ T cells, which can be reversed by blocking the PD-1-PD-L1 interaction. (wikipedia.org)
  • pancreatic
  • UCL scientists have discovered that a vital self-destruct switch in cells is hijacked - making some pancreatic and non small cell lung cancers more aggressive, according to research published in Cancer Cell. (ucl.ac.uk)
  • melanoma
  • PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. (wikipedia.org)
  • membrane
  • The ionic imbalance that occurs subsequently causes the cell to swell without a concurrent change in membrane permeability to reverse the swelling. (wikipedia.org)
  • The lack of intracellular ATP results in a deactivation of sodium and potassium ATPase within the compromised cell membrane. (wikipedia.org)
  • It is when a cell has lost the integrity of its plasma membrane and/or has undergone complete disintegration, including its nucleus, and/or its fragments have been engulfed by a neighboring cell in vivo. (wikipedia.org)
  • murine
  • Liu, Y., B. Jones, W. Brady, and C.A. Janeway,Jr. Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. (springer.com)
  • tissues
  • By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental conditions of lung cancer cells in a manner that leads to their death. (drugs.com)
  • In addition, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions. (drugs.com)
  • One more rising problem is that Kendall Reyes Chargers Jersey , in addition to im pting the advancent and survival of aberrant cells, CR and mTOR inhibition may well also impt the stem mobile partnt and enrich maintenance or fix of tissues. (xobor.com)
  • This deterioration is due to the death of the muscle cells and muscle tissues and leads to ongoing muscle wasting and muscle weakness. (blogspot.com)
  • nuclear
  • It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
  • When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
  • leads
  • This leads to poor oxygen supply or cerebral hypoxia and thus to the death of brain tissue or cerebral infarction / ischemic stroke. (wikipedia.org)
  • risk
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Focal brain ischemia reduces blood flow to a specific brain region, increasing the risk of cell death to that particular area. (wikipedia.org)
  • Includes
  • In addition to the 1889 buildings, the prison complex includes a wing of 1923 cell blocks (blocks C, D, E, and F), a separate additive service building, a 1938 school, and a 1955 cell block extension. (wikipedia.org)
  • phone
  • Results for this survey are based on telephone interviews conducted March 29-April 1, 2012, among a national sample of 1,000 adults 18 years of age or older living in the continental United States (599 respondents were interviewed on a landline telephone, and 401 were interviewed on a cell phone, including 180 who had no landline telephone). (people-press.org)
  • Interviews in the cell sample were conducted with the person who answered the phone, if that person was an adult 18 years of age or older. (people-press.org)
  • The combined landline and cell phone sample are weighted using an iterative technique that matches gender, age, education, race, Hispanic origin and region to parameters from the March 2011 Census Bureau's Current Population Survey and population density to parameters from the Decennial Census. (people-press.org)
  • He is known to live a simple life, possessing no telephone or cell phone of his own, and occasionally visiting bars in the Cass Corridor section of Detroit near Woodbridge and Midtown Detroit, such as the Old Miami pub, where he has performed live concerts for small local crowds. (wikipedia.org)
  • growth
  • The arteriosa of flush of sur ptomains receives a soft attention from the writers that in some nurses the steps of the lessons disappear very with the advice of threatening growth filariae of condition, of tadalafil generic price breakfast, etc. these growths graduated swollen factors of ameri feature attention, who became distinguished as membranes and learned in death, structure and a limited lacteal in zoology. (hughesanderson.com)
  • It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. (wikipedia.org)
  • heart
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts. (wikipedia.org)
  • rate
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • woman
  • Eight medical organizations and a bioethics journal recognize the independent link - that abortion leaves a woman with more cancer-vulnerable cells than she had before she became pregnant. (pfli.org)
  • small
  • Care should be taken when interpreting cells with small numbers. (abs.gov.au)
  • Connected to the Rotunda is the one-story rectangular Cell Block B, which has arched windows along the sides and is five small cupolas used as air vents along the top. (wikipedia.org)
  • level
  • At the level of the cell, Daxx is found in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the nucleus, where it is interacting with some subnuclear structures. (wikipedia.org)
  • development
  • The leader of a Hydra cell within S.H.I.E.L.D., he masterminds Project Insight, the development of Helicarriers intended to carry out mass assassinations of citizens recognized as a threat based on Arnim Zola's algorithm to force the world into submission. (wikipedia.org)
  • It is also essential for development of nerval system by programmed cell death. (wikipedia.org)
  • break
  • At the time of his execution, he barricaded himself in his cell, so they had to break down the door with a battering ram to lead him to the place of execution. (wikipedia.org)
  • group
  • Those under the age of five are most often affected and in this group it results in about 50,000 deaths in the developing world. (wikipedia.org)