• cyclin
  • Cell cycle progression is regulated by the cyclic rise and fall of kinase expression, and their interaction with, and action on, their cyclin targets. (qiagen.com)
  • Key genes that regulate cell cycle progression and checkpoints encode cullins, cyclins, and cyclin-dependent kinases and their inhibitors. (qiagen.com)
  • Cyclin dependent kinases: Cdks) promote cell division by phosphorylating and reversibly inactivating Rb by a hierarchical series of phosphorylation events and sequential conformational changes. (wustl.edu)
  • apoptosis
  • Other cell cycle regulatory genes include apoptosis regulators and DNA damage sensors. (qiagen.com)
  • The retinoblastoma protein: Rb) inhibits both cell division and apoptosis, but the mechanism by which Rb alternatively regulates these divergent outcomes remains poorly understood. (wustl.edu)
  • The stress-regulated mitogen activated protein kinase: MAPK) p38 also phosphorylates Rb, but it does so in a cell cycle-independent manner that is associated with apoptosis rather than with cell division. (wustl.edu)
  • These findings provide a mechanistic explanation for how Rb regulates cell division and apoptosis through different kinases, and reveal how Hdm2 may functionally link the tumor suppressors Rb and p53. (wustl.edu)
  • normally
  • At sea level normally menstruating women show increased ventilation (V̇ e ) and hemodynamic changes due to increased progesterone (P) and estrogen (E2) levels during the mid-luteal (L) compared to the mid-follicular (F) phase of the ovarian cycle. (biologists.org)
  • Methods
  • Practical and comprehensive, Cell Cycle Synchronization: Methods and Protocols, Second Edition is a valuable resource for PhD students and postdoctoral fellows, and researchers interested in general science, pharmacy, medicine and public health, computer science, and life sciences. (springer.com)
  • interaction
  • Phosphorylation by p38, but not Cdks, triggers an interaction between Rb and the human homologue of murine double minute 2: Hdm2), leading to degradation of Rb, release of E2F1 and cell death. (wustl.edu)
  • Measures
  • Using a repeated-measures design on a large study sample, our purpose was to determine whether ovarian cycle-phase affects maximal exercise performance (V̇ O 2 max ) in women who had lived at an altitude of 3600 m since birth or early childhood. (biologists.org)
  • provides
  • This second edition volume provides detailed protocols on the theoretical background of cell cycle synchronization procedures and instructions on how to implement these techniques. (springer.com)