• Efficacy
  • The lower efficacy is believed to be the result of the vaccine preventing only 3 of the 4 serotypes. (cellculturedish.com)
  • The main differences are in release specifications for measuring vaccine lots' safety, efficacy, and quality, mostly due to differences between U.S. and European regulatory standards and tests. (wikipedia.org)
  • Age-related decline in immunological competence, often referred to as immune senescence, is associated with an increased incidence of cancer, infections, and a reduced efficacy of vaccines ( 1 ). (frontiersin.org)
  • Infection
  • During her tenure, Chiron's clinical program included testing of a recombinantly produced HSV gD2/gB2 vaccine with MF59 adjuvant for the amelioration of established genital herpes infection and the prevention of genital herpes in high-risk adults, and the first influenza vaccine combined with the MF59 adjuvant that was licensed intially in Europe and South America and just recently also in the US. (stanford.edu)
  • Detailed cluster analysis of the memory CD8 + T cell development showed that high-dose infection causes a differentiation pathway that progresses faster throughout the life span of the host, suggesting a virus-host balance that is influenced by aging and infectious dose. (frontiersin.org)
  • However, following long-term CMV infection the strength of the CD8 + T cell immunity to LCMV superinfection was affected by the initial CMV infectious dose, wherein a high infectious dose was found to be a prerequisite for impaired heterologous immunity. (frontiersin.org)
  • vitro
  • Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in vitro , there have been few studies on the action of allopurinol on T cells. (frontiersin.org)
  • We have previously demonstrated that the replacement of the S gene from an avirulent strain (Beaudette) of infectious bronchitis virus (IBV) with an S gene from a virulent strain (M41) resulted in a recombinant virus (BeauR-M41(S)) with the in vitro cell tropism of the virulent virus but that was still avirulent. (jove.com)
  • This in vitro culturing system allows the study of viral replication and will facilitate the molecular dissection of important aspects of the MCPyV lifecycle. (jove.com)
  • strain
  • BACKGROUND: The use of cell-culture technologies for the manufacture of influenza vaccines might contribute to improved strain selection and robust vaccine supplies. (flu.org.cn)
  • Analysis of the chimaeric virus showed that it was avirulent indicating that none of the structural or accessory genes derived from a virulent isolate of IBV were able to restore virulence and that therefore, the loss of virulence associated with the Beaudette strain resides in the replicase gene. (jove.com)
  • Several reverse genetics systems for the RVFV MP-12 vaccine strain 2,3 as well as wild-type RVFV strains 4-6 , including ZH548 and ZH501, have been developed since 2006. (jove.com)
  • proteins
  • Another aspect of the invention provides for the alteration of cleavage sites in virus proteins to thereby render them more susceptible to activation in culture. (patentgenius.com)
  • The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. (patents.com)
  • Briefly, this procedure first separates the nuclei from the cell and then extracts soluble nuclear proteins (here termed the "nucleoplasmic" fraction). (jove.com)
  • 1999
  • Dr. Dekker joined the Stanford University School of Medicine faculty in the Division of Pediatric Infectious Diseases and was named Medical Director of the Stanford-LPCH Vaccine Program in 1999. (stanford.edu)
  • antigens
  • It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. (flu.org.cn)
  • Allopurinol markedly decreased the frequency of IFN-γ and IL-2-producing T cells, either after polyclonal or antigen-specific stimulation with Herpes Simplex virus 1, Influenza (Flu) virus, tetanus toxoid and Trypanosoma cruzi -derived antigens. (frontiersin.org)
  • immunization
  • She has served as the Stanford PI on NIH-sponsored Vaccine and Treatment Evaluation Unit subcontracts to study new vaccine candidates and on a CDC-sponsored Clinical Immunization Safety Assessment Center contract evaluating safety of licensed vaccines. (stanford.edu)
  • immune
  • In addition to its essential role in innate immunity, type-I IFN is important for the maturation of dendritic cells and the induction of an adaptive immune response 12-14 . (jove.com)
  • She leads the Stanford Clinical Core for NIH-sponsored studies looking at the detailed immune responses to influenza vaccines in children compared with young and elderly adults that has expanded to investigate genetic factors by also studying responses of identical and fraternal twins. (stanford.edu)
  • Altogether our results underscore the importance of stratification based on the size and differentiation of the CMV-specific memory T cell pools for the impact on immune senescence, and indicate that reduction of the latent/lytic viral load can be beneficial to diminish CMV-associated immune senescence. (frontiersin.org)
  • doses
  • In the Reuters Narcolepsy article, it states that GSK administered 30 million doses of the Pandermix vaccine and 800 developed narcolepsy, mostly children. (cellculturedish.com)
  • genetic
  • Before genetic engineering opened a Pandora's Box, this vaccine "was an uncontrolled experiment in interspecies viral transmission. (wordpress.com)
  • The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
  • Phenotypic
  • We show in experimental mouse models that the degree of mouse CMV (MCMV)-specific memory CD8 + T cell accumulation and the phenotypic T cell profile are directly influenced by the infectious dose, and data on HCMV-specific T cells indicate a similar connection. (frontiersin.org)
  • mutations
  • All integrated viral genomes recovered from MCC tissue or MCC cell lines harbor signature mutations in the early gene transcript encoding for the large T-Antigen (LT-Ag). (jove.com)
  • These mutations selectively abrogate the ability of LT-Ag to support viral replication while still maintaining its Rb-binding activity, suggesting a continuous requirement for LT-Ag mediated cell cycle deregulation during MCC pathogenesis. (jove.com)
  • human
  • In the current study, we have assessed the effect of allopurinol on antigen-specific and mitogen-driven activation and cytokine production in human T cells. (frontiersin.org)
  • The diminished T cell activation and cytokine production in the presence of allopurinol support a direct action of allopurinol on human T cells, offering a potential pharmacological tool for the management of cell-mediated inflammatory diseases. (frontiersin.org)
  • exposure
  • JE vaccine is recommended for travelers who plan to spend a month or longer in endemic areas during the JEV transmission season and for laboratory workers with a potential for exposure to infectious JEV. (cdc.gov)
  • 1992
  • An inactivated mouse brain--derived JE vaccine (JE-VAX [JE-MB]) has been licensed since 1992 to prevent JE in persons aged ≥1 year traveling to JE-endemic countries. (cdc.gov)
  • safety
  • Please NOTE: As of August 1, 2009, no long-term, independent safety trial studies have been done for any of the different and new flu vaccines that are supposed to be given/forced on all Americans -whether we want them or not. (wordpress.com)
  • Dr. Dekker's expertise in vaccines has been tapped by NIH to serve on several vaccine safety and data monitoring boards, and she currently is Chair of the HIV Vaccine Trial Network Safety Monitoring Board. (stanford.edu)
  • children
  • 12,000 children ages 3-12, will be guinea pigs for these flu vaccines. (wordpress.com)
  • To possibly rig the results, the children will be getting injections of different vaccines than will be delivered to the rest of the population this Fall. (wordpress.com)
  • JE-MB is the only JE vaccine available for use in children aged 1−16 years, and remaining supplies will be reserved for use in this group. (cdc.gov)
  • infections
  • Since there is currently no treatment for Dengue Fever and WHO estimates 50-100 million infections each year, finding a vaccine is critical. (cellculturedish.com)
  • Burnet "Influenza Virus Infections Of The Chick Embryo By The Amniotic Route", Austr. (patentgenius.com)
  • Compared to other infections, extraordinary high memory T cell frequencies, on average ~10% of the total memory T cell compartment, are noticed in peripheral blood of healthy individuals ( 3 ). (frontiersin.org)
  • development
  • Dr. Cornelia Dekker is a Pediatric Infectious Diseases physician who came to Stanford after a 12-year career in vaccine clinical development at Lederle Biologicals and Chiron Vaccines where she served as Vice President, Clinical Research and Medical Affairs. (stanford.edu)
  • Efforts by a number of influenza research groups have been pivotal in the development and improvement of influenza A virus reverse genetics. (jove.com)